JP6358735B2 - 光音響顕微鏡装置 - Google Patents

光音響顕微鏡装置 Download PDF

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Publication number
JP6358735B2
JP6358735B2 JP2014035423A JP2014035423A JP6358735B2 JP 6358735 B2 JP6358735 B2 JP 6358735B2 JP 2014035423 A JP2014035423 A JP 2014035423A JP 2014035423 A JP2014035423 A JP 2014035423A JP 6358735 B2 JP6358735 B2 JP 6358735B2
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JP
Japan
Prior art keywords
photoacoustic
objective lens
unit
sensor
fiber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2014035423A
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English (en)
Japanese (ja)
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JP2015161527A5 (enExample
JP2015161527A (ja
Inventor
福島　郁俊
郁俊 福島
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Olympus Corp
Original Assignee
Olympus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olympus Corp filed Critical Olympus Corp
Priority to JP2014035423A priority Critical patent/JP6358735B2/ja
Priority to CN201580003425.0A priority patent/CN105849550A/zh
Priority to PCT/JP2015/050292 priority patent/WO2015129293A1/ja
Publication of JP2015161527A publication Critical patent/JP2015161527A/ja
Priority to US15/248,341 priority patent/US10209226B2/en
Publication of JP2015161527A5 publication Critical patent/JP2015161527A5/ja
Application granted granted Critical
Publication of JP6358735B2 publication Critical patent/JP6358735B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/22—Details, e.g. general constructional or apparatus details
    • G01N29/24—Probes
    • G01N29/2418—Probes using optoacoustic interaction with the material, e.g. laser radiation, photoacoustics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
    • A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/04—Analysing solids
    • G01N29/06—Visualisation of the interior, e.g. acoustic microscopy
    • G01N29/0654—Imaging
    • G01N29/0681—Imaging by acoustic microscopy, e.g. scanning acoustic microscopy
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0028—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders specially adapted for specific applications, e.g. for endoscopes, ophthalmoscopes, attachments to conventional microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0036—Scanning details, e.g. scanning stages
    • G02B21/0048—Scanning details, e.g. scanning stages scanning mirrors, e.g. rotating or galvanomirrors, MEMS mirrors
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/008—Details of detection or image processing, including general computer control
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B26/00—Optical devices or arrangements for the control of light using movable or deformable optical elements
    • G02B26/08—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
    • G02B26/10—Scanning systems
    • G02B26/105—Scanning systems with one or more pivoting mirrors or galvano-mirrors

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Acoustics & Sound (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • General Engineering & Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Microscoopes, Condenser (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
JP2014035423A 2014-02-26 2014-02-26 光音響顕微鏡装置 Expired - Fee Related JP6358735B2 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2014035423A JP6358735B2 (ja) 2014-02-26 2014-02-26 光音響顕微鏡装置
CN201580003425.0A CN105849550A (zh) 2014-02-26 2015-01-07 光声显微镜装置
PCT/JP2015/050292 WO2015129293A1 (ja) 2014-02-26 2015-01-07 光音響顕微鏡装置
US15/248,341 US10209226B2 (en) 2014-02-26 2016-08-26 Photoacoustic microscope apparatus

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2014035423A JP6358735B2 (ja) 2014-02-26 2014-02-26 光音響顕微鏡装置

Publications (3)

Publication Number Publication Date
JP2015161527A JP2015161527A (ja) 2015-09-07
JP2015161527A5 JP2015161527A5 (enExample) 2017-03-16
JP6358735B2 true JP6358735B2 (ja) 2018-07-18

Family

ID=54008623

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014035423A Expired - Fee Related JP6358735B2 (ja) 2014-02-26 2014-02-26 光音響顕微鏡装置

Country Status (4)

Country Link
US (1) US10209226B2 (enExample)
JP (1) JP6358735B2 (enExample)
CN (1) CN105849550A (enExample)
WO (1) WO2015129293A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6433748B2 (ja) * 2014-10-15 2018-12-05 株式会社東芝 超音波発生装置
EP3538941B1 (en) 2016-11-10 2025-04-23 The Trustees of Columbia University in the City of New York Rapid high-resolution imaging methods for large samples
CN108174122A (zh) * 2017-11-28 2018-06-15 武汉华之洋科技有限公司 一种基于光纤传感的多路图像采集装置及方法
US11467388B2 (en) 2017-12-18 2022-10-11 Yokogawa Electric Corporation Objective optical system and microscope system with liquid interposed between liquid contact surface and sample
CN111742210A (zh) * 2018-01-26 2020-10-02 易路美索尼克股份有限公司 相干门控光声遥感（cg-pars）
JPWO2020065727A1 (ja) * 2018-09-25 2021-08-30 オリンパス株式会社 光音響撮影装置および方法
CN110530797A (zh) * 2019-09-25 2019-12-03 南京大学 一种光声鬼成像-荧光成像的双模成像装置及其使用方法
CN111024620B (zh) * 2020-01-13 2024-08-16 深圳大学 基于表面等离相位传感的光纤光声显微镜
CN111912908B (zh) * 2020-08-07 2021-08-17 北京航空航天大学 一种基于光致超声和激光干涉的全光学超声探测装置
JP7593794B2 (ja) * 2020-11-26 2024-12-03 株式会社タムロン 集光対物光学系および光音響装置

