JP6169619B2 - 細菌感染または細菌とウイルスの同時感染を検出するためのキット - Google Patents

細菌感染または細菌とウイルスの同時感染を検出するためのキット Download PDF

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JP6169619B2
JP6169619B2 JP2014556086A JP2014556086A JP6169619B2 JP 6169619 B2 JP6169619 B2 JP 6169619B2 JP 2014556086 A JP2014556086 A JP 2014556086A JP 2014556086 A JP2014556086 A JP 2014556086A JP 6169619 B2 JP6169619 B2 JP 6169619B2
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JP2015510122A (ja
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クフィル オヴド
クフィル オヴド
エラン エデン
エラン エデン
イラン イフェルガン
イラン イフェルガン
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メメド ダイアグノスティクス リミテッド
メメド ダイアグノスティクス リミテッド
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    • GPHYSICS
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    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983Viruses
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44704Details; Accessories
    • G01N27/44717Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44721Arrangements for investigating the separated zones, e.g. localising zones by optical means
    • G01N27/44726Arrangements for investigating the separated zones, e.g. localising zones by optical means using specific dyes, markers or binding molecules
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    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44704Details; Accessories
    • G01N27/44717Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44739Collecting the separated zones, e.g. blotting to a membrane or punching of gel spots
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911Bacteria
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6866Interferon
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70575NGF/TNF-superfamily, e.g. CD70, CD95L, CD153 or CD154
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Immunology (AREA)
  • Molecular Biology (AREA)
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  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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JP2014556086A 2012-02-09 2013-02-08 細菌感染または細菌とウイルスの同時感染を検出するためのキット Active JP6169619B2 (ja)

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US201261596950P 2012-02-09 2012-02-09
US61/596,950 2012-02-09
US201261652631P 2012-05-29 2012-05-29
US61/652,631 2012-05-29
PCT/EP2013/052619 WO2013117746A1 (en) 2012-02-09 2013-02-08 Signatures and determinants for diagnosing infections and methods of use thereof

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JP2015510122A JP2015510122A (ja) 2015-04-02
JP2015510122A5 JP2015510122A5 (OSRAM) 2016-03-31
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JP2017126712A Active JP6725456B2 (ja) 2012-02-09 2017-06-28 対象における細菌感染または細菌/ウイルス混合感染を除外するためのキット
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JP2020109710A Pending JP2020180975A (ja) 2012-02-09 2020-06-25 複数の抗体を含むキット

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US (5) US9726668B2 (OSRAM)
EP (3) EP3882633A1 (OSRAM)
JP (3) JP6169619B2 (OSRAM)
CN (2) CN108802385B (OSRAM)
AU (2) AU2013217935B2 (OSRAM)
BR (1) BR112014019733B1 (OSRAM)
CA (2) CA2863819C (OSRAM)
ES (2) ES2886979T3 (OSRAM)
IL (3) IL233998A (OSRAM)
IN (1) IN2014MN01780A (OSRAM)
WO (1) WO2013117746A1 (OSRAM)
ZA (1) ZA201405993B (OSRAM)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8685898B2 (en) 2009-01-15 2014-04-01 Imdaptive, Inc. Adaptive immunity profiling and methods for generation of monoclonal antibodies
EP2561363B1 (en) 2010-04-21 2021-07-14 Memed Diagnostics, Ltd. Signatures and determinants for distinguishing between a bacterial and viral infection and methods of use thereof
CN108802385B (zh) 2012-02-09 2022-02-08 米密德诊断学有限公司 用于诊断感染的标记和决定因素和其使用方法
