JP6134345B2 - レトロウイルス除去方法 - Google Patents
レトロウイルス除去方法 Download PDFInfo
- Publication number
- JP6134345B2 JP6134345B2 JP2015053655A JP2015053655A JP6134345B2 JP 6134345 B2 JP6134345 B2 JP 6134345B2 JP 2015053655 A JP2015053655 A JP 2015053655A JP 2015053655 A JP2015053655 A JP 2015053655A JP 6134345 B2 JP6134345 B2 JP 6134345B2
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- retrovirus
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Description
本発明は、液体を多孔性電気紡績ナノファイバー液体濾過媒体に通過させることにより、該液体からレトロウイルスを除去する方法に関する。該電気紡績ナノファイバー液体濾過媒体は、多孔性支持体または基体上に配置されて又は配置されないで使用されうる。該電気紡績ナノファイバー液体濾過媒体は、例えば多孔性重合体ナノファイバーマットのような種々の形状、サイズ、厚さおよび密度のものに形成されうる。
本明細書に含まれその一部を構成する添付図面は、本発明の現在想定されている実施形態を例示するものであり、本明細書と共に本発明の原理を説明するのに役立つ。
本明細書中に引用されている全ての刊行物、特許および特許出願の全体を、各刊行物、特許または特許出願が参照により本明細書に組み入れられると具体的かつ個別に示しているものとして、参照により本明細書に組み入れる。
基本重量は、ASTM D−3776(これを参照により本明細書に組み入れることとする)により決定し、g/m2単位で表した。
本発明の以下の実施例は、電気紡績ナノファイバーマットが、高い透過性と高い細菌保持性との両方を同時に有しうることを実証するものである。
ナイロン6(Nylon6)重合体の溶液を電気紡績することにより、ナノファイバー層を製造した。ナイロン6はBASF Corp.(Florham Park,NJ,USA)から商標Ultramid B24として提供された。紡績溶液を、80℃で5時間、酢酸とギ酸との混合物(重量比2:1)中の20% ナイロンストック溶液として調製し、該ストック溶液を、必要なギ酸および水の添加により、それぞれギ酸:酢酸:水の溶媒比2:2:1の13重量%重合体溶液へと更に希釈した。得られた溶液の粘度は約100cPである。82kVの電場下の6−ワイヤ紡績電極を使用して、該溶液を直ちに紡績した。電気紡績中に該ナノファイバーマットを支持するために、帯電防止被覆された不織材を使用した。得られた電気紡績マットの平均ファイバー直径は約25〜30nmであった。紡績時間は30分であり、その後、該ナノファイバー層を該マットから剥し、層化し、保持試験のためのオーバーモールド(overmolded)装置内に配置した。
実施例1の方法に従った。紡績時間を5〜60時間で変動させた(図5)。PR772保持性を、各ナノファイバーマットの単層に関して試験した。電気紡績ナノファイバーマットのバクテリオファージPR772保持性は、紡績時間の増加(マットの厚さの増加)と共に増加した。
実施例1の方法に従った。この場合は、ナイロンに関する溶媒系は4:1の重量比のギ酸/水であった。製造された電気紡績マットの測定ファイバー直径は25〜30nmの範囲であり、平均IPAバブルポイントは120〜140psiの範囲であった。30分の紡績時間のサンプルは完全なレトロウイルス保持性であった(バクテリオファージPR772に関するLRV>6.2)。図3は、実施例3に例示されているナイロン繊維の前端走査電子顕微鏡像である。
本発明の電気紡績ナノファイバー含有液体濾過媒体は、食品、飲料、医薬、バイオテクノロジー、マイクロエレクトロニクス、化学的加工、水処理および他の液体処理産業において有用である。
本発明はまた、液体サンプルから微生物を除去するために使用されうるキットを提供する。該キットは、例えば、本発明の1以上の電気紡績ナノファイバー含有液体濾過媒体、および該媒体のための1以上の液体濾過装置、支持体または基体を含みうる。該キットは1以上の対照を含むことが可能であり、所望により、本発明の実施方法において有用な種々のバッファー、例えば、試薬を除去するための又は非特異的に保持された若しくは結合した物質を除去するための洗浄バッファーを含みうる。
