MX2013006886A - Inhibidores benzimidazol del virus sincitial respiratorio. - Google Patents

Inhibidores benzimidazol del virus sincitial respiratorio.

Info

Publication number
MX2013006886A
MX2013006886A MX2013006886A MX2013006886A MX2013006886A MX 2013006886 A MX2013006886 A MX 2013006886A MX 2013006886 A MX2013006886 A MX 2013006886A MX 2013006886 A MX2013006886 A MX 2013006886A MX 2013006886 A MX2013006886 A MX 2013006886A
Authority
MX
Mexico
Prior art keywords
respiratory syncytial
syncytial virus
virus inhibitors
benzimidazole
compounds
Prior art date
Application number
MX2013006886A
Other languages
English (en)
Other versions
MX340030B (es
Inventor
Abdellah Tahri
Ludwig Paul Cooymans
Pierre Jean-Marie Bernard Raboisson
Sandrine Marie Helene Vendeville
Lili Hu
Tim Hugo Maria Jonckers
Samuel Dominique Demin
Original Assignee
Janssen R & D Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43875271&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2013006886(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen R & D Ireland filed Critical Janssen R & D Ireland
Publication of MX2013006886A publication Critical patent/MX2013006886A/es
Publication of MX340030B publication Critical patent/MX340030B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Bencimidazoles que tienen actividad inhibidora sobre la replicación del RSV y que tienen la fórmula (Ver Formula) los profármacos, N-óxidos, sales de adición, aminas cuaternarias, complejos metálicos y formas isoméricas según la estereoquímica de los mismos, composiciones que contienen estos compuestos como ingrediente activo y procesos para preparar estos compuestos y composiciones.
MX2013006886A 2010-12-16 2011-12-16 Inhibidores benzimidazol del virus sincitial respiratorio. MX340030B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10195467 2010-12-16
PCT/EP2011/073008 WO2012080446A1 (en) 2010-12-16 2011-12-16 Benzimidazole respiratory syncytial virus inhibitors

Publications (2)

Publication Number Publication Date
MX2013006886A true MX2013006886A (es) 2013-07-05
MX340030B MX340030B (es) 2016-06-21

Family

ID=43875271

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013006886A MX340030B (es) 2010-12-16 2011-12-16 Inhibidores benzimidazol del virus sincitial respiratorio.

Country Status (29)

