JP6084967B2 - セピアプテリン及びテトラヒドロラクトイルプテリンの製造法 - Google Patents
セピアプテリン及びテトラヒドロラクトイルプテリンの製造法 Download PDFInfo
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- JP6084967B2 JP6084967B2 JP2014514717A JP2014514717A JP6084967B2 JP 6084967 B2 JP6084967 B2 JP 6084967B2 JP 2014514717 A JP2014514717 A JP 2014514717A JP 2014514717 A JP2014514717 A JP 2014514717A JP 6084967 B2 JP6084967 B2 JP 6084967B2
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- 0 CC(C(C(CN1)=Nc2c1nc(N(C)*)nc2*)=O)O* Chemical compound CC(C(C(CN1)=Nc2c1nc(N(C)*)nc2*)=O)O* 0.000 description 7
- HKCYZTKHPLJZDR-UHFFFAOYSA-N CC(C(C(CN1)NC2=C1N=C(N)NC2=O)=O)O Chemical compound CC(C(C(CN1)NC2=C1N=C(N)NC2=O)=O)O HKCYZTKHPLJZDR-UHFFFAOYSA-N 0.000 description 2
- VPVOXUSPXFPWBN-VKHMYHEASA-N C[C@@H](C(C(CN1)=NC2=C1N=C(N)NC2=O)=O)O Chemical compound C[C@@H](C(C(CN1)=NC2=C1N=C(N)NC2=O)=O)O VPVOXUSPXFPWBN-VKHMYHEASA-N 0.000 description 2
- NZCBEEFQSOUVCK-VKHMYHEASA-N C[C@@H](C(c(cn1)nc2c1N=C(N)NC2=O)=O)O Chemical compound C[C@@H](C(c(cn1)nc2c1N=C(N)NC2=O)=O)O NZCBEEFQSOUVCK-VKHMYHEASA-N 0.000 description 2
- VPVOXUSPXFPWBN-UHFFFAOYSA-N CC(C(C(CN1)=NC2=C1N=C(N)NC2=O)=O)O Chemical compound CC(C(C(CN1)=NC2=C1N=C(N)NC2=O)=O)O VPVOXUSPXFPWBN-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012105758 | 2012-05-07 | ||
| JP2012105758 | 2012-05-07 | ||
| JP2012247255 | 2012-11-09 | ||
| JP2012247255 | 2012-11-09 | ||
| PCT/JP2013/062817 WO2013168693A1 (ja) | 2012-05-07 | 2013-05-07 | セピアプテリン及びテトラヒドロラクトイルプテリンの製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2013168693A1 JPWO2013168693A1 (ja) | 2016-01-07 |
| JP6084967B2 true JP6084967B2 (ja) | 2017-02-22 |
Family
ID=49550728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014514717A Active JP6084967B2 (ja) | 2012-05-07 | 2013-05-07 | セピアプテリン及びテトラヒドロラクトイルプテリンの製造法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9181254B2 (enExample) |
| EP (1) | EP2848619B1 (enExample) |
| JP (1) | JP6084967B2 (enExample) |
| CN (1) | CN104736539B (enExample) |
| ES (1) | ES2681345T3 (enExample) |
| FR (1) | FR25C1044I1 (enExample) |
| IN (1) | IN2014DN09053A (enExample) |
| WO (1) | WO2013168693A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101562078B1 (ko) * | 2008-02-21 | 2015-10-22 | 데이고꾸세이약꾸가부시끼가이샤 | 피부에서의 창상 피복재의 환경 모의 측정장치 및 그 측정방법 |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011132435A1 (ja) | 2010-04-22 | 2011-10-27 | 学校法人日本大学 | 脳機能障害予防・改善用の薬剤及び飲食物 |
| JP6809781B2 (ja) * | 2015-11-18 | 2021-01-06 | 白鳥製薬株式会社 | プテリン誘導体又はその塩 |
| WO2018102315A1 (en) * | 2016-11-29 | 2018-06-07 | Censa Pharmaceuticals Inc. | Polymoprhs of sepiapterin and salts thereof |
