JP2014521319A5 - - Google Patents
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- JP2014521319A5 JP2014521319A5 JP2014521744A JP2014521744A JP2014521319A5 JP 2014521319 A5 JP2014521319 A5 JP 2014521319A5 JP 2014521744 A JP2014521744 A JP 2014521744A JP 2014521744 A JP2014521744 A JP 2014521744A JP 2014521319 A5 JP2014521319 A5 JP 2014521319A5
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- JP
- Japan
- Prior art keywords
- group
- independently
- compound
- alkyl
- sugar alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- -1 antibodies Proteins 0.000 claims description 304
- 150000001875 compounds Chemical class 0.000 claims description 288
- 125000000217 alkyl group Chemical group 0.000 claims description 109
- 229910052739 hydrogen Inorganic materials 0.000 claims description 76
- 239000001257 hydrogen Substances 0.000 claims description 76
- 150000005846 sugar alcohols Chemical class 0.000 claims description 76
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims description 62
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 58
- 150000001336 alkenes Chemical class 0.000 claims description 48
- 239000000126 substance Substances 0.000 claims description 47
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 44
- 125000005103 alkyl silyl group Chemical group 0.000 claims description 44
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 44
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims description 44
- 229910052760 oxygen Inorganic materials 0.000 claims description 43
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 42
- 229910052768 actinide Inorganic materials 0.000 claims description 41
- 150000001255 actinides Chemical class 0.000 claims description 41
- 229910052717 sulfur Inorganic materials 0.000 claims description 41
- 239000000178 monomer Substances 0.000 claims description 39
- 125000001917 2,4-dinitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C(=C1*)[N+]([O-])=O)[N+]([O-])=O 0.000 claims description 30
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 30
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 30
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 claims description 30
- 125000003118 aryl group Chemical group 0.000 claims description 27
- 229910052740 iodine Inorganic materials 0.000 claims description 26
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- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 22
- FXQYOKDNWCSKFS-UHFFFAOYSA-N 3-phenyl-1-(trifluoromethyl)diazirine Chemical class FC(F)(F)N1N=C1C1=CC=CC=C1 FXQYOKDNWCSKFS-UHFFFAOYSA-N 0.000 claims description 20
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims description 18
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- NMHMNPHRMNGLLB-UHFFFAOYSA-N phloretic acid Chemical class OC(=O)CCC1=CC=C(O)C=C1 NMHMNPHRMNGLLB-UHFFFAOYSA-N 0.000 claims description 14
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- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 claims description 9
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- 238000005804 alkylation reaction Methods 0.000 description 1
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- 125000000654 isopropylidene group Chemical group C(C)(C)=* 0.000 description 1
- YNESATAKKCNGOF-UHFFFAOYSA-N lithium bis(trimethylsilyl)amide Chemical compound [Li+].C[Si](C)(C)[N-][Si](C)(C)C YNESATAKKCNGOF-UHFFFAOYSA-N 0.000 description 1
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| US9511150B2 (en) | 2011-07-19 | 2016-12-06 | CellMosaic, Inc. | Crosslinking reagents, macromolecules, therapeutic bioconjugates, and synthetic methods thereof |
