JP6000253B2 - 胃腸機能を改善するための材料および方法 - Google Patents

胃腸機能を改善するための材料および方法 Download PDF

Info

Publication number
JP6000253B2
JP6000253B2 JP2013530396A JP2013530396A JP6000253B2 JP 6000253 B2 JP6000253 B2 JP 6000253B2 JP 2013530396 A JP2013530396 A JP 2013530396A JP 2013530396 A JP2013530396 A JP 2013530396A JP 6000253 B2 JP6000253 B2 JP 6000253B2
Authority
JP
Japan
Prior art keywords
mice
hco
therapeutic composition
secretion
irradiation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2013530396A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013542195A (ja
JP2013542195A5 (https=
Inventor
サダシヴァン ヴィディアサーガー
サダシヴァン ヴィディアサーガー
ポール オクニーフ
ポール オクニーフ
ルーロン チャン
ルーロン チャン
Original Assignee
ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド
ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド, ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド filed Critical ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド
Publication of JP2013542195A publication Critical patent/JP2013542195A/ja
Publication of JP2013542195A5 publication Critical patent/JP2013542195A5/ja
Application granted granted Critical
Publication of JP6000253B2 publication Critical patent/JP6000253B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B2/00—Preservation of foods or foodstuffs, in general
    • A23B2/70—Preservation of foods or foodstuffs, in general by treatment with chemicals
    • A23B2/725—Preservation of foods or foodstuffs, in general by treatment with chemicals in the form of liquids or solids
    • A23B2/788—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/32—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the digestive tract
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nutrition Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Physiology (AREA)
  • Mycology (AREA)
  • Inorganic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2013530396A 2010-09-24 2011-09-26 胃腸機能を改善するための材料および方法 Active JP6000253B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US38631710P 2010-09-24 2010-09-24
US61/386,317 2010-09-24
US201161431629P 2011-01-11 2011-01-11
US61/431,629 2011-01-11
PCT/US2011/053265 WO2012040707A2 (en) 2010-09-24 2011-09-26 Materials and methods for improving gastrointestinal function

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016167829A Division JP6425356B2 (ja) 2010-09-24 2016-08-30 胃腸機能を改善するための材料および方法

Publications (3)

Publication Number Publication Date
JP2013542195A JP2013542195A (ja) 2013-11-21
JP2013542195A5 JP2013542195A5 (https=) 2014-12-04
JP6000253B2 true JP6000253B2 (ja) 2016-09-28

Family

ID=45871248

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2013530396A Active JP6000253B2 (ja) 2010-09-24 2011-09-26 胃腸機能を改善するための材料および方法
JP2016167829A Active JP6425356B2 (ja) 2010-09-24 2016-08-30 胃腸機能を改善するための材料および方法
JP2018187236A Active JP6698777B2 (ja) 2010-09-24 2018-10-02 胃腸機能を改善するための材料および方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2016167829A Active JP6425356B2 (ja) 2010-09-24 2016-08-30 胃腸機能を改善するための材料および方法
JP2018187236A Active JP6698777B2 (ja) 2010-09-24 2018-10-02 胃腸機能を改善するための材料および方法

Country Status (17)

Country Link
US (7) US8993522B2 (https=)
EP (5) EP3494969B1 (https=)
JP (3) JP6000253B2 (https=)
KR (4) KR101758424B1 (https=)
CN (2) CN105663106A (https=)
AP (1) AP2013006826A0 (https=)
AU (2) AU2011305124B2 (https=)
BR (1) BR112013006044B1 (https=)
CA (1) CA2809489C (https=)
EA (1) EA030970B8 (https=)
ES (2) ES2639888T3 (https=)
IL (1) IL277166B (https=)
MX (2) MX350541B (https=)
NZ (1) NZ607189A (https=)
PH (1) PH12013500441A1 (https=)
SG (1) SG188293A1 (https=)
WO (1) WO2012040707A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016222712A (ja) * 2010-09-24 2016-12-28 ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド 胃腸機能を改善するための材料および方法

