JP6240599B2 - 新規の架橋試薬、高分子、治療用コンジュゲートおよびその合成法 - Google Patents

新規の架橋試薬、高分子、治療用コンジュゲートおよびその合成法 Download PDF

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JP6240599B2
JP6240599B2 JP2014521744A JP2014521744A JP6240599B2 JP 6240599 B2 JP6240599 B2 JP 6240599B2 JP 2014521744 A JP2014521744 A JP 2014521744A JP 2014521744 A JP2014521744 A JP 2014521744A JP 6240599 B2 JP6240599 B2 JP 6240599B2
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ユーメイ フアン，
ユーメイ フアン，
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セルモザイク， インコーポレイテッド
セルモザイク， インコーポレイテッド
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    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
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    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
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    • C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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JP2014521744A 2011-07-19 2012-07-18 新規の架橋試薬、高分子、治療用コンジュゲートおよびその合成法 Expired - Fee Related JP6240599B2 (ja)

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US201161509296P 2011-07-19 2011-07-19
US61/509,296 2011-07-19
PCT/US2012/047255 WO2013012961A2 (en) 2011-07-19 2012-07-18 Novel crosslinking reagents, macromolecules, therapeutic conjugates, and synthetic methods thereof

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JP2014521319A JP2014521319A (ja) 2014-08-28
JP2014521319A5 JP2014521319A5 (https=) 2015-09-10
JP6240599B2 true JP6240599B2 (ja) 2017-11-29

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US (1) US8907079B2 (https=)
EP (1) EP2734238B1 (https=)
JP (1) JP6240599B2 (https=)
CN (2) CN107043339B (https=)
AU (1) AU2012284055B2 (https=)
CA (1) CA2841313C (https=)
WO (1) WO2013012961A2 (https=)

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JP2014521319A (ja) 2014-08-28
WO2013012961A3 (en) 2013-08-01
AU2012284055B2 (en) 2017-09-07
CA2841313A1 (en) 2013-01-24
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US8907079B2 (en) 2014-12-09
CA2841313C (en) 2023-10-24
CN107043339B (zh) 2019-09-06
WO2013012961A2 (en) 2013-01-24
EP2734238B1 (en) 2020-02-19
AU2012284055A1 (en) 2014-01-30
CN104066451B (zh) 2017-04-05
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