Claims (34)
- レトロウイルスを液体サンプルから除去するための方法であって、
a)レトロウイルスを含有する液体サンプルを準備し、
b)6を超えるレトロウイルス対数減少値(LRV)、80%〜95%の多孔度および100LMH/psiを超える液体透過性を有する、重合体を電気紡績することにより形成される、多孔性ナノファイバーマットを含む多孔性ナノファイバー含有濾過媒体を準備し、ここで、ナノファイバーマットはサイズに基づく除去によるレトロウイルスの完全保持のための25〜30nmの範囲の有効平均ファイバー直径を有し、
c)レトロウイルスを含有する液体サンプルを濾過媒体に通過させて、レトロウイルスの完全保持をもたらす工程を含む、方法。 - 多孔性ナノファイバーマットが、イソプロパノールで試験された場合に100〜150psiの平均流動バブルポイントを示す、請求項1記載の方法。
- 濾過媒体が1μm〜500μmの厚さを有する、請求項1記載の方法。
- 多孔性ナノファイバーマットが1μm〜50μmの厚さを有する、請求項1記載の方法。
- レトロウイルスがヒト免疫不全ウイルス(HIV)である、請求項1記載の方法。
- レトロウイルスがヒトT細胞白血病ウイルス(HTLV)である、請求項1記載の方法。
- 重合体が、ポリイミド、脂肪族ポリアミド、芳香族ポリアミド、ポリスルホン、酢酸セルロース、ポリエーテルスルホン、ポリウレタン、ポリ(尿素ウレタン)、ポリベンゾイミダゾール、ポリエーテルイミド、ポリアクリロニトリル、ポリ(エチレンテレフタラート)、ポリプロピレン、ポリアニリン、ポリ(エチレンオキシド)、ポリ(エチレンナフタラート)、ポリ(ブチレンテレフタラート)、スチレンブタジエンゴム、ポリスチレン、ポリ(塩化ビニル)、ポリ(ビニルアルコール)、ポリ(ビニリデンフルオリド)、ポリ(ビニルブチレン)からなる群から選択される重合体および共重合体、誘導体化合物またはそれらの混合物である、請求項1記載の方法。
- 重合体が脂肪族ポリアミドを含む、請求項1記載の方法。
- 重合体が重合体の混合物または共重合体を含む、請求項1記載の方法。
- 重合体が多孔性支持体上に配置されている、請求項1記載の方法。
- 多孔性支持体が、スパンボンド不織布、溶融吹込不織布、ニードルパンチ不織布、スパンレース不織布、湿式堆積不織布、樹脂積層不織布、織布、メリヤス生地、紙からなる群およびそれらの組合せから選択される1以上の層を含む、請求項10記載の方法。
- レトロウイルスを液体サンプルから除去してサイズに基づく除去によるレトロウイルスの完全保持をもたらすための多孔性ナノファイバー濾過媒体であって、
6を超えるレトロウイルス対数減少値(LRV)、80%〜95%の多孔度および100LMH/psiを超える液体透過性を有する、重合体を電気紡績することにより形成される、多孔性ナノファイバーマットを含む多孔性ナノファイバー濾過媒体を含み、ナノファイバーがサイズに基づく除去によるレトロウイルスの保持について有効な25nm〜30nmの範囲の平均ファイバー直径を有する、多孔性ナノファイバー濾過媒体。 - 多孔性ナノファイバーマットが、イソプロパノールで試験された場合に100〜150psiの平均流動バブルポイントを更に含む、請求項12記載の媒体。
- 多孔性ナノファイバーマットが、1μm〜500μmの厚さを有する、請求項12記載の媒体。
- 多孔性ナノファイバーマットが、1μm〜50μmの厚さを有する、請求項12記載の媒体。
- レトロウイルスがヒト免疫不全ウイルス(HIV)である、請求項12記載の媒体。
- レトロウイルスがヒトT細胞白血病ウイルス(HTLV)である、請求項12記載の媒体。
- 重合体が、ポリイミド、脂肪族ポリアミド、芳香族ポリアミド、ポリスルホン、酢酸セルロース、ポリエーテルスルホン、ポリウレタン、ポリ(尿素ウレタン)、ポリベンゾイミダゾール、ポリエーテルイミド、ポリアクリロニトリル、ポリ(エチレンテレフタラート)、ポリプロピレン、ポリアニリン、ポリ(エチレンオキシド)、ポリ(エチレンナフタラート)、ポリ(ブチレンテレフタラート)、スチレンブタジエンゴム、ポリスチレン、ポリ(塩化ビニル)、ポリ(ビニルアルコール)、ポリ(ビニリデンフルオリド)、ポリ(ビニルブチレン)からなる群から選択される重合体および共重合体、誘導体化合物またはそれらの混合物である、請求項12記載の媒体。
- 重合体が脂肪族ポリアミドを含む、請求項12記載の媒体。
- 重合体が重合体の混合物または共重合体を含む、請求項12記載の媒体。
