CN107043339B - 新交联试剂、大分子、治疗用偶联物及其合成方法 - Google Patents

新交联试剂、大分子、治疗用偶联物及其合成方法 Download PDF

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CN107043339B
CN107043339B CN201710164951.6A CN201710164951A CN107043339B CN 107043339 B CN107043339 B CN 107043339B CN 201710164951 A CN201710164951 A CN 201710164951A CN 107043339 B CN107043339 B CN 107043339B
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CN107043339A (zh
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黄玉梅
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Xi Mosai Biotechnology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyrrole Compounds (AREA)
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CN201710164951.6A 2011-07-19 2012-07-18 新交联试剂、大分子、治疗用偶联物及其合成方法 Active CN107043339B (zh)

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Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9511150B2 (en) 2011-07-19 2016-12-06 CellMosaic, Inc. Crosslinking reagents, macromolecules, therapeutic bioconjugates, and synthetic methods thereof
ES2859923T3 (es) * 2013-02-28 2021-10-04 Univ Tufts Compuestos de disulfuro para el suministro de agentes farmacéuticos
PL2991683T3 (pl) 2013-05-02 2020-03-31 Glykos Finland Oy Koniugaty glikoproteiny lub glikanu z toksycznym ładunkiem
EP3154587B1 (en) 2014-06-13 2020-01-15 Tenboron OY Conjugates comprising an anti-egfr1 antibody
EP3160513B1 (en) 2014-06-30 2020-02-12 Glykos Finland Oy Saccharide derivative of a toxic payload and antibody conjugates thereof
TWI648271B (zh) * 2014-09-23 2019-01-21 日商住友電木股份有限公司 二氮環丙烯化合物及由其衍生之組成物
CN104560026A (zh) * 2014-12-25 2015-04-29 温州医科大学附属第二医院 一种活体卵巢癌组织的靶向muc1的荧光探针及其制备方法
KR20180056750A (ko) * 2015-10-05 2018-05-29 신젠타 파티서페이션즈 아게 리보핵산의 생물학적 활성을 보존하는 방법
CN107029242A (zh) 2015-11-03 2017-08-11 财团法人工业技术研究院 抗体药物复合物及其制造方法
WO2019050977A1 (en) 2017-09-05 2019-03-14 Torque Therapeutics, Inc. REVERSIBLE LINKS AND THEIR USE
CA3074826A1 (en) 2017-09-05 2019-03-14 Torque Therapeutics, Inc. Therapeutic protein compositions and methods of making and using the same
WO2019159779A1 (ja) * 2018-02-16 2019-08-22 日本ゼオン株式会社 ディップ成形体の製造方法
US12258334B2 (en) * 2018-05-01 2025-03-25 Cellmosaic Inc. Branched sugar alcohol-based compounds, and compositions and methods thereof
CN109142330B (zh) * 2018-07-31 2020-09-11 漯河医学高等专科学校 ZnS-CeO2-WO3-Al2O3丙酮氰醇气体传感器材料的制备方法及丙酮氰醇气体传感器
CN109776625B (zh) * 2019-03-18 2022-08-23 南京江原安迪科正电子研究发展有限公司 一种d-甘露糖的合成方法
WO2020215144A1 (en) * 2019-04-26 2020-10-29 Xlynx Materials Inc. Diazirine-based molecules and uses thereof
CN110563698A (zh) * 2019-07-25 2019-12-13 苏州昊帆生物股份有限公司 一种新型蛋白质交联剂及其制备方法
JP2023554517A (ja) * 2020-12-22 2023-12-27 エフ． ホフマン－ラ ロシュ アーゲー 試料中の目的の分析物を検出するための方法
JP7670072B2 (ja) * 2021-01-18 2025-04-30 味の素株式会社 化合物またはその塩、およびそれらにより得られる抗体
US20220298399A1 (en) * 2021-03-19 2022-09-22 Facebook Technologies, Llc Synthesis and use of multi-functional diazirine adhesives for elastomer bonding
US20240209080A1 (en) 2021-04-10 2024-06-27 Profoundbio Us Co. Folr1 binding agents, conjugates thereof and methods of using the same
CA3216459A1 (en) 2021-04-23 2022-10-27 Profoundbio Us Co. Anti-cd70 antibodies, conjugates thereof and methods of using the same
TW202320857A (zh) 2021-07-06 2023-06-01 美商普方生物製藥美國公司 連接子、藥物連接子及其結合物及其使用方法
CN115043899B (zh) * 2022-05-24 2024-10-22 南开大学 双胺或胺与硫醇偶联的化合物及其制备方法和应用
CN117835778A (zh) * 2022-09-26 2024-04-05 清华大学 图案化量子点薄膜的制备方法、光电器件与电子设备
AR133955A1 (es) 2023-09-26 2025-11-19 Profoundbio Us Co Agentes de unión a ptk7, conjugados de éstos y métodos de uso de los mismos
WO2025149661A1 (en) 2024-01-10 2025-07-17 Genmab A/S Slitrk6 binding agents, conjugates thereof and methods of using the same
US20250381289A1 (en) 2024-02-29 2025-12-18 Genmab A/S Egfr and c-met bispecific binding agents, conjugates thereof and methods of using the same

