HUE052198T2 - Heterociklusos protein kináz inhibitorok - Google Patents

Heterociklusos protein kináz inhibitorok

Info

Publication number
HUE052198T2
HUE052198T2 HUE18162853A HUE18162853A HUE052198T2 HU E052198 T2 HUE052198 T2 HU E052198T2 HU E18162853 A HUE18162853 A HU E18162853A HU E18162853 A HUE18162853 A HU E18162853A HU E052198 T2 HUE052198 T2 HU E052198T2
Authority
HU
Hungary
Prior art keywords
protein kinase
kinase inhibitors
heterocyclic
heterocyclic protein
inhibitors
Prior art date
Application number
HUE18162853A
Other languages
English (en)
Hungarian (hu)
Inventor
Yong Xu
Benjamin Gary Brenning
Steven G Kultgen
Xiaohui Liu
Michael Saunders
Koc-Kan Ho
Original Assignee
Sumitomo Dainippon Pharma Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Dainippon Pharma Oncology Inc filed Critical Sumitomo Dainippon Pharma Oncology Inc
Publication of HUE052198T2 publication Critical patent/HUE052198T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HUE18162853A 2011-07-21 2012-07-20 Heterociklusos protein kináz inhibitorok HUE052198T2 (hu)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161510207P 2011-07-21 2011-07-21
US201161632834P 2011-07-21 2011-07-21
US201261632826P 2012-03-01 2012-03-01
US201261608028P 2012-03-07 2012-03-07

Publications (1)

Publication Number Publication Date
HUE052198T2 true HUE052198T2 (hu) 2021-04-28

Family

ID=47558512

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE18162853A HUE052198T2 (hu) 2011-07-21 2012-07-20 Heterociklusos protein kináz inhibitorok

Country Status (10)

Country Link
US (7) US9416132B2 (https=)
EP (3) EP3812387A1 (https=)
JP (1) JP6105578B2 (https=)
CY (1) CY1123626T1 (https=)
DK (2) DK2734205T3 (https=)
ES (2) ES2671748T3 (https=)
HU (1) HUE052198T2 (https=)
PL (1) PL3409278T3 (https=)
PT (1) PT3409278T (https=)
WO (1) WO2013013188A1 (https=)

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TWI734699B (zh) 2015-09-09 2021-08-01 美商英塞特公司 Ｐｉｍ激酶抑制劑之鹽
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WO2019113487A1 (en) 2017-12-08 2019-06-13 Incyte Corporation Low dose combination therapy for treatment of myeloproliferative neoplasms
JP2021521170A (ja) * 2018-04-13 2021-08-26 スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド 骨髄増殖性新生物およびがんに関連する線維症の処置のためのｐｉｍキナーゼ阻害剤
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KR20260008165A (ko) * 2019-02-12 2026-01-15 스미토모 파마 아메리카, 인크. 헤테로시클릭 단백질 키나제 억제제를 포함하는 제제
IL296921A (en) * 2020-04-15 2022-12-01 Pyramid Biosciences Inc Methods for making receptor tyrosine kinase inhibitors
CN112430632B (zh) * 2020-11-18 2022-09-13 上海合全药物研发有限公司 2-((反式)-4-氨基环己烷基)异丙醇的制备方法
EP4289847A4 (en) * 2021-02-08 2025-01-01 Hangzhou Biosun Pharmaceutical Co., Ltd. PIM KINASE INHIBITOR
US20250042918A1 (en) * 2021-12-01 2025-02-06 Fundación Del Sector Públlco Estatal Centro Nacional De Investigaciones Oncológicas Carlos III Compounds
CN116262753A (zh) * 2021-12-13 2023-06-16 杭州邦顺制药有限公司 一种新颖的pim激酶抑制剂
CN120302975A (zh) 2022-10-31 2025-07-11 住友制药美国公司 治疗骨髓增生性肿瘤的pim1抑制剂
CN116836168B (zh) * 2023-05-24 2026-01-02 浙江大学 7-二氟甲基-5-芳基吡唑并嘧啶类化合物及制备与应用

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US20250129085A1 (en) 2025-04-24

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