IL225640A - Benzimidazole Derivatives, Pharmaceutical Preparations Containing Them, Processes for their Preparation and Uses as Respiratory Systemic Viral Inhibitors - Google Patents

Benzimidazole Derivatives, Pharmaceutical Preparations Containing Them, Processes for their Preparation and Uses as Respiratory Systemic Viral Inhibitors

Info

Publication number
IL225640A
IL225640A IL225640A IL22564013A IL225640A IL 225640 A IL225640 A IL 225640A IL 225640 A IL225640 A IL 225640A IL 22564013 A IL22564013 A IL 22564013A IL 225640 A IL225640 A IL 225640A
Authority
IL
Israel
Prior art keywords
processes
preparation
pharmaceutical compositions
respiratory syncytial
syncytial virus
Prior art date
Application number
IL225640A
Other languages
English (en)
Hebrew (he)
Other versions
IL225640A0 (en
Original Assignee
Janssen R & D Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43875271&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL225640(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen R & D Ireland filed Critical Janssen R & D Ireland
Publication of IL225640A0 publication Critical patent/IL225640A0/en
Publication of IL225640A publication Critical patent/IL225640A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL225640A 2010-12-16 2013-04-09 Benzimidazole Derivatives, Pharmaceutical Preparations Containing Them, Processes for their Preparation and Uses as Respiratory Systemic Viral Inhibitors IL225640A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10195467 2010-12-16
PCT/EP2011/073008 WO2012080446A1 (en) 2010-12-16 2011-12-16 Benzimidazole respiratory syncytial virus inhibitors

Publications (2)

Publication Number Publication Date
IL225640A0 IL225640A0 (en) 2013-06-27
IL225640A true IL225640A (en) 2015-02-26

Family

ID=43875271

Family Applications (1)

Application Number Title Priority Date Filing Date
IL225640A IL225640A (en) 2010-12-16 2013-04-09 Benzimidazole Derivatives, Pharmaceutical Preparations Containing Them, Processes for their Preparation and Uses as Respiratory Systemic Viral Inhibitors

Country Status (30)

Country Link
US (1) US8865705B2 (enExample)
EP (1) EP2651903B1 (enExample)
JP (1) JP6005656B2 (enExample)
KR (1) KR101876240B1 (enExample)
CN (2) CN103313974A (enExample)
AR (1) AR085203A1 (enExample)
AU (1) AU2011343255B2 (enExample)
BR (1) BR112013012137A2 (enExample)
CA (1) CA2821999C (enExample)
CL (1) CL2013001713A1 (enExample)
CY (1) CY1117751T1 (enExample)
DK (1) DK2651903T3 (enExample)
EA (1) EA022972B1 (enExample)
ES (1) ES2576180T3 (enExample)
HK (1) HK1247616A1 (enExample)
HR (1) HRP20160650T1 (enExample)
HU (1) HUE029247T2 (enExample)
IL (1) IL225640A (enExample)
MX (1) MX340030B (enExample)
MY (1) MY156641A (enExample)
NZ (1) NZ609450A (enExample)
PH (1) PH12013500796A1 (enExample)
PL (1) PL2651903T3 (enExample)
PT (1) PT2651903E (enExample)
SG (1) SG190766A1 (enExample)
SI (1) SI2651903T1 (enExample)
TW (1) TWI530495B (enExample)
UA (1) UA112298C2 (enExample)
WO (1) WO2012080446A1 (enExample)
ZA (1) ZA201304424B (enExample)

Families Citing this family (35)

