JP6118792B2 - マクロ環状化合物及びその製造方法 - Google Patents

マクロ環状化合物及びその製造方法 Download PDF

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JP6118792B2
JP6118792B2 JP2014501719A JP2014501719A JP6118792B2 JP 6118792 B2 JP6118792 B2 JP 6118792B2 JP 2014501719 A JP2014501719 A JP 2014501719A JP 2014501719 A JP2014501719 A JP 2014501719A JP 6118792 B2 JP6118792 B2 JP 6118792B2
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compound
formula
hcv
sanglifehrin
cells
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JP2014510746A5 (enExample
JP2014510746A (ja
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ジャメス モスス ステベン
ジャメス モスス ステベン
アラン グレゴリ マトトヘウ
アラン グレゴリ マトトヘウ
ウイルキンソン バルリエ
ウイルキンソン バルリエ
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ネウロビベ プハルマセウトイカル エービー
ネウロビベ プハルマセウトイカル エービー
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Priority claimed from GBGB1105293.3A external-priority patent/GB201105293D0/en
Priority claimed from GBGB1113629.8A external-priority patent/GB201113629D0/en
Priority claimed from GBGB1202060.8A external-priority patent/GB201202060D0/en
Application filed by ネウロビベ プハルマセウトイカル エービー, ネウロビベ プハルマセウトイカル エービー filed Critical ネウロビベ プハルマセウトイカル エービー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biophysics (AREA)
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  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
JP2014501719A 2011-03-29 2012-03-29 マクロ環状化合物及びその製造方法 Expired - Fee Related JP6118792B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB1105293.3 2011-03-29
GBGB1105293.3A GB201105293D0 (en) 2011-03-29 2011-03-29 Novel compounds and methods for their production
GBGB1113629.8A GB201113629D0 (en) 2011-08-08 2011-08-08 Novel compounds and methods for their production
GB1113629.8 2011-08-08
GB1202060.8 2012-02-07
GBGB1202060.8A GB201202060D0 (en) 2012-02-07 2012-02-07 Novel compounds and methods for their production
PCT/GB2012/050700 WO2012131371A1 (en) 2011-03-29 2012-03-29 Macrocyclic compound and methods for its production

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JP2014510746A JP2014510746A (ja) 2014-05-01
JP2014510746A5 JP2014510746A5 (enExample) 2015-05-14
JP6118792B2 true JP6118792B2 (ja) 2017-04-26

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JP2014501719A Expired - Fee Related JP6118792B2 (ja) 2011-03-29 2012-03-29 マクロ環状化合物及びその製造方法
JP2014501720A Active JP6118793B2 (ja) 2011-03-29 2012-03-29 マクロ環状化合物及びそれらの製造方法

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EP (2) EP2691412B1 (enExample)
JP (2) JP6118792B2 (enExample)
KR (2) KR101911484B1 (enExample)
CN (3) CN103619869B (enExample)
AR (1) AR085724A1 (enExample)
AU (2) AU2012235880B2 (enExample)
BR (2) BR112013024965A2 (enExample)
CA (2) CA2830827C (enExample)
CL (2) CL2013002739A1 (enExample)
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DK (2) DK2691413T3 (enExample)
EA (2) EA023848B1 (enExample)
ES (2) ES2533438T3 (enExample)
HR (2) HRP20150187T1 (enExample)
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MX (2) MX345351B (enExample)
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PH (2) PH12013502016A1 (enExample)
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SG (2) SG193569A1 (enExample)
SI (2) SI2691412T1 (enExample)
TW (1) TWI525098B (enExample)
UY (1) UY33993A (enExample)
WO (2) WO2012131377A1 (enExample)
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Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011098809A1 (en) 2010-02-09 2011-08-18 Biotica Technology Limited Sanglifehrin based compounds
JO3063B1 (ar) * 2011-03-29 2017-03-15 Neurovive Pharmaceutical Ab مركب مبتكر وطرق لانتاجه
CN103130734A (zh) * 2011-12-01 2013-06-05 上海药明康德新药开发有限公司 一种合成1,2-吗啉盐酸盐的方法
CN105695541B (zh) * 2016-03-10 2019-03-15 苏州华赛生物工程技术有限公司 一种抗生素nvp018中间体的分离纯化方法
KR20180036522A (ko) * 2016-09-30 2018-04-09 (주)나노믹스 스틸벤 유도체 및 그 제조 방법
BR112019009903A2 (pt) 2016-11-18 2019-08-13 Neurovive Pharmaceutical Ab análogo de sangliferina, combinação, composição farmacêutica, e, método para tratamento de um sujeito sofrendo de câncer ou de malignidade de célula-b
CN112410353B (zh) * 2019-08-23 2023-01-24 上海医药工业研究院 一种fkbS基因、含其的基因工程菌及其制备方法和用途
MX2022005359A (es) 2019-11-04 2022-06-02 Revolution Medicines Inc Inhibidores de ras.
IL301298A (en) 2020-09-15 2023-05-01 Revolution Medicines Inc Indole derivatives as RAS inhibitors in cancer therapy
PE20240088A1 (es) 2021-05-05 2024-01-16 Revolution Medicines Inc Inhibidores de ras
IL308195A (en) 2021-05-05 2024-01-01 Revolution Medicines Inc RAS inhibitors for cancer treatment
AR127308A1 (es) 2021-10-08 2024-01-10 Revolution Medicines Inc Inhibidores ras
CN115028681B (zh) * 2022-08-11 2022-11-15 中国科学院微生物研究所 一种降解亲环素a的嵌合体化合物及其制备方法与应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR006514A1 (es) 1995-07-04 1999-09-08 Sandoz Ag Un macrolido, sus usos, un proceso para producirlo, un aislado biologicamente puro capaz de producirlo, y una composicion farmaceutica quelo comprende
US6124453A (en) 1995-07-04 2000-09-26 Novartis Ag Macrolides
RU2427372C2 (ru) 2005-06-17 2011-08-27 Новартис Аг Применение санглиферина для лечения вируса гепатита с
CN101616683A (zh) 2007-01-04 2009-12-30 德比奥法姆股份有限公司 用于治疗Ullrich先天性肌营养不良的非免疫抑制性环孢霉素
JP5789190B2 (ja) 2008-09-24 2015-10-07 シャンハイ インスティテュート オブ オーガニック ケミストリー，チャイニーズ アカデミー オブ サイエンシズ 新規の遺伝子クラスター
CN101691575B (zh) * 2008-09-24 2013-06-05 中国科学院上海有机化学研究所 一种萨菲菌素的生物合成基因簇
WO2011098809A1 (en) 2010-02-09 2011-08-18 Biotica Technology Limited Sanglifehrin based compounds
WO2011098805A1 (en) 2010-02-09 2011-08-18 Biotica Technology Limited Sanglifehrin based compounds
WO2011098808A1 (en) * 2010-02-09 2011-08-18 Biotica Technology Limited Sanglifehrin based compounds
KR101900974B1 (ko) * 2010-12-20 2018-09-21 뉴로바이브 파마슈티컬 에이비 상글리페린 유도체 및 이의 제조 방법
JO3063B1 (ar) * 2011-03-29 2017-03-15 Neurovive Pharmaceutical Ab مركب مبتكر وطرق لانتاجه

