JP2014521319A5 - - Google Patents
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- JP2014521319A5 JP2014521319A5 JP2014521744A JP2014521744A JP2014521319A5 JP 2014521319 A5 JP2014521319 A5 JP 2014521319A5 JP 2014521744 A JP2014521744 A JP 2014521744A JP 2014521744 A JP2014521744 A JP 2014521744A JP 2014521319 A5 JP2014521319 A5 JP 2014521319A5
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- JP
- Japan
- Prior art keywords
- group
- independently
- compound
- alkyl
- sugar alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- -1 antibodies Proteins 0.000 claims description 304
- 150000001875 compounds Chemical class 0.000 claims description 288
- 125000000217 alkyl group Chemical group 0.000 claims description 109
- 229910052739 hydrogen Inorganic materials 0.000 claims description 76
- 239000001257 hydrogen Substances 0.000 claims description 76
- 150000005846 sugar alcohols Chemical class 0.000 claims description 76
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims description 62
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 58
- 150000001336 alkenes Chemical class 0.000 claims description 48
- 239000000126 substance Substances 0.000 claims description 47
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 44
- 125000005103 alkyl silyl group Chemical group 0.000 claims description 44
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 44
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims description 44
- 229910052760 oxygen Inorganic materials 0.000 claims description 43
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 42
- 229910052768 actinide Inorganic materials 0.000 claims description 41
- 150000001255 actinides Chemical class 0.000 claims description 41
- 229910052717 sulfur Inorganic materials 0.000 claims description 41
- 239000000178 monomer Substances 0.000 claims description 39
- 125000001917 2,4-dinitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C(=C1*)[N+]([O-])=O)[N+]([O-])=O 0.000 claims description 30
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 30
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 30
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 claims description 30
- 125000003118 aryl group Chemical group 0.000 claims description 27
- 229910052740 iodine Inorganic materials 0.000 claims description 26
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- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 22
- FXQYOKDNWCSKFS-UHFFFAOYSA-N 3-phenyl-1-(trifluoromethyl)diazirine Chemical class FC(F)(F)N1N=C1C1=CC=CC=C1 FXQYOKDNWCSKFS-UHFFFAOYSA-N 0.000 claims description 20
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims description 18
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- NMHMNPHRMNGLLB-UHFFFAOYSA-N phloretic acid Chemical class OC(=O)CCC1=CC=C(O)C=C1 NMHMNPHRMNGLLB-UHFFFAOYSA-N 0.000 claims description 14
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- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 claims description 9
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| US9511150B2 (en) | 2011-07-19 | 2016-12-06 | CellMosaic, Inc. | Crosslinking reagents, macromolecules, therapeutic bioconjugates, and synthetic methods thereof |
