JP6005656B2 - ベンゾイミダゾール呼吸合胞体ウイルス阻害剤 - Google Patents

ベンゾイミダゾール呼吸合胞体ウイルス阻害剤 Download PDF

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Publication number
JP6005656B2
JP6005656B2 JP2013543799A JP2013543799A JP6005656B2 JP 6005656 B2 JP6005656 B2 JP 6005656B2 JP 2013543799 A JP2013543799 A JP 2013543799A JP 2013543799 A JP2013543799 A JP 2013543799A JP 6005656 B2 JP6005656 B2 JP 6005656B2
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compound according
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formula
acid
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JP2013545785A (ja
JP2013545785A5 (enExample
Inventor
コーイマン，ルートビヒ・ポール
ドマン，サミユエル・ドミニク
フー，リリ
ヨンカース，テイム・ヒユーゴ・マリア
ラボワソン，ピエール・ジヤン−マリー・ベルナール
ターリ，アブデラー
バンドビル，サンドリーヌ・マリー・エレーヌ
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ヤンセン・サイエンシズ・アイルランド・ユーシー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2013543799A 2010-12-16 2011-12-16 ベンゾイミダゾール呼吸合胞体ウイルス阻害剤 Expired - Fee Related JP6005656B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10195467.5 2010-12-16
EP10195467 2010-12-16
PCT/EP2011/073008 WO2012080446A1 (en) 2010-12-16 2011-12-16 Benzimidazole respiratory syncytial virus inhibitors

Publications (3)

Publication Number Publication Date
JP2013545785A JP2013545785A (ja) 2013-12-26
JP2013545785A5 JP2013545785A5 (enExample) 2014-06-26
JP6005656B2 true JP6005656B2 (ja) 2016-10-12

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ID=43875271

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Application Number Title Priority Date Filing Date
JP2013543799A Expired - Fee Related JP6005656B2 (ja) 2010-12-16 2011-12-16 ベンゾイミダゾール呼吸合胞体ウイルス阻害剤

Country Status (30)

Country Link
US (1) US8865705B2 (enExample)
EP (1) EP2651903B1 (enExample)
JP (1) JP6005656B2 (enExample)
KR (1) KR101876240B1 (enExample)
CN (2) CN103313974A (enExample)
AR (1) AR085203A1 (enExample)
AU (1) AU2011343255B2 (enExample)
BR (1) BR112013012137A2 (enExample)
CA (1) CA2821999C (enExample)
CL (1) CL2013001713A1 (enExample)
CY (1) CY1117751T1 (enExample)
DK (1) DK2651903T3 (enExample)
EA (1) EA022972B1 (enExample)
ES (1) ES2576180T3 (enExample)
HK (1) HK1247616A1 (enExample)
HR (1) HRP20160650T1 (enExample)
HU (1) HUE029247T2 (enExample)
IL (1) IL225640A (enExample)
MX (1) MX340030B (enExample)
MY (1) MY156641A (enExample)
NZ (1) NZ609450A (enExample)
PH (1) PH12013500796A1 (enExample)
PL (1) PL2651903T3 (enExample)
PT (1) PT2651903E (enExample)
SG (1) SG190766A1 (enExample)
SI (1) SI2651903T1 (enExample)
TW (1) TWI530495B (enExample)
UA (1) UA112298C2 (enExample)
WO (1) WO2012080446A1 (enExample)
ZA (1) ZA201304424B (enExample)

