CY1117751T1 - Αναστολεις βενζιμιδαζολης αναπνευστικου συγκυτιακου ιου - Google Patents
Αναστολεις βενζιμιδαζολης αναπνευστικου συγκυτιακου ιουInfo
- Publication number
- CY1117751T1 CY1117751T1 CY20161100561T CY161100561T CY1117751T1 CY 1117751 T1 CY1117751 T1 CY 1117751T1 CY 20161100561 T CY20161100561 T CY 20161100561T CY 161100561 T CY161100561 T CY 161100561T CY 1117751 T1 CY1117751 T1 CY 1117751T1
- Authority
- CY
- Cyprus
- Prior art keywords
- benzimidazol
- virus inhibitors
- synchronic
- respiratory
- compounds
- Prior art date
Links
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title 1
- 241000700605 Viruses Species 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000000241 respiratory effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 150000001556 benzimidazoles Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000002184 metal Chemical class 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10195467 | 2010-12-16 | ||
| PCT/EP2011/073008 WO2012080446A1 (en) | 2010-12-16 | 2011-12-16 | Benzimidazole respiratory syncytial virus inhibitors |
| EP11802054.4A EP2651903B1 (en) | 2010-12-16 | 2011-12-16 | Benzimidazole respiratory syncytial virus inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1117751T1 true CY1117751T1 (el) | 2017-05-17 |
Family
ID=43875271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20161100561T CY1117751T1 (el) | 2010-12-16 | 2016-06-22 | Αναστολεις βενζιμιδαζολης αναπνευστικου συγκυτιακου ιου |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US8865705B2 (enExample) |
| EP (1) | EP2651903B1 (enExample) |
| JP (1) | JP6005656B2 (enExample) |
| KR (1) | KR101876240B1 (enExample) |
| CN (2) | CN107417683A (enExample) |
| AR (1) | AR085203A1 (enExample) |
| AU (1) | AU2011343255B2 (enExample) |
| BR (1) | BR112013012137A2 (enExample) |
| CA (1) | CA2821999C (enExample) |
| CL (1) | CL2013001713A1 (enExample) |
| CY (1) | CY1117751T1 (enExample) |
| DK (1) | DK2651903T3 (enExample) |
| EA (1) | EA022972B1 (enExample) |
| ES (1) | ES2576180T3 (enExample) |
| HK (1) | HK1247616A1 (enExample) |
| HR (1) | HRP20160650T1 (enExample) |
| HU (1) | HUE029247T2 (enExample) |
| IL (1) | IL225640A (enExample) |
| MX (1) | MX340030B (enExample) |
| MY (1) | MY156641A (enExample) |
| NZ (1) | NZ609450A (enExample) |
| PH (1) | PH12013500796A1 (enExample) |
| PL (1) | PL2651903T3 (enExample) |
| PT (1) | PT2651903E (enExample) |
| SG (1) | SG190766A1 (enExample) |
| SI (1) | SI2651903T1 (enExample) |
| TW (1) | TWI530495B (enExample) |
| UA (1) | UA112298C2 (enExample) |
| WO (1) | WO2012080446A1 (enExample) |
| ZA (1) | ZA201304424B (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI530495B (zh) | 2010-12-16 | 2016-04-21 | 健生科學愛爾蘭無限公司 | 苯并咪唑呼吸道融合病毒抑制劑 |
| TWI527814B (zh) | 2010-12-16 | 2016-04-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類 |
| TWI501967B (zh) * | 2010-12-16 | 2015-10-01 | Janssen R&D Ireland | 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類 |
| TWI515187B (zh) * | 2010-12-16 | 2016-01-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之吲哚類 |
| TWI541241B (zh) * | 2010-12-16 | 2016-07-11 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類 |
| PL2864323T3 (pl) | 2012-06-15 | 2017-09-29 | Janssen Sciences Ireland Uc | Pochodne 1,3-dihydro-2h-benzoimidazol-2-onu podstawione heterocyklami jako środki przeciwwirusowe przeciwko wirusowi syncytium nabłonka oddechowego |
| CA2873921A1 (en) * | 2012-06-15 | 2013-12-19 | Janssen R&D Ireland | 1,3-dihydro-2h-benzimidazol-2-one derivatives substituted with benzimidazoles as respiratory syncytial virus antiviral agents |
| JP2015522052A (ja) * | 2012-07-10 | 2015-08-03 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 呼吸器合胞体ウイルス感染症の治療及び予防のための新規インダゾール |
