CY1117751T1 - Αναστολεις βενζιμιδαζολης αναπνευστικου συγκυτιακου ιου - Google Patents
Αναστολεις βενζιμιδαζολης αναπνευστικου συγκυτιακου ιουInfo
- Publication number
- CY1117751T1 CY1117751T1 CY20161100561T CY161100561T CY1117751T1 CY 1117751 T1 CY1117751 T1 CY 1117751T1 CY 20161100561 T CY20161100561 T CY 20161100561T CY 161100561 T CY161100561 T CY 161100561T CY 1117751 T1 CY1117751 T1 CY 1117751T1
- Authority
- CY
- Cyprus
- Prior art keywords
- benzimidazol
- virus inhibitors
- synchronic
- respiratory
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Βενζιμιδαζόλες που έχουν ανασταλτική δράση στον αναδιπλασιασμό RSV και έχουν τον τύπο (I) προφάρμακα, Ν-οξείδια, άλατα προσθήκης, τεταρτοταγείς αμίνες, συμπλέγματα μετάλλων και στερεοχημικά ισομερείς μορφές αυτών, συνθέσεις που περιέχουν αυτές τις ενώσεις ως δραστικό συστατικό και διαδικασίες για την παρασκευή αυτών των ενώσεων και συνθέσεων.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10195467 | 2010-12-16 | ||
| PCT/EP2011/073008 WO2012080446A1 (en) | 2010-12-16 | 2011-12-16 | Benzimidazole respiratory syncytial virus inhibitors |
| EP11802054.4A EP2651903B1 (en) | 2010-12-16 | 2011-12-16 | Benzimidazole respiratory syncytial virus inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1117751T1 true CY1117751T1 (el) | 2017-05-17 |
Family
ID=43875271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20161100561T CY1117751T1 (el) | 2010-12-16 | 2016-06-22 | Αναστολεις βενζιμιδαζολης αναπνευστικου συγκυτιακου ιου |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US8865705B2 (el) |
| EP (1) | EP2651903B1 (el) |
| JP (1) | JP6005656B2 (el) |
| KR (1) | KR101876240B1 (el) |
| CN (2) | CN107417683A (el) |
| AR (1) | AR085203A1 (el) |
| AU (1) | AU2011343255B2 (el) |
| BR (1) | BR112013012137A2 (el) |
| CA (1) | CA2821999C (el) |
| CL (1) | CL2013001713A1 (el) |
| CY (1) | CY1117751T1 (el) |
| DK (1) | DK2651903T3 (el) |
| EA (1) | EA022972B1 (el) |
| ES (1) | ES2576180T3 (el) |
| HK (1) | HK1247616A1 (el) |
| HR (1) | HRP20160650T1 (el) |
| HU (1) | HUE029247T2 (el) |
| IL (1) | IL225640A (el) |
| MX (1) | MX340030B (el) |
| MY (1) | MY156641A (el) |
| NZ (1) | NZ609450A (el) |
| PL (1) | PL2651903T3 (el) |
| PT (1) | PT2651903E (el) |
| SG (1) | SG190766A1 (el) |
| SI (1) | SI2651903T1 (el) |
| TW (1) | TWI530495B (el) |
| UA (1) | UA112298C2 (el) |
| WO (1) | WO2012080446A1 (el) |
| ZA (1) | ZA201304424B (el) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI527814B (zh) | 2010-12-16 | 2016-04-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類 |
| TWI515187B (zh) * | 2010-12-16 | 2016-01-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之吲哚類 |
| TWI541241B (zh) | 2010-12-16 | 2016-07-11 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類 |
| TWI530495B (zh) | 2010-12-16 | 2016-04-21 | 健生科學愛爾蘭無限公司 | 苯并咪唑呼吸道融合病毒抑制劑 |
| TWI501967B (zh) * | 2010-12-16 | 2015-10-01 | Janssen R&D Ireland | 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類 |
| CN104470916A (zh) * | 2012-06-15 | 2015-03-25 | 爱尔兰詹森研发公司 | 新颖的作为呼吸道合胞病毒抗病毒剂的被苯并咪唑取代的1,3-二氢-2h-苯并咪唑-2-酮衍生物 |
| PL2864323T3 (pl) * | 2012-06-15 | 2017-09-29 | Janssen Sciences Ireland Uc | Pochodne 1,3-dihydro-2h-benzoimidazol-2-onu podstawione heterocyklami jako środki przeciwwirusowe przeciwko wirusowi syncytium nabłonka oddechowego |