DK2823060T3 (en) 2012-03-05 2018-05-28 Adaptive Biotechnologies Corp Determination of associated immune receptor chains from frequency-matched subunits
HUE029357T2 (en) 2012-05-08 2017-02-28 Adaptive Biotechnologies Corp Preparations and devices for measuring and calibrating amplification distortion in multiplex PCR reactions
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
AU2015227054A1 (en) 2014-03-05 2016-09-22 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
CN106574295A (zh) * 2014-03-13 2017-04-19 奥普金公司 检测多重抗药性生物体的方法
US11390921B2 (en) 2014-04-01 2022-07-19 Adaptive Biotechnologies Corporation Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
EP3132059B1 (en) 2014-04-17 2020-01-08 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
WO2015184017A1 (en) 2014-05-27 2015-12-03 Opgen, Inc. Systems, apparatus, and methods for generating and analyzing resistome profiles
WO2015192050A1 (en) 2014-06-13 2015-12-17 North Carolina State University Aptamers with binding affinity to norovirus
CA3190715A1 (en) 2014-08-14 2016-02-18 Memed Diagnostics Ltd. Computational analysis of biological data using manifold and a hyperplane
WO2016059636A1 (en) * 2014-10-14 2016-04-21 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections in non-human subjects and methods of use thereof
US10392663B2 (en) 2014-10-29 2019-08-27 Adaptive Biotechnologies Corp. Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from a large number of samples
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
JP6788586B2 (ja) * 2014-11-19 2020-11-25 コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. Hnlを用いる診断方法
WO2016092554A1 (en) 2014-12-11 2016-06-16 Memed Diagnostics Ltd. Marker combinations for diagnosing infections and methods of use thereof
ES3002665T3 (en) * 2015-02-24 2025-03-07 Adaptive Biotechnologies Corp Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing
WO2016161273A1 (en) 2015-04-01 2016-10-06 Adaptive Biotechnologies Corp. Method of identifying human compatible t cell receptors specific for an antigenic target
EP3139171B1 (en) * 2015-09-02 2020-02-12 Labsystems Diagnostics Oy Novel methods and kits for detecting of urea cycle disorders using mass spectrometry
DK3356558T3 (da) * 2015-09-30 2022-04-25 Immunexpress Pty Ltd Sirs patogenbiomarkører og anvendelser deraf
CN106918698B (zh) * 2015-12-25 2019-11-22 广州瑞博奥生物科技有限公司 一种检测人受体酪氨酸激酶的磷酸化抗体芯片试剂盒
US11466331B2 (en) 2016-03-03 2022-10-11 Memed Diagnostics Ltd. RNA determinants for distinguishing between bacterial and viral infections
EP3423589B1 (en) 2016-03-03 2021-07-21 Memed Diagnostics Ltd. Analyzing rna for diagnosing infection type
CN106053831A (zh) * 2016-06-05 2016-10-26 潘时辉 一种用于自身免疫病检测的试剂盒
CA3022616A1 (en) * 2016-06-07 2017-12-14 The Board Of Trustees Of The Leland Stanford Junior University Methods for diagnosis of bacterial and viral infections
EP3475702B3 (en) * 2016-06-23 2024-03-20 Memed Diagnostics Ltd. Measuring trail by lateral flow immunoassay
CN109661578B (zh) * 2016-07-10 2022-05-10 米密德诊断学有限公司 用于区分细菌和病毒感染的蛋白质特征
WO2018011796A1 (en) 2016-07-10 2018-01-18 Memed Diagnostics Ltd. Early diagnosis of infections
US12205677B2 (en) 2016-08-10 2025-01-21 Memed Diagnostics Ltd. System and method for analysis of biological data
US10428325B1 (en) 2016-09-21 2019-10-01 Adaptive Biotechnologies Corporation Identification of antigen-specific B cell receptors
EP3519833B1 (en) 2016-09-29 2024-08-14 MeMed Diagnostics Ltd. Methods of prognosis and treatment
EP3519834A4 (en) * 2016-09-29 2020-06-17 MeMed Diagnostics Ltd. RISK ASSESSMENT AND DISEASE CLASSIFICATION METHODS
JP6903494B2 (ja) * 2017-06-09 2021-07-14 シスメックス株式会社 感染症を識別するための粒子分析方法