| ES2859923T3 (es) * | 2013-02-28 | 2021-10-04 | Univ Tufts | Compuestos de disulfuro para el suministro de agentes farmacéuticos |
| PL2991683T3 (pl) | 2013-05-02 | 2020-03-31 | Glykos Finland Oy | Koniugaty glikoproteiny lub glikanu z toksycznym ładunkiem |
| EP3154587B1 (en) | 2014-06-13 | 2020-01-15 | Tenboron OY | Conjugates comprising an anti-egfr1 antibody |
| EP3160513B1 (en) | 2014-06-30 | 2020-02-12 | Glykos Finland Oy | Saccharide derivative of a toxic payload and antibody conjugates thereof |
| TWI648271B (zh) * | 2014-09-23 | 2019-01-21 | 日商住友電木股份有限公司 | 二氮環丙烯化合物及由其衍生之組成物 |
| CN104560026A (zh) * | 2014-12-25 | 2015-04-29 | 温州医科大学附属第二医院 | 一种活体卵巢癌组织的靶向muc1的荧光探针及其制备方法 |
| KR20180056750A (ko) * | 2015-10-05 | 2018-05-29 | 신젠타 파티서페이션즈 아게 | 리보핵산의 생물학적 활성을 보존하는 방법 |
| CN107029242A (zh) | 2015-11-03 | 2017-08-11 | 财团法人工业技术研究院 | 抗体药物复合物及其制造方法 |
| WO2019050977A1 (en) | 2017-09-05 | 2019-03-14 | Torque Therapeutics, Inc. | REVERSIBLE LINKS AND THEIR USE |
| CA3074826A1 (en) | 2017-09-05 | 2019-03-14 | Torque Therapeutics, Inc. | Therapeutic protein compositions and methods of making and using the same |
| WO2019159779A1 (ja) * | 2018-02-16 | 2019-08-22 | 日本ゼオン株式会社 | ディップ成形体の製造方法 |
| US12258334B2 (en) * | 2018-05-01 | 2025-03-25 | Cellmosaic Inc. | Branched sugar alcohol-based compounds, and compositions and methods thereof |
| CN109142330B (zh) * | 2018-07-31 | 2020-09-11 | 漯河医学高等专科学校 | ZnS-CeO2-WO3-Al2O3丙酮氰醇气体传感器材料的制备方法及丙酮氰醇气体传感器 |
| CN109776625B (zh) * | 2019-03-18 | 2022-08-23 | 南京江原安迪科正电子研究发展有限公司 | 一种d-甘露糖的合成方法 |
| WO2020215144A1 (en) * | 2019-04-26 | 2020-10-29 | Xlynx Materials Inc. | Diazirine-based molecules and uses thereof |
| CN110563698A (zh) * | 2019-07-25 | 2019-12-13 | 苏州昊帆生物股份有限公司 | 一种新型蛋白质交联剂及其制备方法 |
| JP2023554517A (ja) * | 2020-12-22 | 2023-12-27 | エフ． ホフマン－ラ ロシュ アーゲー | 試料中の目的の分析物を検出するための方法 |
| JP7670072B2 (ja) * | 2021-01-18 | 2025-04-30 | 味の素株式会社 | 化合物またはその塩、およびそれらにより得られる抗体 |
| US20220298399A1 (en) * | 2021-03-19 | 2022-09-22 | Facebook Technologies, Llc | Synthesis and use of multi-functional diazirine adhesives for elastomer bonding |
| US20240209080A1 (en) | 2021-04-10 | 2024-06-27 | Profoundbio Us Co. | Folr1 binding agents, conjugates thereof and methods of using the same |
| CA3216459A1 (en) | 2021-04-23 | 2022-10-27 | Profoundbio Us Co. | Anti-cd70 antibodies, conjugates thereof and methods of using the same |
| TW202320857A (zh) | 2021-07-06 | 2023-06-01 | 美商普方生物製藥美國公司 | 連接子、藥物連接子及其結合物及其使用方法 |
| CN115043899B (zh) * | 2022-05-24 | 2024-10-22 | 南开大学 | 双胺或胺与硫醇偶联的化合物及其制备方法和应用 |
| CN117835778A (zh) * | 2022-09-26 | 2024-04-05 | 清华大学 | 图案化量子点薄膜的制备方法、光电器件与电子设备 |
| AR133955A1 (es) | 2023-09-26 | 2025-11-19 | Profoundbio Us Co | Agentes de unión a ptk7, conjugados de éstos y métodos de uso de los mismos |
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| US2258892A (en) * | 1938-08-25 | 1941-10-14 | Benjamin R Harris | Ethers of polyglycerols |
| US2520671A (en) | 1946-10-24 | 1950-08-29 | Gen Mills Inc | Polyhydroxy compounds |
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| US2532036A (en) | 1946-10-24 | 1950-11-28 | Gen Mills Inc | Process of preparing polyhydric alcohols |
| GB723244A (en) * | 1951-04-10 | 1955-02-02 | Unilever Ltd | Improvements in or relating to surface-active agents |
| US4172094A (en) | 1976-12-03 | 1979-10-23 | Merck & Co., Inc. | Polyamine compounds |