| WO2014009302A1 (en) * | 2012-07-10 | 2014-01-16 | F. Hoffmann-La Roche Ag | Novel indazoles for the treatment and prophylaxis of respiratory syncytial virus infection |
| CN104903313B (zh) | 2012-10-16 | 2017-12-29 | 爱尔兰詹森科学公司 | Rsv抗病毒化合物 |
| EA026546B1 (ru) | 2013-01-28 | 2017-04-28 | Янссен Сайенсиз Айрлэнд Юси | Хиноксалиноны и дигидрохиноксалиноны как антивирусные средства против респираторно-синцитиального вируса |
| WO2014184163A1 (en) | 2013-05-14 | 2014-11-20 | F. Hoffmann-La Roche Ag | Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection |
| CN105392787B (zh) * | 2013-05-14 | 2017-11-24 | 豪夫迈·罗氏有限公司 | 用于治疗和预防呼吸道合胞病毒感染的氮杂‑氧代‑吲哚 |
| EP3033333A1 (en) | 2013-08-15 | 2016-06-22 | F. Hoffmann-La Roche AG | Novel aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection |
| JP6485817B2 (ja) | 2013-08-21 | 2019-03-20 | ヤンセン バイオファーマ インク． | 抗ウイルス化合物 |
| WO2015065336A1 (en) * | 2013-10-29 | 2015-05-07 | Medivir Ab | Respiratory syncytial virus inhibitors |
| TWI671299B (zh) | 2014-04-14 | 2019-09-11 | 愛爾蘭商健生科學愛爾蘭無限公司 | 作為ｒｓｖ抗病毒化合物之螺脲化合物 |
| CA2957017A1 (en) * | 2014-08-05 | 2016-02-11 | Alios Biopharma, Inc. | Combination therapy for treating a paramyxovirus |
| MA41614A (fr) | 2015-02-25 | 2018-01-02 | Alios Biopharma Inc | Composés antiviraux |
| LT3324977T (lt) | 2015-07-22 | 2022-10-25 | Enanta Pharmaceuticals, Inc. | Benzodiazepino dariniai kaip rsv inhibitoriai |
| WO2017123884A1 (en) | 2016-01-15 | 2017-07-20 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as rsv inhibitors |
| EP3582784B1 (en) | 2017-02-16 | 2022-06-08 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of benzodiazepine derivatives |
| US11091501B2 (en) | 2017-06-30 | 2021-08-17 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as RSV inhibitors |
| CN111386118B (zh) | 2017-09-29 | 2023-05-09 | 英安塔制药有限公司 | 作为rsv抑制剂的组合药物剂 |
| CA3080138A1 (en) | 2017-11-13 | 2019-05-16 | Enanta Pharmaceuticals, Inc. | Processes for the resolution of benzodiazepin-2-one and benzoazepin-2-one derivatives |
| CN113710276B (zh) | 2019-03-18 | 2024-03-29 | 英安塔制药有限公司 | 苯二氮䓬衍生物作为rsv抑制剂 |
| US11505558B1 (en) | 2019-10-04 | 2022-11-22 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| TW202115085A (zh) | 2019-10-04 | 2021-04-16 | 美商安塔製藥公司 | 抗病毒雜環化合物 |
| UY39032A (es) | 2020-01-24 | 2021-07-30 | Enanta Pharm Inc | Compuestos heterocíclicos como agentes antivirales |
| WO2022010882A1 (en) | 2020-07-07 | 2022-01-13 | Enanta Pharmaceuticals, Inc, | Dihydroquinoxaline and dihydropyridopyrazine derivatives as rsv inhibitors |
| US11945824B2 (en) | 2020-10-19 | 2024-04-02 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as anti-viral agents |
| CA3173354A1 (en) | 2021-02-26 | 2022-09-01 | Adam SZYMANIAK | Antiviral heterocyclic compounds |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0960102A1 (en) | 1996-07-08 | 1999-12-01 | Du Pont Pharmaceuticals Company | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN |
| WO2000020400A1 (en) | 1998-10-05 | 2000-04-13 | Axys Pharmaceuticals, Inc. | Novel compounds and compositions for treating hepatitis c infections |
| SK18942001A3 (sk) | 1999-06-28 | 2002-10-08 | Janssen Pharmaceutica N. V. | Inhibítory replikácie respiračného syncytiálneho vírusu |