US10209260B2 (en) 2017-07-05 2019-02-19 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections and methods of use thereof
CA3070522A1 (en) * 2017-07-31 2019-02-07 University Health Network Biomarkers in ex vivo lung perfusion (evlp) perfusate
EP3707161A4 (en) * 2017-11-07 2021-10-27 Memed Diagnostics Ltd. ANTI-TRAIL ANTIBODIES AND METHOD OF USING THEM
JP7267606B2 (ja) * 2017-11-28 2023-05-02 国立大学法人三重大学 検出方法
US11254980B1 (en) 2017-11-29 2022-02-22 Adaptive Biotechnologies Corporation Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements
CN108039206B (zh) * 2017-12-21 2021-11-09 北京大学深圳研究生院 一种传染病的诊治方法及系统
CN117783514A (zh) * 2018-01-27 2024-03-29 贝克顿·迪金森公司 区分细菌感染和病毒感染的多重横向流测定物
US11484273B2 (en) * 2018-03-06 2022-11-01 International Business Machines Corporation Determining functional age indices based upon sensor data
US12344893B2 (en) 2018-06-05 2025-07-01 Washington University Nasal genes used to identify, characterize, and diagnose viral respiratory infections
CN108486246B (zh) * 2018-06-06 2020-06-09 青岛泱深生物医药有限公司 子痫前期的诊治标志物
CN112840314A (zh) * 2018-08-02 2021-05-25 布莱特临床研究有限公司 对正在运行中的临床试验进行动态数据监测和实时优化的系统、方法及实施过程
CA3100035A1 (en) 2018-08-27 2020-03-05 Regeneron Pharmaceuticals, Inc. Use of raman spectroscopy in downstream purification
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
US20210389329A1 (en) * 2018-10-29 2021-12-16 Thomas Jefferson University Compositions and Methods for Discriminating Infectious from Non-Infectious CNS Disorders
CN112578125B (zh) * 2019-09-27 2022-10-25 成都中医药大学 检测粪钙卫蛋白含量的试剂在制备卵巢病变筛查试剂盒中的用途
CN110923333B (zh) * 2019-12-11 2020-09-29 湖北省农业科学院畜牧兽医研究所 山羊zbp1基因第一内含子内与产羔数关联的单倍型标记及其应用
WO2021117044A1 (en) 2019-12-11 2021-06-17 Ichilov Tech Ltd. Non-invasive assay for differentiating between bacterial and viral infections
US20230094142A1 (en) * 2020-01-29 2023-03-30 Memed Diagnostics Ltd. Methods of diagnosing and classifying viral infections
CN115335532A (zh) * 2020-02-09 2022-11-11 Nlc制药有限公司 Sars-cov-2快速检测测试
EP4133281A1 (en) 2020-04-09 2023-02-15 B.R.A.H.M.S GmbH Biomarkers for the diagnosis of respiratory tract infections
CN113533170A (zh) * 2020-04-21 2021-10-22 贝克曼考尔特公司 病毒感染的血液学参数
JPWO2022004730A1 (OSRAM) * 2020-06-30 2022-01-06
CN111816245B (zh) * 2020-07-20 2022-09-09 成都博欣医学检验实验室有限公司 结合mNGS和临床知识库的病原微生物检测方法及系统
WO2022153323A1 (en) * 2021-01-18 2022-07-21 Memed Diagnostics Ltd. Markers for diagnosing infections
US20220298572A1 (en) * 2021-03-16 2022-09-22 Cepheid Compositions and methods for discriminating bacterial and viral infections in a human subject
WO2023023125A1 (en) * 2021-08-17 2023-02-23 Predigen, Inc. Methods for characterizing infections and methods for developing tests for the same
CN113945712A (zh) * 2021-12-21 2022-01-18 山东中鸿特检生物科技有限公司 一种区别细菌、病毒感染的检测方法及检测试剂盒
CN114441506B (zh) * 2022-04-08 2022-06-21 港湾之星健康生物(深圳)有限公司 量子磁光传感器
EP4357778A1 (en) 2022-10-20 2024-04-24 Heraeus Medical GmbH Treatment of microbial infections diagnosed using the biomarker d-lactate
CN119913247B (zh) * 2025-01-21 2025-12-19 浙江大学医学院附属邵逸夫医院 单核细胞和淋巴细胞cd45分子表达相对变化在诊断感染和炎症中的应用

Family Cites Families (144)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1178414A (en) 1978-02-08 1984-11-27 Toyo Boseki Kabushiki Kaisha (Trading Under The Name Of Toyobo Co., Ltd.) Packaging material having excellent seal packaging property
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4233402A (en) 1978-04-05 1980-11-11 Syva Company Reagents and method employing channeling
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4659678A (en) 1982-09-29 1987-04-21 Serono Diagnostics Limited Immunoassay of antigens
US4727022A (en) 1984-03-14 1988-02-23 Syntex (U.S.A.) Inc. Methods for modulating ligand-receptor interactions and their application