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102584819B1 (ko) * 2011-01-19 2023-10-05 프랙틸 헬쓰, 인코포레이티드 조직의 치료를 위한 장치 및 방법
HK1204290A1 (en) * 2012-02-08 2015-11-13 University Of Florida Research Foundation, Inc. Materials and methods for treating diarrhea
KR101969199B1 (ko) 2013-03-11 2019-04-15 유니버시티 오브 플로리다 리서치 파운데이션, 인크. 폐 기능의 개선 및 방사선 유발된 폐 합병증의 예방 및/또는 치료를 위한 물질 및 방법
US10258810B2 (en) 2013-09-27 2019-04-16 Mevion Medical Systems, Inc. Particle beam scanning
US10675487B2 (en) 2013-12-20 2020-06-09 Mevion Medical Systems, Inc. Energy degrader enabling high-speed energy switching
US9962560B2 (en) 2013-12-20 2018-05-08 Mevion Medical Systems, Inc. Collimator and energy degrader
US9661736B2 (en) 2014-02-20 2017-05-23 Mevion Medical Systems, Inc. Scanning system for a particle therapy system
EP3459540A1 (en) * 2014-11-24 2019-03-27 Entrinsic Health Solutions, Inc. Amino acid compositions for the treatment of symptoms of disease
US20180038873A1 (en) * 2015-02-05 2018-02-08 University Of Florida Research Foundation, Inc. Use of nhe3 as a biomarker for radiation biodosimetry
US20160339086A1 (en) * 2015-05-19 2016-11-24 Suzy Cohen Compositions and methods for treating thyroid disease
US10786689B2 (en) 2015-11-10 2020-09-29 Mevion Medical Systems, Inc. Adaptive aperture
CN105685973B (zh) * 2016-02-04 2018-08-24 中山大学附属第六医院 一种肠内营养剂
US10702590B2 (en) 2016-04-12 2020-07-07 Script Essentials, Llc Compositions and methods for treating thyroid disease
EP3481503B1 (en) 2016-07-08 2021-04-21 Mevion Medical Systems, Inc. Treatment planning
EP3494968A4 (en) * 2016-08-05 2020-04-15 The University Of Tokyo COMPOSITION FOR USE IN TREATING T-CELL LEUKEMIA / LYMPHOMA IN ADULTS AND METHOD FOR THE PRODUCTION THEREOF
EP3522882A4 (en) 2016-10-04 2020-06-24 The University of Florida Research Foundation Incorporated AMINO ACID COMPOSITIONS AND USES THEREOF
US11103730B2 (en) 2017-02-23 2021-08-31 Mevion Medical Systems, Inc. Automated treatment in particle therapy
JP6940676B2 (ja) 2017-06-30 2021-09-29 メビオン・メディカル・システムズ・インコーポレーテッド リニアモーターを使用して制御される構成可能コリメータ
WO2019070750A1 (en) 2017-10-02 2019-04-11 University Of Florida Research Foundation , Incorporated MATERIALS AND METHODS FOR INHIBITING TUMOR GROWTH
WO2019070753A1 (en) * 2017-10-02 2019-04-11 University Of Florida Research Foundation, Incorporated AMINO ACID COMPOSITIONS AND METHODS FOR TREATING DIARRHEA
KR20200139776A (ko) * 2018-04-04 2020-12-14 유니버시티 오브 플로리다 리서치 파운데이션, 인크. 피부 치료용 조성물
CN109601761A (zh) * 2018-11-01 2019-04-12 山东大学 一种大菱鲆肠炎病的营养性修复剂
IT201900002109A1 (it) 2019-02-13 2020-08-13 Professional Dietetics Spa Composizioni comprendenti amminoacidi per l'uso nel trattamento di lesioni del sistema nervoso centrale
JP7311620B2 (ja) 2019-03-08 2023-07-19 メビオン・メディカル・システムズ・インコーポレーテッド 粒子線治療システムのためのコリメータおよびエネルギーデグレーダ
EP3958855A4 (en) * 2019-04-26 2023-01-18 Increvet, Inc. METHODS TO REDUCE WEIGHT LOSS OR INCREASE WEIGHT IN A CAT IN NEED OF WEIGHT LOSS
RU2699222C1 (ru) * 2019-04-29 2019-09-04 Алексей Владимирович Воронов Солевой электролитный раствор для проведения энтеральных инфузий
TWI761849B (zh) * 2019-06-14 2022-04-21 南韓商Ｃｊ第一製糖股份有限公司 含有棒狀桿菌屬菌株及其培養物的用於預防、治療或改善胃病症的組成物
EP4058044A4 (en) * 2019-11-11 2023-05-17 Ohio State Innovation Foundation Treatment for inflammatory bowel disease and radiation-induced intestinal injury
IT202000000442A1 (it) 2020-01-13 2021-07-13 Professional Dietetics Spa Composizioni comprendenti amino acidi per l'uso nella prevenzione e nel trattamento di effetti collaterali della chemioterapia
CA3177889A1 (en) * 2020-06-02 2021-12-09 Sadasivan Vidyasagar Formulations and methods for treating diarrhea
IL299488A (en) 2020-07-02 2023-02-01 Univ Florida Preparations for promoting hydration and methods of using them
IT202200013354A1 (it) * 2022-06-23 2023-12-23 Professional Dietetics Spa Composizioni comprendenti amminoacidi per l'uso nella prevenzione e/o nel trattamento di malattie intestinali
US11878073B1 (en) 2022-09-20 2024-01-23 Entrinsic, LLC Generation of hydration-targeted formulations and methods of use therein

