WO2020042841A1 - 一种(1r,3s)-3-氨基-1-环戊醇及其盐的制备方法 - Google Patents
一种(1r,3s)-3-氨基-1-环戊醇及其盐的制备方法 Download PDFInfo
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- WO2020042841A1 WO2020042841A1 PCT/CN2019/097921 CN2019097921W WO2020042841A1 WO 2020042841 A1 WO2020042841 A1 WO 2020042841A1 CN 2019097921 W CN2019097921 W CN 2019097921W WO 2020042841 A1 WO2020042841 A1 WO 2020042841A1
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- 0 *[C@](C(N1O[C@@]2C[C@@]1CC2)=O)O Chemical compound *[C@](C(N1O[C@@]2C[C@@]1CC2)=O)O 0.000 description 3
- ILDRDZLIMSVQOI-AKGZTFGVSA-N C(C1)C2NO[C@@H]1C2 Chemical compound C(C1)C2NO[C@@H]1C2 ILDRDZLIMSVQOI-AKGZTFGVSA-N 0.000 description 1
- QPPSINBVIBSVHS-QJPTWQEYSA-N O[C@@H](C(N1O[C@H]2C[C@@H]1CC2)=O)c1ccccc1 Chemical compound O[C@@H](C(N1O[C@H]2C[C@@H]1CC2)=O)c1ccccc1 QPPSINBVIBSVHS-QJPTWQEYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/44—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton bound to carbon atoms of the same ring or condensed ring system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Definitions
- the present disclosure relates to the field of organic synthesis, and in particular, to a method for preparing (1R, 3S) -3-amino-1-cyclopentanol and a salt thereof.
- Bictegravir is a HIV drug developed by Gilead Company.
- Bictargravir (50mg), Emtricitabine (200mg), and Tenofovir alafenamide (25mg) are composed of three ingredients, Biktarvy, which was approved by the FDA for market launch on February 8, 2018. Among them, the structural formula of Bictegravir is as follows,
- (1R, 3S) -3-amino-1-cyclopentanol is an important intermediate for the synthesis of Bictegravir.
- (1R, 3S) -3-amino-1-cyclopentanol contains two chiral centers.
- the existing synthetic scheme There are mainly chiral splitting and chiral source synthesis. Among them, chiral resolution includes enzymatic resolution with enzymes and chemical resolution with chiral acids. However, the theoretical yield of chiral resolution can only reach 50%, and the actual yield can only reach 30% to 45%, causing a lot of waste of raw materials.
- Chiral source synthesis that is, synthesis using chiral raw materials, greatly improves the utilization rate of raw materials, but also has the disadvantages of difficult synthesis of chiral raw materials, high prices, and high economic costs.
- the purpose of the present disclosure includes, for example, providing a method for preparing (1R, 3S) -3-amino-1-cyclopentanol and a salt thereof, the raw materials of which are simple and readily available, the raw material utilization is high, and the production cost is low. Moreover, the operation is simple, the conditions are mild, and the obtained product has high optical purity and stable quality, which is suitable for large-scale production.
- the object of the present disclosure includes, for example, providing an intermediate for synthesizing (1R, 3S) -3-amino-1-cyclopentanol and a salt thereof, which has simple preparation and wide sources, and is suitable for (1R, 3S)- Mass production of 3-amino-1-cyclopentanol and its salts.
- the present disclosure provides a method for preparing (1R, 3S) -3-amino-1-cyclopentanol, which includes:
- the structural formula of the N-acyl hydroxylamine compound is The structural formula of intermediate I is The structural formula of intermediate II is The structural formula of intermediate III is The structural formula of (1R, 3S) -3-amino-1-cyclopentanol is
- R is selected from a C1 to C4 alkyl group or a C6 to C10 aryl group.
