JO3654B1 - مركبات ازا بنزيميدازول واستخدامها كمعدلات للمستقبلات ذات النمط الإمبائي (ampa) - Google Patents
مركبات ازا بنزيميدازول واستخدامها كمعدلات للمستقبلات ذات النمط الإمبائي (ampa)Info
- Publication number
- JO3654B1 JO3654B1 JOP/2016/0085A JOP20160085A JO3654B1 JO 3654 B1 JO3654 B1 JO 3654B1 JO P20160085 A JOP20160085 A JO P20160085A JO 3654 B1 JO3654 B1 JO 3654B1
- Authority
- JO
- Jordan
- Prior art keywords
- azabenzimidazoles
- receptor modulators
- ampa receptor
- compounds
- formula
- Prior art date
Links
- 102000003678 AMPA Receptors Human genes 0.000 title 1
- 108090000078 AMPA Receptors Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
يتوفر بهذا الاختراع مركبات بالصيغة (I) وأملاحها المقبولة صيدلانيًا أو أكاسيدها النيتروجينية أو تذاوباتها، (I) يتوفر بهذا الاختراع أيضًا مركبات صيدلانية تتضمن مركبات بالصيغة (I) وطرق استخدام مركبات بالصيغة (I).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562154313P | 2015-04-29 | 2015-04-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
JO3654B1 true JO3654B1 (ar) | 2020-08-27 |
Family
ID=56008859
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2016/0085A JO3654B1 (ar) | 2015-04-29 | 2016-04-28 | مركبات ازا بنزيميدازول واستخدامها كمعدلات للمستقبلات ذات النمط الإمبائي (ampa) |
Country Status (39)
Country | Link |
---|---|
US (4) | US11312712B2 (ar) |
EP (3) | EP3901153A1 (ar) |
JP (2) | JP6800886B2 (ar) |
KR (2) | KR20170140382A (ar) |
CN (1) | CN107835814B (ar) |
AR (1) | AR104447A1 (ar) |
AU (2) | AU2016255434C1 (ar) |
BR (2) | BR112017023147B1 (ar) |
CA (1) | CA2983826A1 (ar) |
CO (1) | CO2017011017A2 (ar) |
CR (1) | CR20170484A (ar) |
CY (1) | CY1124059T1 (ar) |
DK (1) | DK3288940T5 (ar) |
EA (1) | EA033281B1 (ar) |
EC (1) | ECSP17074645A (ar) |
ES (1) | ES2865330T3 (ar) |
GT (1) | GT201700231A (ar) |
HK (1) | HK1252249A1 (ar) |
HR (1) | HRP20210403T1 (ar) |
HU (1) | HUE053943T2 (ar) |
IL (1) | IL254848B (ar) |
JO (1) | JO3654B1 (ar) |
LT (1) | LT3288940T (ar) |
MA (1) | MA41988B1 (ar) |
MD (1) | MD3288940T2 (ar) |
MX (1) | MX2017013886A (ar) |
MY (1) | MY194104A (ar) |
NI (1) | NI201700129A (ar) |
PH (1) | PH12017501816A1 (ar) |
PL (1) | PL3288940T3 (ar) |
PT (1) | PT3288940T (ar) |
RS (1) | RS61688B1 (ar) |
SG (1) | SG11201708190UA (ar) |
SI (1) | SI3288940T1 (ar) |
TW (1) | TWI706952B (ar) |
UA (1) | UA120304C2 (ar) |
UY (1) | UY36654A (ar) |
WO (1) | WO2016176460A1 (ar) |
ZA (1) | ZA201708065B (ar) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20170141768A (ko) * | 2015-04-29 | 2017-12-26 | 얀센 파마슈티카 엔.브이. | 이미다조피라진 및 피라졸로피리미딘 및 ampa 수용체 조절제로서의 이의 용도 |
CN107383004B (zh) * | 2017-07-05 | 2020-04-17 | 浙江大学 | 2-氨基咪唑并吡啶类衍生物及制备和应用 |
EP3679027A1 (en) | 2017-09-04 | 2020-07-15 | C4 Therapeutics, Inc. | Dihydrobenzimidazolones |
ES2971497T3 (es) | 2017-10-06 | 2024-06-05 | Takeda Pharmaceuticals Co | Compuestos heterocíclicos |