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TWI541241B (zh) * 2010-12-16 2016-07-11 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類
TWI501967B (zh) 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
TWI530495B (zh) 2010-12-16 2016-04-21 健生科學愛爾蘭無限公司 苯并咪唑呼吸道融合病毒抑制劑
TWI527814B (zh) * 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
JP2015523350A (ja) * 2012-06-15 2015-08-13 ヤンセン・アールアンドデイ・アイルランド Ｒｓウイルス抗ウイルス薬としての、ベンゾイミダゾールによって置換された新規１，３−ジヒドロ−２ｈ−ベンゾイミダゾル−２−オン誘導体
DK2864323T3 (en) * 2012-06-15 2017-08-14 Janssen Sciences Ireland Uc 1,3-DIHYDRO-2H-BENZIMIDAZOLE-2 UNDERIVATIVES SUBSTITUTED BY HETEROCYCLES AS ANTIVIRUS AGENTS AGAINST RESPIRATORY SYNCYTIAL VIRUS
BR112015000392A2 (pt) * 2012-07-10 2017-06-27 Hoffmann La Roche novos indazóis para o tratamento e profilaxia da infecção por vírus sincicial respiratório
TWI598351B (zh) 2012-10-16 2017-09-11 健生科學愛爾蘭無限公司 Ｒｓｖ抗病毒化合物
KR102254837B1 (ko) 2013-01-28 2021-05-24 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 호흡기 합포체 바이러스의 항바이러스제로서의 퀴녹살리논 및 디하이드로퀴녹살리논
CA2910508A1 (en) 2013-05-14 2014-11-20 Song Feng Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection
CN105392787B (zh) * 2013-05-14 2017-11-24 豪夫迈·罗氏有限公司 用于治疗和预防呼吸道合胞病毒感染的氮杂‑氧代‑吲哚
EP3033333A1 (en) * 2013-08-15 2016-06-22 F. Hoffmann-La Roche AG Novel aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection
WO2015026792A1 (en) 2013-08-21 2015-02-26 Alios Biopharma, Inc. Antiviral compounds
WO2015065336A1 (en) * 2013-10-29 2015-05-07 Medivir Ab Respiratory syncytial virus inhibitors
TWI671299B (zh) 2014-04-14 2019-09-11 愛爾蘭商健生科學愛爾蘭無限公司 作為ｒｓｖ抗病毒化合物之螺脲化合物
CA2957017A1 (en) * 2014-08-05 2016-02-11 Alios Biopharma, Inc. Combination therapy for treating a paramyxovirus
MA41614A (fr) 2015-02-25 2018-01-02 Alios Biopharma Inc Composés antiviraux
SMT202200437T1 (it) 2015-07-22 2023-01-13 Enanta Pharm Inc Derivati benzodiazepinaci come inibitori del rsv
CN108699077B (zh) 2016-01-15 2021-03-02 英安塔制药有限公司 作为rsv抑制剂的杂环化合物
KR102573499B1 (ko) 2017-02-16 2023-08-31 이난타 파마슈티칼스, 인코포레이티드 벤조디아제핀 유도체의 제조 방법
WO2019006295A1 (en) 2017-06-30 2019-01-03 Enanta Pharmaceuticals, Inc. HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS
JP7198811B2 (ja) 2017-09-29 2023-01-04 エナンタ ファーマシューティカルズ インコーポレイテッド Ｒｓｖ阻害剤としての組み合わせ医薬剤
NZ764647A (en) 2017-11-13 2025-12-19 Enanta Pharm Inc Processes for the resolution of benzodiazepin-2-one and benzoazepin-2-one derivatives
AU2020240024B2 (en) 2019-03-18 2025-06-26 Enanta Pharmaceuticals, Inc Benzodiazepine derivatives as RSV inhibitors
CN114761016A (zh) 2019-10-04 2022-07-15 英安塔制药有限公司 抗病毒杂环化合物
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TWI501967B (zh) 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
TWI527814B (zh) 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
TWI530495B (zh) 2010-12-16 2016-04-21 健生科學愛爾蘭無限公司 苯并咪唑呼吸道融合病毒抑制劑

Also Published As

Publication number Publication date
NZ609450A (en) 2014-10-31
MY156641A (en) 2016-03-15
EA201390888A1 (ru) 2013-12-30
TWI530495B (zh) 2016-04-21
MX340030B (es) 2016-06-21
AU2011343255B2 (en) 2014-12-11
HK1247616A1 (zh) 2018-09-28
AR085203A1 (es) 2013-09-18
UA112298C2 (uk) 2016-08-25
TW201305142A (zh) 2013-02-01
MX2013006886A (es) 2013-07-05
SG190766A1 (en) 2013-07-31
EA022972B1 (ru) 2016-03-31
EP2651903B1 (en) 2016-03-23
CA2821999A1 (en) 2012-06-21
CN103313974A (zh) 2013-09-18
HUE029247T2 (en) 2017-02-28
ES2576180T3 (es) 2016-07-06
PH12013500796A1 (en) 2013-06-24
US8865705B2 (en) 2014-10-21
CA2821999C (en) 2019-02-26
SI2651903T1 (sl) 2016-07-29
DK2651903T3 (da) 2016-06-27
JP2013545785A (ja) 2013-12-26
PL2651903T3 (pl) 2016-10-31
KR101876240B1 (ko) 2018-08-02
WO2012080446A1 (en) 2012-06-21
BR112013012137A2 (pt) 2016-08-16
CL2013001713A1 (es) 2013-10-11
HRP20160650T1 (hr) 2016-07-15
CN107417683A (zh) 2017-12-01
IL225640A (en) 2015-02-26
ZA201304424B (en) 2014-12-23
US20130267508A1 (en) 2013-10-10
IL225640A0 (en) 2013-06-27
KR20140025321A (ko) 2014-03-04
EP2651903A1 (en) 2013-10-23
AU2011343255A1 (en) 2013-05-02
CY1117751T1 (el) 2017-05-17
PT2651903E (pt) 2016-06-17

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