JP6368383B2 - 鉱質コルチコイド受容体修飾因子としてのベンゾオキサジノンアミド - Google Patents

鉱質コルチコイド受容体修飾因子としてのベンゾオキサジノンアミド Download PDF

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Publication number
JP6368383B2
JP6368383B2 JP2016575499A JP2016575499A JP6368383B2 JP 6368383 B2 JP6368383 B2 JP 6368383B2 JP 2016575499 A JP2016575499 A JP 2016575499A JP 2016575499 A JP2016575499 A JP 2016575499A JP 6368383 B2 JP6368383 B2 JP 6368383B2
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dihydro
benzoxazin
oxo
carbonyl
mmol
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Japanese (ja)
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JP2017522300A5 (enExample
JP2017522300A (ja
Inventor
ギャビン・オマホニー
ミーケル・コッセンヤンス
カール・エドマン
ヨハン・カヤヌス
カール・アンデシュ・ホグナー
フィリップ・コーンウォール
アンドリュー・ターナー
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AstraZeneca AB
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AstraZeneca AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP2016575499A 2014-06-30 2015-06-26 鉱質コルチコイド受容体修飾因子としてのベンゾオキサジノンアミド Active JP6368383B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462018790P 2014-06-30 2014-06-30
US62/018,790 2014-06-30
PCT/GB2015/051860 WO2016001631A1 (en) 2014-06-30 2015-06-26 Benzoxazinone amides as mineralocorticoid receptor modulators

Publications (3)

Publication Number Publication Date
JP2017522300A JP2017522300A (ja) 2017-08-10
JP2017522300A5 JP2017522300A5 (enExample) 2018-07-19
JP6368383B2 true JP6368383B2 (ja) 2018-08-01

Family

ID=53539739

Family Applications (1)

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JP2016575499A Active JP6368383B2 (ja) 2014-06-30 2015-06-26 鉱質コルチコイド受容体修飾因子としてのベンゾオキサジノンアミド

Country Status (26)

Country Link
US (2) US10017502B2 (enExample)
EP (1) EP3160948B1 (enExample)
JP (1) JP6368383B2 (enExample)
KR (1) KR102012222B1 (enExample)
CN (1) CN106536491B (enExample)
AR (1) AR101036A1 (enExample)
AU (1) AU2015282450C1 (enExample)
CA (1) CA2953655C (enExample)
CY (1) CY1121596T1 (enExample)
DK (1) DK3160948T3 (enExample)
EA (1) EA029518B1 (enExample)
ES (1) ES2707726T3 (enExample)
HR (1) HRP20190147T1 (enExample)
HU (1) HUE042370T2 (enExample)
LT (1) LT3160948T (enExample)
ME (1) ME03316B (enExample)
MX (1) MX367404B (enExample)
PL (1) PL3160948T3 (enExample)
PT (1) PT3160948T (enExample)
RS (1) RS58274B1 (enExample)
SI (1) SI3160948T1 (enExample)
SM (1) SMT201900039T1 (enExample)
TR (1) TR201900659T4 (enExample)
TW (1) TWI677498B (enExample)
UY (1) UY36195A (enExample)
WO (1) WO2016001631A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR201900659T4 (tr) * 2014-06-30 2019-02-21 Astrazeneca Ab Mineralokortikoid reseptör modülatörleri olarak benzoksazinon amidleri.
MY210508A (en) 2018-07-19 2025-09-28 Astrazeneca Ab Methods of treating hfpef employing dapagliflozin and compositions comprising the same
CN112107568B (zh) * 2019-06-19 2022-03-25 北京龙嘉博创医药科技有限公司 二芳基酰胺类化合物及其应用
PE20211267A1 (es) * 2019-08-30 2021-07-19 Astrazeneca Ab Metodos de tratamiento de la insuficiencia cardiaca con fraccion de eyeccion reducida con dapagliflozina
EP4188389B1 (en) 2020-07-27 2025-09-17 AstraZeneca AB Dapagliflozin for use in methods of treating chronic kidney disease
US12409186B2 (en) 2020-07-27 2025-09-09 Astrazeneca Ab Methods of treating chronic kidney disease with dapagliflozin
EP4357336A4 (en) * 2021-06-15 2025-07-02 Chia Tai Tianqing Pharmaceutical Group Co Ltd BENZOXAZINONE DERIVATIVES
TW202409023A (zh) 2022-07-14 2024-03-01 美商富曼西公司 除草苯并𠯤
JP2025527854A (ja) 2022-09-01 2025-08-22 アストラゼネカ・アクチエボラーグ 心腎疾患の治療に使用するためのｓｇｌｔ２阻害剤と鉱質コルチコイド受容体調節剤との組み合わせ
CN120344508A (zh) * 2022-12-15 2025-07-18 正大天晴药业集团股份有限公司 苯并恶嗪酮类化合物的结晶及其制备
WO2025111184A1 (en) 2023-11-21 2025-05-30 Fmc Corporation Substituted tetrahydroquinoline and tetrahydroquinoxaline herbicides