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MY170618A (en) 2019-08-21
CA2830827A1 (en) 2012-10-04
IL228508A0 (en) 2013-12-31
CA2830831A1 (en) 2012-10-04
EP2691412B1 (en) 2014-12-24
IL228508B (en) 2018-01-31
MY170637A (en) 2019-08-21
KR101868084B1 (ko) 2018-06-18
AU2012235961B2 (en) 2016-09-01
MX345352B (es) 2017-01-26
SG193568A1 (en) 2013-11-29
IL228509A0 (en) 2013-12-31
AU2012235880B2 (en) 2016-11-17
KR20140071958A (ko) 2014-06-12
CA2830831C (en) 2020-03-10
CN103619869B (zh) 2015-11-25
EP2691412A1 (en) 2014-02-05
KR101911484B1 (ko) 2018-10-24
BR112013024974A2 (pt) 2016-09-06
EP2691413A1 (en) 2014-02-05
JO3063B1 (ar) 2017-03-15
AR085724A1 (es) 2013-10-23
ZA201307149B (en) 2015-04-29
AU2012235961A1 (en) 2013-10-10
DK2691413T3 (en) 2015-04-07
HK1189237A1 (en) 2014-05-30
SI2691412T1 (sl) 2015-05-29
WO2012131371A1 (en) 2012-10-04
WO2012131377A1 (en) 2012-10-04
PT2691412E (pt) 2015-03-25
JP2014510746A (ja) 2014-05-01
ES2533437T3 (es) 2015-04-10
US9139613B2 (en) 2015-09-22
CY1116318T1 (el) 2017-02-08
PH12013502000B1 (en) 2018-08-10
BR112013024965A2 (pt) 2017-04-18
EA023848B1 (ru) 2016-07-29
CN103635484A (zh) 2014-03-12
JP6118793B2 (ja) 2017-04-26
CN103635484B (zh) 2017-05-10
AU2012235880A1 (en) 2013-10-17
IL228509B (en) 2018-02-28
UY33993A (es) 2012-10-31
CL2013002739A1 (es) 2014-07-11
US20140038885A1 (en) 2014-02-06
PL2691413T3 (pl) 2015-05-29
JP2014514290A (ja) 2014-06-19
KR20140057481A (ko) 2014-05-13
MX345351B (es) 2017-01-26
EA201391399A1 (ru) 2014-02-28
CN107417766A (zh) 2017-12-01
ES2533438T3 (es) 2015-04-10
PH12013502000A1 (en) 2013-12-02
PL2691412T3 (pl) 2015-08-31
HRP20150187T1 (xx) 2015-06-05
PH12013502016A1 (en) 2013-12-16
EA023907B1 (ru) 2016-07-29
EA201391396A1 (ru) 2014-02-28
RS53963B1 (sr) 2015-08-31
HRP20150184T1 (hr) 2015-05-08
SI2691413T1 (sl) 2015-05-29
MX2013011043A (es) 2014-04-25
TWI525098B (zh) 2016-03-11
DK2691412T3 (en) 2015-04-07
EP2691413B1 (en) 2014-12-24
ZA201307231B (en) 2015-05-27
CY1116186T1 (el) 2017-02-08
HK1189236A1 (en) 2014-05-30
CN103619869A (zh) 2014-03-05
US20120251581A1 (en) 2012-10-04
TW201300398A (zh) 2013-01-01
CA2830827C (en) 2020-03-10
PT2691413E (pt) 2015-03-25
SG193569A1 (en) 2013-11-29
RS53964B1 (sr) 2015-08-31
US9090657B2 (en) 2015-07-28
MX2013011051A (es) 2014-03-13
CL2013002740A1 (es) 2014-07-11

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