US5018067A (en) 1987-01-12 1991-05-21 Iameter Incorporated Apparatus and method for improved estimation of health resource consumption through use of diagnostic and/or procedure grouping and severity of illness indicators
DE4322330A1 (de) 1992-08-31 1994-03-03 Behringwerke Ag Verwendung des IL-4-Rezeptors zur Therapie, Prophylaxe und Diagnose von allergischen, viralen, parasitären und bakteriellen Erkrankungen sowie von Pilzinfektionen
DE4227454C1 (de) 1992-08-19 1994-02-03 Henning Berlin Gmbh Verfahren zur Früherkennung, zur Erkennung des Schweregrads sowie zur therapiebegleitenden Verlaufsbeurteilung einer Sepsis sowie Mittel zur Durchführung des Verfahrens
SE9401351D0 (sv) 1994-04-21 1994-04-21 Venge A method for diagnosis
US5910421A (en) 1995-12-21 1999-06-08 University Of Florida Rapid diagnostic method for distinguishing allergies and infections
US6077665A (en) 1996-05-07 2000-06-20 The Board Of Trustees Of The Leland Stanford Junior University Rapid assay for infection in neonates
WO1999033965A1 (en) 1997-12-24 1999-07-08 Diatech Pty. Ltd. Bifunctional molecules
WO1999060171A1 (en) 1998-05-18 1999-11-25 Apoptosis Technology, Inc. Compounds, screening methods, and uses involving anti-apoptotic genes and gene products
DE19847690A1 (de) 1998-10-15 2000-04-20 Brahms Diagnostica Gmbh Verfahren und Substanzen für die Diagnose und Therapie von Sepsis und sepsisähnlichen systemischen Infektionen
US6709855B1 (en) 1998-12-18 2004-03-23 Scios, Inc. Methods for detection and use of differentially expressed genes in disease states
AU1853600A (en) 1999-01-06 2000-07-24 Choong-Chin Liew Method for the detection of gene transcripts in blood and uses thereof
US6635461B1 (en) 1999-08-24 2003-10-21 Glycozym Aps UDP-N-acetylglucosamine: galactose-β1, 3-N-acetylgalactosamine-α-R/(GlcNAc to GalNAc) β1,6-N-acetylglucosaminyltransferase, C2GnT3
IL132687A0 (en) 1999-11-01 2001-03-19 Keren Mechkarim Ichilov Pnimit System and method for evaluating body fluid samples
US20020038227A1 (en) 2000-02-25 2002-03-28 Fey Christopher T. Method for centralized health data management
US7668661B2 (en) 2000-04-28 2010-02-23 Siemens Healthcare Diagnostics Inc. Liver disease-related methods and systems
AU2001273486A1 (en) 2000-07-17 2002-01-30 Labnetics, Inc. Method and apparatus for the processing of remotely collected electronic information characterizing properties of biological entities
US20020055176A1 (en) 2000-11-08 2002-05-09 Ray Robert A. Diagnostic assay system
CN1286985C (zh) 2001-03-27 2006-11-29 株式会社东芝 与疾病相关的核酸
US7713705B2 (en) 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
DE10119804A1 (de) 2001-04-23 2002-10-24 Brahms Ag Entzündungsspezifische Peptide und deren Verwendungen
WO2002094880A1 (fr) 2001-05-18 2002-11-28 Kirin Beer Kabushiki Kaisha Anticorps anti-trail-r
FI115165B (fi) 2001-06-04 2005-03-15 Aboatech Ab Oy Menetelmä infektion laadun määrittämiseksi
DE10130985B4 (de) 2001-06-27 2004-03-18 B.R.A.H.M.S Ag Verfahren zur Diagnose von Sepsis und schweren Infektionen unter Bestimmung löslicher Cytokeratin-1-Fragmente
US20040209307A1 (en) * 2001-08-20 2004-10-21 Biosite Incorporated Diagnostic markers of stroke and cerebral injury and methods of use thereof
EP1318407B1 (de) 2001-12-07 2004-09-29 B.R.A.H.M.S Aktiengesellschaft Verwendungen der Aldose-1-Epimerase (Mutarotase) für die Diagnose von Entzündungserkrankungen und Sepsis
DE60207183T2 (de) 2001-12-10 2006-08-10 Kabushiki Gaisha K-And-S Vorrichtung zur Beobachtung biologischer Daten
US20040038201A1 (en) 2002-01-22 2004-02-26 Whitehead Institute For Biomedical Research Diagnostic and therapeutic applications for biomarkers of infection