- the present disclosure also provides a method for preparing (1R, 3S) -3-amino-1-cyclopentanolate, which includes:
- the structural formula of the chiral N-acyl hydroxylamine compound is The structural formula of intermediate I is The structural formula of intermediate II is The structure of the salt of intermediate III is The structural formula of (1R, 3S) -3-amino-1-cyclopentanol salt is
- R is selected from C1 to C4 alkyl or C6 to C10 aryl
- HA is selected from any one of HCl, HBr, H 2 SO 4 , HOTs, and HOMs.
- the present disclosure also provides an amide intermediate for synthesizing (1R, 3S) -3-amino-1-cyclopentanol, whose structural formula is
- R is selected from a C1 to C4 alkyl group or a C6 to C10 aryl group.
- the present disclosure also provides an amine salt intermediate for synthesizing (1R, 3S) -3-amino-1-cyclopentanol, whose structural formula is
- HA is selected from any one of HCl, HBr, H 2 SO 4 , HOTs, and HOMs.
- the present disclosure also provides the use of a compound of formula as an intermediate for the synthesis of (1R, 3S) -3-amino-1-cyclopentanol,
- R is selected from a C1 to C4 alkyl group or a C6 to C10 aryl group.
- the present disclosure also provides the use of a compound of the following formula or a salt thereof as an intermediate for the synthesis of (1R, 3S) -3-amino-1-cyclopentanol,
- HA is selected from any one of HCl, HBr, H 2 SO 4 , HOTs, and HOMs.
- R is selected from C2 to C4 alkyl or C6 to C10 aryl.
- R is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, and tert-butyl, for example, R is tert-butyl.
- R is selected from the group including methyl, ethyl, n-propyl, isopropyl, and tert-butyl.
- R is tert-butyl
- R is selected from phenyl and substituted phenyl, preferably, R is phenyl
- the embodiment of the present disclosure provides a method for preparing (1R, 3S) -3-amino-1-cyclopentanol and a salt thereof, which uses a chiral center in an N-acyl hydroxylamine compound as a chiral induction and Diene undergoes asymmetric cycloaddition reaction to construct two chiral centers of the target product.
- the N-acyl hydroxylamine compound can be obtained by one-step derivation of hydroxylamine, which has a wide range of sources, is cheap and easy to obtain, and can effectively reduce the cost of raw materials.
- the preparation method has a reasonable route, simple operation, mild reaction conditions, and high atomic economy. In addition, its stereoselectivity is good, and the prepared product has high optical purity and stable quality, which is suitable for large-scale industrial production.
- the embodiment of the present disclosure also provides an intermediate for synthesizing (1R, 3S) -3-amino-1-cyclopentanol and a salt thereof, which has simple preparation and wide sources, and is suitable for (1R, 3S)- Mass production of 3-amino-1-cyclopentanol and its salts.
- the embodiment of the present disclosure provides a method for preparing (1R, 3S) -3-amino-1-cyclopentanol, which includes:
- the structural formula of the N-acyl hydroxylamine compound is The structural formula of intermediate I is The structural formula of intermediate II is The structural formula of intermediate III is The structural formula of (1R, 3S) -3-amino-1-cyclopentanol is
- R is selected from a C1 to C4 alkyl group or a C6 to C10 aryl group.
- the C1-C4 alkyl group includes, but is not limited to, methyl, ethyl, n-propyl, isopropyl, tert-butyl and the like.
- C6-C10 aryl groups include, but are not limited to, phenyl, naphthyl, and substituted phenyl.
- the substituted phenyl group includes a phenyl group in which at least one of the ortho, meta, and para positions is substituted with an alkyl group, a halogen group, a nitro group, an alkoxy group, or the like.
- R is phenyl.
- R is selected from C2 to C4 alkyl or C6 to C10 aryl.
- R is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, and tert-butyl.
- R is tert-butyl.
- R is selected from the group including methyl, ethyl, n-propyl, isopropyl, and tert-butyl.
- R is tert-butyl
- the reaction of the N-acylhydroxylamine compound with cyclopentadiene is performed in the presence of an oxidant.