| DE4124283A1 (de) | 1991-07-15 | 1993-01-21 | Degussa | Umesterung von peptiden |
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| FR2701949B1 (fr) | 1993-02-22 | 1997-01-24 | Picardie Jules Verne Universit | Procédé de synthèse de nouveaux composés disaccharidiques, sans jonction glycosidique, produits obtenus par ce procédé et leurs applications comme médicament tensioactif ou agent chélatant. |
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| DE01918975T1 (de) * | 2000-03-24 | 2006-04-13 | Biosphere Medical, Inc., Rockland | Mikrokügelchen zur aktiven Embolisierung |
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| FI20021772A7 (fi) * | 2002-10-04 | 2004-04-05 | Biotie Therapies Oyj | Uudet hiilihydraattikoostumukset ja menetelmä niiden valmistamiseksi |
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| US7560231B2 (en) * | 2002-12-20 | 2009-07-14 | Roche Molecular Systems, Inc. | Mannitol and glucitol derivatives |
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| CN1897812B (zh) | 2003-12-03 | 2011-08-17 | 生物种属学股份公司 | 糖聚乙二醇化的粒细胞集落刺激因子 |
| JP2007515410A (ja) | 2003-12-03 | 2007-06-14 | ネオス テクノロジーズ インコーポレイテッド | ＧｌｙｃｏＰＥＧ化卵胞刺激ホルモン |
| EP1797192A1 (en) * | 2004-09-29 | 2007-06-20 | Novo Nordisk Health Care AG | Modified proteins |
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| JP2008526864A (ja) | 2005-01-06 | 2008-07-24 | ネオス テクノロジーズ インコーポレイテッド | 糖断片を用いる糖結合 |
| EP1850878A2 (en) | 2005-02-10 | 2007-11-07 | Novo Nordisk A/S | C-terminally pegylated growth hormones |
| KR100699279B1 (ko) * | 2005-04-28 | 2007-03-23 | 학교법인 포항공과대학교 | 당 또는 당 유사체를 골격으로 하는 분자 수송체 및 그의제조방법 |
| DK3248613T3 (da) * | 2005-07-18 | 2022-03-14 | Seagen Inc | Beta-glucuronid-lægemiddel-linkerkonjugater |
| PL206420B1 (pl) | 2006-08-03 | 2010-08-31 | Politechnika Wroclawska | Nowe pochodne disorbityloaminy i sposób ich otrzymywania |
| ITMI20061624A1 (it) | 2006-08-11 | 2008-02-12 | Bioker Srl | Mono-coniugati sito-specifici di g-csf |
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| BRPI0720280A2 (pt) * | 2006-12-11 | 2014-01-28 | Wyeth Corp | Métodos e composições para tratar e monitorar tratamento de desordens associadas à il-13 |
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| EP2123304A1 (en) * | 2008-05-23 | 2009-11-25 | Freie Universität Berlin | Compounds suited as nanocarriers for active agents and their use |
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| US20110275576A1 (en) * | 2009-01-06 | 2011-11-10 | Utah State University | Carbohydrate-Cyclopamine Conjugates as Anticancer Agents |
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- 2012-07-18 EP EP12745599.6A patent/EP2734238B1/en active Active
- 2012-07-18 WO PCT/US2012/047255 patent/WO2013012961A2/en not_active Ceased
- 2012-07-18 CN CN201710164951.6A patent/CN107043339B/zh active Active
- 2012-07-18 JP JP2014521744A patent/JP6240599B2/ja not_active Expired - Fee Related
- 2012-07-18 CN CN201280034231.3A patent/CN104066451B/zh active Active
- 2012-07-18 AU AU2012284055A patent/AU2012284055B2/en active Active
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2014
- 2014-03-13 US US14/210,121 patent/US8907079B2/en active Active - Reinstated
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