JP6021893B2 - 軽度認知機能障害(MCI)およびアルツハイマー病(AD)の早期検出ならびにモニタリングのために体液からのmiRNAを使用する方法 - Google Patents
軽度認知機能障害(MCI)およびアルツハイマー病(AD)の早期検出ならびにモニタリングのために体液からのmiRNAを使用する方法 Download PDFInfo
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- C12Q2600/00—Oligonucleotides characterized by their use
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161476591P | 2011-04-18 | 2011-04-18 | |
| US61/476,591 | 2011-04-18 | ||
| US201161478766P | 2011-04-25 | 2011-04-25 | |
| US61/478,766 | 2011-04-25 | ||
| US201161546431P | 2011-10-12 | 2011-10-12 | |
| US61/546,431 | 2011-10-12 | ||
| PCT/US2012/034025 WO2012145363A1 (en) | 2011-04-18 | 2012-04-18 | METHODS OF USING miRNA FROM BODILY FLUIDS FOR EARLY DETECTION AND MONITORING OF MILD COGNITIVE IMPAIRMENT (MCI) AND ALZHEIMER'S DISEASE (AD) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014513528A JP2014513528A (ja) | 2014-06-05 |
| JP2014513528A5 JP2014513528A5 (cg-RX-API-DMAC7.html) | 2015-06-18 |
| JP6021893B2 true JP6021893B2 (ja) | 2016-11-09 |
Family
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
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| JP2014506501A Active JP6021893B2 (ja) | 2011-04-18 | 2012-04-18 | 軽度認知機能障害(MCI)およびアルツハイマー病(AD)の早期検出ならびにモニタリングのために体液からのmiRNAを使用する方法 |
| JP2014506516A Active JP6211511B2 (ja) | 2011-04-18 | 2012-04-18 | miRNAに基づくユニバーサルスクリーニングテスト(UST) |
| JP2017174778A Pending JP2018027089A (ja) | 2011-04-18 | 2017-09-12 | miRNAに基づくユニバーサルスクリーニングテスト(UST) |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2014506516A Active JP6211511B2 (ja) | 2011-04-18 | 2012-04-18 | miRNAに基づくユニバーサルスクリーニングテスト(UST) |
| JP2017174778A Pending JP2018027089A (ja) | 2011-04-18 | 2017-09-12 | miRNAに基づくユニバーサルスクリーニングテスト(UST) |
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| EP (4) | EP3327145A1 (cg-RX-API-DMAC7.html) |
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| CN (3) | CN103620057B (cg-RX-API-DMAC7.html) |
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Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6021893B2 (ja) | 2011-04-18 | 2016-11-09 | ディアミール, エルエルシーDiamir, Llc | 軽度認知機能障害(MCI)およびアルツハイマー病(AD)の早期検出ならびにモニタリングのために体液からのmiRNAを使用する方法 |
| US20140087964A1 (en) * | 2012-09-24 | 2014-03-27 | University Of Virginia Patent Foundation | Compositions and methods for detecting aberrant regulation, expression, and levels of hgh |
| WO2014055117A1 (en) * | 2012-10-04 | 2014-04-10 | Asuragen, Inc. | Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions |
| EP2733220B1 (en) * | 2012-11-16 | 2017-10-18 | Siemens Aktiengesellschaft | Novel miRNA as a diagnostic marker for Alzheimer's Disease |
| EP2733219B1 (en) | 2012-11-16 | 2017-09-20 | Siemens Aktiengesellschaft | Diagnostic miRNA markers for Alzheimer |
| US10011873B2 (en) | 2012-11-16 | 2018-07-03 | Universitat Des Saarlandes | Diagnostic miRNA markers for Parkinson disease |
| JP2014128249A (ja) * | 2012-12-28 | 2014-07-10 | Hokkaido Univ | 神経変性疾患の検査と治療に対するmiRNA又はその標的遺伝子の利用 |
| CN103805693B (zh) * | 2013-10-29 | 2017-01-11 | 宁夏医科大学 | 微小分子RNA-508-5p作为抗肿瘤标志物的用途 |
| ES2813699T3 (es) | 2013-11-18 | 2021-03-24 | Diamir Llc | Métodos de uso de miARN de fluidos corporales para la detección y monitoreo de la enfermedad de Parkinson (PD) |
