CN103619869B - 大环化合物及其制备方法 - Google Patents

大环化合物及其制备方法 Download PDF

Info

Publication number
CN103619869B
CN103619869B CN201280026190.3A CN201280026190A CN103619869B CN 103619869 B CN103619869 B CN 103619869B CN 201280026190 A CN201280026190 A CN 201280026190A CN 103619869 B CN103619869 B CN 103619869B
Authority
CN
China
Prior art keywords
compound
hcv
compounds
formula
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201280026190.3A
Other languages
English (en)
Chinese (zh)
Other versions
CN103619869A (zh
Inventor
S·J·摩斯
M·A·格雷戈里
B·威尔金森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aiboliwa Co ltd
Original Assignee
Biotica Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1105293.3A external-priority patent/GB201105293D0/en
Priority claimed from GBGB1113629.8A external-priority patent/GB201113629D0/en
Priority claimed from GBGB1202060.8A external-priority patent/GB201202060D0/en
Application filed by Biotica Technology Ltd filed Critical Biotica Technology Ltd
Publication of CN103619869A publication Critical patent/CN103619869A/zh
Application granted granted Critical
Publication of CN103619869B publication Critical patent/CN103619869B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
CN201280026190.3A 2011-03-29 2012-03-29 大环化合物及其制备方法 Expired - Fee Related CN103619869B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB1105293.3A GB201105293D0 (en) 2011-03-29 2011-03-29 Novel compounds and methods for their production
GB1105293.3 2011-03-29
GB1113629.8 2011-08-08
GBGB1113629.8A GB201113629D0 (en) 2011-08-08 2011-08-08 Novel compounds and methods for their production
GBGB1202060.8A GB201202060D0 (en) 2012-02-07 2012-02-07 Novel compounds and methods for their production
GB1202060.8 2012-02-07
PCT/GB2012/050700 WO2012131371A1 (en) 2011-03-29 2012-03-29 Macrocyclic compound and methods for its production

Publications (2)

Publication Number Publication Date
CN103619869A CN103619869A (zh) 2014-03-05
CN103619869B true CN103619869B (zh) 2015-11-25

Family

ID=46001313

Family Applications (3)

Application Number Title Priority Date Filing Date
CN201280026190.3A Expired - Fee Related CN103619869B (zh) 2011-03-29 2012-03-29 大环化合物及其制备方法
CN201611126823.4A Pending CN107417766A (zh) 2011-03-29 2012-03-29 大环化合物及其制备方法
CN201280026793.3A Active CN103635484B (zh) 2011-03-29 2012-03-29 大环化合物及其制备方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201611126823.4A Pending CN107417766A (zh) 2011-03-29 2012-03-29 大环化合物及其制备方法
CN201280026793.3A Active CN103635484B (zh) 2011-03-29 2012-03-29 大环化合物及其制备方法

Country Status (29)