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267732A (en) 1978-11-29 1981-05-19 Stanford University Board Of Trustees Acoustic microscope and method
DE3037983C2 (de) * 1980-10-08 1983-03-31 Fa. Carl Zeiss, 7920 Heidenheim Verfahren und Vorrichtung zur lichtinduzierten rastermikroskopischen Darstellung von Probenparametern in ihrer räumlichen Verteilung
JPS63306413A (ja) * 1987-06-09 1988-12-14 Olympus Optical Co Ltd 走査型光学顕微鏡
JPH02150764A (ja) * 1988-11-30 1990-06-11 Mitsubishi Heavy Ind Ltd 剥離検知方法及び装置
JP2659429B2 (ja) * 1989-03-17 1997-09-30 株式会社日立製作所 光音響信号検出方法及びその装置並びに半導体素子内部欠陥検出方法
EP0459392B1 (en) * 1990-05-30 1999-08-18 Hitachi, Ltd. Method and apparatus for processing a minute portion of a specimen
US5037180A (en) * 1990-07-19 1991-08-06 At&T Bell Laboratories Optical filter on optical fiber end face
US5208648A (en) * 1991-03-11 1993-05-04 International Business Machines Corporation Apparatus and a method for high numerical aperture microscopic examination of materials
US5781294A (en) * 1991-12-24 1998-07-14 Hitachi, Ltd. Method and apparatus for detecting photoacoustic signal to detect surface and subsurface information of the specimen
WO1998051993A1 (fr) * 1997-05-16 1998-11-19 Olympus Optical Co., Ltd. Dispositif servant a mesurer une hauteur
JP4786027B2 (ja) * 2000-12-08 2011-10-05 オリンパス株式会社 光学系及び光学装置
JP3848125B2 (ja) * 2001-10-22 2006-11-22 日本板硝子株式会社 光熱変換分光分析方法及びマイクロ化学システム
JP2005175919A (ja) * 2003-12-11 2005-06-30 Mitsubishi Heavy Ind Ltd 超音波受信センサ及び超音波受信装置
EP1810610B1 (en) * 2006-01-20 2016-09-14 Olympus Corporation Method and apparatus for analyzing characteristic information of object with the use of mutual interaction between ultrasound wave and light
JP5410651B2 (ja) * 2007-02-22 2014-02-05 株式会社東芝 表面劣化検出装置およびその方法
EP2203733B1 (en) 2007-10-25 2017-05-03 Washington University in St. Louis Confocal photoacoustic microscopy with optical lateral resolution
WO2012018991A2 (en) * 2010-08-05 2012-02-09 Bioptigen, Inc. Compact multimodality optical coherence tomography imaging systems and related methods and computer program products
CN101949839B (zh) * 2010-09-03 2012-10-03 西安工业大学 一种光学表面亚表层损伤测量装置的测量方法
US8997572B2 (en) * 2011-02-11 2015-04-07 Washington University Multi-focus optical-resolution photoacoustic microscopy with ultrasonic array detection
JP5832182B2 (ja) * 2011-07-19 2015-12-16 キヤノン株式会社 音響信号受信装置およびイメージング装置
WO2013023210A1 (en) * 2011-08-11 2013-02-14 University Of Washington Through Its Center For Commercialization Methods and systems for integrated imaging using optical coherence tomography and photoacoustic imaging
JP5896702B2 (ja) * 2011-11-30 2016-03-30 オリンパス株式会社 光音響顕微鏡
EP2805676A4 (en) * 2012-01-18 2015-09-02 Canon Kk DEVICE FOR COLLECTING PERSONNEL INFORMATION AND METHOD FOR DETECTING PERSONNEL INFORMATION
JP2013255707A (ja) * 2012-06-13 2013-12-26 Canon Inc 被検体情報取得装置、および、光音響プローブ
JP5885600B2 (ja) * 2012-06-20 2016-03-15 オリンパス株式会社 光音響顕微鏡
CN102928346B (zh) * 2012-10-18 2014-08-27 中国科学院深圳先进技术研究院 双模成像系统
CN102944521B (zh) * 2012-11-29 2015-01-21 华南师范大学 非接触式光声和光学相干断层双成像装置及其检测方法
WO2014103106A1 (ja) * 2012-12-25 2014-07-03 オリンパス株式会社 光音響顕微鏡
US9155474B2 (en) * 2013-08-14 2015-10-13 Omega Optical, Inc. System for multispectral imaging of fluorescence
JP6210873B2 (ja) * 2013-12-25 2017-10-11 オリンパス株式会社 光音響顕微鏡
CA3252660A1 (en) * 2014-10-22 2026-03-02 Illumisonics Inc. Photoacoustic remote sensing (pars)
JP6587385B2 (ja) * 2014-11-27 2019-10-09 キヤノン株式会社 被検体情報取得装置および被検体情報取得方法

Also Published As

Publication number Publication date
US20160363563A1 (en) 2016-12-15
JP2015161527A (ja) 2015-09-07
US10209226B2 (en) 2019-02-19
CN105849550A (zh) 2016-08-10
WO2015129293A1 (ja) 2015-09-03

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