JP2022508648A (ja) | 2018-10-05 | 2022-01-19 | アンナプルナ バイオ インコーポレイテッド | Apj受容体活性に関連する状態を処置するための化合物および組成物 |
EP3873905A4 (en) * | 2018-10-30 | 2022-08-17 | Repare Therapeutics Inc. | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF MAKING COMPOUNDS AND THEIR USE AS ATR KINASE INHIBITORS |
MX2022000854A (es) * | 2019-07-22 | 2022-02-10 | Repare Therapeutics Inc | Derivados de 2-morfolinopiridina sustituidos como inhibidores de la cinasa atr. |
CN117222634A (zh) * | 2020-12-16 | 2023-12-12 | 艾福姆德尤股份有限公司 | 用于治疗与sting活性有关的疾病的化合物和组合物 |
CN114591338B (zh) * | 2022-03-31 | 2023-05-09 | 苏州欧康维视生物科技有限公司 | 一种Syk和VEGFR2双靶点抑制剂的制备方法及其用途 |
CN115304599A (zh) * | 2022-09-20 | 2022-11-08 | 浙大宁波理工学院 | 一种3-溴-6-异丙基-1氢-哌咯[2,3-b]并吡啶及其制备方法 |
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JPS55167282A (en) | 1979-06-12 | 1980-12-26 | Fujisawa Pharmaceut Co Ltd | Piperazine derivative or its salt and its preparation |
CN1051313A (zh) | 1990-11-07 | 1991-05-15 | 鞍山市振东工业尼龙厂 | 尼龙球磨罐及其热装工艺 |
GB9210400D0 (en) * | 1992-05-15 | 1992-07-01 | Merck Sharp & Dohme | Therapeutic agents |
TW251284B (ar) | 1992-11-02 | 1995-07-11 | Pfizer | |
CA2183084A1 (en) | 1994-02-10 | 1995-08-17 | John Eugene Macor | 5-heteroarylindole derivatives |
US5565483A (en) | 1995-06-07 | 1996-10-15 | Bristol-Myers Squibb Company | 3-substituted oxindole derivatives as potassium channel modulators |
UA54403C2 (uk) | 1996-10-01 | 2003-03-17 | Н'Юросерч А/С | Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму |
DE19812331A1 (de) | 1998-03-20 | 1999-09-23 | Merck Patent Gmbh | Piperidinderivate |
JP2002519373A (ja) | 1998-07-02 | 2002-07-02 | エーザイ株式会社 | 製薬組成物及びそれらの使用 |
AU760964B2 (en) | 1998-12-31 | 2003-05-22 | Sugen, Inc. | 3-heteroarylidenyl-2-indolinone compounds for modulating protein kinase activityand for use in cancer chemotherapy |
GB0018473D0 (en) | 2000-07-27 | 2000-09-13 | Merck Sharp & Dohme | Therapeutic agents |
EP1309577A2 (en) | 2000-08-11 | 2003-05-14 | Eli Lilly And Company | Heterocyclic sulfonamide derivatives and their use for potentiating glutamate receptor function |
US6548576B1 (en) | 2001-11-07 | 2003-04-15 | Bourns, Inc. | Epoxy formulation adapted to be used in conjunction with no-lead solder in electronic components |
GT200500185A (es) | 2004-08-09 | 2006-04-10 | Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos | |
CA2576765C (en) * | 2004-09-03 | 2013-05-28 | Applied Research Systems Ars Holding N.V. | Pyridine methylene azolidinones and use thereof phosphoinositide inhibitors |
EA016286B1 (ru) | 2005-09-30 | 2012-03-30 | Глэксо Груп Лимитед | Соединения, которые обладают активностью по отношению к рецепторам м, и их применения в медицине |
WO2007135529A2 (en) * | 2006-05-23 | 2007-11-29 | Pfizer Products Inc. | Azabenzimidazolyl compounds as mglur2 potentiators |
ATE502675T1 (de) | 2006-11-03 | 2011-04-15 | Glaxo Group Ltd | Verbindungen, die den ampa-rezeptor verstärken, und deren anwendung in der medizin |
