PE20091057A1 - Antagonistas del receptor mineralcorticoide y metodos de uso - Google Patents

Antagonistas del receptor mineralcorticoide y metodos de uso

Info

Publication number
PE20091057A1
PE20091057A1 PE2008002008A PE2008002008A PE20091057A1 PE 20091057 A1 PE20091057 A1 PE 20091057A1 PE 2008002008 A PE2008002008 A PE 2008002008A PE 2008002008 A PE2008002008 A PE 2008002008A PE 20091057 A1 PE20091057 A1 PE 20091057A1
Authority
PE
Peru
Prior art keywords
oxepin
iliden
dibenzo
methyl
mineralcorticoid receptor
Prior art date
Application number
PE2008002008A
Other languages
English (en)
Inventor
Konstantinos Gavardinas
Prabhakar Kondaji Jadhav
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40430143&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20091057(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE20091057A1 publication Critical patent/PE20091057A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE DIBENZO[b,e]OXEPIN DE FORMULA (I) DONDE R1 Y R2 SON CADA UNO H O F; L ES -(CH2)2-, -CH(CH3)-CH2- O UN ENLACE DIRECTO; R3 ES UN COMPUESTO DE FORMULA (i), (ii), (iii), ENTRE OTROS; R4 ES CN O -C(O)NH2. SON COMPUESTOS PREFERIDOS: (E)-N-(5-((E)-3-FLUORO-6H-DIBENZO[b,e]OXEPIN-11-ILIDENMETIL)-1-(1-METIL-AZETIDIN-3-IL)-1,3-DIHIDRO-BENZOIMIDAZOL-2-ILIDEN)-CIANAMIDA, (E)-N-(5-((E)-(3-FLUORODIBENZO[b,e]OXEPIN-11(6H)-ILIDEN)METIL)-1-((3S,4S)-4-HIDROXI-1-METILPIRROLIDIN-3-IL)-1H-BENZO[d]IMIDAZOL-2(3H)-ILIDEN)CIANAMIDA, (E)-N-[5-((E)-3-FLUORO-6H-DIBENZO[b,e]OXEPIN-11-ILIDENMETIL)-1-((3S,4S)-4-HIDROXI-1-METIL-PIRROLIDIN-3-IL)-1,3-DIHIDRO-BENZOIMIDAZOL-2-ILIDEN]-UREA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR MINERALCORTICOIDE SIENDO UTILES EN EL TRATAMIENTO DE NEFROPATIA DIABETICA, ENFERMEDAD RENAL CRONICA, ARRITMIA MIOCARDIAL, HIPERALDOSTERONISMO
PE2008002008A 2007-12-19 2008-12-02 Antagonistas del receptor mineralcorticoide y metodos de uso PE20091057A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1477607P 2007-12-19 2007-12-19

Publications (1)

Publication Number Publication Date
PE20091057A1 true PE20091057A1 (es) 2009-07-20

Family

ID=40430143

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008002008A PE20091057A1 (es) 2007-12-19 2008-12-02 Antagonistas del receptor mineralcorticoide y metodos de uso

Country Status (34)

Country Link
US (1) US7994164B2 (es)
EP (2) EP2537845B1 (es)
JP (1) JP5562866B2 (es)
KR (1) KR101254382B1 (es)
CN (1) CN101903377B (es)
AR (1) AR069554A1 (es)
AU (1) AU2008343524B2 (es)
BR (1) BRPI0820805A2 (es)
CA (1) CA2710409C (es)
CL (1) CL2008003600A1 (es)
CO (1) CO6300953A2 (es)
DK (1) DK2235007T3 (es)
DO (1) DOP2010000185A (es)
EA (1) EA017668B1 (es)
EC (2) ECSP10010266A (es)
ES (2) ES2459318T3 (es)
GT (1) GT201000179A (es)
HK (1) HK1144284A1 (es)
HR (1) HRP20120916T1 (es)
IL (1) IL206353A (es)
MA (1) MA31910B1 (es)
MX (1) MX2010006911A (es)
MY (1) MY150474A (es)
NZ (1) NZ586300A (es)
PE (1) PE20091057A1 (es)
PL (1) PL2235007T3 (es)
PT (1) PT2235007E (es)
RS (1) RS52594B (es)
SI (1) SI2235007T1 (es)
TN (1) TN2010000292A1 (es)
TW (1) TWI431010B (es)
UA (1) UA100131C2 (es)
WO (1) WO2009085584A1 (es)
ZA (1) ZA201004257B (es)

Families Citing this family (15)