| CN1210275C (zh) | 1999-06-28 | 2005-07-13 | 詹森药业有限公司 | 呼吸道合胞病毒复制抑制剂 |
| AU6762400A (en) | 1999-08-12 | 2001-03-13 | Cor Therapeutics, Inc. | Inhibitors of factor xa |
| US6489338B2 (en) | 2000-06-13 | 2002-12-03 | Bristol-Myers Squibb Company | Imidazopyridine and imidazopyrimidine antiviral agents |
| US6506738B1 (en) | 2000-09-27 | 2003-01-14 | Bristol-Myers Squibb Company | Benzimidazolone antiviral agents |
| US6919331B2 (en) * | 2001-12-10 | 2005-07-19 | Bristol-Myers Squibb Company | Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents |
| WO2004043913A2 (en) | 2002-11-08 | 2004-05-27 | Trimeris, Inc. | Hetero-substituted benzimidazole compounds and antiviral uses thereof |
| TWI541241B (zh) | 2010-12-16 | 2016-07-11 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類 |
| TWI530495B (zh) | 2010-12-16 | 2016-04-21 | 健生科學愛爾蘭無限公司 | 苯并咪唑呼吸道融合病毒抑制劑 |
| TWI501967B (zh) | 2010-12-16 | 2015-10-01 | Janssen R&D Ireland | 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類 |
| TWI527814B (zh) | 2010-12-16 | 2016-04-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類 |
| TWI515187B (zh) | 2010-12-16 | 2016-01-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之吲哚類 |
-
2011
- 2011-12-15 TW TW100146390A patent/TWI530495B/zh not_active IP Right Cessation
- 2011-12-16 EP EP11802054.4A patent/EP2651903B1/en active Active
- 2011-12-16 PL PL11802054.4T patent/PL2651903T3/pl unknown
- 2011-12-16 MX MX2013006886A patent/MX340030B/es active IP Right Grant
- 2011-12-16 JP JP2013543799A patent/JP6005656B2/ja active Active
- 2011-12-16 ES ES11802054.4T patent/ES2576180T3/es active Active
- 2011-12-16 MY MYPI2013001281A patent/MY156641A/en unknown
- 2011-12-16 CA CA2821999A patent/CA2821999C/en active Active
- 2011-12-16 WO PCT/EP2011/073008 patent/WO2012080446A1/en active Application Filing
- 2011-12-16 BR BR112013012137A patent/BR112013012137A2/pt not_active Application Discontinuation
- 2011-12-16 CN CN201710103106.8A patent/CN107417683A/zh active Pending
- 2011-12-16 AU AU2011343255A patent/AU2011343255B2/en not_active Ceased
- 2011-12-16 CN CN2011800602778A patent/CN103313974A/zh active Pending
- 2011-12-16 DK DK11802054.4T patent/DK2651903T3/da active
- 2011-12-16 SG SG2013026711A patent/SG190766A1/en unknown
- 2011-12-16 HU HUE11802054A patent/HUE029247T2/en unknown
- 2011-12-16 US US13/993,107 patent/US8865705B2/en active Active
- 2011-12-16 UA UAA201305027A patent/UA112298C2/uk unknown
- 2011-12-16 SI SI201130853A patent/SI2651903T1/sl unknown
- 2011-12-16 PT PT118020544T patent/PT2651903E/pt unknown
- 2011-12-16 EA EA201390888A patent/EA022972B1/ru not_active IP Right Cessation
- 2011-12-16 NZ NZ609450A patent/NZ609450A/en not_active IP Right Cessation
- 2011-12-16 KR KR1020137016944A patent/KR101876240B1/ko active IP Right Grant
- 2011-12-16 AR ARP110104739A patent/AR085203A1/es active IP Right Grant
-
2013
- 2013-04-09 IL IL225640A patent/IL225640A/en active IP Right Grant
- 2013-06-13 CL CL2013001713A patent/CL2013001713A1/es unknown
- 2013-06-14 ZA ZA2013/04424A patent/ZA201304424B/en unknown
-
2016
- 2016-06-10 HR HRP20160650TT patent/HRP20160650T1/hr unknown
- 2016-06-22 CY CY20161100561T patent/CY1117751T1/el unknown
-
2018
- 2018-05-31 HK HK18107115.5A patent/HK1247616A1/zh unknown
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