Country Link
US (2) US9090657B2 (enExample)
EP (2) EP2691413B1 (enExample)
JP (2) JP6118792B2 (enExample)
KR (2) KR101911484B1 (enExample)
CN (3) CN103619869B (enExample)
AR (1) AR085724A1 (enExample)
AU (2) AU2012235880B2 (enExample)
BR (2) BR112013024974A2 (enExample)
CA (2) CA2830831C (enExample)
CL (2) CL2013002739A1 (enExample)
CY (2) CY1116318T1 (enExample)
DK (2) DK2691413T3 (enExample)
EA (2) EA023907B1 (enExample)
ES (2) ES2533437T3 (enExample)
HR (2) HRP20150187T1 (enExample)
IL (2) IL228508B (enExample)
JO (1) JO3063B1 (enExample)
MX (2) MX345352B (enExample)
MY (2) MY170618A (enExample)
PH (2) PH12013502000B1 (enExample)
PL (2) PL2691413T3 (enExample)
PT (2) PT2691412E (enExample)
RS (2) RS53964B1 (enExample)
SG (2) SG193568A1 (enExample)
SI (2) SI2691412T1 (enExample)
TW (1) TWI525098B (enExample)
UY (1) UY33993A (enExample)
WO (2) WO2012131377A1 (enExample)
ZA (2) ZA201307149B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5894935B2 (ja) 2010-02-09 2016-03-30 ニューロヴィベ プハルマセウトイカル エービー サングリフェリン系化合物
JO3063B1 (ar) * 2011-03-29 2017-03-15 Neurovive Pharmaceutical Ab مركب مبتكر وطرق لانتاجه
CN103130734A (zh) * 2011-12-01 2013-06-05 上海药明康德新药开发有限公司 一种合成1,2-吗啉盐酸盐的方法
CN105695541B (zh) * 2016-03-10 2019-03-15 苏州华赛生物工程技术有限公司 一种抗生素nvp018中间体的分离纯化方法
KR20180036522A (ko) 2016-09-30 2018-04-09 (주)나노믹스 스틸벤 유도체 및 그 제조 방법
EP3541388A1 (en) 2016-11-18 2019-09-25 Neurovive Pharmaceutical AB Use of sanglifehrin macrocyclic analogues as anticancer compounds
CN112410353B (zh) * 2019-08-23 2023-01-24 上海医药工业研究院 一种fkbS基因、含其的基因工程菌及其制备方法和用途
CN115894606A (zh) 2019-11-04 2023-04-04 锐新医药公司 Ras抑制剂
KR20230067635A (ko) 2020-09-15 2023-05-16 레볼루션 메디슨즈, 인크. 암의 치료에서 ras 억제제로서 인돌 유도체
CN118852330A (zh) 2021-05-05 2024-10-29 锐新医药公司 用于治疗癌症的ras抑制剂
AR127308A1 (es) 2021-10-08 2024-01-10 Revolution Medicines Inc Inhibidores ras
CN115028681B (zh) * 2022-08-11 2022-11-15 中国科学院微生物研究所 一种降解亲环素a的嵌合体化合物及其制备方法与应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006138507A1 (en) * 2005-06-17 2006-12-28 Novartis Ag Use of sanglifehrin in hcv
CN102770139A (zh) * 2010-02-09 2012-11-07 百奥帝卡技术有限公司 基于Sanglifehrin的化合物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6124453A (en) 1995-07-04 2000-09-26 Novartis Ag Macrolides
AR006514A1 (es) 1995-07-04 1999-09-08 Sandoz Ag Un macrolido, sus usos, un proceso para producirlo, un aislado biologicamente puro capaz de producirlo, y una composicion farmaceutica quelo comprende
MX2009007045A (es) 2007-01-04 2009-10-07 Debiopharm Sa Ciclosporina no inmunosupresora para el tratamiento de distrofia muscular congenita de ullrich.
EP2342335B1 (en) 2008-09-24 2015-09-16 Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences Novel gene cluster
CN101691575B (zh) * 2008-09-24 2013-06-05 中国科学院上海有机化学研究所 一种萨菲菌素的生物合成基因簇
WO2011098805A1 (en) * 2010-02-09 2011-08-18 Biotica Technology Limited Sanglifehrin based compounds
WO2011098808A1 (en) * 2010-02-09 2011-08-18 Biotica Technology Limited Sanglifehrin based compounds
CN103619336B (zh) * 2010-12-20 2017-10-27 纽洛维弗制药有限公司 Sanglifehrin衍生物及其制备方法
JO3063B1 (ar) * 2011-03-29 2017-03-15 Neurovive Pharmaceutical Ab مركب مبتكر وطرق لانتاجه

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006138507A1 (en) * 2005-06-17 2006-12-28 Novartis Ag Use of sanglifehrin in hcv
CN102770139A (zh) * 2010-02-09 2012-11-07 百奥帝卡技术有限公司 基于Sanglifehrin的化合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Sanglifehrin-cyclophilin interaction: degradation work, synthetic macrocyclic analogues, X-ray crystal structure, and binding data;Richard Sedrani et al;《J. AM. CHEM. SOC. 》;20030306;第125卷;第3853页图3 *