US7468032B2 (en) 2002-12-18 2008-12-23 Cardiac Pacemakers, Inc. Advanced patient management for identifying, displaying and assisting with correlating health-related data
US20040122296A1 (en) 2002-12-18 2004-06-24 John Hatlestad Advanced patient management for triaging health-related data
WO2004040263A2 (en) 2002-10-31 2004-05-13 Health Research, Inc. Diagnostic test for west nile virus
US20050227223A1 (en) 2002-03-22 2005-10-13 Toshio Miyawaki Method of judging viral infection
US7485298B2 (en) * 2002-05-23 2009-02-03 Michael Powell Diagnosis and treatment of human dormancy-related sequellae
JP2005529599A (ja) 2002-06-11 2005-10-06 アイダホ リサーチ ファウンデーション ウィルス感染を検出するためのタイプiインターフェロン誘導タンパク質
US8563476B2 (en) 2002-11-15 2013-10-22 Morehouse School Of Medicine Anti-CXCL9, anti-CXCL10, anti-CXCL11, anti-CXCL13, anti-CXCR3 and anti-CXCR5 agents for inflammatory disorders
WO2004108899A2 (en) 2003-06-04 2004-12-16 The Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Pni microarray and uses
JP2007518062A (ja) 2003-09-29 2007-07-05 バイオサイト インコーポレイテッド 敗血症を診断する方法および診断するための組成物
JP2005106694A (ja) 2003-09-30 2005-04-21 Mochida Pharmaceut Co Ltd 敗血症早期検出及び重篤度評価
GB0401730D0 (en) 2004-01-27 2004-03-03 Bioxell Spa Diagnosis method
US8906630B2 (en) 2004-02-27 2014-12-09 The Trustees Of The University Of Pennsylvania Assays for detecting pathogenic respiratory bacteria
US7892539B2 (en) * 2004-03-24 2011-02-22 The Regents Of The University Of California Modulation of an innate immune response by altering TRIAL-R signaling
US8155993B2 (en) 2004-06-15 2012-04-10 Janssen Pharmaceutica, N.V. Apparatus and methods for assessing a pharmaceutical product
US20080261258A1 (en) 2004-07-09 2008-10-23 Amaox, Inc. Immune Cell Biosensors and Methods of Using Same
WO2006023312A2 (en) 2004-08-20 2006-03-02 Carl Deirmengian Diagnostic assay for source of inflammation
US7572640B2 (en) 2004-09-28 2009-08-11 Singulex, Inc. Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties
EP1805500A4 (en) 2004-09-28 2008-05-07 Singulex Inc SYSTEM AND METHOD FOR THE SPECTROSCOPIC ANALYSIS OF INDIVIDUAL PARTICLES
EP1807540A4 (en) 2004-11-05 2008-12-10 Us Gov Sec Navy DIAGNOSIS AND PROGNOSIS OF CLINICAL PHENOTYPES OF INFECTION DISEASES AND OTHER PHYSIOLOGICAL CONDITIONS USING GENE EXPRESSION OF A HOSTS AS BIOMARKERS IN THE BLOOD
US20060099628A1 (en) 2004-11-10 2006-05-11 Wei-Mei Ching Diagnostic assay for rickettsia prowazekii disease by detection of responsive gene expression
EP1869463A4 (en) 2005-04-15 2010-05-05 Becton Dickinson Co SEPSIS DIAGNOSIS
CN101208602A (zh) 2005-04-15 2008-06-25 贝克顿迪金森公司 脓毒症的诊断
US20070015172A1 (en) 2005-06-01 2007-01-18 Z-Biomed, Inc. Expression profiles for microbial infection
UA78641C2 (en) 2005-08-29 2007-04-10 Open Joint Stock Company Conce A process for the preparation of carbamide-formaldehyde resin
DE102005050933A1 (de) 2005-10-21 2007-04-26 Justus-Liebig-Universität Giessen Erfindung betreffend Expressionsprofile zur Vorhersage von septischen Zuständen
US20070231816A1 (en) 2005-12-09 2007-10-04 Baylor Research Institute Module-Level Analysis of Peripheral Blood Leukocyte Transcriptional Profiles
GB0601959D0 (en) 2006-01-31 2006-03-15 King S College London Sepsis test
US20070184460A1 (en) 2006-02-09 2007-08-09 Wei-Mei Ching Diagnostic assay for Orientia tsutsugamushi by detection of responsive gene expression
KR20090023360A (ko) 2006-04-26 2009-03-04 버텍스 파마슈티칼스 인코포레이티드 C형 간염 바이러스 감염 바이오마커
WO2008024642A2 (en) 2006-08-11 2008-02-28 Baylor Research Institute Gene expression signatures in blood leukocytes permit differential diagnosis of acute infections
JP5805368B2 (ja) 2006-09-05 2015-11-04 ステイテンス・セラム・インスティテュート Ip−10に基づく免疫学的モニタリング
AU2012244350B2 (en) 2006-09-05 2013-08-15 Statens Serum Institut Ip-10 based immunological monitoring