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004031244A1 (en) * 2002-10-04 2004-04-15 Glykos Finland Oy Novel carbohydrate compositions and a process of preparing same
US20080108557A1 (en) * 2004-09-29 2008-05-08 Novo Nordisk Healthcare A/G Modified Proteins
CN101600456A (zh) * 2006-12-11 2009-12-09 惠氏公司 治疗il-13相关疾病和监测il-13相关疾病治疗的方法和组合物
WO2010080817A2 (en) * 2009-01-06 2010-07-15 Utah State University Carbohydrate-cyclopamine conjugates as anticancer agents
US20100330608A1 (en) * 2005-04-28 2010-12-30 Postech Foundation Molecular transporters based on sugar and its analogues and processes for the preparation thereof

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2258892A (en) * 1938-08-25 1941-10-14 Benjamin R Harris Ethers of polyglycerols
US2520671A (en) 1946-10-24 1950-08-29 Gen Mills Inc Polyhydroxy compounds
US2520670A (en) 1946-10-24 1950-08-29 Gen Mills Inc Polyglycerols
US2532036A (en) 1946-10-24 1950-11-28 Gen Mills Inc Process of preparing polyhydric alcohols
GB723244A (en) * 1951-04-10 1955-02-02 Unilever Ltd Improvements in or relating to surface-active agents
US4172094A (en) 1976-12-03 1979-10-23 Merck & Co., Inc. Polyamine compounds
DE4124283A1 (de) 1991-07-15 1993-01-21 Degussa Umesterung von peptiden
GB9121279D0 (en) 1991-10-08 1991-11-20 Cerestar Holding Bv Process for the production of aminopolyols
FR2701949B1 (fr) 1993-02-22 1997-01-24 Picardie Jules Verne Universit Procédé de synthèse de nouveaux composés disaccharidiques, sans jonction glycosidique, produits obtenus par ce procédé et leurs applications comme médicament tensioactif ou agent chélatant.
EP0691327B1 (en) 1993-03-17 1999-07-21 Kao Corporation Amine derivative and dermatologic preparation containing the same
BR0012498A (pt) 1999-07-16 2002-04-02 Ici Ltd Composição agroquìmica, composto, e, métodos para tratar vegetação, para matar ou inibir vegetação, e para matar ou inibir pestes de plantas
DE01918975T1 (de) * 2000-03-24 2006-04-13 Biosphere Medical, Inc., Rockland Mikrokügelchen zur aktiven Embolisierung
DE60336555D1 (de) 2002-06-21 2011-05-12 Novo Nordisk Healthcare Ag Pegylierte glykoformen von faktor vii
EP2157429A3 (en) 2002-07-30 2011-12-28 Reverse Proteomics Research Institute Co., Ltd Method of inhibiting nonspecific interaction between molecules on solid phase support
US7538092B2 (en) * 2002-10-08 2009-05-26 Fresenius Kabi Deutschland Gmbh Pharmaceutically active oligosaccharide conjugates
US7560231B2 (en) * 2002-12-20 2009-07-14 Roche Molecular Systems, Inc. Mannitol and glucitol derivatives
CA2527665A1 (en) 2003-05-30 2004-12-16 Centocor, Inc. Formation of novel erythropoietin conjugates using transglutaminase
