ES2506116T3 - Nuevo biomarcador para diagnóstico, predicción y/o pronóstico de septicemia y usos del mismo - Google Patents

Nuevo biomarcador para diagnóstico, predicción y/o pronóstico de septicemia y usos del mismo Download PDF

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Publication number
ES2506116T3
ES2506116T3 ES09749849.7T ES09749849T ES2506116T3 ES 2506116 T3 ES2506116 T3 ES 2506116T3 ES 09749849 T ES09749849 T ES 09749849T ES 2506116 T3 ES2506116 T3 ES 2506116T3
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Spain
Prior art keywords
trem
sepsis
subject
sample
prognosis
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Active
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ES09749849.7T
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English (en)
Inventor
Koen Kas
Griet Vanpoucke
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Biocartis NV
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Biocartis NV
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/26—Infectious diseases, e.g. generalised sepsis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Método para la predicción, pronóstico y/o diagnóstico de septicemia, septicemia grave, choque septicémico, o MODS en un sujeto de prueba que comprende: (a) medir el nivel de transcrito de receptor similar a TREM-1 soluble (sTLT1) y TREM-1 en una muestra de sangre o suero extraída de dicho sujeto de prueba, y (b) comparar dicho nivel de transcrito de receptor similar a TREM-1 soluble (sTLT1) y TREM-1 con un nivel de referencia de transcrito de receptor similar a TREM-1 soluble (sTLT1) y TREM-1 obtenido de una muestra de un sujeto sano, en la que (c) un nivel de expresión reducida de sTLT-1 y una expresión aumentada de TREM-1 en la muestra del sujeto de prueba en comparación con los de una muestra de un sujeto sano o sin septicemia indica que el sujeto de prueba tiene o corre el riesgo de tener septicemia, septicemia grave, choque septicémico o MODS.

Description

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Claims (1)

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ES09749849.7T 2008-05-23 2009-05-19 Nuevo biomarcador para diagnóstico, predicción y/o pronóstico de septicemia y usos del mismo Active ES2506116T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08156837 2008-05-23
EP08156837 2008-05-23
PCT/EP2009/056094 WO2009141359A1 (en) 2008-05-23 2009-05-19 New biomarker for diagnosis, prediction and/or prognosis of sepsis and uses thereof

Publications (1)

Publication Number Publication Date
ES2506116T3 true ES2506116T3 (es) 2014-10-13

Family

ID=40897625

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09749849.7T Active ES2506116T3 (es) 2008-05-23 2009-05-19 Nuevo biomarcador para diagnóstico, predicción y/o pronóstico de septicemia y usos del mismo

Country Status (5)

Country Link
US (1) US8697370B2 (es)
EP (2) EP2796878A1 (es)
CA (1) CA2721742A1 (es)
ES (1) ES2506116T3 (es)
WO (1) WO2009141359A1 (es)