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1285491C (en) * 1985-09-12 1991-07-02 Robert J. Smith Method of treating catabolic dysfunction
SE8601828D0 (sv) * 1986-04-21 1986-04-21 Novo Industri As Enteral diet product and agent for production thereof
US5254572A (en) * 1987-11-27 1993-10-19 Vesta Medicines (Pty) Ltd. Method and composition for supplementing vitamin B6 where the PN-PLP pathway is disturbed
US5290538A (en) 1988-12-22 1994-03-01 Skrezek Christian Nephro protective infusion solutions
DE69430303T2 (de) 1991-03-05 2002-11-28 Aradigm Corp Verfahren und vorrichtung zur korrektur eines nullsignals eines drucksensors fur einen durchflussmesser
WO1993000951A1 (en) 1991-07-02 1993-01-21 Inhale, Inc. Method and device for delivering aerosolized medicaments
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
US5558085A (en) 1993-01-29 1996-09-24 Aradigm Corporation Intrapulmonary delivery of peptide drugs
US5934272A (en) 1993-01-29 1999-08-10 Aradigm Corporation Device and method of creating aerosolized mist of respiratory drug
US5514656A (en) 1993-05-28 1996-05-07 Abbott Laboratories Method of providing enteral nutritional support for patients undergoing radiation therapy and/or chemotherapy
NZ248605A (en) * 1993-05-28 1994-12-22 Abbott Lab Enteral nutritional product comprising protein and fat
JP3177918B2 (ja) * 1993-06-24 2001-06-18 日本電信電話株式会社 パケット交換機のルーチング装置
US6051256A (en) 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
US5780451A (en) 1994-04-01 1998-07-14 Abbott Laboratories Nutritional product for a person having ulcerative colitis
JPH07330583A (ja) * 1994-06-03 1995-12-19 Terumo Corp 遊離型グルタミン酸を含有する液状製剤
JPH0873351A (ja) * 1994-06-30 1996-03-19 Ajinomoto Co Inc 炎症性腸疾患用栄養組成物
EP0689835A3 (en) 1994-06-30 1996-04-17 Ajinomoto Kk Composition containing an amino acid mixture and at least one N-3 fatty acid
JP4011638B2 (ja) * 1994-12-27 2007-11-21 イーエヌ大塚製薬株式会社 経口経腸栄養組成物
BR9607336A (pt) 1995-02-23 1997-11-25 Novartis Nutrition Ag Composições de aminoácidos e utilidades das mesmas em nutrição clinica
ES2237767T3 (es) 1995-04-14 2005-08-01 Nektar Therapeutics Composiciones farmaceuticas en polvo que tienen una dispersabilidad mejorada.
CA2224697A1 (en) 1995-06-14 1997-01-03 Peng Tian Rotavirus enterotoxin nsp4 and methods of using same
US6673355B1 (en) 1995-06-14 2004-01-06 Baylor College Of Medicine Rotavirus enterotoxin NSP4 and methods of using same
US5821217A (en) 1995-10-27 1998-10-13 Beth Israel Deaconess Medical Center, Inc. Enteral formulation: low in fat and containing protein hydrolysates
US6077543A (en) 1996-12-31 2000-06-20 Inhale Therapeutic Systems Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
AU776679B2 (en) 1998-11-13 2004-09-16 Children's Hospital Of Los Angeles Methods of facilitating vascular growth
EP2258183A1 (en) 1998-12-22 2010-12-08 The University of North Carolina at Chapel Hill Compounds and uses for the treatment of airway diseases and for the delivery of airway drugs
GB0009056D0 (en) * 2000-04-12 2000-05-31 Nestle Sa Composition comprising free amino acids
US6956023B1 (en) * 2001-04-19 2005-10-18 University Of Florida Materials and methods for providing nutrition to neonates
JP4255656B2 (ja) 2001-09-17 2009-04-15 株式会社メニコン 眼科用液剤及びコンタクトレンズ用液剤
US20030105104A1 (en) * 2001-11-27 2003-06-05 Burzynski Stanislaw R. Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy
US20030143293A1 (en) 2002-01-31 2003-07-31 Sergei Shushunov Compositions and methods for treating diarrhea
JP2004123642A (ja) 2002-10-04 2004-04-22 Shimizu Pharmaceutical Co Ltd 電解質組成物
