JP6335796B2 - Ｃｄｉｍ結合タンパク質及びその使用 - Google Patents

Ｃｄｉｍ結合タンパク質及びその使用 Download PDF

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Publication number
JP6335796B2
JP6335796B2 JP2014556751A JP2014556751A JP6335796B2 JP 6335796 B2 JP6335796 B2 JP 6335796B2 JP 2014556751 A JP2014556751 A JP 2014556751A JP 2014556751 A JP2014556751 A JP 2014556751A JP 6335796 B2 JP6335796 B2 JP 6335796B2
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Prior art keywords
binding protein
cdim
seq
antigen binding
antibody
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English (en)
Japanese (ja)
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JP2015511817A5 (enExample
JP2015511817A (ja
Inventor
ネルソン， エヌ．エイチ． テン，
ネルソン， エヌ．エイチ． テン，
ニーリーナ， エム． バート，
ニーリーナ， エム． バート，
マルシア， エム． ビーバー，
マルシア， エム． ビーバー，
ブルース， エー． キート，
ブルース， エー． キート，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teng Nelson NH
IGM Biosciences Inc
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Teng Nelson NH
IGM Biosciences Inc
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Publication of JP2015511817A publication Critical patent/JP2015511817A/ja
Publication of JP2015511817A5 publication Critical patent/JP2015511817A5/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2014556751A 2012-02-08 2013-02-08 Ｃｄｉｍ結合タンパク質及びその使用 Active JP6335796B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261633330P 2012-02-08 2012-02-08
US61/633,330 2012-02-08
PCT/US2013/025430 WO2013120012A2 (en) 2012-02-08 2013-02-08 Cdim binding proteins and uses thereof

Publications (3)

Publication Number Publication Date
JP2015511817A JP2015511817A (ja) 2015-04-23
JP2015511817A5 JP2015511817A5 (enExample) 2015-12-03
JP6335796B2 true JP6335796B2 (ja) 2018-06-06

Family

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JP2014556751A Active JP6335796B2 (ja) 2012-02-08 2013-02-08 Ｃｄｉｍ結合タンパク質及びその使用

Country Status (14)

Country Link
US (1) US9409976B2 (enExample)
EP (1) EP2812356B1 (enExample)
JP (1) JP6335796B2 (enExample)
KR (1) KR102102111B1 (enExample)
CN (1) CN104254544B (enExample)
AU (1) AU2013200903B2 (enExample)
BR (1) BR112014019459B1 (enExample)
CA (1) CA2863714C (enExample)
DK (1) DK2812356T3 (enExample)
ES (1) ES2735289T3 (enExample)
IN (1) IN2014MN01781A (enExample)
MX (1) MX363819B (enExample)
TW (1) TWI606064B (enExample)
WO (1) WO2013120012A2 (enExample)

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AU2015213593B2 (en) 2014-02-10 2020-09-03 Igm Biosciences, Inc. IgA multi-specific binding molecules
KR102380402B1 (ko) 2014-04-03 2022-03-31 아이쥐엠 바이오사이언스 인코포레이티드 변형된 j-사슬
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CN115093479A (zh) 2015-03-04 2022-09-23 Igm生物科学股份有限公司 Cd20结合分子及其用途
JP6882184B2 (ja) 2015-03-25 2021-06-02 アイジーエム バイオサイエンシズ インコーポレイテッド 多価ｂ型肝炎ウイルス抗原結合分子およびその使用
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EA202190468A1 (ru) 2018-08-08 2021-07-06 Драгонфлай Терапьютикс, Инк. Мультиспецифические связывающие белки, которые связывают bcma, nkg2d и cd16, и способы их применения
EP4640698A3 (en) * 2018-11-16 2026-02-25 Memorial Sloan Kettering Cancer Center Antibodies to mucin-16 and methods of use thereof
CN114269785A (zh) 2019-08-15 2022-04-01 Igm生物科学股份有限公司 免疫刺激性多聚体结合分子
EP4146271A4 (en) 2020-05-06 2024-09-04 Dragonfly Therapeutics, Inc. PROTEINS THAT BIND NKG2D, CD16 AND CLEC12A
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Also Published As

Publication number Publication date
TWI606064B (zh) 2017-11-21
BR112014019459B1 (pt) 2023-04-18
DK2812356T3 (da) 2019-07-08
MX2014009628A (es) 2015-03-19
EP2812356A2 (en) 2014-12-17
ES2735289T3 (es) 2019-12-17
CA2863714A1 (en) 2013-08-15
US20140044739A1 (en) 2014-02-13
CN104254544A (zh) 2014-12-31
CA2863714C (en) 2022-07-05
WO2013120012A3 (en) 2013-11-07
AU2013200903A1 (en) 2013-08-22
HK1205136A1 (en) 2015-12-11
US9409976B2 (en) 2016-08-09
AU2013200903B2 (en) 2015-05-14
MX363819B (es) 2019-04-03
KR20150001728A (ko) 2015-01-06
WO2013120012A2 (en) 2013-08-15
TW201345921A (zh) 2013-11-16
EP2812356B1 (en) 2019-03-27
IN2014MN01781A (enExample) 2015-07-03
BR112014019459A8 (pt) 2023-01-10
CN104254544B (zh) 2017-04-26
JP2015511817A (ja) 2015-04-23
BR112014019459A2 (pt) 2017-06-27
KR102102111B1 (ko) 2020-04-20

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