US7842661B2 (en) 2003-11-24 2010-11-30 Novo Nordisk A/S Glycopegylated erythropoietin formulations
CN1897812B (zh) 2003-12-03 2011-08-17 生物种属学股份公司 糖聚乙二醇化的粒细胞集落刺激因子
JP2007515410A (ja) 2003-12-03 2007-06-14 ネオス テクノロジーズ インコーポレイテッド ＧｌｙｃｏＰＥＧ化卵胞刺激ホルモン
US20070134243A1 (en) * 2004-12-01 2007-06-14 Gazzard Lewis J Antibody drug conjugates and methods
JP2008526864A (ja) 2005-01-06 2008-07-24 ネオス テクノロジーズ インコーポレイテッド 糖断片を用いる糖結合
EP1850878A2 (en) 2005-02-10 2007-11-07 Novo Nordisk A/S C-terminally pegylated growth hormones
DK3248613T3 (da) * 2005-07-18 2022-03-14 Seagen Inc Beta-glucuronid-lægemiddel-linkerkonjugater
PL206420B1 (pl) 2006-08-03 2010-08-31 Politechnika Wroclawska Nowe pochodne disorbityloaminy i sposób ich otrzymywania
ITMI20061624A1 (it) 2006-08-11 2008-02-12 Bioker Srl Mono-coniugati sito-specifici di g-csf
FR2906245A1 (fr) 2006-09-25 2008-03-28 Oreal Diamides hydroxyles agent d'hydratation de la peau
BRPI0720280A2 (pt) * 2006-12-11 2014-01-28 Wyeth Corp Métodos e composições para tratar e monitorar tratamento de desordens associadas à il-13
FR2921838A1 (fr) 2007-10-05 2009-04-10 Guerbet Sa Nouveau procede de preparation de nanoparticules recouvertes d'une couche stabilisatrice gem-bisphosphonate couplee a des ligands de biodistribution hydrophile
JP2009249500A (ja) 2008-04-07 2009-10-29 Hakuto Co Ltd 重合性高分岐ポリマー及びその製造方法
EP2123304A1 (en) * 2008-05-23 2009-11-25 Freie Universität Berlin Compounds suited as nanocarriers for active agents and their use
US20100024286A1 (en) 2008-07-31 2010-02-04 Smith Susan Jane Liquid fuel compositions
WO2010134476A1 (ja) 2009-05-19 2010-11-25 日産化学工業株式会社 長鎖グリシルポリオール型ゲル化剤およびゲル

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004031244A1 (en) * 2002-10-04 2004-04-15 Glykos Finland Oy Novel carbohydrate compositions and a process of preparing same
US20080108557A1 (en) * 2004-09-29 2008-05-08 Novo Nordisk Healthcare A/G Modified Proteins
US20100330608A1 (en) * 2005-04-28 2010-12-30 Postech Foundation Molecular transporters based on sugar and its analogues and processes for the preparation thereof
CN101600456A (zh) * 2006-12-11 2009-12-09 惠氏公司 治疗il-13相关疾病和监测il-13相关疾病治疗的方法和组合物
WO2010080817A2 (en) * 2009-01-06 2010-07-15 Utah State University Carbohydrate-cyclopamine conjugates as anticancer agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Eric S. Underbakke等.Isotope-Coded Affinity Tags with Tunable Reactivities for Protein Footprinting.《Angew. Chem. Int. Ed.》.2008,第47卷第9677-9680页.
Junkichi Iwasa等.Synthesis of photoaffinity and Tritium-labeled Grayanotoxin via Reductive Amination.《Biosci.Biotech.Biochem.》.1994,第58卷(第5期),第972-973页.

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