| EP3108012A4 (en) * | 2014-02-18 | 2017-10-11 | Baylor Research Institute | Mir-320e and colorectal cancer |
| EP4560026A3 (en) * | 2014-04-10 | 2025-08-27 | The Trustees of the University of Pennsylvania | Use of micro-ribonucleic acid (mirna) to diagnose transplant rejection and tolerance of immunosuppression therapy |
| CN103937888B (zh) * | 2014-04-14 | 2016-08-17 | 上海交通大学 | 鉴别胃癌的血浆microRNA标志物的筛选与应用 |
| US10370717B2 (en) * | 2014-04-22 | 2019-08-06 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Methods for the measurement of post-traumatic stress disorder microRNA markers |
| US20170198354A1 (en) * | 2014-05-28 | 2017-07-13 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods of glucocorticoid therapy and determining responsiveness thereof |
| WO2015194627A1 (ja) * | 2014-06-18 | 2015-12-23 | 東レ株式会社 | 食道がんの検出キット又はデバイス及び検出方法 |
| WO2016138287A1 (en) * | 2015-02-25 | 2016-09-01 | Washington University | METHODS TO DETECT MOTOR NEURON DISEASE COMPRISING MICRO-RNAs |
| JP2018525703A (ja) * | 2015-05-28 | 2018-09-06 | イミューンエクスプレス・プロプライエタリー・リミテッドImmuneXpress Pty Ltd | バイオマーカー測定の妥当性確認 |
| HK1253405A1 (zh) | 2015-06-05 | 2019-06-14 | MiRagen Therapeutics, Inc. | 用於治疗皮肤t细胞淋巴瘤(ctcl)的mir-155抑制剂 |
| CN104940954B (zh) * | 2015-06-23 | 2017-12-26 | 同济大学 | MicroRNA‑7在制备抗胶质化药物中的应用 |
| JP2018526021A (ja) * | 2015-09-11 | 2018-09-13 | コーニング インコーポレイテッド | 血液試料からの核酸精製のための組成物及び方法 |
| ES2734678T3 (es) * | 2015-12-22 | 2019-12-11 | Siemens Ag | Firmas específicas en enfermedad de alzheimer por perfiles de miarn multicéntricos |
| WO2017120285A1 (en) * | 2016-01-05 | 2017-07-13 | Diamir, Llc | METHODS OF USING miRNA FROM BODILY FLUIDS FOR DIAGNOSIS AND MONITORING OF NEURODEVELOPMENTAL DISORDERS |
| US10975436B2 (en) | 2016-01-05 | 2021-04-13 | Diamir, Llc | Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders |
| WO2017165458A1 (en) | 2016-03-21 | 2017-09-28 | Diamir, Llc | Methods of using mirnas from bodily fluids for detection and differentiation of neurodegenerative diseases |
| WO2017186719A1 (en) * | 2016-04-25 | 2017-11-02 | Instytut Biologii Doswiadczalnej Im. Marcelego Nenckiego Polska Akademia Nauk | Microrna biomarkers in blood for diagnosis of alzheimer's disease |
| WO2018053260A1 (en) * | 2016-09-16 | 2018-03-22 | Dyax Corp. | Rna biomarkers for hereditary angioedema |
| CN106544435A (zh) * | 2016-09-30 | 2017-03-29 | 河北医科大学第医院 | 检测miR‑206所需逆转录引物对在制备预测试剂盒中的应用 |
| GB201616691D0 (en) * | 2016-09-30 | 2016-11-16 | King S College London | Assay |
| SG10201709799SA (en) * | 2016-11-29 | 2018-06-28 | Helios Bioelectronics Inc | Method for quantitatively profiling nucleic acids |
| US20190345551A1 (en) * | 2016-12-28 | 2019-11-14 | National University Corporation Kumamoto University | METHOD FOR DETECTING MITOCHONDRIAL tRAN MODIFICATION |
| WO2018139759A1 (ko) * | 2017-01-26 | 2018-08-02 | 주식회사 바이오오케스트라 | 마이크로 rna를 이용한 알츠하이머병 진단방법 |
| EP3652340A4 (en) * | 2017-07-12 | 2021-04-07 | Texas Tech University System | MICROARN-455-3P AS A PERIPHERAL BIOMARKER FOR ALZHEIMER'S DISEASE |
| US10781487B2 (en) | 2017-07-24 | 2020-09-22 | Diamir, Llc | miRNA-based methods for detecting and monitoring aging |
| KR101830583B1 (ko) * | 2017-08-11 | 2018-02-20 | 주식회사 인피니트헬스케어 | Wsi 스트리밍 방법 |