| NZ705759A (en) * | 2012-10-16 | 2019-01-25 | Janssen Sciences Ireland Uc | Rsv antiviral compounds |
| WO2014114776A1 (en) | 2013-01-28 | 2014-07-31 | Janssen R&D Ireland | Quinoxalinones and dihydroquinoxalinones as respiratory syncytial virus antiviral agents |
| BR112015028475A2 (pt) | 2013-05-14 | 2017-07-25 | Hoffmann La Roche | novos aza-oxo-indois para o tratamento ou profilaxia de infecção virótica respiratória sincitial |
| CN105392787B (zh) * | 2013-05-14 | 2017-11-24 | 豪夫迈·罗氏有限公司 | 用于治疗和预防呼吸道合胞病毒感染的氮杂‑氧代‑吲哚 |
| RU2016105969A (ru) * | 2013-08-15 | 2017-09-20 | Ф. Хоффманн-Ля Рош Аг | Новые азаоксоиндолы для лечения и профилактики респираторно-синцитиальной вирусной инфекции |
| PH12021550330A1 (en) | 2013-08-21 | 2022-09-28 | Janssen Biopharma Inc | Antiviral compounds |
| WO2015065336A1 (en) * | 2013-10-29 | 2015-05-07 | Medivir Ab | Respiratory syncytial virus inhibitors |
| TWI671299B (zh) | 2014-04-14 | 2019-09-11 | 愛爾蘭商健生科學愛爾蘭無限公司 | 作為ｒｓｖ抗病毒化合物之螺脲化合物 |
| JP2017523988A (ja) * | 2014-08-05 | 2017-08-24 | アリオス バイオファーマ インク． | パラミクソウイルスを治療するための併用療法 |
| MA41614A (fr) | 2015-02-25 | 2018-01-02 | Alios Biopharma Inc | Composés antiviraux |
| MY197231A (en) | 2015-07-22 | 2023-06-06 | Enanta Pharm Inc | Benzodiazepine derivatives as rsv inhibitors |
| EP3402799B1 (en) | 2016-01-15 | 2022-05-04 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as rsv inhibitors |
| AU2018221820B2 (en) | 2017-02-16 | 2023-11-02 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of benzodiazepine derivatives |
| WO2019006295A1 (en) | 2017-06-30 | 2019-01-03 | Enanta Pharmaceuticals, Inc. | HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS |
| WO2019067864A1 (en) | 2017-09-29 | 2019-04-04 | Enanta Pharmaceuticals, Inc. | PHARMACEUTICAL AGENTS IN COMBINATION AS INHIBITORS OF RSV |
| ES3043734T3 (en) | 2017-11-13 | 2025-11-25 | Enanta Pharm Inc | Processes for the resolution of benzodiazepin-2-one and benzoazepin-2-one derivatives |
| CA3133300A1 (en) | 2019-03-18 | 2020-09-24 | Enanta Pharmaceuticals, Inc. | Benzodiazepine derivatives as rsv inhibitors |
| US11505558B1 (en) | 2019-10-04 | 2022-11-22 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| IL291834B1 (en) | 2019-10-04 | 2026-02-01 | Enanta Pharm Inc | Antiviral heterocyclic compounds |
| UY39032A (es) | 2020-01-24 | 2021-07-30 | Enanta Pharm Inc | Compuestos heterocíclicos como agentes antivirales |
| WO2021250180A1 (en) | 2020-06-11 | 2021-12-16 | Janssen Sciences Ireland Unlimited Company | Hemi (l)-tartrate forms of 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1h-indol-2 yl} methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2h-imidazo[4,5-c]pyridin-2-one and pharmaceutical compositions comprising the same |
| US11534439B2 (en) | 2020-07-07 | 2022-12-27 | Enanta Pharmaceuticals, Inc. | Dihydroquinoxaline and dihydropyridopyrazine derivatives as RSV inhibitors |
| WO2022086840A1 (en) | 2020-10-19 | 2022-04-28 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as anti-viral agents |
| US12612412B2 (en) | 2021-02-26 | 2026-04-28 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| IL305189A (en) | 2021-02-26 | 2023-10-01 | Enanta Pharm Inc | Heterocyclic antiviral compounds |
| AR129003A1 (es) | 2022-04-07 | 2024-07-03 | Enanta Pharm Inc | Compuestos heterocíclicos antivirales |
| WO2023211997A1 (en) | 2022-04-27 | 2023-11-02 | Enanta Pharmaceuticals, Inc. | Antiviral compounds |
| WO2024174953A1 (zh) * | 2023-02-21 | 2024-08-29 | 苏州隆博泰药业有限公司 | 苯并咪唑类衍生物及其医药用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002514162A (ja) | 1996-07-08 | 2002-05-14 | デュポン ファーマシューティカルズ カンパニー | Ｘａ因子阻害薬およびトロンビン阻害薬としてのアミジノインドール類、アミジノアゾール類、およびそれらの類似体 |