WO2008113795A1 (en) | 2007-03-20 | 2008-09-25 | Glaxo Group Limited | Compounds which potentiate ampa receptor and uses thereof in medicine |
GB0711089D0 (en) | 2007-06-08 | 2007-07-18 | Glaxo Group Ltd | Compounds |
GB0716292D0 (en) | 2007-08-21 | 2007-09-26 | Biofocus Dpi Ltd | Imidazopyrazine compounds |
WO2009067607A2 (en) | 2007-11-20 | 2009-05-28 | Memory Pharmaceuticals Corporation | Combinations of pde4 inhibitors and antipsychotics for the treatment of psychotic disorders |
WO2009073777A1 (en) | 2007-12-06 | 2009-06-11 | Schering Corporation | Gamma secretase modulators |
TW201012803A (en) | 2008-06-06 | 2010-04-01 | Organon Nv | Heterocyclic derivatives |
WO2010005528A2 (en) * | 2008-06-30 | 2010-01-14 | Ironwood Pharmaceuticals Incorporated | Pyrrolopyridine carboxylic acid derivatives |
GB0822425D0 (en) | 2008-12-09 | 2009-01-14 | Glaxo Group Ltd | Compounds |
GB0822981D0 (en) | 2008-12-17 | 2009-01-21 | Summit Corp Plc | Compounds for treatment of duchenne muscular dystrophy |
WO2011056985A2 (en) | 2009-11-04 | 2011-05-12 | Gilead Sciences, Inc. | Substituted heterocyclic compounds |
US8765784B2 (en) * | 2010-06-09 | 2014-07-01 | Merck Sharp & Dohme Corp. | Positive allosteric modulators of MGLUR2 |
WO2012020848A1 (en) | 2010-08-10 | 2012-02-16 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
WO2012021382A1 (en) | 2010-08-12 | 2012-02-16 | Merck Sharp & Dohme Corp. | Positive allosteric modulators of mglur2 |
KR20140105445A (ko) | 2011-10-31 | 2014-09-01 | 제논 파마슈티칼스 인크. | 비아릴 에테르 술폰아미드 및 치료제로서의 그의 용도 |
WO2013130501A1 (en) | 2012-03-01 | 2013-09-06 | The Board Of Regents Of The University Of Texas System | Bivalent ampa receptor positive allosteric modulators |
GB201205669D0 (en) * | 2012-03-30 | 2012-05-16 | Agency Science Tech & Res | Bicyclic heterocyclic derivatives as mnk2 and mnk2 modulators and uses thereof |
JO3225B1 (ar) * | 2012-11-27 | 2018-03-08 | Lilly Co Eli | 6-((s)-1-{1-[5-(2-هيدروكسي-إيثوكسي)-بيريدين-2-يل]-1h-بيرازول-3-يل}إيثيل)-3h-1 ، 3-بنزو ثيازول-2- أون باعتباره مضاد مستقبل ampa يعتمد على tarp- جاما 8 |
WO2014128585A1 (en) | 2013-02-19 | 2014-08-28 | Pfizer Inc. | Azabenzimidazole compounds as inhibitors of pde4 isozymes for the treatment of cns and other disorders |
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2016
- 2016-04-28 LT LTEP16723204.0T patent/LT3288940T/lt unknown
- 2016-04-28 JP JP2017556634A patent/JP6800886B2/ja active Active
- 2016-04-28 ES ES16723204T patent/ES2865330T3/es active Active
- 2016-04-28 SI SI201631171T patent/SI3288940T1/sl unknown
- 2016-04-28 TW TW105113298A patent/TWI706952B/zh active
- 2016-04-28 EP EP21157913.1A patent/EP3901153A1/en active Pending
- 2016-04-28 BR BR112017023147-6A patent/BR112017023147B1/pt active IP Right Grant
- 2016-04-28 UY UY0001036654A patent/UY36654A/es unknown
- 2016-04-28 MD MDE20180234T patent/MD3288940T2/ro unknown
