EA029518B1 - Бензоксазиноновые амиды в качестве модуляторов минералокортикоидного рецептора - Google Patents
Бензоксазиноновые амиды в качестве модуляторов минералокортикоидного рецептора Download PDFInfo
- Publication number
- EA029518B1 EA029518B1 EA201790046A EA201790046A EA029518B1 EA 029518 B1 EA029518 B1 EA 029518B1 EA 201790046 A EA201790046 A EA 201790046A EA 201790046 A EA201790046 A EA 201790046A EA 029518 B1 EA029518 B1 EA 029518B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- dihydro
- benzoxazin
- oxo
- carbonyl
- mmol
- Prior art date
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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Applications Claiming Priority (2)
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| US201462018790P | 2014-06-30 | 2014-06-30 | |
| PCT/GB2015/051860 WO2016001631A1 (en) | 2014-06-30 | 2015-06-26 | Benzoxazinone amides as mineralocorticoid receptor modulators |
Publications (2)
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| EA201790046A1 EA201790046A1 (ru) | 2017-08-31 |
| EA029518B1 true EA029518B1 (ru) | 2018-04-30 |
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Family Applications (1)
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| EA201790046A EA029518B1 (ru) | 2014-06-30 | 2015-06-26 | Бензоксазиноновые амиды в качестве модуляторов минералокортикоидного рецептора |
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| SM (1) | SMT201900039T1 (enExample) |
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| WO (1) | WO2016001631A1 (enExample) |
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| CA2953655C (en) * | 2014-06-30 | 2020-05-12 | Astrazeneca Ab | Benzoxazinone amides as mineralocorticoid receptor modulators |
| SG11202100417RA (en) | 2018-07-19 | 2021-02-25 | Astrazeneca Ab | Methods of treating hfpef employing dapagliflozin and compositions comprising the same |
| CN112107568B (zh) * | 2019-06-19 | 2022-03-25 | 北京龙嘉博创医药科技有限公司 | 二芳基酰胺类化合物及其应用 |
| MX2020005388A (es) | 2019-08-30 | 2022-10-25 | Astrazeneca Ab | Uso de composiciones farmacéuticas que comprenden dapagliflozina e inhibidores de sglt2. |
| TW202220672A (zh) | 2020-07-27 | 2022-06-01 | 瑞典商阿斯特捷利康公司 | 用達格列淨治療慢性腎臟病之方法 |
| TWI808786B (zh) * | 2021-06-15 | 2023-07-11 | 大陸商正大天晴藥業集團股份有限公司 | 酮類衍生物 |
| TW202409023A (zh) | 2022-07-14 | 2024-03-01 | 美商富曼西公司 | 除草苯并𠯤 |
| CR20250276A (es) | 2022-09-01 | 2025-09-04 | Astrazeneca Ab | Combinación de inhibidores de sglt2 y moduladores del receptor mineralcorticoide para usar en el tratamiento de enfermedades cardiorrenales (divisional 2025-0112) |
| WO2024125591A1 (zh) * | 2022-12-15 | 2024-06-20 | 正大天晴药业集团股份有限公司 | 苯并恶嗪酮类化合物的结晶及其制备 |
| WO2025111184A1 (en) | 2023-11-21 | 2025-05-30 | Fmc Corporation | Substituted tetrahydroquinoline and tetrahydroquinoxaline herbicides |
Citations (1)
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| WO2006015259A2 (en) * | 2004-07-28 | 2006-02-09 | Irm Llc | Compounds and compositions as modulators of steroid hormone nuclear receptors |
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| WO2002085868A1 (en) * | 2001-04-23 | 2002-10-31 | Astrazeneca Ab | Benzoxazinone derivatives for use in the treatment of angiogenesis |
