CN106536491B - 作为盐皮质激素受体调节剂的苯并噁嗪酮酰胺 - Google Patents

作为盐皮质激素受体调节剂的苯并噁嗪酮酰胺 Download PDF

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Publication number
CN106536491B
CN106536491B CN201580035032.8A CN201580035032A CN106536491B CN 106536491 B CN106536491 B CN 106536491B CN 201580035032 A CN201580035032 A CN 201580035032A CN 106536491 B CN106536491 B CN 106536491B
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dihydro
benzoxazine
base
oxo
carbonyl
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Chinese (zh)
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CN106536491A (zh
Inventor
G.奥马霍尼
M.科森延斯
K.埃德曼
J.卡雅努斯
C.A.霍格纳
P.科恩沃尔
A.特纳
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AstraZeneca AB
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AstraZeneca AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CN201580035032.8A 2014-06-30 2015-06-26 作为盐皮质激素受体调节剂的苯并噁嗪酮酰胺 Active CN106536491B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462018790P 2014-06-30 2014-06-30
US62/018790 2014-06-30
PCT/GB2015/051860 WO2016001631A1 (en) 2014-06-30 2015-06-26 Benzoxazinone amides as mineralocorticoid receptor modulators

Publications (2)

Publication Number Publication Date
CN106536491A CN106536491A (zh) 2017-03-22
CN106536491B true CN106536491B (zh) 2018-12-18

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US (2) US10017502B2 (enExample)
EP (1) EP3160948B1 (enExample)
JP (1) JP6368383B2 (enExample)
KR (1) KR102012222B1 (enExample)
CN (1) CN106536491B (enExample)
AR (1) AR101036A1 (enExample)
AU (1) AU2015282450C1 (enExample)
CA (1) CA2953655C (enExample)
CY (1) CY1121596T1 (enExample)
DK (1) DK3160948T3 (enExample)
EA (1) EA029518B1 (enExample)
ES (1) ES2707726T3 (enExample)
HR (1) HRP20190147T1 (enExample)
HU (1) HUE042370T2 (enExample)
LT (1) LT3160948T (enExample)
ME (1) ME03316B (enExample)
MX (1) MX367404B (enExample)
PL (1) PL3160948T3 (enExample)
PT (1) PT3160948T (enExample)
RS (1) RS58274B1 (enExample)
SI (1) SI3160948T1 (enExample)
SM (1) SMT201900039T1 (enExample)
TR (1) TR201900659T4 (enExample)
TW (1) TWI677498B (enExample)
UY (1) UY36195A (enExample)
WO (1) WO2016001631A1 (enExample)

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ME03316B (me) * 2014-06-30 2019-10-20 Astrazeneca Ab Benzoksazinon amidi као modulatori mineralokorтikoidnog receptora
JOP20210009A1 (ar) 2018-07-19 2021-01-12 Astrazeneca Ab طرق لعلاج HFpEF باستعمال داباجليفلوزين وتركيبات تشمله
CN112107568B (zh) * 2019-06-19 2022-03-25 北京龙嘉博创医药科技有限公司 二芳基酰胺类化合物及其应用
BR112020008705A2 (pt) * 2019-08-30 2022-03-22 Astrazeneca Ab Métodos de tratamento da insuficiência cardíaca com fração de ejeção reduzida com dapagliflozina
JP2023536009A (ja) 2020-07-27 2023-08-23 アストラゼネカ・アクチエボラーグ ダパグリフロジンによる慢性腎疾患の処置方法
BR112023025793A2 (pt) * 2021-06-15 2024-02-27 Chia Tai Tianqing Pharmaceutical Group Co Ltd Composto de fórmula (ii), um estereoisômero deste ou um sal farmaceuticamente aceitável deste, composição farmacêutica e uso do composto
TW202409023A (zh) 2022-07-14 2024-03-01 美商富曼西公司 除草苯并𠯤
US20250381145A1 (en) 2022-09-01 2025-12-18 Astrazeneca Ab Combination of sglt2 inhibitors and mineralcorticoid receptor modulators for use in treatment of cardiorenal diseases
WO2024125591A1 (zh) * 2022-12-15 2024-06-20 正大天晴药业集团股份有限公司 苯并恶嗪酮类化合物的结晶及其制备
AU2024387082A1 (en) 2023-11-21 2026-06-04 Fmc Corporation Substituted tetrahydroquinoline and tetrahydroquinoxaline herbicides