- 重合体が多孔性支持体上に配置されている、請求項12記載の媒体。
- 多孔性支持体が、スパンボンド不織布、溶融吹込不織布、ニードルパンチ不織布、スパンレース不織布、湿式堆積不織布、樹脂積層不織布、織布、メリヤス生地、紙およびそれらの組合せからなる群から選択される1以上の層を含む、請求項21記載の媒体。
- 液体濾過装置を通過する液体サンプルからのサイズに基づく除去によりレトロウイルスを完全に保持させるために使用される、6を超えるレトロウイルスLRVを有する液体濾過装置であって、濾過装置が、(a)6を超えるLRV、80%〜95%の多孔度および100LMH/psiを超える液体透過性を有する、重合体を電気紡績することにより形成される、多孔性ナノファイバーマットを含む多孔性電気紡績ナノファイバー濾過媒体と(b)多孔性支持体とを含み、ナノファイバー濾過媒体が多孔性支持体上に配置されており、多孔性ナノファイバーマットがサイズに基づく除去によるレトロウイルスの保持について有効な25nm〜30nmのファイバー直径を有する、液体濾過装置。
- 多孔性ナノファイバーマットが10μm〜100μmの厚さを有する、請求項23記載の装置。
- 多孔性ナノファイバーマットが1μm〜50μmの厚さを有する、請求項23記載の装置。
- 多孔性ナノファイバーマットがイソプロパノールで試験された場合に100〜150psiの平均流動バブルポイントを示す、請求項23記載の装置。
- 多孔性ナノファイバーマットが0.05μm〜3μmの平均孔径を有する、請求項23記載の装置。
- ナノファイバーが、ポリイミド、脂肪族ポリアミド、芳香族ポリアミド、ポリスルホン、酢酸セルロース、ポリエーテルスルホン、ポリウレタン、ポリ(尿素ウレタン)、ポリベンゾイミダゾール、ポリエーテルイミド、ポリアクリロニトリル、ポリ(エチレンテレフタラート)、ポリプロピレン、ポリアニリン、ポリ(エチレンオキシド)、ポリ(エチレンナフタラート)、ポリ(ブチレンテレフタラート)、スチレンブタジエンゴム、ポリスチレン、ポリ(塩化ビニル)、ポリ(ビニルアルコール)、ポリ(ビニリデンフルオリド)、ポリ(ビニルブチレン)からなる群から選択される重合体および共重合体、誘導体化合物またはそれらの混合物を含む、請求項23記載の装置。
- ナノファイバーが脂肪族ポリアミドを含む、請求項23記載の装置。
- ナノファイバーが重合体の混合物または共重合体を含む、請求項23記載の装置。
- ナノファイバーが多孔性支持体上に配置されている、請求項23記載の装置。
- 多孔性支持体が、スパンボンド不織布、溶融吹込不織布、ニードルパンチ不織布、スパンレース不織布、湿式堆積不織布、樹脂積層不織布、織布、メリヤス生地、紙およびそれらの組合せからなる群から選択される1以上の層を含む、請求項23記載の装置。
- レトロウイルスがヒト免疫不全ウイルス(HIV)である、請求項23記載の装置。
- レトロウイルスがヒトT細胞白血病ウイルス(HTLV)である、請求項23記載の装置。
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KR20130030804A (ko) | 2013-03-27 |
JP2015199062A (ja) | 2015-11-12 |
SG185659A1 (en) | 2012-12-28 |
US20120061332A1 (en) | 2012-03-15 |
CN108579207A (zh) | 2018-09-28 |
EP2603611B1 (en) | 2019-12-18 |
CN103069011A (zh) | 2013-04-24 |
JP2017124179A (ja) | 2017-07-20 |
WO2012021308A2 (en) | 2012-02-16 |
EP2603611A4 (en) | 2014-08-27 |
WO2012021308A3 (en) | 2012-06-14 |
US20170173511A1 (en) | 2017-06-22 |
EP2603611A2 (en) | 2013-06-19 |
ES2774949T3 (es) | 2020-07-23 |
KR101520752B1 (ko) | 2015-05-15 |
US10252199B2 (en) | 2019-04-09 |
JP2013541408A (ja) | 2013-11-14 |
US9623352B2 (en) | 2017-04-18 |
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