JP6004364B2 - 皮膚外用剤 - Google Patents
皮膚外用剤 Download PDFInfo
- Publication number
- JP6004364B2 JP6004364B2 JP2013538552A JP2013538552A JP6004364B2 JP 6004364 B2 JP6004364 B2 JP 6004364B2 JP 2013538552 A JP2013538552 A JP 2013538552A JP 2013538552 A JP2013538552 A JP 2013538552A JP 6004364 B2 JP6004364 B2 JP 6004364B2
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- JP
- Japan
- Prior art keywords
- skin
- taurine
- mass
- external preparation
- diisopropyl
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Description
(1)タウリン、並びに、アジピン酸ジイソプロピル及びセバシン酸ジイソプロピルの少なくとも1種を含有することを特徴とする皮膚外用剤。
(2)アジピン酸ジイソプロピル及びセバシン酸ジイソプロピルの少なくとも1種の含有量が、タウリンの1質量部に対してアジピン酸ジイソプロピルでは0.3質量部以上、セバシン酸ジイソプロピルでは0.8質量部以上である(1)の皮膚外用剤。
電気シェーバーで腹部を剃毛したヘアレスラット(雄、9週齢、(株)埼玉実験動物供給所)の腹部剃毛部より皮膚を摘出した。摘出した皮膚を平均有効面積0.98cm2の横型拡散セルに装着した後、ドナー側のセル内に表1に示した各外用剤(検体)3mLを加え、レシーバー側のセルにpH7.4リン酸緩衝液3mLを加えた。拡散セルの外層には37℃の恒温水を還流し、レシーバー液は撹拌子により撹拌した。
ウサギ(雄、9〜11週齢、日本白色種、北山ラベス(株))を用いた皮膚一次刺激性試験を実施した結果、セバシン酸ジイソプロピル及びアジピン酸ジイソプロピルの皮膚刺激スコアは0と非常に低値で安全な成分であることが確認された。
Claims (1)
- タウリン、並びに、アジピン酸ジイソプロピル及びセバシン酸ジイソプロピルの少なくとも1種を含有することを特徴とする皮膚外用剤であって、アジピン酸ジイソプロピル及びセバシン酸ジイソプロピルの少なくとも1種の含有量が、タウリンの1質量部に対してアジピン酸ジイソプロピルでは0.3質量部以上、セバシン酸ジイソプロピルでは0.8質量部以上である皮膚外用剤。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011226566 | 2011-10-14 | ||
JP2011226566 | 2011-10-14 | ||
PCT/JP2012/076190 WO2013054809A1 (ja) | 2011-10-14 | 2012-10-10 | 皮膚外用剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPWO2013054809A1 JPWO2013054809A1 (ja) | 2015-03-30 |
JP6004364B2 true JP6004364B2 (ja) | 2016-10-05 |
Family
ID=48081864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013538552A Active JP6004364B2 (ja) | 2011-10-14 | 2012-10-10 | 皮膚外用剤 |
Country Status (3)
Country | Link |
---|---|
JP (1) | JP6004364B2 (ja) |
TW (1) | TW201330846A (ja) |
WO (1) | WO2013054809A1 (ja) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106572986A (zh) * | 2014-03-10 | 2017-04-19 | 本杰明·M·余 | 用于经皮递送的方法和组合物 |
WO2023210059A1 (ja) * | 2022-04-25 | 2023-11-02 | コスメディ製薬株式会社 | 有用成分包含タウリン結晶を配合した皮膚外用剤組成物 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60185708A (ja) * | 1984-03-06 | 1985-09-21 | Shiseido Co Ltd | 皮膚外用剤 |
JPS61145109A (ja) * | 1984-12-19 | 1986-07-02 | Nakanishi Eiko | 化粧料 |
JPH0543457A (ja) * | 1991-08-08 | 1993-02-23 | Sekisui Chem Co Ltd | 経皮吸収製剤 |
JPH05310548A (ja) * | 1992-05-13 | 1993-11-22 | Taisho Pharmaceut Co Ltd | 皮膚外用剤 |
FR2732223B1 (fr) * | 1995-03-30 | 1997-06-13 | Sanofi Sa | Composition pharmaceutique pour administration transdermique |
KR100215027B1 (ko) * | 1997-01-27 | 1999-08-16 | 성재갑 | 스테로이드계 약물의 경피흡수투여용 조성물 및 이를 포함하는 경피흡수투여용 제형 |
JP2002212064A (ja) * | 2001-01-19 | 2002-07-31 | Minoru Obara | 化粧品、医薬品貼付剤用基材 |
JP2003160511A (ja) * | 2001-11-29 | 2003-06-03 | Shiseido Co Ltd | 経皮吸収促進剤 |
JP2004269368A (ja) * | 2003-03-05 | 2004-09-30 | Ogawa & Co Ltd | 冷感剤組成物および該冷感剤組成物を含有する冷感化粧料 |
JP4820065B2 (ja) * | 2004-05-24 | 2011-11-24 | 同仁医薬化工株式会社 | 消炎鎮痛外用水性液剤 |
WO2006001251A1 (ja) * | 2004-06-24 | 2006-01-05 | Kowa Co., Ltd. | アトルバスタチン外用剤組成物 |
JP4260078B2 (ja) * | 2004-08-06 | 2009-04-30 | 正人 清水 | 経皮吸収促進性皮膚外用組成物 |
JP4943643B2 (ja) * | 2004-10-29 | 2012-05-30 | テイカ製薬株式会社 | 経皮吸収製剤 |
JP2007137848A (ja) * | 2005-11-22 | 2007-06-07 | Nippon Fine Chem Co Ltd | 化粧料及び皮膚外用剤 |
JP5061984B2 (ja) * | 2007-03-31 | 2012-10-31 | 大正製薬株式会社 | アダパレン含有外用剤組成物 |
TWI414296B (zh) * | 2007-08-17 | 2013-11-11 | Eisai R&D Man Co Ltd | Innovative agents |
EP2318011A4 (en) * | 2008-07-17 | 2011-09-14 | Georgia Levis | METHODS AND MATERIALS FOR TREATING ACNE |
FR2940059B1 (fr) * | 2008-12-24 | 2011-04-29 | Lvmh Rech | Compostion cosmetique contenant au moins deux osmolytes a effet hydratant ou anti-age |
JP5966261B2 (ja) * | 2010-06-17 | 2016-08-10 | 大正製薬株式会社 | 外用組成物 |
-
2012
- 2012-10-10 WO PCT/JP2012/076190 patent/WO2013054809A1/ja active Application Filing
- 2012-10-10 JP JP2013538552A patent/JP6004364B2/ja active Active
- 2012-10-12 TW TW101137721A patent/TW201330846A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
WO2013054809A1 (ja) | 2013-04-18 |
JPWO2013054809A1 (ja) | 2015-03-30 |
TW201330846A (zh) | 2013-08-01 |
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