JP2010506166A (ja) 2006-10-05 2010-02-25 エージェンシー フォー サイエンス,テクノロジー アンド リサーチ デング熱の診断及び治療
RU2527068C2 (ru) 2006-12-06 2014-08-27 Медиммун, Ллк Фармакодинамические маркеры, индуцированные интерфероном альфа
DE102006060112A1 (de) 2006-12-20 2008-06-26 Brahms Aktiengesellschaft Diagnose und Risikostratifizierung mittels dem neuen Marker CT-proADM
WO2008076077A1 (en) 2006-12-21 2008-06-26 Innogene Kalbiotech Pte Ltd Method of early diagnosis of epstein-barr virus-related cancer and respective reagents and kits
WO2008088747A2 (en) * 2007-01-11 2008-07-24 Duke University Method of monitoring hiv infection
US8293489B2 (en) 2007-01-31 2012-10-23 Henkin Robert I Methods for detection of biological substances
WO2008104953A2 (en) 2007-02-28 2008-09-04 The Procter & Gamble Company Methods and targets for identifying compounds for regulating rhinovirus infection
DE102007009751A1 (de) * 2007-02-28 2008-09-04 B.R.A.H.M.S Aktiengesellschaft Verfahren zur selektiven Bestimmung von Procalcitonin 1-116 für diagnostische Zwecke sowie Antikörper und Kits zur Durchführung eines solchen Verfahrens
JP5718049B2 (ja) 2007-06-01 2015-05-13 カウンスィル オブ サイエンティフィック アンド インダストリアル リサーチCouncil Of Scientific & Industrial Research 眼および中枢神経系の細菌、真菌、寄生虫およびウイルス感染の同時検出と識別のための新規な方法
RU2352948C1 (ru) 2007-06-15 2009-04-20 Государственное образовательное учреждение высшего профессионального образования "КРАСНОЯРСКАЯ ГОСУДАРСТВЕННАЯ МЕДИЦИНСКАЯ АКАДЕМИЯ ФЕДЕРАЛЬНОГО АГЕНТСТВА ПО ЗДРАВООХРАНЕНИЮ И СОЦИАЛЬНОМУ РАЗВИТИЮ" Способ прогноза исхода заболевания пациентов с ургентной хирургической патологией органов брюшной полости
IL184478A (en) 2007-07-08 2017-07-31 Hadasit Medical Res Services & Development Ltd Preparations, methods and kits for identifying carriers of mutations in genes 1brca and 2brca and for the early detection of cancers associated with mutations in these genes
DE102007035640A1 (de) 2007-07-27 2009-01-29 Lkh-Kunststoffwerk Gmbh & Co. Kg Tauchkolben
EP2020603A1 (en) 2007-08-03 2009-02-04 BRAHMS Aktiengesellschaft Method for risk stratification in stable coronary artery disease
DE602008021800C5 (de) * 2007-08-03 2022-05-05 B.R.A.H.M.S Gmbh Antibiotikum zur Behandlung von lokaler Infektion
TW200920358A (en) 2007-08-13 2009-05-16 Lundbeck & Co As H Method of treating stress-mediated depression
WO2009025743A2 (en) * 2007-08-17 2009-02-26 University Of Massachusetts Medical School Use of trail compositions as antiviral agents
ATE463700T1 (de) 2007-09-24 2010-04-15 Bmdsys Production Gmbh Kryostat mit stabilisiertem aussengefäss
EP2071334A1 (en) 2007-12-14 2009-06-17 Transmedi SA Compositions and methods of detecting TIABS
WO2009100907A1 (en) 2008-02-14 2009-08-20 Dianeering Diagnostics Engineering And Research Gmbh Means and methods for assessing the risk of patients presenting to emergency departments based on very low concentrations of troponin i or t or using a combination of markers
US8293880B2 (en) 2008-03-25 2012-10-23 University Of Southern California Prognostic panel for urinary bladder cancer
KR20110014979A (ko) 2008-04-21 2011-02-14 노파르티스 포르슝스티프퉁 쯔바이크니덜라쑹 프리드리히 미셔 인스티튜트 포 바이오메디칼 리서치 항바이러스 요법
US9910036B2 (en) 2008-05-20 2018-03-06 Rapid Pathogen Screening, Inc. Method and device for combined detection of viral and bacterial infections
ES2506116T3 (es) 2008-05-23 2014-10-13 Biocartis Nv Nuevo biomarcador para diagnóstico, predicción y/o pronóstico de septicemia y usos del mismo
TW201022492A (en) 2008-06-25 2010-06-16 Baylor Res Inst Blood transcriptional signature of mycobacterium tuberculosis infection
WO2010046136A1 (en) 2008-10-24 2010-04-29 B.R.A.H.M.S. Ag Prognosis and risk assessment in stroke patients by determining the level of marker peptides