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Publication number Priority date Publication date Assignee Title
JP2010535156A (ja) 2007-08-03 2010-11-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ウイルスポリメラーゼ阻害剤
KR20100098534A (ko) 2007-12-19 2010-09-07 베링거 인겔하임 인터내셔날 게엠베하 바이러스 폴리머라제 억제제
KR101312179B1 (ko) * 2009-03-12 2013-09-26 일라이 릴리 앤드 캄파니 미네랄로코르티코이드 수용체 길항제 및 사용 방법
US8957052B2 (en) 2010-05-10 2015-02-17 Universite Paris Descartes Methods and compositions for the treatment of fluid accumulation in and/or under the retina
WO2011157798A1 (en) 2010-06-16 2011-12-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for stimulating reepithelialisation during wound healing
CN102060670A (zh) * 2011-01-04 2011-05-18 常州大学 一种2-溴-6-氟苯甲醇的制备方法
MD20150103A2 (ro) 2013-05-02 2016-02-29 Pfizer Inc. Derivaţi ai imidazo-triazinei ca inhibitori ai PDE10
AR099416A1 (es) 2014-02-28 2016-07-20 Lilly Co Eli Terapia combinada para la hipertensión resistente
WO2016001631A1 (en) 2014-06-30 2016-01-07 Astrazeneca Ab Benzoxazinone amides as mineralocorticoid receptor modulators
EA201790868A1 (ru) * 2014-11-21 2017-10-31 Эли Лилли Энд Компани 1,2-бензотиазольные соединения для лечения почечного расстройства
EP3362095B1 (en) 2015-10-13 2020-11-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of choroidal neovascularisation
WO2018019843A1 (en) 2016-07-26 2018-02-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Antagonist of mineralocorticoid receptor for the treatment of osteoarthritis
MX2019003339A (es) * 2016-09-24 2019-06-03 Kbp Biosciences Co Ltd Composicion farmaceutica con antagonista del receptor de mineralocorticoides y su uso.
US20230151425A1 (en) 2020-03-11 2023-05-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of determining whether a subject has or is at risk of having a central serous chorioretinopathy
WO2023031277A1 (en) 2021-08-31 2023-03-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of ocular rosacea

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US4072756A (en) * 1973-05-17 1978-02-07 Sandoz Ltd. Tricyclo piperidino ketones and soporific compositions thereof
SE426341C (sv) * 1980-02-14 1985-09-23 Fagersta Ab Sett att forhindra korrosion i en forbrenningsanleggnings kylare och skorsten vid kylning av rokgaser
DE3730258A1 (de) * 1986-09-10 1988-04-07 Canon Kk Elektrophotographisches lichtempfindliches aufzeichnungsmaterial, 5h-dibenzo(a,d)cycloheptanylidenderivat, 5h-dibenzo(a,d)cycloheptenylidenderivat und verfahren zu ihrer herstellung
CA1338625C (en) * 1988-06-09 1996-10-01 Kyowa Hakko Kogyo Co., Ltd. Tricyclic compounds
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KR101312179B1 (ko) 2009-03-12 2013-09-26 일라이 릴리 앤드 캄파니 미네랄로코르티코이드 수용체 길항제 및 사용 방법

Also Published As

Publication number Publication date
EA201070762A1 (ru) 2010-12-30
EP2537845A1 (en) 2012-12-26
ECSP12012048A (es) 2012-08-31
EA017668B1 (ru) 2013-02-28
NZ586300A (en) 2012-06-29
CN101903377B (zh) 2014-07-09
TW200930721A (en) 2009-07-16
US7994164B2 (en) 2011-08-09
CL2008003600A1 (es) 2010-02-19
MA31910B1 (fr) 2010-12-01
RS52594B (en) 2013-04-30
BRPI0820805A2 (pt) 2015-06-16
AU2008343524A1 (en) 2009-07-09
KR20100082866A (ko) 2010-07-20
TN2010000292A1 (en) 2011-11-11
JP5562866B2 (ja) 2014-07-30
HK1144284A1 (en) 2011-02-11
IL206353A (en) 2014-06-30
CA2710409C (en) 2012-11-06
EP2235007B1 (en) 2012-10-31
ES2459318T3 (es) 2014-05-09
US20090163472A1 (en) 2009-06-25
HRP20120916T1 (hr) 2012-12-31
WO2009085584A1 (en) 2009-07-09
IL206353A0 (en) 2010-12-30
TWI431010B (zh) 2014-03-21
SI2235007T1 (sl) 2013-01-31
PT2235007E (pt) 2013-01-22
EP2235007A1 (en) 2010-10-06
ES2396605T3 (es) 2013-02-22
MX2010006911A (es) 2010-10-05
JP2011507868A (ja) 2011-03-10
MY150474A (en) 2014-01-30
PL2235007T3 (pl) 2013-03-29
DOP2010000185A (es) 2010-09-15
DK2235007T3 (da) 2012-12-17
CN101903377A (zh) 2010-12-01
KR101254382B1 (ko) 2013-04-15
AR069554A1 (es) 2010-02-03
ZA201004257B (en) 2011-11-30
CA2710409A1 (en) 2009-07-09
UA100131C2 (uk) 2012-11-26
CO6300953A2 (es) 2011-07-21
ECSP10010266A (es) 2010-07-30
AU2008343524B2 (en) 2012-03-08
EP2537845B1 (en) 2014-03-19
GT201000179A (es) 2012-04-16

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