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TWI515187B (zh) * 2010-12-16 2016-01-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之吲哚類
TWI541241B (zh) * 2010-12-16 2016-07-11 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類
TWI501967B (zh) 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
TWI530495B (zh) 2010-12-16 2016-04-21 健生科學愛爾蘭無限公司 苯并咪唑呼吸道融合病毒抑制劑
TWI527814B (zh) * 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
JP2015523350A (ja) * 2012-06-15 2015-08-13 ヤンセン・アールアンドデイ・アイルランド Ｒｓウイルス抗ウイルス薬としての、ベンゾイミダゾールによって置換された新規１，３−ジヒドロ−２ｈ−ベンゾイミダゾル−２−オン誘導体
DK2864323T3 (en) * 2012-06-15 2017-08-14 Janssen Sciences Ireland Uc 1,3-DIHYDRO-2H-BENZIMIDAZOLE-2 UNDERIVATIVES SUBSTITUTED BY HETEROCYCLES AS ANTIVIRUS AGENTS AGAINST RESPIRATORY SYNCYTIAL VIRUS
BR112015000392A2 (pt) * 2012-07-10 2017-06-27 Hoffmann La Roche novos indazóis para o tratamento e profilaxia da infecção por vírus sincicial respiratório
TWI598351B (zh) 2012-10-16 2017-09-11 健生科學愛爾蘭無限公司 Ｒｓｖ抗病毒化合物
KR102254837B1 (ko) 2013-01-28 2021-05-24 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 호흡기 합포체 바이러스의 항바이러스제로서의 퀴녹살리논 및 디하이드로퀴녹살리논
CA2910508A1 (en) 2013-05-14 2014-11-20 Song Feng Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection
CN105392787B (zh) * 2013-05-14 2017-11-24 豪夫迈·罗氏有限公司 用于治疗和预防呼吸道合胞病毒感染的氮杂‑氧代‑吲哚
EP3033333A1 (en) * 2013-08-15 2016-06-22 F. Hoffmann-La Roche AG Novel aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection
WO2015026792A1 (en) 2013-08-21 2015-02-26 Alios Biopharma, Inc. Antiviral compounds
WO2015065336A1 (en) * 2013-10-29 2015-05-07 Medivir Ab Respiratory syncytial virus inhibitors
TWI671299B (zh) 2014-04-14 2019-09-11 愛爾蘭商健生科學愛爾蘭無限公司 作為ｒｓｖ抗病毒化合物之螺脲化合物
CA2957017A1 (en) * 2014-08-05 2016-02-11 Alios Biopharma, Inc. Combination therapy for treating a paramyxovirus
MA41614A (fr) 2015-02-25 2018-01-02 Alios Biopharma Inc Composés antiviraux
SMT202200437T1 (it) 2015-07-22 2023-01-13 Enanta Pharm Inc Derivati benzodiazepinaci come inibitori del rsv
CN108699077B (zh) 2016-01-15 2021-03-02 英安塔制药有限公司 作为rsv抑制剂的杂环化合物
KR102573499B1 (ko) 2017-02-16 2023-08-31 이난타 파마슈티칼스, 인코포레이티드 벤조디아제핀 유도체의 제조 방법
WO2019006295A1 (en) 2017-06-30 2019-01-03 Enanta Pharmaceuticals, Inc. HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS
JP7198811B2 (ja) 2017-09-29 2023-01-04 エナンタ ファーマシューティカルズ インコーポレイテッド Ｒｓｖ阻害剤としての組み合わせ医薬剤
NZ764647A (en) 2017-11-13 2025-12-19 Enanta Pharm Inc Processes for the resolution of benzodiazepin-2-one and benzoazepin-2-one derivatives
AU2020240024B2 (en) 2019-03-18 2025-06-26 Enanta Pharmaceuticals, Inc Benzodiazepine derivatives as RSV inhibitors
CN114761016A (zh) 2019-10-04 2022-07-15 英安塔制药有限公司 抗病毒杂环化合物
US11505558B1 (en) 2019-10-04 2022-11-22 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
UY39032A (es) 2020-01-24 2021-07-30 Enanta Pharm Inc Compuestos heterocíclicos como agentes antivirales
WO2021250180A1 (en) 2020-06-11 2021-12-16 Janssen Sciences Ireland Unlimited Company Hemi (l)-tartrate forms of 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1h-indol-2 yl} methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2h-imidazo[4,5-c]pyridin-2-one and pharmaceutical compositions comprising the same
WO2022010882A1 (en) 2020-07-07 2022-01-13 Enanta Pharmaceuticals, Inc, Dihydroquinoxaline and dihydropyridopyrazine derivatives as rsv inhibitors
US11945824B2 (en) 2020-10-19 2024-04-02 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as anti-viral agents
US11945830B2 (en) 2021-02-26 2024-04-02 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
AR129003A1 (es) 2022-04-07 2024-07-03 Enanta Pharm Inc Compuestos heterocíclicos antivirales
US12162857B2 (en) 2022-04-27 2024-12-10 Enanta Pharmaceuticals, Inc. Antiviral compounds
WO2024174953A1 (zh) * 2023-02-21 2024-08-29 苏州隆博泰药业有限公司 苯并咪唑类衍生物及其医药用途