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US8981061B2 (en) 2001-03-20 2015-03-17 Novo Nordisk A/S Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof
GB0426146D0 (en) 2004-11-29 2004-12-29 Bioxell Spa Therapeutic peptides and method
WO2010132370A2 (en) * 2009-05-11 2010-11-18 Government Of The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Soluble tlt-1 for the treatment and diagnosis of sepsis
US11348667B2 (en) * 2010-10-08 2022-05-31 Cerner Innovation, Inc. Multi-site clinical decision support
EP2694974B1 (en) 2011-04-04 2015-10-21 Universiteit Gent Biomarkers for acute kidney injury
RU2463606C1 (ru) * 2011-08-17 2012-10-10 Учреждение Российской академии медицинских наук Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний Сибирского отделения Российской академии медицинских наук (УРАМН НИИ КПССЗ СО РАМН) Способ ранней диагностики осложненного системного воспалительного ответа у пациентов, оперированных в условиях искусственного кровообращения
CA2863393C (en) 2012-02-07 2022-04-26 Hector R. Wong A multi-biomarker-based outcome risk stratification model for pediatric septic shock
WO2013119869A1 (en) * 2012-02-07 2013-08-15 Children's Hospital Medical Center A multi-biomarker-based outcome risk stratification model for adult septic shock
CA2863819C (en) 2012-02-09 2021-11-23 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections and methods of use thereof
US9550830B2 (en) 2012-02-15 2017-01-24 Novo Nordisk A/S Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1)
EP3196214B1 (en) 2012-02-15 2019-07-31 Novo Nordisk A/S Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (trem-1)
PL2814842T3 (pl) 2012-02-15 2018-12-31 Novo Nordisk A/S Przeciwciała wiążące białko 1 rozpoznające peptydoglikan
CA2893158A1 (en) * 2012-11-30 2014-06-05 Applied Proteomics, Inc. Method for evaluation of presence of or risk of colon tumors
CA2915611A1 (en) * 2013-06-28 2014-12-31 Acumen Research Laboratories Pte. Ltd. Sepsis biomarkers and uses thereof
CN105555800A (zh) * 2013-08-07 2016-05-04 罗切斯特大学 诊断败血症或败血症风险的方法
EP3074536B1 (en) 2013-11-25 2019-06-19 Children's Hospital Medical Center Temporal pediatric sepsis biomarker risk model
KR101569334B1 (ko) 2013-12-20 2015-11-17 경북대학교 산학협력단 래프틀린을 함유하는 패혈증 진단용 바이오마커 조성물 및 이를 이용한 진단방법
US10260111B1 (en) 2014-01-20 2019-04-16 Brett Eric Etchebarne Method of detecting sepsis-related microorganisms and detecting antibiotic-resistant sepsis-related microorganisms in a fluid sample
RS65136B1 (sr) 2014-07-17 2024-02-29 Novo Nordisk As Mutageza usmerena na lokaciju trem-1 antitela za smanjenje viskoziteta
EP3180621B1 (en) 2014-08-14 2020-04-01 Memed Diagnostics Ltd. Computational analysis of biological data using manifold and a hyperplane
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CA2968650A1 (en) * 2014-12-11 2016-06-16 Memed Diagnostics Ltd. Marker combinations for diagnosing infections and methods of use thereof
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US10261068B2 (en) 2015-06-04 2019-04-16 Children's Hospital Medical Center Persevere-II: redefining the pediatric sepsis biomarker risk model with septic shock phenotype
US20180187246A1 (en) 2015-07-15 2018-07-05 Universiteit Gent Probes and a methylation in situ hybridization assay
CN108699583B (zh) 2016-03-03 2022-11-01 米密德诊断学有限公司 用于区分细菌和病毒感染的rna决定子
US11340223B2 (en) 2016-07-10 2022-05-24 Memed Diagnostics Ltd. Early diagnosis of infections
CA3027341A1 (en) 2016-07-10 2018-01-18 Memed Diagnostics Ltd. Protein signatures for distinguishing between bacterial and viral infections
US11353456B2 (en) 2016-09-29 2022-06-07 Memed Diagnostics Ltd. Methods of risk assessment and disease classification for appendicitis
GB201616557D0 (en) * 2016-09-29 2016-11-16 Secretary Of State For Health The Assay for distinguishing between sepsis and systemic inflammatory response syndrome
US11385241B2 (en) 2016-09-29 2022-07-12 Memed Diagnostics Ltd. Methods of prognosis and treatment
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AU2019248547A1 (en) 2018-04-02 2020-09-10 Bristol-Myers Squibb Company Anti-TREM-1 antibodies and uses thereof
US11154240B2 (en) 2019-04-02 2021-10-26 Kpn Innovations Llc Methods and systems for utilizing diagnostics for informed vibrant constitutional guidance
WO2021123249A1 (en) * 2019-12-20 2021-06-24 Gerencia Regional de Salud de Castilla y León In vitro method for the differential diagnosis between septic shock and non-septic shock patients
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Also Published As

Publication number Publication date
US8697370B2 (en) 2014-04-15
CA2721742A1 (en) 2009-11-26
WO2009141359A1 (en) 2009-11-26
EP2796878A1 (en) 2014-10-29
EP2300829A1 (en) 2011-03-30
EP2300829B1 (en) 2014-07-23
US20110059858A1 (en) 2011-03-10

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