DK175877B1 (da) 2002-11-11 2005-05-09 Pharmalett As Præparater til anvendelse som terapeutisk middel
US20040213838A1 (en) 2003-04-24 2004-10-28 Mazer Terrence B. Medical food tablets containing free amino acids
US20050100637A1 (en) 2003-11-12 2005-05-12 Robert Murray Carbohydrate and electrolyte replacement composition
WO2006049286A1 (ja) 2004-11-02 2006-05-11 Ajinomoto Co., Inc. アレルギー性疾患予防・治療剤
US20070010459A1 (en) 2005-01-14 2007-01-11 Ying Liu Application of asiatic acid and its derivatives to treat pulmonary fibrosis
GB0503337D0 (en) 2005-02-17 2005-03-23 Glaxosmithkline Biolog Sa Compositions
JP4811576B2 (ja) 2005-03-31 2011-11-09 味の素株式会社 水分電解質補給飲料
JPWO2007004613A1 (ja) 2005-07-01 2009-01-29 味の素株式会社 炎症性腸疾患治療薬及びＴＮＦ−α産生抑制剤
US7595079B2 (en) 2005-07-08 2009-09-29 Bomac Vets Plus, Inc. Nutritional conjunctive support therapy for recovery in animals following stress or illness
JP4512013B2 (ja) 2005-09-07 2010-07-28 和光堂株式会社 液体飲料組成物及びその製造方法
US20070202058A1 (en) 2006-02-27 2007-08-30 Calwood Nutritionals, Inc. Compositions for treating gastric reflux
CN100522183C (zh) 2006-03-02 2009-08-05 上海交通大学 治疗咳喘病的地龙酸性部位药及其制备方法
EP1864692A1 (en) 2006-06-07 2007-12-12 Biotempt B.V. Use of peptides for the control of radiation injury
DE102006018293A1 (de) 2006-04-20 2007-10-25 Fresenius Kabi Deutschland Gmbh Pädiatrische Aminosäurelösung zur parenteralen Ernäherung
US20070270355A1 (en) * 2006-05-11 2007-11-22 Garcia Ramon D Sport drink containing amino acids and carbohydrates
JP2009536822A (ja) 2006-05-12 2009-10-22 ザ・コカ−コーラ・カンパニー 飲料保存剤
JP5100033B2 (ja) 2006-05-16 2012-12-19 大塚製薬株式会社 消化管及び腎臓の萎縮抑制剤
GB0612671D0 (en) * 2006-06-27 2006-08-09 Shs Int Ltd Nutritional formulation
AU2007280272A1 (en) 2006-08-04 2008-02-07 Shs International Ltd Protein free formula
EP2185004B1 (en) 2007-08-03 2017-03-15 Aminotech AS Amino acid and peptide products
KR101325374B1 (ko) 2008-02-19 2013-11-08 가부시키가이샤 오츠까 세이야꾸 고죠 신체 기능의 회복에 유용한 경구 또는 경장 조성물
US20090318556A1 (en) 2008-05-15 2009-12-24 Idle Jeffrey R Biomarkers for detecting radiation exposure: methods and uses thereof
JP5576097B2 (ja) 2009-11-17 2014-08-20 大塚製薬株式会社 気道抵抗改善剤
IT1396935B1 (it) 2009-11-26 2012-12-20 Solartium Entpr Ltd Uso di una combinazione per il trattamento delle mucositi indotte da radiazioni o da chemioterapici
CN101779750A (zh) * 2010-03-24 2010-07-21 舒世洪 一种乳猪教槽料及制备方法
WO2011127056A2 (en) 2010-04-05 2011-10-13 The Uab Research Foundation Biomarkers for assessing exposure to ionizing radiation and absorbed dose
WO2012020357A1 (en) 2010-08-09 2012-02-16 Advinus Therapeutics Ltd. Acetamide compounds, their process and pharmaceutical application
KR101758424B1 (ko) * 2010-09-24 2017-07-14 유니버시티 오브 플로리다 리서치 파운데이션, 인크. 위장 기능을 증진시키기 위한 물질 및 방법
US20120321729A1 (en) 2011-06-15 2012-12-20 Ven Subbiah Nutritional formula for managing chronic obstructive pulmonary disease (copd) and lung health
US8557301B2 (en) 2011-07-01 2013-10-15 Drip Drop, Inc. Oral rehydration composition
HK1204290A1 (en) 2012-02-08 2015-11-13 University Of Florida Research Foundation, Inc. Materials and methods for treating diarrhea
WO2013151744A1 (en) 2012-04-05 2013-10-10 University Of Florida Research Foundation, Inc. Materials and methods for treatment of cystic fibrosis and for induction of ion secretion
KR101969199B1 (ko) 2013-03-11 2019-04-15 유니버시티 오브 플로리다 리서치 파운데이션, 인크. 폐 기능의 개선 및 방사선 유발된 폐 합병증의 예방 및/또는 치료를 위한 물질 및 방법
EP3400027A4 (en) 2016-01-06 2019-11-06 Parasonic Ltd. Device and method for damaging parasites using ultrasonic reflection
EP3522882A4 (en) 2016-10-04 2020-06-24 The University of Florida Research Foundation Incorporated AMINO ACID COMPOSITIONS AND USES THEREOF