TW201021778A (en) 2008-11-12 2010-06-16 Alcon Res Ltd Intraocular lens delivery device with a multi-part plunger tip
WO2010056337A2 (en) 2008-11-12 2010-05-20 Caris Mpi, Inc. Methods and systems of using exosomes for determining phenotypes
US20160041153A1 (en) 2008-11-12 2016-02-11 Kirk Brown Biomarker compositions and markers
UA92843C2 (ru) 2009-05-21 2010-12-10 Институт Технической Теплофизики Национальной Академии Наук Украины Способ получения порошкообразного пищевого красителя из столовой свеклы
WO2010138618A1 (en) 2009-05-26 2010-12-02 Duke University Molecular predictors of fungal infection
JP5731489B2 (ja) 2009-06-05 2015-06-10 ベー.エル.アー.ハー.エム.エス ゲゼルシャフト ミット ベシュレンクテル ハフツング 呼吸困難を起こした患者における細菌感染の検出
CA2770189A1 (en) 2009-08-07 2011-02-10 Rules-Based Medicine, Inc. Methods and devices for detecting kidney transplant rejection
JP5667353B2 (ja) 2009-09-25 2015-02-12 シスメックス株式会社 血球計数装置、診断支援装置、診断支援方法及びコンピュータプログラム
JP5722587B2 (ja) 2009-10-13 2015-05-20 ベー.エル.アー.ハー.エム.エス ゲゼルシャフト ミット ベシュレンクテル ハフツング 急性脳卒中または一過性脳虚血発作を有する患者における細菌感染の診断のためのプロカルシトニン及び抗生物質治療のガイダンス
KR20120105444A (ko) 2009-10-15 2012-09-25 오클라호마 메디컬 리써치 화운데이션 염증성 질병의 활성 측정 및 모니터링을 위한 바이오마커 및 방법
EP2510116A2 (en) 2009-12-09 2012-10-17 Aviir, Inc. Biomarker assay for diagnosis and classification of cardiovascular disease
US20110312534A1 (en) 2010-03-05 2011-12-22 Erasmus University Medical Center Rotterdam Method for prediction of human iris color
EP2365456B1 (en) 2010-03-11 2016-07-20 CompuGroup Medical SE Data structure, method and system for predicting medical conditions
EP2561363B1 (en) 2010-04-21 2021-07-14 Memed Diagnostics, Ltd. Signatures and determinants for distinguishing between a bacterial and viral infection and methods of use thereof
CN103097891B (zh) 2010-05-31 2015-09-09 国立大学法人德岛大学 疾病重症度的检查方法
GB2482187A (en) 2010-07-23 2012-01-25 Univ Exeter Predicting response to surgery
US8877212B2 (en) 2011-02-07 2014-11-04 Trudeau Institute Use of an IL12 receptor-beta 1 splice variant to diagnose active tuberculosis
RU2476887C2 (ru) 2011-03-29 2013-02-27 Учреждение Российской академии медицинских наук Дальневосточный научный центр физиологии и патологии дыхания Сибирского отделения РАМН Способ прогнозирования развития осложнений у больных внебольничной пневмонией
JPWO2012176779A1 (ja) 2011-06-20 2015-02-23 協和発酵キリン株式会社 抗erbB3抗体
EP2756103A4 (en) 2011-09-12 2015-06-03 Univ Vanderbilt CHARACTERIZATION OF MULTIPLE SCLEROSIS
JP5842107B2 (ja) 2011-10-19 2016-01-13 パナソニックIpマネジメント株式会社 循環動態測定装置
ES2656150T3 (es) 2011-11-14 2018-02-23 Universitätsklinikum Jena Diagnóstico de la sepsis y del síndrome de respuesta inflamatoria sistémica
WO2013119632A1 (en) 2012-02-07 2013-08-15 Ingber Michael Apparatus and methods for analyzing a medical condition
CN108802385B (zh) 2012-02-09 2022-02-08 米密德诊断学有限公司 用于诊断感染的标记和决定因素和其使用方法
EP2637023A1 (en) 2012-03-08 2013-09-11 B.R.A.H.M.S GmbH Prediction of outcome in patients with chronic obstructive pulmonary disease
US9669111B2 (en) 2012-03-08 2017-06-06 Thommen Medical Ag Device for the diagnosis of inflammatory tissues in dental applications
WO2013148319A1 (en) 2012-03-30 2013-10-03 Visen Medical, Inc. Bacterial imaging agents and methods of using same
GB201211982D0 (en) 2012-07-05 2012-08-22 Isis Innovation Biomarker
BR112015000685A2 (pt) 2012-07-10 2017-11-28 Nepean Blue Mountains Local Health Distr método para a identificação de risco clínico em um paciente possuindo ou suspeito de possuir uma infecção por influenza, método para a identificação de influenza ou pneumonia viral em um paciente, kit, método para avaliar a eficácia de um agente para o tratamento de influenza e para reduzir a severidade da doença em um indivíduo exposto a um vírus influenza.
