CY1117751T1 - Αναστολεις βενζιμιδαζολης αναπνευστικου συγκυτιακου ιου - Google Patents

Αναστολεις βενζιμιδαζολης αναπνευστικου συγκυτιακου ιου

Info

Publication number
CY1117751T1
CY1117751T1 CY20161100561T CY161100561T CY1117751T1 CY 1117751 T1 CY1117751 T1 CY 1117751T1 CY 20161100561 T CY20161100561 T CY 20161100561T CY 161100561 T CY161100561 T CY 161100561T CY 1117751 T1 CY1117751 T1 CY 1117751T1
Authority
CY
Cyprus
Prior art keywords
benzimidazol
virus inhibitors
synchronic
respiratory
compounds
Prior art date
Application number
CY20161100561T
Other languages
Greek (el)
English (en)
Inventor
Ludwig Paul Cooymans
Samuël Dominique Demin
Lili Hu
Tim Hugo Maria Jonckers
Pierre Jean-Marie Bernard Raboisson
Abdellah Tahri
Sandrine Marie Helene Vendeville
Original Assignee
Janssen Sciences Ireland Uc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43875271&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1117751(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Sciences Ireland Uc filed Critical Janssen Sciences Ireland Uc
Publication of CY1117751T1 publication Critical patent/CY1117751T1/el

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CY20161100561T 2010-12-16 2016-06-22 Αναστολεις βενζιμιδαζολης αναπνευστικου συγκυτιακου ιου CY1117751T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10195467 2010-12-16
EP11802054.4A EP2651903B1 (en) 2010-12-16 2011-12-16 Benzimidazole respiratory syncytial virus inhibitors
PCT/EP2011/073008 WO2012080446A1 (en) 2010-12-16 2011-12-16 Benzimidazole respiratory syncytial virus inhibitors

Publications (1)

Publication Number Publication Date
CY1117751T1 true CY1117751T1 (el) 2017-05-17

Family

ID=43875271

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20161100561T CY1117751T1 (el) 2010-12-16 2016-06-22 Αναστολεις βενζιμιδαζολης αναπνευστικου συγκυτιακου ιου

Country Status (30)

Country Link
US (1) US8865705B2 (enExample)
EP (1) EP2651903B1 (enExample)
JP (1) JP6005656B2 (enExample)
KR (1) KR101876240B1 (enExample)
CN (2) CN103313974A (enExample)
AR (1) AR085203A1 (enExample)
AU (1) AU2011343255B2 (enExample)
BR (1) BR112013012137A2 (enExample)
CA (1) CA2821999C (enExample)
CL (1) CL2013001713A1 (enExample)
CY (1) CY1117751T1 (enExample)
DK (1) DK2651903T3 (enExample)
EA (1) EA022972B1 (enExample)
ES (1) ES2576180T3 (enExample)
HK (1) HK1247616A1 (enExample)
HR (1) HRP20160650T1 (enExample)
HU (1) HUE029247T2 (enExample)
IL (1) IL225640A (enExample)
MX (1) MX340030B (enExample)
MY (1) MY156641A (enExample)
NZ (1) NZ609450A (enExample)
PH (1) PH12013500796A1 (enExample)
PL (1) PL2651903T3 (enExample)
PT (1) PT2651903E (enExample)
SG (1) SG190766A1 (enExample)
SI (1) SI2651903T1 (enExample)
TW (1) TWI530495B (enExample)
UA (1) UA112298C2 (enExample)
WO (1) WO2012080446A1 (enExample)
ZA (1) ZA201304424B (enExample)