Country Link
US (1) US8865705B2 (es)
EP (1) EP2651903B1 (es)
JP (1) JP6005656B2 (es)
KR (1) KR101876240B1 (es)
CN (2) CN107417683A (es)
AR (1) AR085203A1 (es)
AU (1) AU2011343255B2 (es)
BR (1) BR112013012137A2 (es)
CA (1) CA2821999C (es)
CL (1) CL2013001713A1 (es)
CY (1) CY1117751T1 (es)
DK (1) DK2651903T3 (es)
EA (1) EA022972B1 (es)
ES (1) ES2576180T3 (es)
HK (1) HK1247616A1 (es)
HR (1) HRP20160650T1 (es)
HU (1) HUE029247T2 (es)
IL (1) IL225640A (es)
MX (1) MX340030B (es)
MY (1) MY156641A (es)
NZ (1) NZ609450A (es)
PL (1) PL2651903T3 (es)
PT (1) PT2651903E (es)
SG (1) SG190766A1 (es)
SI (1) SI2651903T1 (es)
TW (1) TWI530495B (es)
UA (1) UA112298C2 (es)
WO (1) WO2012080446A1 (es)
ZA (1) ZA201304424B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI527814B (zh) 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
TWI515187B (zh) * 2010-12-16 2016-01-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之吲哚類
TWI541241B (zh) 2010-12-16 2016-07-11 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類
TWI530495B (zh) 2010-12-16 2016-04-21 健生科學愛爾蘭無限公司 苯并咪唑呼吸道融合病毒抑制劑
TWI501967B (zh) * 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
CN104470916A (zh) * 2012-06-15 2015-03-25 爱尔兰詹森研发公司 新颖的作为呼吸道合胞病毒抗病毒剂的被苯并咪唑取代的1,3-二氢-2h-苯并咪唑-2-酮衍生物
PL2864323T3 (pl) * 2012-06-15 2017-09-29 Janssen Sciences Ireland Uc Pochodne 1,3-dihydro-2h-benzoimidazol-2-onu podstawione heterocyklami jako środki przeciwwirusowe przeciwko wirusowi syncytium nabłonka oddechowego
WO2014009302A1 (en) * 2012-07-10 2014-01-16 F. Hoffmann-La Roche Ag Novel indazoles for the treatment and prophylaxis of respiratory syncytial virus infection
CN104903313B (zh) 2012-10-16 2017-12-29 爱尔兰詹森科学公司 Rsv抗病毒化合物
EA026546B1 (ru) 2013-01-28 2017-04-28 Янссен Сайенсиз Айрлэнд Юси Хиноксалиноны и дигидрохиноксалиноны как антивирусные средства против респираторно-синцитиального вируса
WO2014184163A1 (en) 2013-05-14 2014-11-20 F. Hoffmann-La Roche Ag Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection
CN105392787B (zh) * 2013-05-14 2017-11-24 豪夫迈·罗氏有限公司 用于治疗和预防呼吸道合胞病毒感染的氮杂‑氧代‑吲哚
EP3033333A1 (en) 2013-08-15 2016-06-22 F. Hoffmann-La Roche AG Novel aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection
JP6485817B2 (ja) 2013-08-21 2019-03-20 ヤンセン バイオファーマ インク． 抗ウイルス化合物
WO2015065336A1 (en) * 2013-10-29 2015-05-07 Medivir Ab Respiratory syncytial virus inhibitors
TWI671299B (zh) 2014-04-14 2019-09-11 愛爾蘭商健生科學愛爾蘭無限公司 作為ｒｓｖ抗病毒化合物之螺脲化合物
CA2957017A1 (en) * 2014-08-05 2016-02-11 Alios Biopharma, Inc. Combination therapy for treating a paramyxovirus
MA41614A (fr) 2015-02-25 2018-01-02 Alios Biopharma Inc Composés antiviraux
LT3324977T (lt) 2015-07-22 2022-10-25 Enanta Pharmaceuticals, Inc. Benzodiazepino dariniai kaip rsv inhibitoriai
WO2017123884A1 (en) 2016-01-15 2017-07-20 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as rsv inhibitors
EP3582784B1 (en) 2017-02-16 2022-06-08 Enanta Pharmaceuticals, Inc. Processes for the preparation of benzodiazepine derivatives
US11091501B2 (en) 2017-06-30 2021-08-17 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
CN111386118B (zh) 2017-09-29 2023-05-09 英安塔制药有限公司 作为rsv抑制剂的组合药物剂
CA3080138A1 (en) 2017-11-13 2019-05-16 Enanta Pharmaceuticals, Inc. Processes for the resolution of benzodiazepin-2-one and benzoazepin-2-one derivatives
CN113710276B (zh) 2019-03-18 2024-03-29 英安塔制药有限公司 苯二氮䓬衍生物作为rsv抑制剂
US11505558B1 (en) 2019-10-04 2022-11-22 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
TW202115085A (zh) 2019-10-04 2021-04-16 美商安塔製藥公司 抗病毒雜環化合物
UY39032A (es) 2020-01-24 2021-07-30 Enanta Pharm Inc Compuestos heterocíclicos como agentes antivirales
WO2022010882A1 (en) 2020-07-07 2022-01-13 Enanta Pharmaceuticals, Inc, Dihydroquinoxaline and dihydropyridopyrazine derivatives as rsv inhibitors
US11945824B2 (en) 2020-10-19 2024-04-02 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as anti-viral agents
CA3173354A1 (en) 2021-02-26 2022-09-01 Adam SZYMANIAK Antiviral heterocyclic compounds

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0960102A1 (en) 1996-07-08 1999-12-01 Du Pont Pharmaceuticals Company AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN
WO2000020400A1 (en) 1998-10-05 2000-04-13 Axys Pharmaceuticals, Inc. Novel compounds and compositions for treating hepatitis c infections
SK18942001A3 (sk) 1999-06-28 2002-10-08 Janssen Pharmaceutica N. V. Inhibítory replikácie respiračného syncytiálneho vírusu
CN1210275C (zh) 1999-06-28 2005-07-13 詹森药业有限公司 呼吸道合胞病毒复制抑制剂
AU6762400A (en) 1999-08-12 2001-03-13 Cor Therapeutics, Inc. Inhibitors of factor xa
US6489338B2 (en) 2000-06-13 2002-12-03 Bristol-Myers Squibb Company Imidazopyridine and imidazopyrimidine antiviral agents
US6506738B1 (en) 2000-09-27 2003-01-14 Bristol-Myers Squibb Company Benzimidazolone antiviral agents
US6919331B2 (en) * 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
WO2004043913A2 (en) 2002-11-08 2004-05-27 Trimeris, Inc. Hetero-substituted benzimidazole compounds and antiviral uses thereof
TWI541241B (zh) 2010-12-16 2016-07-11 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類
TWI530495B (zh) 2010-12-16 2016-04-21 健生科學愛爾蘭無限公司 苯并咪唑呼吸道融合病毒抑制劑
TWI501967B (zh) 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
TWI527814B (zh) 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
TWI515187B (zh) 2010-12-16 2016-01-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之吲哚類