Citations (3)

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WO2002085868A1 (en) * 2001-04-23 2002-10-31 Astrazeneca Ab Benzoxazinone derivatives for use in the treatment of angiogenesis
CN101365696A (zh) * 2004-07-28 2009-02-11 Irm责任有限公司 作为类固醇激素核受体调节剂的化合物和组合物
CN102124003A (zh) * 2008-06-18 2011-07-13 阿斯利康(瑞典)有限公司 作为治疗呼吸系统疾病的β2肾上腺素受体拮抗剂的苯并噁嗪酮衍生物

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CN101018552A (zh) * 2004-07-14 2007-08-15 利亘制药公司 细胞内受体调节剂化合物和方法
TW200732331A (en) 2005-12-28 2007-09-01 Takeda Pharmaceuticals Co Fused heterocyclic compound and use thereof
TWI385161B (zh) 2006-02-02 2013-02-11 Mitsubishi Tanabe Pharma Corp 含氮雜雙環化合物
ES2375877T3 (es) 2006-10-31 2012-03-07 Pfizer Products Inc. Compuestos de pirazolina como antagonistas de receptores de mineralocorticoides.
DE102007009494A1 (de) 2007-02-27 2008-08-28 Bayer Healthcare Ag Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung
US8063090B2 (en) 2007-03-23 2011-11-22 Merck Sharp & Dohme Corp. Mineralocorticoid receptor modulators
TWI444185B (zh) 2007-04-09 2014-07-11 Daiichi Sankyo Co Ltd 吡咯衍生物之阻轉異構物
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TWI431010B (zh) 2007-12-19 2014-03-21 Lilly Co Eli 礦皮質素受體拮抗劑及使用方法
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CN101365696A (zh) * 2004-07-28 2009-02-11 Irm责任有限公司 作为类固醇激素核受体调节剂的化合物和组合物
CN102124003A (zh) * 2008-06-18 2011-07-13 阿斯利康(瑞典)有限公司 作为治疗呼吸系统疾病的β2肾上腺素受体拮抗剂的苯并噁嗪酮衍生物

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Also Published As

Publication number Publication date
HUE042370T2 (hu) 2019-06-28
ES2707726T3 (es) 2019-04-04
SI3160948T1 (sl) 2020-06-30
AU2015282450B2 (en) 2018-05-10
MX2017000183A (es) 2017-04-25
JP2017522300A (ja) 2017-08-10
LT3160948T (lt) 2019-02-11
TWI677498B (zh) 2019-11-21
JP6368383B2 (ja) 2018-08-01
CN106536491A (zh) 2017-03-22
RS58274B1 (sr) 2019-03-29
US20150376170A1 (en) 2015-12-31
ME03316B (me) 2019-10-20
MX367404B (es) 2019-08-20
WO2016001631A1 (en) 2016-01-07
KR20170021883A (ko) 2017-02-28
US9394291B2 (en) 2016-07-19
EA029518B1 (ru) 2018-04-30
EP3160948B1 (en) 2018-10-24
CY1121596T1 (el) 2020-05-29
AR101036A1 (es) 2016-11-16
CA2953655A1 (en) 2016-01-07
US20170217945A1 (en) 2017-08-03
AU2015282450C1 (en) 2018-09-20
AU2015282450A1 (en) 2017-02-02
PT3160948T (pt) 2019-02-01
PL3160948T3 (pl) 2019-04-30
EA201790046A1 (ru) 2017-08-31
UY36195A (es) 2016-01-08
EP3160948A1 (en) 2017-05-03
US10017502B2 (en) 2018-07-10
TR201900659T4 (tr) 2019-02-21
KR102012222B1 (ko) 2019-10-21
SMT201900039T1 (it) 2019-02-28
CA2953655C (en) 2020-05-12
DK3160948T3 (en) 2019-02-18
TW201613909A (en) 2016-04-16
HRP20190147T1 (hr) 2019-03-22

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