- an asymmetric cycloaddition reaction between the N-acylhydroxylamine compound and cyclopentadiene occurs to obtain intermediate I.
- the oxidant includes at least one of periodate, oxygen, hydrogen peroxide, and NBS.
- the hydrogenation reduction of the intermediate I is performed under a hydrogen atmosphere and using palladium carbon or Raney nickel as a catalyst.
- the intermediate I is subjected to hydrogenation reduction.
- the hydrogen pressure needs to be controlled under the conditions of 0.05 to 0.1 MPa and a temperature of -10 to 15 ° C. Next.
- the intermediate I is subjected to hydrogenation reduction.
- the lower activity Raney nickel is used as the catalyst, it needs to be controlled under the conditions of a hydrogen pressure of 0.1 to 2 MPa and a temperature of -10 to 15 ° C. ongoing.
- the hydrolysis of the amide bond of the intermediate II is performed under the catalysis of an acid or a base.
- the acid includes at least one of hydrochloric acid, hydrogen bromide, sulfuric acid, p-toluenesulfonic acid, and methanesulfonic acid
- the base includes at least one of ammonia gas, hydrazine hydrate, aqueous hydroxylamine solution, sodium methoxide, and sodium ethoxide.
- the hydrolysis of the amide bond of the intermediate II is performed under base catalysis, and the reaction temperature is -10 to 40 ° C. After completion of the reaction, the reaction solution was acidified, and the aqueous phase was collected and subjected to alkaline extraction to obtain intermediate III.
- the hydrolysis of the amide bond of the intermediate II is performed under acid catalysis, and the reaction temperature is 0-60 ° C. After completion of the reaction, the solvent can be directly removed by concentration to obtain a salt of Intermediate III. It is worth noting that, even if the salt of intermediate III is obtained, there is not much difference in nature between acid catalysis and base catalysis.
- the salt of intermediate III can be directly subjected to hydrogenation reaction,
- the hydrogenation reduction of the intermediate III or a salt thereof is performed under a hydrogen atmosphere and using palladium carbon as a catalyst.
- the hydrogenation conditions of the intermediate III are more severe, and it is necessary to use a more active palladium carbon as a catalyst under a hydrogen pressure of 0.1-1 MPa and a temperature of 20-50 ° C.
- the embodiment of the present disclosure also provides a method for preparing (1R, 3S) -3-amino-1-cyclopentanolate, which includes:
- the structural formula of the chiral N-acyl hydroxylamine compound is The structural formula of intermediate I is The structural formula of intermediate II is The structure of the salt of intermediate III is The structural formula of (1R, 3S) -3-amino-1-cyclopentanol salt is
- R is selected from C1 to C4 alkyl or C6 to C10 aryl
- HA is selected from any one of HCl, HBr, H 2 SO 4 , HOTs, and HOMs.
- the alcoholysis of the amide bond of the intermediate II is performed under the condition of an acid catalyst and a reaction temperature of 0 to 60 ° C.
- the acid includes at least one of HCl, HBr, H 2 SO 4 , HOTs, and HOMs.
- the hydrogenation reduction of the salt of the intermediate III is performed under a hydrogen atmosphere and using palladium carbon or Raney nickel as a catalyst.
- the hydrogenation reduction of the salt of the intermediate III is performed using palladium-carbon as a catalyst under a hydrogen pressure of 0.1 to 1 MPa and a temperature of 20 to 50 ° C.
- the reduction of the salt of the intermediate III is performed by using Raney nickel as a catalyst under the conditions of a hydrogen pressure of 0.1 to 2 MPa and a temperature of 20 to 50 ° C.
- the embodiment of the present disclosure also provides an amide intermediate for synthesizing (1R, 3S) -3-amino-1-cyclopentanol. Its structural formula is
- R is selected from a C1 to C4 alkyl group or a C6 to C10 aryl group.