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016222712A (ja) * 2010-09-24 2016-12-28 ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド 胃腸機能を改善するための材料および方法

Also Published As

Publication number Publication date
US20210196679A1 (en) 2021-07-01
JP2019011361A (ja) 2019-01-24
US12239633B2 (en) 2025-03-04
MX350541B (es) 2017-09-08
EP3494969A1 (en) 2019-06-12
EP3173079B1 (en) 2020-04-22
CN103153298B (zh) 2015-11-25
KR20170084354A (ko) 2017-07-19
EP2624825B1 (en) 2017-06-14
EP3173079A1 (en) 2017-05-31
US20250248972A1 (en) 2025-08-07
CA2809489C (en) 2017-10-24
EA030970B1 (ru) 2018-10-31
AU2015207919A1 (en) 2015-08-20
US10322109B2 (en) 2019-06-18
KR20200009145A (ko) 2020-01-29
JP2013542195A (ja) 2013-11-21
EP4406557A2 (en) 2024-07-31
MX2013003282A (es) 2013-05-09
ES2639888T3 (es) 2017-10-30
ES2805535T3 (es) 2021-02-12
AU2011305124B2 (en) 2015-04-30
KR102205124B1 (ko) 2021-01-20
US20120077748A1 (en) 2012-03-29
WO2012040707A2 (en) 2012-03-29
KR102069790B1 (ko) 2020-01-23
EP2624825A4 (en) 2014-02-19
EP2624825A2 (en) 2013-08-14
IL277166A (en) 2020-10-29
US8993522B2 (en) 2015-03-31
EA030970B8 (ru) 2019-01-31
KR20180132974A (ko) 2018-12-12
US20150196534A1 (en) 2015-07-16
EP3494969B1 (en) 2024-03-13
EP4406557A3 (en) 2025-06-18
EP3970715A1 (en) 2022-03-23
EA201300323A1 (ru) 2014-03-31
SG188293A1 (en) 2013-04-30
US11752132B2 (en) 2023-09-12
NZ607189A (en) 2015-04-24
US20190307724A1 (en) 2019-10-10
PH12013500441A1 (en) 2016-06-22
KR101758424B1 (ko) 2017-07-14
JP2016222712A (ja) 2016-12-28
CN103153298A (zh) 2013-06-12
BR112013006044A2 (pt) 2016-06-07
WO2012040707A3 (en) 2012-07-05
KR20130108308A (ko) 2013-10-02
AU2015207919B2 (en) 2017-03-02
AP2013006826A0 (en) 2013-04-30
JP6425356B2 (ja) 2018-11-21
JP6698777B2 (ja) 2020-05-27
US10940137B2 (en) 2021-03-09
AU2011305124A1 (en) 2013-03-14
US20240024286A1 (en) 2024-01-25
CN105663106A (zh) 2016-06-15
US20190046504A1 (en) 2019-02-14
CA2809489A1 (en) 2012-03-29
BR112013006044B1 (pt) 2022-03-29
IL277166B (en) 2021-06-30

Similar Documents

Publication Publication Date Title
JP6000253B2 (ja) 胃腸機能を改善するための材料および方法
HK1224577A1 (en) Materials and methods for improving gastrointestinal function

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140905

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20140905

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20141017

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20150519

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150803

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20151102

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160201

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20160707

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20160808

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20160830

R150 Certificate of patent or registration of utility model

Ref document number: 6000253

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250