| WO2004056820A1 (en) * | 2002-12-20 | 2004-07-08 | Warner-Lambert Company Llc | Benzoxazines and derivatives thereof as inhibitors of pi3ks |
| JP2008506689A (ja) * | 2004-07-14 | 2008-03-06 | リガンド・ファーマシューティカルズ・インコーポレイテッド | 細胞間受容体のモジュレーター化合物および方法 |
| AR056893A1 (es) | 2005-12-28 | 2007-10-31 | Takeda Pharmaceutical | Compuestos heterociclicos fusionados y no fusionados, antagonistas de receptores mineralocorticoides |
| TWI385161B (zh) | 2006-02-02 | 2013-02-11 | Mitsubishi Tanabe Pharma Corp | 含氮雜雙環化合物 |
| WO2008053300A1 (en) | 2006-10-31 | 2008-05-08 | Pfizer Products Inc. | Pyrazoline compounds as mineralocorticoid receptor antagonists |
| DE102007009494A1 (de) | 2007-02-27 | 2008-08-28 | Bayer Healthcare Ag | Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung |
| JP2010522168A (ja) | 2007-03-23 | 2010-07-01 | メルク・シャープ・エンド・ドーム・コーポレイション | 鉱質コルチコイドレセプターモジュレータ |
| BRPI0809656B8 (pt) | 2007-04-09 | 2021-05-25 | Daiichi Sankyo Co Ltd | atropisômero, composto, agente profilático ou terapêutico, e, composição farmacêutica |
| JP5173653B2 (ja) * | 2007-08-01 | 2013-04-03 | 田辺三菱製薬株式会社 | 医薬組成物 |
| US8258131B2 (en) | 2007-08-01 | 2012-09-04 | Mitsubishi Tanabe Pharma Corporation | Fused bicyclic compound |
| PE20091057A1 (es) | 2007-12-19 | 2009-07-20 | Lilly Co Eli | Antagonistas del receptor mineralcorticoide y metodos de uso |
| WO2009154557A1 (en) * | 2008-06-18 | 2009-12-23 | Astrazeneca Ab | Benzoxazinone derivatives acting as beta2-adrenoreceptor agonist for the treatment of respiratory disorders |
| US20100094000A1 (en) | 2008-09-03 | 2010-04-15 | Takeda Pharmaceutical Company Limited | Pyrazole compounds |
| WO2010098286A1 (ja) | 2009-02-25 | 2010-09-02 | 第一三共株式会社 | ミネラルコルチコイド受容体拮抗薬を含有する医薬 |
| KR101312179B1 (ko) | 2009-03-12 | 2013-09-26 | 일라이 릴리 앤드 캄파니 | 미네랄로코르티코이드 수용체 길항제 및 사용 방법 |
| WO2010116282A1 (en) | 2009-04-10 | 2010-10-14 | Pfizer Inc. | 4, 5-dihydro-lh-pyrazole compounds and their pharmaceutical uses |
| EP2569576B1 (en) | 2010-05-11 | 2016-07-06 | Koninklijke Philips N.V. | Lighting module |
| CA2798831A1 (en) | 2010-05-11 | 2011-11-17 | Pfizer Inc. | Morpholine compounds as mineralocorticoid receptor antagonists |
| JPWO2012008435A1 (ja) | 2010-07-13 | 2013-09-09 | 大日本住友製薬株式会社 | ビアリールアミド誘導体またはその薬理学的に許容される塩 |
| EP2638012A1 (en) | 2010-11-10 | 2013-09-18 | Boehringer Ingelheim International GmbH | Pyridyl ureas as mineralocorticoid receptor antagonists |
| CA2953655C (en) * | 2014-06-30 | 2020-05-12 | Astrazeneca Ab | Benzoxazinone amides as mineralocorticoid receptor modulators |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006015259A2 (en) * | 2004-07-28 | 2006-02-09 | Irm Llc | Compounds and compositions as modulators of steroid hormone nuclear receptors |
Non-Patent Citations (1)
| Title |
|---|
| HASUI TOMOAKI; OHRA TAIICHI; OHYABU NORIO; ASANO KOUHEI; MATSUI HIDEKI; MIZUKAMI ATSUSHI; HABUKA NORIYUKI; SOGABE SATOSHI; ENDO SA: "Design, synthesis, and structure–activity relationships of dihydrofuran-2-one and dihydropyrrol-2-one derivatives as novel benzoxazin-3-one-based mineralocorticoid receptor antagon", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 21, no. 19, 1 January 1900 (1900-01-01), GB, pages 5983 - 5994, XP028706278, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2013.07.043 * |
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