- R is selected from phenyl and substituted phenyl, for example, R is phenyl.
- R is selected from C2 to C4 alkyl or C6 to C10 aryl.
- R is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl and tert-butyl.
- R is selected from ethyl, n-propyl, isopropyl And t-butyl, for example, R is t-butyl.
- R is selected from the group including methyl, ethyl, n-propyl, isopropyl, and tert-butyl.
- R is tert-butyl
- the embodiment of the present disclosure also provides an amine salt intermediate for synthesizing (1R, 3S) -3-amino-1-cyclopentanol. Its structural formula is:
- HA is selected from any one of HCl, HBr, H 2 SO 4 , HOTs, and HOMs.
- the HA is selected from HCl.
- This embodiment provides a method for preparing intermediate I.
- the reaction formula is
- This embodiment provides a method for preparing intermediate I.
- the reaction formula is
- This embodiment provides a method for preparing intermediate I.
- the reaction formula is
- This embodiment provides a method for preparing intermediate I.
- the reaction formula is
- This embodiment provides a method for preparing intermediate II.
- the reaction formula is:
- This embodiment provides a method for preparing intermediate II.
- the reaction formula is:
- This embodiment provides a method for preparing intermediate II.
- the reaction formula is:
- This embodiment provides a method for preparing intermediate III.
- the reaction formula is
- This embodiment provides a method for preparing intermediate III.
- the reaction formula is
- This embodiment provides a method for preparing intermediate III.
- the reaction formula is
- This embodiment provides a method for preparing intermediate III.
- the reaction formula is
- This embodiment provides a method for preparing intermediate III.
- the reaction formula is
- This embodiment provides a method for preparing the hydrochloride salt of intermediate III.
- the reaction formula is
- HRMS The detection value is 100.0814, and the theoretical value is 100.0757. (Calculated as C 5 H 10 NO + ).
- This embodiment provides a method for preparing a hydrobromide salt of intermediate III.
- the reaction formula is
- This embodiment provides a method for preparing a sulfate of intermediate III.
- the reaction formula is
- This embodiment provides a method for preparing p-toluenesulfonate of intermediate III.
- the reaction formula is
- This embodiment provides a method for preparing a mesylate salt of intermediate III.
- the reaction formula is
- This embodiment provides a method for preparing (1R, 3S) -3-amino-1-cyclopentanol.
- the reaction formula is
- This embodiment provides a method for preparing (1R, 3S) -3-amino-1-cyclopentanol hydrochloride.
- the reaction formula is
- This embodiment provides a method for preparing (1R, 3S) -3-amino-1-cyclopentanol hydrochloride.
- the reaction formula is
- the embodiment of the present disclosure provides a method for preparing (1R, 3S) -3-amino-1-cyclopentanol and a salt thereof, which uses a chiral center in an N-acylhydroxylamine compound as the chirality.
- Induction asymmetric cycloaddition reaction with cyclopentadiene is performed to construct two chiral centers of the target product.
- the N-acyl hydroxylamine compound can be obtained by one-step derivation of hydroxylamine, which has a wide range of sources, is cheap and easy to obtain, and can effectively reduce the cost of raw materials.
- the preparation method has a reasonable route, simple operation, mild reaction conditions, and high atomic economy.
- its stereoselectivity is good, and the prepared product has high optical purity and stable quality, which is suitable for large-scale industrial production.
- the embodiment of the present disclosure also provides an intermediate for synthesizing (1R, 3S) -3-amino-1-cyclopentanol and a salt thereof, which has simple preparation and wide sources, and is suitable for (1R, 3S)- Mass production of 3-amino-1-cyclopentanol and its salts.
- the embodiment of the present disclosure provides a method for preparing (1R, 3S) -3-amino-1-cyclopentanol and a salt thereof, which uses a chiral center in an N-acyl hydroxylamine compound as a chiral induction and Diene undergoes asymmetric cycloaddition reaction to construct two chiral centers of the target product.
