JP6297590B2 - １−（［１，３］ジオキソラン−４−イルメチル）−１ｈ−ピラゾール−３−イルアミンを調製するための方法 - Google Patents
１−（［１，３］ジオキソラン−４−イルメチル）−１ｈ−ピラゾール−３−イルアミンを調製するための方法 Download PDFInfo
- Publication number
- JP6297590B2 JP6297590B2 JP2015550041A JP2015550041A JP6297590B2 JP 6297590 B2 JP6297590 B2 JP 6297590B2 JP 2015550041 A JP2015550041 A JP 2015550041A JP 2015550041 A JP2015550041 A JP 2015550041A JP 6297590 B2 JP6297590 B2 JP 6297590B2
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- process according
- phenyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 *C1(O[C@](CCl)CO1)I Chemical compound *C1(O[C@](CCl)CO1)I 0.000 description 2
- UQSJYATYBNAWHK-UHFFFAOYSA-O CC1(C)OC(C[NH2+]C=CC(N)=N)CO1 Chemical compound CC1(C)OC(C[NH2+]C=CC(N)=N)CO1 UQSJYATYBNAWHK-UHFFFAOYSA-O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012087380 | 2012-12-25 | ||
| CNPCT/CN2012/087380 | 2012-12-25 | ||
| PCT/EP2013/077563 WO2014102164A1 (en) | 2012-12-25 | 2013-12-20 | Process for the preparation of 1-([1,3]dioxolan-4-ylmethyl)-1h-pyrazol-3-ylamine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016503812A JP2016503812A (ja) | 2016-02-08 |
| JP2016503812A5 JP2016503812A5 (https=) | 2016-12-22 |
| JP6297590B2 true JP6297590B2 (ja) | 2018-03-20 |
Family
ID=49876646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015550041A Active JP6297590B2 (ja) | 2012-12-25 | 2013-12-20 | １−（［１，３］ジオキソラン−４−イルメチル）−１ｈ−ピラゾール−３−イルアミンを調製するための方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US9388168B2 (https=) |
| EP (1) | EP2938609B1 (https=) |
| JP (1) | JP6297590B2 (https=) |
| KR (1) | KR102122569B1 (https=) |
| CN (1) | CN105051031B (https=) |
| AU (1) | AU2013369473B2 (https=) |
| BR (1) | BR112015015229B1 (https=) |
| CA (1) | CA2896155C (https=) |
| CY (1) | CY1119040T1 (https=) |
| DK (1) | DK2938609T3 (https=) |
| ES (1) | ES2629313T3 (https=) |
| HR (1) | HRP20170653T1 (https=) |
| HU (1) | HUE032621T2 (https=) |
| IL (1) | IL239558A (https=) |
| LT (1) | LT2938609T (https=) |
| NZ (1) | NZ709362A (https=) |
| PL (1) | PL2938609T3 (https=) |
| PT (1) | PT2938609T (https=) |
| RU (1) | RU2621725C2 (https=) |
| SG (1) | SG11201504951TA (https=) |
| SI (1) | SI2938609T1 (https=) |
| WO (1) | WO2014102164A1 (https=) |
| ZA (1) | ZA201504601B (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2728824C1 (ru) | 2016-12-15 | 2020-07-31 | Хуа Медсин (Шанхай) Лтд. | Препарат активатора глюкокиназы для перорального введения и способ его получения |
| CN113493442B (zh) * | 2020-04-03 | 2024-11-08 | 天津药物研究院有限公司 | 作为葡萄糖激酶活化剂的吡咯烷酮衍生物及其制备方法和用途 |
| US11813274B2 (en) | 2020-04-22 | 2023-11-14 | Hua Medicine (Shanghai) Ltd. | Treating untreated or treatment-resistant diabetes with glucokinase activator and sodium-glucose cotransporter-2 inhibitor |
| WO2021212360A1 (en) * | 2020-04-22 | 2021-10-28 | Hua Medicine (Shanghai) Ltd. | Treating untreated or treatment-resistant diabetes with glucokinase activator and sodium-glucose cotransporter-2 inhibitor |
| CN111732543A (zh) * | 2020-08-14 | 2020-10-02 | 浙江鼎龙科技有限公司 | 一种4,5-二氨基-1-（2-羟乙基）吡唑硫酸盐的制备方法 |
| CN113750100B (zh) * | 2021-08-31 | 2022-12-30 | 海南中济医药科技有限公司 | 一种含有多扎格列艾汀与西格列汀的药物组合物及其制备方法 |
| AR127064A1 (es) * | 2021-09-15 | 2023-12-13 | Hua Medicine Shanghai Ltd | Prodroga de derivados de pirrolidona como activador de glucoquinasa |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4160841A (en) * | 1977-01-31 | 1979-07-10 | Janssen Pharmaceutica, N.V. | Heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles |
| FR2748274B1 (fr) * | 1996-05-03 | 1998-06-12 | Oreal | Nouveaux diamino pyrazoles, leur synthese, compositions de teinture des fibres keratiniques les contenant, procede de teinture des fibres keratiniques |
| AU2009205070A1 (en) | 2008-01-18 | 2009-07-23 | Astellas Pharma Inc. | Phenyl acetamide derivative |
| US7741327B2 (en) * | 2008-04-16 | 2010-06-22 | Hoffmann-La Roche Inc. | Pyrrolidinone glucokinase activators |
| US8178689B2 (en) * | 2010-06-17 | 2012-05-15 | Hoffman-La Roche Inc. | Tricyclic compounds |
-
2013
- 2013-12-20 JP JP2015550041A patent/JP6297590B2/ja active Active
- 2013-12-20 RU RU2015126911A patent/RU2621725C2/ru active
- 2013-12-20 BR BR112015015229-5A patent/BR112015015229B1/pt active IP Right Grant
- 2013-12-20 EP EP13811542.3A patent/EP2938609B1/en active Active
- 2013-12-20 NZ NZ709362A patent/NZ709362A/en unknown
- 2013-12-20 PT PT138115423T patent/PT2938609T/pt unknown
- 2013-12-20 WO PCT/EP2013/077563 patent/WO2014102164A1/en not_active Ceased
- 2013-12-20 US US14/655,287 patent/US9388168B2/en active Active
- 2013-12-20 SG SG11201504951TA patent/SG11201504951TA/en unknown
- 2013-12-20 KR KR1020157019691A patent/KR102122569B1/ko active Active
- 2013-12-20 LT LTEP13811542.3T patent/LT2938609T/lt unknown
- 2013-12-20 ES ES13811542.3T patent/ES2629313T3/es active Active
- 2013-12-20 SI SI201330684A patent/SI2938609T1/sl unknown
- 2013-12-20 CN CN201380068179.8A patent/CN105051031B/zh active Active
- 2013-12-20 HR HRP20170653TT patent/HRP20170653T1/hr unknown
- 2013-12-20 PL PL13811542T patent/PL2938609T3/pl unknown
- 2013-12-20 DK DK13811542.3T patent/DK2938609T3/en active
- 2013-12-20 HU HUE13811542A patent/HUE032621T2/en unknown
- 2013-12-20 AU AU2013369473A patent/AU2013369473B2/en active Active
- 2013-12-20 CA CA2896155A patent/CA2896155C/en active Active
-
2015
- 2015-06-21 IL IL239558A patent/IL239558A/en active IP Right Grant
- 2015-06-25 ZA ZA2015/04601A patent/ZA201504601B/en unknown
-
2017
- 2017-07-10 CY CY20171100727T patent/CY1119040T1/el unknown
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