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WO1998001428A1 (en) 1996-07-08 1998-01-15 Du Pont Pharmaceuticals Company AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN
WO2000020400A1 (en) 1998-10-05 2000-04-13 Axys Pharmaceuticals, Inc. Novel compounds and compositions for treating hepatitis c infections
WO2001000612A2 (en) 1999-06-28 2001-01-04 Janssen Pharmaceutica N.V. Respiratory syncytial virus replication inhibitors
TR200600172T2 (tr) 1999-06-28 2007-10-22 Janssen Pharmaceutica N.V Solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler.
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US6489338B2 (en) * 2000-06-13 2002-12-03 Bristol-Myers Squibb Company Imidazopyridine and imidazopyrimidine antiviral agents
US6506738B1 (en) 2000-09-27 2003-01-14 Bristol-Myers Squibb Company Benzimidazolone antiviral agents
US6919331B2 (en) 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
US20040166137A1 (en) 2002-11-08 2004-08-26 Lackey John William Hetero-substituted benzimidazole compounds and antiviral uses thereof
TWI541241B (zh) 2010-12-16 2016-07-11 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類
TWI515187B (zh) 2010-12-16 2016-01-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之吲哚類
TWI501967B (zh) 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
TWI527814B (zh) 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
TWI530495B (zh) 2010-12-16 2016-04-21 健生科學愛爾蘭無限公司 苯并咪唑呼吸道融合病毒抑制劑

Also Published As

Publication number Publication date
NZ609450A (en) 2014-10-31
MY156641A (en) 2016-03-15
EA201390888A1 (ru) 2013-12-30
TWI530495B (zh) 2016-04-21
MX340030B (es) 2016-06-21
AU2011343255B2 (en) 2014-12-11
HK1247616A1 (zh) 2018-09-28
AR085203A1 (es) 2013-09-18
UA112298C2 (uk) 2016-08-25
TW201305142A (zh) 2013-02-01
MX2013006886A (es) 2013-07-05
SG190766A1 (en) 2013-07-31
EA022972B1 (ru) 2016-03-31
EP2651903B1 (en) 2016-03-23
CA2821999A1 (en) 2012-06-21
CN103313974A (zh) 2013-09-18
HUE029247T2 (en) 2017-02-28
ES2576180T3 (es) 2016-07-06
PH12013500796A1 (en) 2013-06-24
JP6005656B2 (ja) 2016-10-12
US8865705B2 (en) 2014-10-21
CA2821999C (en) 2019-02-26
SI2651903T1 (sl) 2016-07-29
DK2651903T3 (da) 2016-06-27
JP2013545785A (ja) 2013-12-26
PL2651903T3 (pl) 2016-10-31
KR101876240B1 (ko) 2018-08-02
WO2012080446A1 (en) 2012-06-21
BR112013012137A2 (pt) 2016-08-16
CL2013001713A1 (es) 2013-10-11
HRP20160650T1 (hr) 2016-07-15
CN107417683A (zh) 2017-12-01
ZA201304424B (en) 2014-12-23
US20130267508A1 (en) 2013-10-10
IL225640A0 (en) 2013-06-27
KR20140025321A (ko) 2014-03-04
EP2651903A1 (en) 2013-10-23
AU2011343255A1 (en) 2013-05-02
CY1117751T1 (el) 2017-05-17
PT2651903E (pt) 2016-06-17

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