FR2996003B1 (fr) 2012-09-25 2014-10-17 Commissariat Energie Atomique Methode pour detecter specifiquement dans un echantillon une metalloprotease matricielle (mmp) d'interet uniquement dans sa forme active
US20140127827A1 (en) 2012-11-05 2014-05-08 Gwangju Institute Of Science And Technology Method for detection of antigen using fluorescence resonance energy transfer immunoassay
AU2013351947A1 (en) 2012-11-30 2015-06-18 Applied Proteomics, Inc. Method for evaluation of presence of or risk of colon tumors
EP3608416A1 (en) 2013-01-22 2020-02-12 Imicroq, S.L. Rapid method for detection of pathogen
EP2951744A1 (en) 2013-01-29 2015-12-09 Molecular Health GmbH Systems and methods for clinical decision support
EP2968952B1 (en) 2013-03-15 2018-07-11 Boston Scientific Neuromodulation Corporation Clinical response data mapping
US10689701B2 (en) 2013-03-15 2020-06-23 Duke University Biomarkers for the molecular classification of bacterial infection
EP3693738A1 (en) 2013-09-20 2020-08-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of appendicitis and differentiation of causes of abdominal pain
WO2015048098A1 (en) 2013-09-24 2015-04-02 Washington University Diagnostic methods for infectious disease using endogenous gene expression
CA3190715A1 (en) * 2014-08-14 2016-02-18 Memed Diagnostics Ltd. Computational analysis of biological data using manifold and a hyperplane
WO2016059636A1 (en) 2014-10-14 2016-04-21 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections in non-human subjects and methods of use thereof
JP6788586B2 (ja) 2014-11-19 2020-11-25 コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. Hnlを用いる診断方法
WO2016092554A1 (en) 2014-12-11 2016-06-16 Memed Diagnostics Ltd. Marker combinations for diagnosing infections and methods of use thereof
KR20160072626A (ko) 2014-12-15 2016-06-23 전북대학교산학협력단 패혈증 인자 il-6 간이 진단 키트
WO2017072777A1 (en) 2015-11-01 2017-05-04 Elminda Ltd. Method and system for estimating potential distribution on cortical surface
EP3423589B1 (en) 2016-03-03 2021-07-21 Memed Diagnostics Ltd. Analyzing rna for diagnosing infection type
US11466331B2 (en) 2016-03-03 2022-10-11 Memed Diagnostics Ltd. RNA determinants for distinguishing between bacterial and viral infections
EP3475702B3 (en) 2016-06-23 2024-03-20 Memed Diagnostics Ltd. Measuring trail by lateral flow immunoassay
CN109661578B (zh) 2016-07-10 2022-05-10 米密德诊断学有限公司 用于区分细菌和病毒感染的蛋白质特征
WO2018011796A1 (en) 2016-07-10 2018-01-18 Memed Diagnostics Ltd. Early diagnosis of infections
EP3514518A4 (en) 2016-09-16 2020-09-02 On-chip Biotechnologies Co., Ltd. FINE PARTICLE DISTRIBUTION DEVICE, FINE PARTICLE ANALYSIS DEVICE, REACTION DETECTION DEVICE AND PROCESS USING SAID DEVICES
EP3519833B1 (en) 2016-09-29 2024-08-14 MeMed Diagnostics Ltd. Methods of prognosis and treatment
EP3519834A4 (en) 2016-09-29 2020-06-17 MeMed Diagnostics Ltd. RISK ASSESSMENT AND DISEASE CLASSIFICATION METHODS
US10209260B2 (en) 2017-07-05 2019-02-19 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections and methods of use thereof
US12348304B2 (en) 2021-04-08 2025-07-01 Infinidome Ltd. Adjustable null steering in a stationary network

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