Also Published As

Publication number Publication date
CY1117751T1 (el) 2017-05-17
AU2011343255A1 (en) 2013-05-02
HRP20160650T1 (hr) 2016-07-15
WO2012080446A1 (en) 2012-06-21
AU2011343255B2 (en) 2014-12-11
ES2576180T3 (es) 2016-07-06
EP2651903B1 (en) 2016-03-23
CN103313974A (zh) 2013-09-18
IL225640A (en) 2015-02-26
DK2651903T3 (da) 2016-06-27
EA201390888A1 (ru) 2013-12-30
JP2013545785A (ja) 2013-12-26
MX340030B (es) 2016-06-21
EP2651903A1 (en) 2013-10-23
US8865705B2 (en) 2014-10-21
MY156641A (en) 2016-03-15
NZ609450A (en) 2014-10-31
KR20140025321A (ko) 2014-03-04
IL225640A0 (en) 2013-06-27
CA2821999C (en) 2019-02-26
TW201305142A (zh) 2013-02-01
UA112298C2 (uk) 2016-08-25
AR085203A1 (es) 2013-09-18
CA2821999A1 (en) 2012-06-21
BR112013012137A2 (pt) 2016-08-16
TWI530495B (zh) 2016-04-21
HUE029247T2 (en) 2017-02-28
KR101876240B1 (ko) 2018-08-02
PL2651903T3 (pl) 2016-10-31
US20130267508A1 (en) 2013-10-10
PT2651903E (pt) 2016-06-17
SG190766A1 (en) 2013-07-31
EA022972B1 (ru) 2016-03-31
CN107417683A (zh) 2017-12-01
CL2013001713A1 (es) 2013-10-11
HK1247616A1 (zh) 2018-09-28
JP6005656B2 (ja) 2016-10-12
SI2651903T1 (sl) 2016-07-29
ZA201304424B (en) 2014-12-23

Similar Documents

Publication Publication Date Title
MX340030B (es) Inhibidores benzimidazol del virus sincitial respiratorio.
MX2013006887A (es) Indoles como agentes antivirales para el virus sincitial respiratorio.
PH12019500163A1 (en) Tetrahydro- and dihydro-isoquinoline prmt5 inhibitors and uses thereof
EA201390885A1 (ru) Азаиндолы в качестве противовирусных агентов против респираторного синцитиального вируса
WO2014153100A3 (en) Arginine methyltransferase inhibitors and uses thereof
WO2014153235A3 (en) Arginine methyltransferase inhibitors and uses thereof
PH12017502407B1 (en) Fused pyrimidine compound or salt thereof
MX2015012850A (es) Inhibidores de la arginina metiltransferasa y usos de los mismos.
EA201390884A1 (ru) Азабензимидазолы в качестве противовирусных средств в отношении респираторного синцитиального вируса
WO2015200680A8 (en) Prmt5 inhibitors and uses thereof
SA515360469B1 (ar) مركبات حلقية غير متجانسة لتثبيط إنزيم جلوتاميناز والطرق الخاصة باستخدامها
UA114531C2 (uk) Противірусні сполуки проти rsv
MY172924A (en) Neprilysin inhibitors
EP2883875A4 (en) DERIVED FROM N2, N4-BIS (4- (PIPERAZIN-1-YL) PHENYL) PIRIMIDINE-2,4-DIAMINE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND COMPOSITION CONTAINING THE SAME AS ACTIVE SUBSTANCE FOR PREVENTING OR TREATING CANCER
IL229260A0 (en) Preparations, methods and systems for respiratory administration of two or more active agents
MX340190B (es) Compuestos para tratar infecciones por virus sincitial respiratorio.
WO2013009527A3 (en) Factor ixa inhibitors
MY178583A (en) Hydantoin derivative
NZ702073A (en) Methanethione compounds having antiviral activity
PH12015500282A1 (en) N-acylhydrazone derivatives for selective t cell inhibitor and anti-lymphoid malignancy drug
AU2014298561A8 (en) Substituted pyridine-piperazinyl analogues as RSV antiviral compounds
TN2015000058A1 (en) Salts of benzothiazolone compound as beta-2-adrenoceptor agonist
WO2013175347A3 (en) Compositions and methods for treatment of respiratory disorders
NZ747821A (en) Tetrahydro- and dihydro-isoquinoline prmt5 inhibitors and uses thereof

Legal Events

Date Code Title Description
GB Transfer or rights

Owner name: JANSSEN SCIENCES IRELAND UC

FG Grant or registration