| US11723579B2 (en) | 2017-09-19 | 2023-08-15 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement |
| CN107811609B (zh) * | 2017-09-22 | 2020-06-09 | 中国医学科学院北京协和医院 | 一种脑老化评估系统 |
| EP3717660B1 (en) * | 2017-11-30 | 2025-11-12 | Provincial Health Services Authority | Methods for evaluating head and neck cancers |
| US11717686B2 (en) | 2017-12-04 | 2023-08-08 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to facilitate learning and performance |
| US12280219B2 (en) | 2017-12-31 | 2025-04-22 | NeuroLight, Inc. | Method and apparatus for neuroenhancement to enhance emotional response |
| US11318277B2 (en) | 2017-12-31 | 2022-05-03 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to enhance emotional response |
| EP4498086A3 (en) | 2018-02-13 | 2025-04-02 | Toray Industries, Inc. | Kit or device and method for detecting dementia |
| US11364361B2 (en) | 2018-04-20 | 2022-06-21 | Neuroenhancement Lab, LLC | System and method for inducing sleep by transplanting mental states |
| RU2677280C1 (ru) * | 2018-05-17 | 2019-01-16 | федеральное государственное бюджетное образовательное учреждение высшего образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации | Способ диагностики многососудистого атеросклеротического поражения коронарных артерий у больных ишемической болезнью сердца при абдоминальном ожирении |
| US11332789B2 (en) | 2018-05-21 | 2022-05-17 | Temple University-Of The Commonwealth System Of Higher Education | Compositions and methods for diagnosing and treating hyperlipidemia-related diseases |
| EP3807422B1 (en) | 2018-06-15 | 2025-12-03 | Universitat Autònoma de Barcelona | Circulating mirnas as biomarkers for diagnosis of mild cognitive impairment and alzheimer´s disease |
| EP3849410A4 (en) | 2018-09-14 | 2022-11-02 | Neuroenhancement Lab, LLC | System and method of improving sleep |
| CN109055541B (zh) * | 2018-09-26 | 2020-08-28 | 上海市精神卫生中心(上海市心理咨询培训中心) | Ad所致mci诊断标志物及其应用 |
| US11786694B2 (en) | 2019-05-24 | 2023-10-17 | NeuroLight, Inc. | Device, method, and app for facilitating sleep |
| EP3983549A4 (en) * | 2019-06-17 | 2023-06-28 | Biorchestra Co., Ltd. | Compositions and methods for preparing an alzheimer's disease animal model using microrna |
| US11198908B2 (en) | 2019-06-17 | 2021-12-14 | Biorchestra Co., Ltd. | Method for diagnosis of Alzheimer's disease using microRNA |
| CA3175419A1 (en) * | 2020-04-23 | 2021-10-28 | Jin-Hyeob RYU | Diagnostic methods using mir-485-3p expression |
| US20220073992A1 (en) * | 2020-11-24 | 2022-03-10 | Hossein Abdul Tehrani Abdul Tehrani | Diagnosis of chronic kidney disease (ckd) and its subgroups |
| CN112562867A (zh) * | 2021-02-22 | 2021-03-26 | 天津迈德新医药科技有限公司 | 一种预测极早期hiv感染风险的装置、存储介质和电子装置 |
| CN112980954B (zh) * | 2021-03-03 | 2022-02-25 | 首都医科大学宣武医院 | 一种预测神经退行性疾病风险的试剂盒及其用途 |
| CN115976194A (zh) * | 2022-12-12 | 2023-04-18 | 天津市肿瘤医院空港医院 | 一种基于外泌体微小rna的神经系统疾病诊断方法 |
| WO2025089057A1 (ja) * | 2023-10-24 | 2025-05-01 | アークレイ株式会社 | スモールrna測定用血液試料の調製方法及び保存方法、スモールrnaの発現量の測定方法、疾患の判定方法、検査方法、モデルの生成方法、検査装置、検査システム、検査プログラム、並びに記録媒体 |
Family Cites Families (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US743A (en) | 1838-05-17 | Improvement in plows | ||