| WO2014134445A1 (en) * | 2013-02-28 | 2014-09-04 | Tufts Unversity | Disulfide compounds for delivery of pharmaceutical agents |
| PL2991683T3 (pl) | 2013-05-02 | 2020-03-31 | Glykos Finland Oy | Koniugaty glikoproteiny lub glikanu z toksycznym ładunkiem |
| JP5924795B2 (ja) | 2014-06-13 | 2016-05-25 | テンボロン オイ | 複合体 |
| EP3160513B1 (en) | 2014-06-30 | 2020-02-12 | Glykos Finland Oy | Saccharide derivative of a toxic payload and antibody conjugates thereof |
| TWI648271B (zh) | 2014-09-23 | 2019-01-21 | 日商住友電木股份有限公司 | 二氮環丙烯化合物及由其衍生之組成物 |
| CN104560026A (zh) * | 2014-12-25 | 2015-04-29 | 温州医科大学附属第二医院 | 一种活体卵巢癌组织的靶向muc1的荧光探针及其制备方法 |
| WO2017060122A1 (en) * | 2015-10-05 | 2017-04-13 | Syngenta Participations Ag | Methods of preserving the biological activity of ribonucleic acids |
| JP6486316B2 (ja) | 2015-11-03 | 2019-03-20 | 財團法人工業技術研究院Ｉｎｄｕｓｔｒｉａｌ Ｔｅｃｈｎｏｌｏｇｙ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ | 抗体−薬物複合体（ａｄｃ）およびそれを形成するための方法 |
| JP7285828B2 (ja) | 2017-09-05 | 2023-06-02 | トルク セラピューティクス， インコーポレイテッド | 治療用タンパク質組成物ならびにその作製および使用方法 |
| KR20210031848A (ko) | 2017-09-05 | 2021-03-23 | 토크 테라퓨틱스, 인코포레이티드 | 가역적 링커 및 이의 용도 |
| US12515382B2 (en) * | 2018-02-16 | 2026-01-06 | Zeon Corporation | Production method for dip-molded article |
| US12258334B2 (en) * | 2018-05-01 | 2025-03-25 | Cellmosaic Inc. | Branched sugar alcohol-based compounds, and compositions and methods thereof |
| CN109142330B (zh) * | 2018-07-31 | 2020-09-11 | 漯河医学高等专科学校 | ZnS-CeO2-WO3-Al2O3丙酮氰醇气体传感器材料的制备方法及丙酮氰醇气体传感器 |
| CN109776625B (zh) * | 2019-03-18 | 2022-08-23 | 南京江原安迪科正电子研究发展有限公司 | 一种d-甘露糖的合成方法 |
| CA3137379A1 (en) * | 2019-04-26 | 2020-10-29 | Xlynx Materials Inc. | Diazirine-based molecules and uses thereof |
| CN110563698A (zh) * | 2019-07-25 | 2019-12-13 | 苏州昊帆生物股份有限公司 | 一种新型蛋白质交联剂及其制备方法 |
| CN116635083A (zh) * | 2020-12-22 | 2023-08-22 | 豪夫迈·罗氏有限公司 | 用于检测样品中的目标分析物的方法 |
| EP4279502A4 (en) * | 2021-01-18 | 2026-02-11 | Ajinomoto Kk | COMPOUND OR ITS SALT, AND ANTIBODIES THUS OBTAINED |
| US20220298399A1 (en) * | 2021-03-19 | 2022-09-22 | Facebook Technologies, Llc | Synthesis and use of multi-functional diazirine adhesives for elastomer bonding |
| JP7717832B2 (ja) | 2021-04-10 | 2025-08-04 | ジェンマブ エー／エス | Ｆｏｌｒ１結合剤、そのコンジュゲートおよびこれを使用する方法 |
| WO2022226317A1 (en) | 2021-04-23 | 2022-10-27 | Profoundbio Us Co. | Anti-cd70 antibodies, conjugates thereof and methods of using the same |
| TW202320857A (zh) | 2021-07-06 | 2023-06-01 | 美商普方生物製藥美國公司 | 連接子、藥物連接子及其結合物及其使用方法 |
| CN115043899B (zh) * | 2022-05-24 | 2024-10-22 | 南开大学 | 双胺或胺与硫醇偶联的化合物及其制备方法和应用 |
| CN117835778A (zh) * | 2022-09-26 | 2024-04-05 | 清华大学 | 图案化量子点薄膜的制备方法、光电器件与电子设备 |
| AU2024353316A1 (en) | 2023-09-26 | 2026-03-26 | Genmab A/S | Ptk7 binding agents, conjugates thereof and methods of using the same |
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-
2012
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- 2012-07-18 EP EP12745599.6A patent/EP2734238B1/en active Active
- 2012-07-18 CN CN201710164951.6A patent/CN107043339B/zh active Active
- 2012-07-18 AU AU2012284055A patent/AU2012284055B2/en active Active
- 2012-07-18 JP JP2014521744A patent/JP6240599B2/ja not_active Expired - Fee Related
- 2012-07-18 WO PCT/US2012/047255 patent/WO2013012961A2/en not_active Ceased
- 2012-07-18 CN CN201280034231.3A patent/CN104066451B/zh active Active
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2014
- 2014-03-13 US US14/210,121 patent/US8907079B2/en active Active - Reinstated
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