| AU1099000A (en) | 1998-10-05 | 2000-04-26 | Axys Pharmaceuticals, Inc. | Novel compounds and compositions for treating hepatitis c infections |
| EP1418175A1 (en) | 1999-06-28 | 2004-05-12 | Janssen Pharmaceutica N.V. | Respiratory syncytial virus replication inhibitors |
| ATE258928T1 (de) | 1999-06-28 | 2004-02-15 | Janssen Pharmaceutica Nv | Respiratorisches syncytialvirus replikation inhibitoren |
| US6534535B1 (en) | 1999-08-12 | 2003-03-18 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| US6489338B2 (en) * | 2000-06-13 | 2002-12-03 | Bristol-Myers Squibb Company | Imidazopyridine and imidazopyrimidine antiviral agents |
| US6506738B1 (en) | 2000-09-27 | 2003-01-14 | Bristol-Myers Squibb Company | Benzimidazolone antiviral agents |
| US6919331B2 (en) * | 2001-12-10 | 2005-07-19 | Bristol-Myers Squibb Company | Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents |
| WO2004043913A2 (en) | 2002-11-08 | 2004-05-27 | Trimeris, Inc. | Hetero-substituted benzimidazole compounds and antiviral uses thereof |
| TWI501967B (zh) | 2010-12-16 | 2015-10-01 | Janssen R&D Ireland | 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類 |
| TWI541241B (zh) | 2010-12-16 | 2016-07-11 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類 |
| TWI527814B (zh) | 2010-12-16 | 2016-04-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類 |
| TWI530495B (zh) | 2010-12-16 | 2016-04-21 | 健生科學愛爾蘭無限公司 | 苯并咪唑呼吸道融合病毒抑制劑 |
| TWI515187B (zh) | 2010-12-16 | 2016-01-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之吲哚類 |
-
2011
- 2011-12-15 TW TW100146390A patent/TWI530495B/zh not_active IP Right Cessation
- 2011-12-16 UA UAA201305027A patent/UA112298C2/uk unknown
- 2011-12-16 SI SI201130853A patent/SI2651903T1/sl unknown
- 2011-12-16 EP EP11802054.4A patent/EP2651903B1/en active Active
- 2011-12-16 BR BR112013012137A patent/BR112013012137A2/pt not_active Application Discontinuation
- 2011-12-16 CN CN201710103106.8A patent/CN107417683A/zh active Pending
- 2011-12-16 JP JP2013543799A patent/JP6005656B2/ja not_active Expired - Fee Related
- 2011-12-16 HR HRP20160650TT patent/HRP20160650T1/hr unknown
- 2011-12-16 PH PH1/2013/500796A patent/PH12013500796A1/en unknown
- 2011-12-16 KR KR1020137016944A patent/KR101876240B1/ko not_active Expired - Fee Related
- 2011-12-16 DK DK11802054.4T patent/DK2651903T3/da active
- 2011-12-16 SG SG2013026711A patent/SG190766A1/en unknown
- 2011-12-16 US US13/993,107 patent/US8865705B2/en active Active
- 2011-12-16 WO PCT/EP2011/073008 patent/WO2012080446A1/en not_active Ceased
- 2011-12-16 AU AU2011343255A patent/AU2011343255B2/en not_active Ceased
- 2011-12-16 CA CA2821999A patent/CA2821999C/en active Active
- 2011-12-16 EA EA201390888A patent/EA022972B1/ru not_active IP Right Cessation
- 2011-12-16 PT PT118020544T patent/PT2651903E/pt unknown
- 2011-12-16 MX MX2013006886A patent/MX340030B/es active IP Right Grant
- 2011-12-16 ES ES11802054.4T patent/ES2576180T3/es active Active
- 2011-12-16 HU HUE11802054A patent/HUE029247T2/en unknown
- 2011-12-16 MY MYPI2013001281A patent/MY156641A/en unknown
- 2011-12-16 CN CN2011800602778A patent/CN103313974A/zh active Pending
- 2011-12-16 AR ARP110104739A patent/AR085203A1/es active IP Right Grant
- 2011-12-16 PL PL11802054.4T patent/PL2651903T3/pl unknown
- 2011-12-16 NZ NZ609450A patent/NZ609450A/en not_active IP Right Cessation
-
2013
- 2013-04-09 IL IL225640A patent/IL225640A/en active IP Right Grant
- 2013-06-13 CL CL2013001713A patent/CL2013001713A1/es unknown
- 2013-06-14 ZA ZA2013/04424A patent/ZA201304424B/en unknown
-
2016
- 2016-06-22 CY CY20161100561T patent/CY1117751T1/el unknown
-
2018
- 2018-05-31 HK HK18107115.5A patent/HK1247616A1/zh unknown
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