| MA46972A (fr) | 2016-11-29 | 2019-10-09 | Censa Pharmaceuticals Inc | Forme polymorphe de sépiaptérine |
| JP2020532535A (ja) | 2017-09-01 | 2020-11-12 | ピーティーシー セラピューティクス エムピー，インコーポレイテッド | セピアプテリンを含む医薬組成物及びその使用 |
| EP3807279B1 (en) | 2018-05-30 | 2025-12-31 | PTC Therapeutics MP, Inc. | Pharmaceutically acceptable sepiapterin salts with improved stability |
| JP7502197B2 (ja) | 2018-05-30 | 2024-06-18 | ピーティーシー セラピューティクス エムピー，インコーポレイテッド | セピアプテリン血漿曝露を増加させるための方法 |
| WO2019232126A1 (en) | 2018-05-30 | 2019-12-05 | Censa Pharmaceuticals Inc. | Compositions and methods for increasing tetrahydrobiopterin plasma exposure |
| CN117088883B (zh) * | 2022-12-05 | 2025-10-21 | 哈尔滨工业大学（深圳） | 一种以Pd/Al2O3为催化剂连续加氢制备四氢叶酸的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1262347A (en) | 1985-01-28 | 1989-10-17 | Suntory Limited | Preparation process of (6r)-tetrahydro-l-biopterin |
| JPS61172877A (ja) * | 1985-01-28 | 1986-08-04 | Shiratori Seiyaku Kk | （６ｒ）−テトラヒドロ−ｌ−バイオプテリンの製造方法 |
| JP5184783B2 (ja) | 2003-11-17 | 2013-04-17 | バイオマリン ファーマシューティカル インコーポレイテッド | テトラヒドロビオプテリン、及びテトラヒドロビオプテリン類似体の製造方法 |
| JP2011011976A (ja) | 2007-10-10 | 2011-01-20 | Shiratori Pharmaceutical Co Ltd | プテリジン化合物及びｌ−ビオプテリンの製造方法 |
| WO2011132435A1 (ja) | 2010-04-22 | 2011-10-27 | 学校法人日本大学 | 脳機能障害予防・改善用の薬剤及び飲食物 |
-
2013
- 2013-05-07 EP EP13787263.6A patent/EP2848619B1/en active Active
- 2013-05-07 WO PCT/JP2013/062817 patent/WO2013168693A1/ja not_active Ceased
- 2013-05-07 ES ES13787263.6T patent/ES2681345T3/es active Active
- 2013-05-07 US US14/398,884 patent/US9181254B2/en active Active
- 2013-05-07 CN CN201380022709.5A patent/CN104736539B/zh active Active
- 2013-05-07 IN IN9053DEN2014 patent/IN2014DN09053A/en unknown
- 2013-05-07 JP JP2014514717A patent/JP6084967B2/ja active Active
-
2025
- 2025-11-18 FR FR25C1044C patent/FR25C1044I1/fr active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101562078B1 (ko) * | 2008-02-21 | 2015-10-22 | 데이고꾸세이약꾸가부시끼가이샤 | 피부에서의 창상 피복재의 환경 모의 측정장치 및 그 측정방법 |
Also Published As
| Publication number | Publication date |
|---|---|
| US9181254B2 (en) | 2015-11-10 |
| CN104736539A (zh) | 2015-06-24 |
| ES2681345T3 (es) | 2018-09-12 |
| FR25C1044I1 (fr) | 2026-01-02 |
| IN2014DN09053A (enExample) | 2015-05-22 |
| US20150119574A1 (en) | 2015-04-30 |
| EP2848619B1 (en) | 2018-07-11 |
| CN104736539B (zh) | 2017-09-01 |
| EP2848619A4 (en) | 2015-11-04 |
| WO2013168693A1 (ja) | 2013-11-14 |
| JPWO2013168693A1 (ja) | 2016-01-07 |
| EP2848619A1 (en) | 2015-03-18 |
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