- 2016-04-28 MY MYPI2017703998A patent/MY194104A/en unknown
- 2016-04-28 PT PT167232040T patent/PT3288940T/pt unknown
- 2016-04-28 EA EA201792374A patent/EA033281B1/ru unknown
- 2016-04-28 UA UAA201711635A patent/UA120304C2/uk unknown
- 2016-04-28 RS RS20210362A patent/RS61688B1/sr unknown
- 2016-04-28 MA MA41988A patent/MA41988B1/fr unknown
- 2016-04-28 MX MX2017013886A patent/MX2017013886A/es active IP Right Grant
- 2016-04-28 KR KR1020177034350A patent/KR20170140382A/ko active Application Filing
- 2016-04-28 US US15/569,299 patent/US11312712B2/en active Active
- 2016-04-28 CN CN201680038830.0A patent/CN107835814B/zh active Active
- 2016-04-28 BR BR122023023802-8A patent/BR122023023802A2/pt not_active Application Discontinuation
- 2016-04-28 AU AU2016255434A patent/AU2016255434C1/en active Active
- 2016-04-28 AR ARP160101217A patent/AR104447A1/es unknown
- 2016-04-28 CA CA2983826A patent/CA2983826A1/en active Pending
- 2016-04-28 KR KR1020247003619A patent/KR20240017991A/ko active Application Filing
- 2016-04-28 HU HUE16723204A patent/HUE053943T2/hu unknown
- 2016-04-28 EP EP22200371.7A patent/EP4144736A1/en active Pending
- 2016-04-28 WO PCT/US2016/029801 patent/WO2016176460A1/en active Application Filing
- 2016-04-28 PL PL16723204T patent/PL3288940T3/pl unknown
- 2016-04-28 SG SG11201708190UA patent/SG11201708190UA/en unknown
- 2016-04-28 EP EP16723204.0A patent/EP3288940B9/en active Active
- 2016-04-28 JO JOP/2016/0085A patent/JO3654B1/ar active
- 2016-04-28 CR CR20170484A patent/CR20170484A/es unknown
- 2016-04-28 DK DK16723204.0T patent/DK3288940T5/da active
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2017
- 2017-10-02 IL IL254848A patent/IL254848B/en active IP Right Grant
- 2017-10-03 PH PH12017501816A patent/PH12017501816A1/en unknown
- 2017-10-27 CO CONC2017/0011017A patent/CO2017011017A2/es unknown
- 2017-10-27 GT GT201700231A patent/GT201700231A/es unknown
- 2017-10-27 NI NI201700129A patent/NI201700129A/es unknown
- 2017-11-10 EC ECIEPI201774645A patent/ECSP17074645A/es unknown
- 2017-11-28 ZA ZA2017/08065A patent/ZA201708065B/en unknown
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2018
- 2018-09-06 HK HK18111488.6A patent/HK1252249A1/zh unknown
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2020
- 2020-07-30 AU AU2020210231A patent/AU2020210231B2/en active Active
- 2020-11-25 JP JP2020195323A patent/JP7026194B2/ja active Active
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2021
- 2021-03-09 HR HRP20210403TT patent/HRP20210403T1/hr unknown
- 2021-04-23 CY CY20211100354T patent/CY1124059T1/el unknown
- 2021-05-19 US US17/324,520 patent/US20210284641A1/en active Pending
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2022
- 2022-10-17 US US17/967,508 patent/US20230114165A1/en active Pending
- 2022-10-17 US US17/967,483 patent/US20230110576A1/en active Pending
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