JP6105578B2 - 複素環式プロテインキナーゼ阻害剤 - Google Patents

複素環式プロテインキナーゼ阻害剤 Download PDF

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JP6105578B2
JP6105578B2 JP2014521840A JP2014521840A JP6105578B2 JP 6105578 B2 JP6105578 B2 JP 6105578B2 JP 2014521840 A JP2014521840 A JP 2014521840A JP 2014521840 A JP2014521840 A JP 2014521840A JP 6105578 B2 JP6105578 B2 JP 6105578B2
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mmol
compound
stereoisomer
pharmaceutically acceptable
mixture
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JP2014520898A5 (https=
JP2014520898A (ja
Inventor
ヨン スー，
ヨン スー，
ベンジャミン ゲイリー ブレニング，
ベンジャミン ゲイリー ブレニング，
スティーブン ジー． クルトゲン，
スティーブン ジー． クルトゲン，
シャオフイ リウ，
シャオフイ リウ，
マイケル サンダーズ，
マイケル サンダーズ，
コク−カン ホ，
コク−カン ホ，
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トレロ ファーマシューティカルズ， インコーポレイテッド
トレロ ファーマシューティカルズ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2014521840A 2011-07-21 2012-07-20 複素環式プロテインキナーゼ阻害剤 Active JP6105578B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201161510207P 2011-07-21 2011-07-21
US201161632834P 2011-07-21 2011-07-21
US61/632,834 2011-07-21
US61/510,207 2011-07-21
US201261632826P 2012-03-01 2012-03-01
US61/632,826 2012-03-01
US201261608028P 2012-03-07 2012-03-07
US61/608,028 2012-03-07
PCT/US2012/047685 WO2013013188A1 (en) 2011-07-21 2012-07-20 Heterocyclic protein kinase inhibitors

Publications (3)

Publication Number Publication Date
JP2014520898A JP2014520898A (ja) 2014-08-25
JP2014520898A5 JP2014520898A5 (https=) 2015-09-10
JP6105578B2 true JP6105578B2 (ja) 2017-03-29

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JP2014521840A Active JP6105578B2 (ja) 2011-07-21 2012-07-20 複素環式プロテインキナーゼ阻害剤

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US (7) US9416132B2 (https=)
EP (3) EP3812387A1 (https=)
JP (1) JP6105578B2 (https=)
CY (1) CY1123626T1 (https=)
DK (2) DK2734205T3 (https=)
ES (2) ES2671748T3 (https=)
HU (1) HUE052198T2 (https=)
PL (1) PL3409278T3 (https=)
PT (1) PT3409278T (https=)
WO (1) WO2013013188A1 (https=)

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TWI734699B (zh) 2015-09-09 2021-08-01 美商英塞特公司 Ｐｉｍ激酶抑制劑之鹽
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WO2019113487A1 (en) 2017-12-08 2019-06-13 Incyte Corporation Low dose combination therapy for treatment of myeloproliferative neoplasms
JP2021521170A (ja) * 2018-04-13 2021-08-26 スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド 骨髄増殖性新生物およびがんに関連する線維症の処置のためのｐｉｍキナーゼ阻害剤
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KR20260008165A (ko) * 2019-02-12 2026-01-15 스미토모 파마 아메리카, 인크. 헤테로시클릭 단백질 키나제 억제제를 포함하는 제제
IL296921A (en) * 2020-04-15 2022-12-01 Pyramid Biosciences Inc Methods for making receptor tyrosine kinase inhibitors
CN112430632B (zh) * 2020-11-18 2022-09-13 上海合全药物研发有限公司 2-((反式)-4-氨基环己烷基)异丙醇的制备方法
EP4289847A4 (en) * 2021-02-08 2025-01-01 Hangzhou Biosun Pharmaceutical Co., Ltd. PIM KINASE INHIBITOR
US20250042918A1 (en) * 2021-12-01 2025-02-06 Fundación Del Sector Públlco Estatal Centro Nacional De Investigaciones Oncológicas Carlos III Compounds
CN116262753A (zh) * 2021-12-13 2023-06-16 杭州邦顺制药有限公司 一种新颖的pim激酶抑制剂
CN120302975A (zh) 2022-10-31 2025-07-11 住友制药美国公司 治疗骨髓增生性肿瘤的pim1抑制剂
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JP2021521170A (ja) 2018-04-13 2021-08-26 スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド 骨髄増殖性新生物およびがんに関連する線維症の処置のためのｐｉｍキナーゼ阻害剤

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