JP6358735B2 - 光音響顕微鏡装置 - Google Patents
光音響顕微鏡装置 Download PDFInfo
- Publication number
- JP6358735B2 JP6358735B2 JP2014035423A JP2014035423A JP6358735B2 JP 6358735 B2 JP6358735 B2 JP 6358735B2 JP 2014035423 A JP2014035423 A JP 2014035423A JP 2014035423 A JP2014035423 A JP 2014035423A JP 6358735 B2 JP6358735 B2 JP 6358735B2
- Authority
- JP
- Japan
- Prior art keywords
- photoacoustic
- objective lens
- unit
- sensor
- fiber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- 230000005284 excitation Effects 0.000 claims description 50
- 230000003287 optical effect Effects 0.000 claims description 40
- 238000001514 detection method Methods 0.000 claims description 37
- 239000010409 thin film Substances 0.000 claims description 15
- 230000007274 generation of a signal involved in cell-cell signaling Effects 0.000 claims description 6
- 238000005286 illumination Methods 0.000 claims description 5
- 230000002093 peripheral effect Effects 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 230000035945 sensitivity Effects 0.000 description 10
- 238000012986 modification Methods 0.000 description 9
- 230000004048 modification Effects 0.000 description 9
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 8
- 229910052710 silicon Inorganic materials 0.000 description 8
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- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/22—Details, e.g. general constructional or apparatus details
- G01N29/24—Probes
- G01N29/2418—Probes using optoacoustic interaction with the material, e.g. laser radiation, photoacoustics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/04—Analysing solids
- G01N29/06—Visualisation of the interior, e.g. acoustic microscopy
- G01N29/0654—Imaging
- G01N29/0681—Imaging by acoustic microscopy, e.g. scanning acoustic microscopy
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0028—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders specially adapted for specific applications, e.g. for endoscopes, ophthalmoscopes, attachments to conventional microscopes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0036—Scanning details, e.g. scanning stages
- G02B21/0048—Scanning details, e.g. scanning stages scanning mirrors, e.g. rotating or galvanomirrors, MEMS mirrors
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/008—Details of detection or image processing, including general computer control
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/06—Means for illuminating specimens
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B26/00—Optical devices or arrangements for the control of light using movable or deformable optical elements
- G02B26/08—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
- G02B26/10—Scanning systems
- G02B26/105—Scanning systems with one or more pivoting mirrors or galvano-mirrors
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Optics & Photonics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Acoustics & Sound (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Computer Vision & Pattern Recognition (AREA)
- General Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Radiology & Medical Imaging (AREA)
- Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
- Microscoopes, Condenser (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014035423A JP6358735B2 (ja) | 2014-02-26 | 2014-02-26 | 光音響顕微鏡装置 |
| PCT/JP2015/050292 WO2015129293A1 (ja) | 2014-02-26 | 2015-01-07 | 光音響顕微鏡装置 |
| CN201580003425.0A CN105849550A (zh) | 2014-02-26 | 2015-01-07 | 光声显微镜装置 |
| US15/248,341 US10209226B2 (en) | 2014-02-26 | 2016-08-26 | Photoacoustic microscope apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014035423A JP6358735B2 (ja) | 2014-02-26 | 2014-02-26 | 光音響顕微鏡装置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015161527A JP2015161527A (ja) | 2015-09-07 |
| JP2015161527A5 JP2015161527A5 (enExample) | 2017-03-16 |
| JP6358735B2 true JP6358735B2 (ja) | 2018-07-18 |
Family
ID=54008623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014035423A Expired - Fee Related JP6358735B2 (ja) | 2014-02-26 | 2014-02-26 | 光音響顕微鏡装置 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US10209226B2 (enExample) |
| JP (1) | JP6358735B2 (enExample) |
| CN (1) | CN105849550A (enExample) |
| WO (1) | WO2015129293A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6433748B2 (ja) * | 2014-10-15 | 2018-12-05 | 株式会社東芝 | 超音波発生装置 |
| US11506877B2 (en) | 2016-11-10 | 2022-11-22 | The Trustees Of Columbia University In The City Of New York | Imaging instrument having objective axis and light sheet or light beam projector axis intersecting at less than 90 degrees |
| CN108174122A (zh) * | 2017-11-28 | 2018-06-15 | 武汉华之洋科技有限公司 | 一种基于光纤传感的多路图像采集装置及方法 |
| WO2019123958A1 (ja) * | 2017-12-18 | 2019-06-27 | 横河電機株式会社 | 対物光学系及び顕微鏡システム |
| CN111742210A (zh) * | 2018-01-26 | 2020-10-02 | 易路美索尼克股份有限公司 | 相干门控光声遥感(cg-pars) |
| WO2020065727A1 (ja) * | 2018-09-25 | 2020-04-02 | オリンパス株式会社 | 光音響撮影装置および方法 |
| CN110530797A (zh) * | 2019-09-25 | 2019-12-03 | 南京大学 | 一种光声鬼成像-荧光成像的双模成像装置及其使用方法 |
| CN111024620B (zh) * | 2020-01-13 | 2024-08-16 | 深圳大学 | 基于表面等离相位传感的光纤光声显微镜 |
| CN111912908B (zh) * | 2020-08-07 | 2021-08-17 | 北京航空航天大学 | 一种基于光致超声和激光干涉的全光学超声探测装置 |
| JP7593794B2 (ja) * | 2020-11-26 | 2024-12-03 | 株式会社タムロン | 集光対物光学系および光音響装置 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4267732A (en) | 1978-11-29 | 1981-05-19 | Stanford University Board Of Trustees | Acoustic microscope and method |
| DE3037983C2 (de) * | 1980-10-08 | 1983-03-31 | Fa. Carl Zeiss, 7920 Heidenheim | Verfahren und Vorrichtung zur lichtinduzierten rastermikroskopischen Darstellung von Probenparametern in ihrer räumlichen Verteilung |
| JPS63306413A (ja) * | 1987-06-09 | 1988-12-14 | Olympus Optical Co Ltd | 走査型光学顕微鏡 |
| JPH02150764A (ja) * | 1988-11-30 | 1990-06-11 | Mitsubishi Heavy Ind Ltd | 剥離検知方法及び装置 |
| JP2659429B2 (ja) * | 1989-03-17 | 1997-09-30 | 株式会社日立製作所 | 光音響信号検出方法及びその装置並びに半導体素子内部欠陥検出方法 |
| DE69131528T2 (de) * | 1990-05-30 | 2000-05-04 | Hitachi, Ltd. | Verfahren und Vorrichtung zur Behandlung eines sehr kleinen Bereichs einer Probe |
| US5037180A (en) * | 1990-07-19 | 1991-08-06 | At&T Bell Laboratories | Optical filter on optical fiber end face |
| US5208648A (en) * | 1991-03-11 | 1993-05-04 | International Business Machines Corporation | Apparatus and a method for high numerical aperture microscopic examination of materials |