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US6951855B2 (en) * 2001-04-23 2005-10-04 Astrazeneca Ab Benzoxazinone derivatives for use in the treatment of angiogenesis
BR0317572A (pt) * 2002-12-20 2005-11-22 Warner Lambert Co Benzoxazinas e seus derivados como inibidores de pi3ks
WO2006019716A1 (en) * 2004-07-14 2006-02-23 Ligand Pharmaceuticals, Inc. Intracellular receptor modulator compounds and methods
BRPI0512674A (pt) * 2004-07-28 2007-09-25 Irm Llc compostos e composições como moduladores de receptores nucleares de hormÈnio esteróide
WO2007077961A2 (en) 2005-12-28 2007-07-12 Takeda Pharmaceutical Company Limited Fused heterocyclic compounds and their use as mineralocorticoid receptor ligands
TWI385161B (zh) 2006-02-02 2013-02-11 Mitsubishi Tanabe Pharma Corp 含氮雜雙環化合物
BRPI0717937A2 (pt) 2006-10-31 2013-12-03 Pfizer Prod Inc Compostos de pirazona como antagonistas do receptor mineralocorticóide
DE102007009494A1 (de) 2007-02-27 2008-08-28 Bayer Healthcare Ag Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung
WO2008118319A2 (en) 2007-03-23 2008-10-02 Merck & Co., Inc. Mineralocorticoid receptor modulators
DK2133330T3 (da) 2007-04-09 2014-03-31 Daiichi Sankyo Co Ltd Atropisomer af pyrrolderivat
US8258131B2 (en) 2007-08-01 2012-09-04 Mitsubishi Tanabe Pharma Corporation Fused bicyclic compound
JP5173653B2 (ja) * 2007-08-01 2013-04-03 田辺三菱製薬株式会社 医薬組成物
PE20091057A1 (es) 2007-12-19 2009-07-20 Lilly Co Eli Antagonistas del receptor mineralcorticoide y metodos de uso
KR20110017456A (ko) * 2008-06-18 2011-02-21 아스트라제네카 아베 호흡기 장애의 치료를 위한 베타2-아드레날린성 수용체 효능제로서 작용하는 벤족사지논 유도체
US20100094000A1 (en) 2008-09-03 2010-04-15 Takeda Pharmaceutical Company Limited Pyrazole compounds
WO2010098286A1 (ja) 2009-02-25 2010-09-02 第一三共株式会社 ミネラルコルチコイド受容体拮抗薬を含有する医薬
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TR201900659T4 (tr) * 2014-06-30 2019-02-21 Astrazeneca Ab Mineralokortikoid reseptör modülatörleri olarak benzoksazinon amidleri.

Also Published As

Publication number Publication date
EA201790046A1 (ru) 2017-08-31
US20170217945A1 (en) 2017-08-03
CY1121596T1 (el) 2020-05-29
TWI677498B (zh) 2019-11-21
EP3160948B1 (en) 2018-10-24
CN106536491A (zh) 2017-03-22
KR20170021883A (ko) 2017-02-28
CN106536491B (zh) 2018-12-18
TR201900659T4 (tr) 2019-02-21
DK3160948T3 (en) 2019-02-18
SI3160948T1 (sl) 2020-06-30
HRP20190147T1 (hr) 2019-03-22
US20150376170A1 (en) 2015-12-31
JP2017522300A (ja) 2017-08-10
EA029518B1 (ru) 2018-04-30
ME03316B (me) 2019-10-20
AU2015282450C1 (en) 2018-09-20
PT3160948T (pt) 2019-02-01
EP3160948A1 (en) 2017-05-03
AU2015282450B2 (en) 2018-05-10
AU2015282450A1 (en) 2017-02-02
MX367404B (es) 2019-08-20
CA2953655A1 (en) 2016-01-07
TW201613909A (en) 2016-04-16
AR101036A1 (es) 2016-11-16
ES2707726T3 (es) 2019-04-04
LT3160948T (lt) 2019-02-11
RS58274B1 (sr) 2019-03-29
PL3160948T3 (pl) 2019-04-30
MX2017000183A (es) 2017-04-25
KR102012222B1 (ko) 2019-10-21
US9394291B2 (en) 2016-07-19
UY36195A (es) 2016-01-08
US10017502B2 (en) 2018-07-10
WO2016001631A1 (en) 2016-01-07
SMT201900039T1 (it) 2019-02-28
CA2953655C (en) 2020-05-12
HUE042370T2 (hu) 2019-06-28

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