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TWI527814B (zh) 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
TWI501967B (zh) * 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
TWI515187B (zh) 2010-12-16 2016-01-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之吲哚類
TWI541241B (zh) 2010-12-16 2016-07-11 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類
CA2873921A1 (en) * 2012-06-15 2013-12-19 Janssen R&D Ireland 1,3-dihydro-2h-benzimidazol-2-one derivatives substituted with benzimidazoles as respiratory syncytial virus antiviral agents
CA2873920C (en) 2012-06-15 2021-07-20 Janssen R&D Ireland 1,3-dihydro-2h-benzimidazol-2-one derivatives substituted with heterocycles as respiratory syncytial virus antiviral agents
RU2015102792A (ru) * 2012-07-10 2016-08-27 Ф. Хоффманн-Ля Рош Аг Новые индазолы для лечения и профилактики респираторно-синцитиальной вирусной инфекции
PT2909195T (pt) 2012-10-16 2017-09-13 Janssen Sciences Ireland Uc Compostos antivirais de vsr
CN105073736B (zh) 2013-01-28 2017-12-29 爱尔兰詹森科学公司 作为呼吸道合胞病毒抗病毒剂的喹喔啉酮和二氢喹喔啉酮
JP2016518421A (ja) 2013-05-14 2016-06-23 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 呼吸器合胞体ウイルス感染症の処置および予防のためのアザ−オキソ−インドール
CN105392787B (zh) * 2013-05-14 2017-11-24 豪夫迈·罗氏有限公司 用于治疗和预防呼吸道合胞病毒感染的氮杂‑氧代‑吲哚
MX2016001858A (es) 2013-08-15 2016-05-24 Hoffmann La Roche Aza-oxo-indoles novedosos para el tratamiento y profilaxis de la infeccion por el virus sincicial respiratorio.
NZ716822A (en) 2013-08-21 2017-10-27 Alios Biopharma Inc Antiviral compounds
WO2015065336A1 (en) * 2013-10-29 2015-05-07 Medivir Ab Respiratory syncytial virus inhibitors
TWI671299B (zh) 2014-04-14 2019-09-11 愛爾蘭商健生科學愛爾蘭無限公司 作為rsv抗病毒化合物之螺脲化合物
SG11201700851WA (en) * 2014-08-05 2017-03-30 Alios Biopharma Inc Combination therapy for treating a paramyxovirus
MA41614A (fr) 2015-02-25 2018-01-02 Alios Biopharma Inc Composés antiviraux
CA2992839A1 (en) 2015-07-22 2017-01-26 Enanta Pharmaceuticals, Inc. Benzodiazepine derivatives as rsv inhibitors
EP3402799B1 (en) 2016-01-15 2022-05-04 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as rsv inhibitors
AU2018221820B2 (en) 2017-02-16 2023-11-02 Enanta Pharmaceuticals, Inc. Processes for the preparation of benzodiazepine derivatives
WO2019006295A1 (en) 2017-06-30 2019-01-03 Enanta Pharmaceuticals, Inc. HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS
CA3077309A1 (en) 2017-09-29 2019-04-04 Enanta Pharmaceuticals, Inc. Combination pharmaceutical agents as rsv inhibitors
JP7228588B2 (ja) 2017-11-13 2023-02-24 エナンタ ファーマシューティカルズ インコーポレイテッド ベンゾジアゼピン-2-オンおよびベンゾアゼピン-2-オン誘導体の分割方法
AU2020240024B2 (en) 2019-03-18 2025-06-26 Enanta Pharmaceuticals, Inc Benzodiazepine derivatives as RSV inhibitors
TWI864048B (zh) 2019-10-04 2024-12-01 美商安塔製藥公司 抗病毒雜環化合物、其醫藥組成物及其用途
US11505558B1 (en) 2019-10-04 2022-11-22 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
UY39032A (es) 2020-01-24 2021-07-30 Enanta Pharm Inc Compuestos heterocíclicos como agentes antivirales
US12145933B2 (en) 2020-06-11 2024-11-19 Janssen Sciences Ireland Unlimited Company Hemi (L)-tartrate forms of 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethy)-1,3-dihydro-2H-imidazo[4,5-C]pyridin-2-one and pharmaceutical compositions comprising the same
US11534439B2 (en) 2020-07-07 2022-12-27 Enanta Pharmaceuticals, Inc. Dihydroquinoxaline and dihydropyridopyrazine derivatives as RSV inhibitors
US11945824B2 (en) 2020-10-19 2024-04-02 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as anti-viral agents
JP2024507561A (ja) 2021-02-26 2024-02-20 エナンタ ファーマシューティカルズ インコーポレイテッド 抗ウイルス複素環式化合物
AR129003A1 (es) 2022-04-07 2024-07-03 Enanta Pharm Inc Compuestos heterocíclicos antivirales
US12162857B2 (en) 2022-04-27 2024-12-10 Enanta Pharmaceuticals, Inc. Antiviral compounds
WO2024174953A1 (zh) * 2023-02-21 2024-08-29 苏州隆博泰药业有限公司 苯并咪唑类衍生物及其医药用途

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TWI530495B (zh) 2010-12-16 2016-04-21 健生科學愛爾蘭無限公司 苯并咪唑呼吸道融合病毒抑制劑
TWI515187B (zh) 2010-12-16 2016-01-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之吲哚類
TWI527814B (zh) 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
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Also Published As

Publication number Publication date
PL2651903T3 (pl) 2016-10-31
UA112298C2 (uk) 2016-08-25
ZA201304424B (en) 2014-12-23
WO2012080446A1 (en) 2012-06-21
BR112013012137A2 (pt) 2016-08-16
EA201390888A1 (ru) 2013-12-30
TWI530495B (zh) 2016-04-21
AU2011343255B2 (en) 2014-12-11
IL225640A0 (en) 2013-06-27
JP6005656B2 (ja) 2016-10-12
CA2821999C (en) 2019-02-26
SG190766A1 (en) 2013-07-31
US20130267508A1 (en) 2013-10-10
JP2013545785A (ja) 2013-12-26
PT2651903E (pt) 2016-06-17
AR085203A1 (es) 2013-09-18
HUE029247T2 (en) 2017-02-28
MY156641A (en) 2016-03-15
PH12013500796A1 (en) 2013-06-24
TW201305142A (zh) 2013-02-01
EP2651903B1 (en) 2016-03-23
CA2821999A1 (en) 2012-06-21
HK1247616A1 (zh) 2018-09-28
EA022972B1 (ru) 2016-03-31
SI2651903T1 (sl) 2016-07-29
KR101876240B1 (ko) 2018-08-02
CN103313974A (zh) 2013-09-18
MX2013006886A (es) 2013-07-05
CL2013001713A1 (es) 2013-10-11
KR20140025321A (ko) 2014-03-04
IL225640A (en) 2015-02-26
CN107417683A (zh) 2017-12-01
AU2011343255A1 (en) 2013-05-02
DK2651903T3 (da) 2016-06-27
EP2651903A1 (en) 2013-10-23
US8865705B2 (en) 2014-10-21
NZ609450A (en) 2014-10-31
MX340030B (es) 2016-06-21
HRP20160650T1 (hr) 2016-07-15
ES2576180T3 (es) 2016-07-06

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