| US5071A (en) | 1847-04-17 | George page | ||
| FR2552909B1 (fr) | 1983-09-30 | 1985-11-08 | Thomson Csf | Appareil indicateur cartographique de relief et son u tilisation pour la navigation aerienne |
| US4829304A (en) | 1986-05-20 | 1989-05-09 | Harris Corp. | Map-aided navigation system employing TERCOM-SITAN signal processing |
| KR940002799B1 (ko) | 1986-07-28 | 1994-04-02 | 가부시끼가이샤 도요다지도오쇽기 세이사꾸쇼 | 보텀 드래프트 로울러의 청소장치 |
| US4939663A (en) | 1988-04-04 | 1990-07-03 | Harris Corporation | Elevation map-referenced mechanism for updating vehicle navigation system estimates |
| EP0381178A1 (en) | 1989-02-02 | 1990-08-08 | Honeywell Inc. | Method and apparatus for aircraft navigation |
| US5071743A (en) | 1989-10-27 | 1991-12-10 | Her Majesty The Queen In Right Of Canada, As Represented By The National Research Council Of Canada | Process for conducting site-directed mutagenesis |
| JP3442774B2 (ja) | 1991-07-01 | 2003-09-02 | バーレックス ラボラトリーズ,インコーポレイティド | 新規な突然変異誘発法および組成物 |
| US5789166A (en) | 1995-12-08 | 1998-08-04 | Stratagene | Circular site-directed mutagenesis |
| US6242222B1 (en) | 1996-06-07 | 2001-06-05 | Massachusetts Institute Of Technology | Programmed sequential mutagenesis |
| US5780270A (en) | 1996-07-17 | 1998-07-14 | Promega Corporation | Site-specific mutagenesis and mutant selection utilizing antibiotic-resistant markers encoding gene products having altered substrate specificity |
| EP1771563A2 (en) | 2004-05-28 | 2007-04-11 | Ambion, Inc. | METHODS AND COMPOSITIONS INVOLVING MicroRNA |
| EP1838852A2 (en) * | 2004-11-12 | 2007-10-03 | Asuragen, Inc. | Methods and compositions involving mirna and mirna inhibitor molecules |
| EP1966390A1 (en) | 2005-12-29 | 2008-09-10 | Exiqon A/S | Detection of tissue origin of cancer |
| EP2468895B1 (en) * | 2006-01-05 | 2014-09-24 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers |
| CA2647793C (en) | 2006-02-28 | 2016-07-05 | University Of Louisville Research Foundation | Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms |
| EP2115138A2 (en) * | 2006-09-19 | 2009-11-11 | Asuragen, Inc. | Micrornas differentially expressed in pancreatic diseases and uses thereof |
| US9163229B2 (en) | 2006-10-10 | 2015-10-20 | Trovagene, Inc. | Compositions, methods and kits for isolating nucleic acids from body fluids using anion exchange media |
| CA2673793C (en) * | 2007-02-16 | 2016-01-26 | The Johns Hopkins University | Micrornas for diagnosis and treatment of cancer |
| WO2008153692A2 (en) * | 2007-05-22 | 2008-12-18 | The Brigham And Women's Hospital, Inc. | Microrna expression profiling of cerebrospinal fluid |
| US20090004668A1 (en) | 2007-06-22 | 2009-01-01 | The Board Of Trustees Of The Leland Stanford Junior University | Pre-miRNA loop-modulated target regulation |
| WO2009009457A1 (en) * | 2007-07-06 | 2009-01-15 | University Of Louisville Research Foundation, Inc. | Alzheimer's disease-specific micro-rna microarray and related methods |
| AU2008275877B2 (en) | 2007-07-18 | 2015-01-22 | The Regents Of The University Of Colorado, A Body Corporate | Differential expression of microRNAs in nonfailing versus failing human hearts |