| US5781294A (en) * | 1991-12-24 | 1998-07-14 | Hitachi, Ltd. | Method and apparatus for detecting photoacoustic signal to detect surface and subsurface information of the specimen |
| WO1998051993A1 (fr) * | 1997-05-16 | 1998-11-19 | Olympus Optical Co., Ltd. | Dispositif servant a mesurer une hauteur |
| JP4786027B2 (ja) * | 2000-12-08 | 2011-10-05 | オリンパス株式会社 | 光学系及び光学装置 |
| JP3848125B2 (ja) * | 2001-10-22 | 2006-11-22 | 日本板硝子株式会社 | 光熱変換分光分析方法及びマイクロ化学システム |
| JP2005175919A (ja) * | 2003-12-11 | 2005-06-30 | Mitsubishi Heavy Ind Ltd | 超音波受信センサ及び超音波受信装置 |
| KR100906270B1 (ko) * | 2006-01-20 | 2009-07-06 | 올림푸스 메디칼 시스템즈 가부시키가이샤 | 피검체 정보 분석 장치, 내시경 장치 및 피검체 정보 분석방법 |
| JP5410651B2 (ja) * | 2007-02-22 | 2014-02-05 | 株式会社東芝 | 表面劣化検出装置およびその方法 |
| US8454512B2 (en) * | 2007-10-25 | 2013-06-04 | Washington University | Confocal photoacoustic microscopy with optical lateral resolution |
| WO2012018991A2 (en) * | 2010-08-05 | 2012-02-09 | Bioptigen, Inc. | Compact multimodality optical coherence tomography imaging systems and related methods and computer program products |
| CN101949839B (zh) * | 2010-09-03 | 2012-10-03 | 西安工业大学 | 一种光学表面亚表层损伤测量装置的测量方法 |
| US8997572B2 (en) * | 2011-02-11 | 2015-04-07 | Washington University | Multi-focus optical-resolution photoacoustic microscopy with ultrasonic array detection |
| JP5832182B2 (ja) * | 2011-07-19 | 2015-12-16 | キヤノン株式会社 | 音響信号受信装置およびイメージング装置 |
| WO2013023210A1 (en) * | 2011-08-11 | 2013-02-14 | University Of Washington Through Its Center For Commercialization | Methods and systems for integrated imaging using optical coherence tomography and photoacoustic imaging |
| JP5896702B2 (ja) * | 2011-11-30 | 2016-03-30 | オリンパス株式会社 | 光音響顕微鏡 |
| EP2805676A4 (en) * | 2012-01-18 | 2015-09-02 | Canon Kk | DEVICE FOR COLLECTING PERSONNEL INFORMATION AND METHOD FOR DETECTING PERSONNEL INFORMATION |
| JP2013255707A (ja) * | 2012-06-13 | 2013-12-26 | Canon Inc | 被検体情報取得装置、および、光音響プローブ |
| JP5885600B2 (ja) * | 2012-06-20 | 2016-03-15 | オリンパス株式会社 | 光音響顕微鏡 |
| CN102928346B (zh) * | 2012-10-18 | 2014-08-27 | 中国科学院深圳先进技术研究院 | 双模成像系统 |
| CN102944521B (zh) * | 2012-11-29 | 2015-01-21 | 华南师范大学 | 非接触式光声和光学相干断层双成像装置及其检测方法 |
| WO2014103106A1 (ja) * | 2012-12-25 | 2014-07-03 | オリンパス株式会社 | 光音響顕微鏡 |
| US9155474B2 (en) * | 2013-08-14 | 2015-10-13 | Omega Optical, Inc. | System for multispectral imaging of fluorescence |
| JP6210873B2 (ja) * | 2013-12-25 | 2017-10-11 | オリンパス株式会社 | 光音響顕微鏡 |
| US10117583B2 (en) * | 2014-10-22 | 2018-11-06 | illumiSonics, Inc. | Photoacoustic remote sensing (PARS) |
| JP6587385B2 (ja) * | 2014-11-27 | 2019-10-09 | キヤノン株式会社 | 被検体情報取得装置および被検体情報取得方法 |
-
2014
- 2014-02-26 JP JP2014035423A patent/JP6358735B2/ja not_active Expired - Fee Related
-
2015
- 2015-01-07 CN CN201580003425.0A patent/CN105849550A/zh active Pending
- 2015-01-07 WO PCT/JP2015/050292 patent/WO2015129293A1/ja not_active Ceased
-
2016
- 2016-08-26 US US15/248,341 patent/US10209226B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015129293A1 (ja) | 2015-09-03 |
| CN105849550A (zh) | 2016-08-10 |
| JP2015161527A (ja) | 2015-09-07 |
| US20160363563A1 (en) | 2016-12-15 |
| US10209226B2 (en) | 2019-02-19 |
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