- the N-acyl hydroxylamine compound can be obtained by one-step derivation of hydroxylamine, which has a wide range of sources, is cheap and easy to obtain, and can effectively reduce the cost of raw materials.
- the preparation method has a reasonable route, simple operation, mild reaction conditions, and high atomic economy. In addition, its stereoselectivity is good, and the prepared product has high optical purity and stable quality, which is suitable for large-scale industrial production.
- the embodiment of the present disclosure also provides an intermediate for synthesizing (1R, 3S) -3-amino-1-cyclopentanol and a salt thereof, which has simple preparation and wide sources, and is suitable for (1R, 3S)- Mass production of 3-amino-1-cyclopentanol and its salts.
Abstract
Description
Claims (23)
- 根据权利要求1所述的制备方法,其中,R选自C2~C4烷基或C6~C10芳基。
- 根据权利要求1所述的制备方法,其中,R选自由甲基、乙基、正丙基、异丙基和叔丁基组成的组,优选地,R选自乙基、正丙基、异丙基和叔丁基组成的组,优选地,R为叔丁基。
- 根据权利要求1或2所述的制备方法,其中,R选自苯基及取代苯基,优选地,R为苯基。
- 根据权利要求1-4任一项所述的制备方法,其中,所述N-酰基羟胺化合物与所述环戊二烯的反应是在氧化剂存在下进行的,所述氧化剂包括高碘酸盐、氧气、双氧水和NBS中的至少一种。
- 根据权利要求1-5任一项所述的制备方法,其中,对所述中间体I进行氢化还原,是在氢气氛围下,以钯碳或兰尼镍作为催化剂的条件下进行的;优选地,是以钯碳作为催化剂,在氢气压力为0.05~0.1MPa,温度为-10~15℃的条件下进行的;或优选地,是以兰尼镍作为催化剂,在氢气压力为0.1~2MPa,温度为-10~15℃的条件下进行的。
- 根据权利要求1-6任一项所述的制备方法,其中,将所述中间体II的酰胺键进行氨解或醇解,是在酸或碱的催化下进行的。
- 根据权利要求7所述的制备方法,其中,所述酸包括盐酸、溴化氢、硫酸、对甲苯磺酸和甲磺酸中的至少一种。
- 根据权利要求7所述的制备方法,其中,所述碱包括氨气、水合肼、羟胺水溶液、甲醇钠和乙醇钠中的至少一种。
- 根据权利要求9所述的制备方法,其中,将所述中间体II的酰胺键进行氨解或醇解,是在所述碱的催化下进行的,反应温度为-10~40℃。
- 根据权利要求1-10任一项所述的制备方法,其中,对所述中间体III进行氢化还原,是在氢气氛围下,以钯碳或兰尼镍作为催化剂的条件下进行的;优选地,是以钯碳作为催化剂,在氢气压力为0.1~1MPa,温度为20~50℃下的条件下进行的;或优选地,是以兰尼镍作为催化剂,在氢气压力为0.1~2MPa,温度为20~50℃下的条件下进行的。
- 一种(1R,3S)-3-氨基-1-环戊醇盐的制备方法,包括:以手性N-酰基羟胺化合物为原料,与环戊二烯发生不对称环加成反应,得到中间体I;将所述中间体I进行氢化还原,得到中间体II;将所述中间体II的酰胺键在酸催化下进行醇解,得到中间体III的盐;将所述中间体III的盐进行氢化还原,得到(1R,3S)-3-氨基-1-环戊醇的盐;式中,R选自C1~C4烷基或C6~C10芳基,HA选自HCl、HBr、H 2SO 4、HOTs和HOMs中的任一种。
- 根据权利要求12所述的制备方法,其中,将所述中间体II的酰胺键进行醇解, 是在所述酸的催化下,反应温度为0~60℃的条件下进行的。
- 根据权利要求13所述的制备方法,其中,所述酸包括HCl、HBr、H 2SO 4、HOTs和HOMs中的至少一种。
- 根据权利要求12-14任一项所述的制备方法,其中,对所述中间体III的盐进行氢化还原,是在氢气氛围下,以钯碳或兰尼镍作为催化剂的条件下进行的;优选地,是以钯碳作为催化剂,在氢气压力为0.1~1MPa,温度为20~50℃下的条件下进行的;或优选地,是以兰尼镍作为催化剂,在氢气压力为0.1~2MPa,温度为20~50℃下的条件下进行的。
- 根据权利要求16所述的酰胺中间体,其中,R选自C2~C4烷基或C6~C10芳基。
- 根据权利要求16所述的酰胺中间体,其中,R选自由甲基、乙基、正丙基、异丙基、叔丁基组成的组,优选地,R选自乙基、正丙基、异丙基和叔丁基组成的组,优选地,R为叔丁基。