| EP2613149B1 (en) | 2007-07-25 | 2014-09-17 | University Of Louisville Research Foundation, Inc. | Exosome-associated microRNA as a diagnostic marker |
| DK2195450T4 (en) | 2007-08-22 | 2016-10-24 | Trovagene Inc | Methods of using miRNA FOR DETECTION IN VIVO cell death |
| US7653509B2 (en) | 2007-08-29 | 2010-01-26 | Verity Software House | Probability state models |
| US7993831B2 (en) * | 2007-09-14 | 2011-08-09 | Asuragen, Inc. | Methods of normalization in microRNA detection assays |
| ES2419129T3 (es) | 2007-09-14 | 2013-08-19 | The Ohio State University Research Foundation | Expresión de miARN en microvesículas de sangre periférica humana y usos del mismo |
| CN101918594A (zh) | 2007-11-30 | 2010-12-15 | 俄亥俄州立大学研究基金会 | 肺癌中外周血中的微rna表达特征谱和靶向 |
| KR20100127768A (ko) | 2008-02-01 | 2010-12-06 | 더 제너럴 하스피탈 코포레이션 | 의학적 질환 및 병태의 진단, 예후, 및 치료에 있어서 미세소포체의 용도 |
| JP5662166B2 (ja) * | 2008-02-28 | 2015-01-28 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイションThe Ohio State University Research Foundation | 胃癌の診断、予後診断及び治療のためのマイクロrnaに基づいた方法及び組成物 |
| RU2367959C1 (ru) * | 2008-03-05 | 2009-09-20 | Государственное образовательное учреждение высшего профессионального образования "Омский государственный университет им. Ф.М. Достоевского" | Способ лабораторной диагностики заболеваний ротовой полости по элементному составу слюны |
| WO2009114681A2 (en) | 2008-03-13 | 2009-09-17 | Dharmacon, Inc. | Identification of mirna profiles that are diagnostic of hypertrophic cardiomyopathy |
| US20110117111A1 (en) | 2008-03-26 | 2011-05-19 | Johns Hopkins University | Microrna-based diagnostic testing and therapies for inflammatory bowel disease and related diseases |
| WO2009132273A2 (en) | 2008-04-25 | 2009-10-29 | Merck & Co., Inc. | Microrna biomarkers of tissue injury |
| EP2281903B1 (en) | 2008-04-30 | 2017-01-04 | NEC Corporation | METHOD FOR EVALUATION OF CANCER BY USING miRNA CANCER MARKER |
| WO2009143379A2 (en) | 2008-05-21 | 2009-11-26 | Fred Hutchinson Cancer Research Center | Use of extracellular rna to measure disease |
| US20100167937A1 (en) | 2008-07-08 | 2010-07-01 | Power3 Medical Products, Inc. | Multiple forms of Alzheimer's disease based on differences in concentrations of protein biomarkers in blood serum |
| EP4219760A3 (en) | 2008-11-10 | 2023-09-06 | Battelle Memorial Institute | Methods, compositions, and devices utilizing microrna to determine physiological conditions |
| EP2730662A1 (en) * | 2008-11-12 | 2014-05-14 | Caris Life Sciences Luxembourg Holdings | Methods and systems of using exosomes for determining phenotypes |
| US20110086348A1 (en) | 2009-02-19 | 2011-04-14 | The Cleveland Clinic Foundation | Method for assessing heart disease |
| AU2009217433A1 (en) * | 2009-03-05 | 2010-09-23 | Newcastle Innovation Limited | Diagnostic, prognostic and treatment methods |
| AU2010234806B2 (en) * | 2009-03-31 | 2014-05-22 | The United States Of America As Represented By The Secretary Department Of Health And Human Services | Differentially expressed microRNAs as biomarkers for the diagnosis and treatment of Sjogren's syndrome |
| US20120093936A1 (en) | 2009-04-07 | 2012-04-19 | Velin-Pharma A/S | Method and device for treatment of conditions associated with inflammation or undesirable activation of the immune system |