Also Published As

Publication number Publication date
SI2691413T1 (sl) 2015-05-29
EP2691413A1 (en) 2014-02-05
AU2012235880B2 (en) 2016-11-17
RS53963B1 (sr) 2015-08-31
CL2013002740A1 (es) 2014-07-11
CY1116318T1 (el) 2017-02-08
PH12013502000B1 (en) 2018-08-10
HK1189237A1 (en) 2014-05-30
CA2830831A1 (en) 2012-10-04
KR20140071958A (ko) 2014-06-12
PL2691413T3 (pl) 2015-05-29
CA2830827A1 (en) 2012-10-04
WO2012131377A1 (en) 2012-10-04
CN107417766A (zh) 2017-12-01
BR112013024965A2 (pt) 2017-04-18
IL228508A0 (en) 2013-12-31
SI2691412T1 (sl) 2015-05-29
ES2533437T3 (es) 2015-04-10
WO2012131371A1 (en) 2012-10-04
EP2691412B1 (en) 2014-12-24
AU2012235880A1 (en) 2013-10-17
CA2830827C (en) 2020-03-10
AU2012235961B2 (en) 2016-09-01
ZA201307149B (en) 2015-04-29
CN103635484A (zh) 2014-03-12
PT2691413E (pt) 2015-03-25
EP2691412A1 (en) 2014-02-05
HRP20150184T1 (hr) 2015-05-08
US9139613B2 (en) 2015-09-22
EP2691413B1 (en) 2014-12-24
MY170637A (en) 2019-08-21
EA023907B1 (ru) 2016-07-29
JP6118793B2 (ja) 2017-04-26
TW201300398A (zh) 2013-01-01
JP2014514290A (ja) 2014-06-19
HK1189236A1 (en) 2014-05-30
MX345351B (es) 2017-01-26
MX2013011043A (es) 2014-04-25
US20140038885A1 (en) 2014-02-06
DK2691413T3 (en) 2015-04-07
US9090657B2 (en) 2015-07-28
KR101868084B1 (ko) 2018-06-18
TWI525098B (zh) 2016-03-11
PT2691412E (pt) 2015-03-25
CY1116186T1 (el) 2017-02-08
AR085724A1 (es) 2013-10-23
CL2013002739A1 (es) 2014-07-11
SG193569A1 (en) 2013-11-29
UY33993A (es) 2012-10-31
CN103635484B (zh) 2017-05-10
MX345352B (es) 2017-01-26
JO3063B1 (ar) 2017-03-15
JP6118792B2 (ja) 2017-04-26
EA023848B1 (ru) 2016-07-29
PL2691412T3 (pl) 2015-08-31
ZA201307231B (en) 2015-05-27
EA201391399A1 (ru) 2014-02-28
PH12013502000A1 (en) 2013-12-02
JP2014510746A (ja) 2014-05-01
PH12013502016A1 (en) 2013-12-16
IL228509A0 (en) 2013-12-31
MY170618A (en) 2019-08-21
HRP20150187T1 (xx) 2015-06-05
IL228508B (en) 2018-01-31
ES2533438T3 (es) 2015-04-10
EA201391396A1 (ru) 2014-02-28
BR112013024974A2 (pt) 2016-09-06
AU2012235961A1 (en) 2013-10-10
RS53964B1 (sr) 2015-08-31
KR101911484B1 (ko) 2018-10-24
CN103619869A (zh) 2014-03-05
DK2691412T3 (en) 2015-04-07
US20120251581A1 (en) 2012-10-04
IL228509B (en) 2018-02-28
SG193568A1 (en) 2013-11-29
CA2830831C (en) 2020-03-10
MX2013011051A (es) 2014-03-13
KR20140057481A (ko) 2014-05-13

Similar Documents

Publication Publication Date Title
CN103619869B (zh) 大环化合物及其制备方法
MX2012008873A (es) Compuestos a base de sangliferina.
WO2011098808A1 (en) Sanglifehrin based compounds
US9271977B2 (en) Sanglifehrin derivatives and methods for their production
WO2011098805A1 (en) Sanglifehrin based compounds
AU2011346823B8 (en) Sanglifehrin derivatives and methods for their production
HK1189236B (en) Macrocyclic compound and methods for its production
HK1189237B (en) Macrocyclic compounds and methods for their production

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CP03 Change of name, title or address

Address after: Rand, Sweden

Patentee after: Aiboliwa Co.,Ltd.

Address before: Lund, Sweden

Patentee before: BIOTICA TECHNOLOGY Ltd.

CP03 Change of name, title or address
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20151125

CF01 Termination of patent right due to non-payment of annual fee