- 根据权利要求16或17所述的酰胺中间体,其中,R选自苯基及取代苯基,优选地,R为苯基。
- 根据权利要求20所述的胺盐中间体,其中,HA选自HCl。
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CA3108358A CA3108358C (en) | 2018-08-28 | 2019-07-26 | Preparation method for (1r,3s)-3-amino-1-cyclopentanol and salts thereof |
EP19853589.0A EP3845518A4 (en) | 2018-08-28 | 2019-07-26 | PROCESS FOR THE PREPARATION OF (1R, 3S) -3-AMINO-1-CYCLOPENTANOL AND ITS SALTS |
KR1020217003015A KR102658673B1 (ko) | 2018-08-28 | 2019-07-26 | (1r,3s)-3-아미노기-1-사이클로펜탄올 및 그 염의 제조방법 |
JP2021527275A JP7174851B2 (ja) | 2018-08-28 | 2019-07-26 | (1r,3s)-3-アミノ-1-シクロペンタノール及びその塩の調製方法 |
US17/163,532 US11459291B2 (en) | 2018-08-28 | 2021-01-31 | Method of preparation of (1R,3S)-3-amino-1-cyclopentanol and salt thereof |
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WO2018005328A1 (en) * | 2016-06-27 | 2018-01-04 | Concert Pharmaceuticals, Inc. | Deuterated bictegravir |
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CN103923055B (zh) * | 2014-04-02 | 2015-11-18 | 黄河三角洲京博化工研究院有限公司 | 一种制备(1s,2r,3s,4r)-2,3-o-亚异丙基-4-氨基环戊烷-1,2,3-三醇的方法 |
TWI744723B (zh) * | 2014-06-20 | 2021-11-01 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
CN106279095A (zh) * | 2015-06-01 | 2017-01-04 | 重庆圣华曦药业股份有限公司 | 一种替格瑞洛关键中间体的制备方法 |
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2019
- 2019-07-26 WO PCT/CN2019/097921 patent/WO2020042841A1/zh unknown
- 2019-07-26 CA CA3108358A patent/CA3108358C/en active Active
- 2019-07-26 JP JP2021527275A patent/JP7174851B2/ja active Active
- 2019-07-26 EP EP19853589.0A patent/EP3845518A4/en active Pending
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2021
- 2021-01-31 US US17/163,532 patent/US11459291B2/en active Active
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Also Published As
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EP3845518A1 (en) | 2021-07-07 |
CN110862325A (zh) | 2020-03-06 |
JP7174851B2 (ja) | 2022-11-17 |
EP3845518A4 (en) | 2021-11-10 |
JP2021532184A (ja) | 2021-11-25 |
US20210147339A1 (en) | 2021-05-20 |
CA3108358A1 (en) | 2020-03-05 |
US11459291B2 (en) | 2022-10-04 |
CA3108358C (en) | 2023-08-01 |
KR20210028665A (ko) | 2021-03-12 |
CN110862325B (zh) | 2020-08-25 |
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