| US20120034608A1 (en) | 2009-04-14 | 2012-02-09 | Merck Sharp & Dohme Corp. | Microrna as a biomarker of pancreatic islet beta-cell engagement |
| CN102428567B (zh) | 2009-05-20 | 2015-01-07 | E.I.内穆尔杜邦公司 | 在硅片正面上形成栅极的方法 |
| FR2948687B1 (fr) | 2009-07-29 | 2015-09-04 | Centre Nat Rech Scient | Utilisation de microarn pour le traitement de pathologies respiratoires chroniques |
| EP2775300A3 (en) * | 2009-08-28 | 2015-04-01 | Asuragen, INC. | miRNA Biomarkers of Lung Disease |
| EP2496714B1 (en) | 2009-11-04 | 2016-08-31 | DiamiR, LLC | Methods of using micro-rna from bodily fluids for diagnosis and monitoring of mild cognitive impairment |
| US8592151B2 (en) | 2009-11-17 | 2013-11-26 | Musc Foundation For Research Development | Assessing left ventricular remodeling via temporal detection and measurement of microRNA in body fluids |
| CN101942502B (zh) | 2009-12-24 | 2014-09-17 | 北京命码生科科技有限公司 | 胰腺癌标记物及其检测方法、试剂盒和生物芯片 |
| EP2561091B1 (en) | 2010-04-20 | 2014-08-06 | Comprehensive Biomarker Center GmbH | Complex mirna sets as novel biomarkers for an acute coronary syndrome |
| PT2619576T (pt) | 2010-09-24 | 2020-09-14 | Niels Grabe | Meios e métodos para a previsão de resposta ao tratamento de um paciente com cancro |
| CN101962685B (zh) * | 2010-11-11 | 2012-09-19 | 江苏省疾病预防控制中心 | 一种基于液相芯片检测微小核糖核酸的方法 |
| JP6021893B2 (ja) | 2011-04-18 | 2016-11-09 | ディアミール, エルエルシーDiamir, Llc | 軽度認知機能障害(MCI)およびアルツハイマー病(AD)の早期検出ならびにモニタリングのために体液からのmiRNAを使用する方法 |
| EP3135774B1 (en) | 2011-08-19 | 2019-10-09 | Hummingbird Diagnostics GmbH | Complex sets of mirnas as non-invasive biomarkers for kidney cancer |
| WO2013036936A1 (en) | 2011-09-09 | 2013-03-14 | Van Andel Research Institute | Microrna biomarkers for diagnosing parkinson's disease |
| US9447471B2 (en) | 2011-12-29 | 2016-09-20 | Quest Diagnostics Investments Incorporated | Microrna profiling for diagnosis of dysplastic nevi and melanoma |
| US9540692B2 (en) | 2012-07-25 | 2017-01-10 | Rush University Medical Center | MiRNAs as novel therapeutic targets and diagnostic biomarkers for parkinsons disease |
| US9809857B2 (en) | 2013-02-28 | 2017-11-07 | Washington University | Methods and signatures for oropharyngeal cancer prognosis |
| ES2813699T3 (es) | 2013-11-18 | 2021-03-24 | Diamir Llc | Métodos de uso de miARN de fluidos corporales para la detección y monitoreo de la enfermedad de Parkinson (PD) |
| US9605315B2 (en) | 2014-03-26 | 2017-03-28 | The University Of Montana | Detection of traumatic brain injury |
| US9708667B2 (en) | 2014-05-13 | 2017-07-18 | Rosetta Genomics, Ltd. | MiRNA expression signature in the classification of thyroid tumors |
| WO2017120285A1 (en) | 2016-01-05 | 2017-07-13 | Diamir, Llc | METHODS OF USING miRNA FROM BODILY FLUIDS FOR DIAGNOSIS AND MONITORING OF NEURODEVELOPMENTAL DISORDERS |
| WO2017165458A1 (en) | 2016-03-21 | 2017-09-28 | Diamir, Llc | Methods of using mirnas from bodily fluids for detection and differentiation of neurodegenerative diseases |
| EP3464639A4 (en) | 2016-05-31 | 2020-01-01 | Goetzl, Edward, J. | DIAGNOSTIC METHOD AND DRUG EFFECT TEST METHOD FOR DEMENTIA WITH THE USE OF ASTROCYTE-DERIVED EXOSOMES |
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