EA201300323A1 - Материалы и способы улучшения функции желудочно-кишечного тракта - Google Patents

Материалы и способы улучшения функции желудочно-кишечного тракта

Info

Publication number
EA201300323A1
EA201300323A1 EA201300323A EA201300323A EA201300323A1 EA 201300323 A1 EA201300323 A1 EA 201300323A1 EA 201300323 A EA201300323 A EA 201300323A EA 201300323 A EA201300323 A EA 201300323A EA 201300323 A1 EA201300323 A1 EA 201300323A1
Authority
EA
Eurasian Patent Office
Prior art keywords
improvement
materials
methods
function
gastrointestinal tract
Prior art date
Application number
EA201300323A
Other languages
English (en)
Other versions
EA030970B1 (ru
EA030970B8 (ru
Inventor
Садасиван Видьясагар
Пол Окунефф
Ларонг Чжан
Original Assignee
Юниверсити Оф Флорида Рисёч Фаундейшн, Инс.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Юниверсити Оф Флорида Рисёч Фаундейшн, Инс. filed Critical Юниверсити Оф Флорида Рисёч Фаундейшн, Инс.
Publication of EA201300323A1 publication Critical patent/EA201300323A1/ru
Publication of EA030970B1 publication Critical patent/EA030970B1/ru
Publication of EA030970B8 publication Critical patent/EA030970B8/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
    • A23L3/358—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/32—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the digestive tract
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nutrition Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Physiology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Mycology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение обеспечивает терапевтические композиции и их применение для лечения или ослабления повреждения слизистой оболочки тонкого кишечника. В предпочтительных вариантах осуществления композиция включает одно или несколько питательных веществ и/или электролитов, приобретающих или сохраняющих значительную поглощающую способность.
EA201300323A 2010-09-24 2011-09-26 Композиция для восстановления функции тонкого кишечника, способы ее приготовления и применения EA030970B8 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38631710P 2010-09-24 2010-09-24
US201161431629P 2011-01-11 2011-01-11
PCT/US2011/053265 WO2012040707A2 (en) 2010-09-24 2011-09-26 Materials and methods for improving gastrointestinal function

Publications (3)

Publication Number Publication Date
EA201300323A1 true EA201300323A1 (ru) 2014-03-31
EA030970B1 EA030970B1 (ru) 2018-10-31
EA030970B8 EA030970B8 (ru) 2019-01-31

Family

ID=45871248

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201300323A EA030970B8 (ru) 2010-09-24 2011-09-26 Композиция для восстановления функции тонкого кишечника, способы ее приготовления и применения

Country Status (16)

Country Link
US (6) US8993522B2 (ru)
EP (4) EP3173079B1 (ru)
JP (3) JP6000253B2 (ru)
KR (4) KR102069790B1 (ru)
CN (2) CN105663106A (ru)
AP (1) AP2013006826A0 (ru)
AU (2) AU2011305124B2 (ru)
BR (1) BR112013006044B1 (ru)
CA (1) CA2809489C (ru)
EA (1) EA030970B8 (ru)
ES (2) ES2805535T3 (ru)
IL (1) IL277166B (ru)
MX (2) MX2013003282A (ru)
NZ (1) NZ607189A (ru)
SG (1) SG188293A1 (ru)
WO (1) WO2012040707A2 (ru)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102069790B1 (ko) * 2010-09-24 2020-01-23 유니버시티 오브 플로리다 리서치 파운데이션, 인크. 위장 기능을 증진시키기 위한 물질 및 방법
KR101922514B1 (ko) * 2011-01-19 2018-11-28 프랙틸 래브러토리스 인코포레이티드 조직의 치료를 위한 장치 및 방법
CN104093410B (zh) 2012-02-08 2018-04-27 佛罗里达大学研究基金会有限公司 用于治疗腹泻的物质和方法
EP3427730A1 (en) * 2013-03-11 2019-01-16 University of Florida Research Foundation, Inc. Materials and methods for improving lung function
US10258810B2 (en) 2013-09-27 2019-04-16 Mevion Medical Systems, Inc. Particle beam scanning
US9962560B2 (en) 2013-12-20 2018-05-08 Mevion Medical Systems, Inc. Collimator and energy degrader
US10675487B2 (en) 2013-12-20 2020-06-09 Mevion Medical Systems, Inc. Energy degrader enabling high-speed energy switching
US9661736B2 (en) 2014-02-20 2017-05-23 Mevion Medical Systems, Inc. Scanning system for a particle therapy system
BR112017010832A2 (pt) 2014-11-24 2017-12-26 Entrinsic Health Solutions Llc composições de aminoácido para o tratamento de sintomas de doença
EP3254115A4 (en) * 2015-02-05 2018-06-20 University of Florida Research Foundation, Inc. Use of nhe3 as biomarker for radiation biodosimetry
US20160339086A1 (en) * 2015-05-19 2016-11-24 Suzy Cohen Compositions and methods for treating thyroid disease
US10786689B2 (en) 2015-11-10 2020-09-29 Mevion Medical Systems, Inc. Adaptive aperture
CN105685973B (zh) * 2016-02-04 2018-08-24 中山大学附属第六医院 一种肠内营养剂
US10702590B2 (en) 2016-04-12 2020-07-07 Script Essentials, Llc Compositions and methods for treating thyroid disease
EP3481503B1 (en) 2016-07-08 2021-04-21 Mevion Medical Systems, Inc. Treatment planning
JP6732226B2 (ja) * 2016-08-05 2020-07-29 国立大学法人 東京大学 成人ｔ細胞白血病リンパ腫を処置することに用いるための組成物およびその製造方法
CA3135553C (en) * 2016-10-04 2024-05-21 University Of Florida Research Foundation, Incorporated Amino acid compositions and uses thereof
US11103730B2 (en) 2017-02-23 2021-08-31 Mevion Medical Systems, Inc. Automated treatment in particle therapy
CN111093767B (zh) 2017-06-30 2022-08-23 美国迈胜医疗系统有限公司 使用线性电动机而被控制的可配置准直仪
CN111417391B (zh) 2017-10-02 2024-06-18 佛罗里达大学研究基金会公司 用于抑制肿瘤生长的材料和方法
WO2019070753A1 (en) * 2017-10-02 2019-04-11 University Of Florida Research Foundation, Incorporated AMINO ACID COMPOSITIONS AND METHODS FOR TREATING DIARRHEA
JP2021520351A (ja) * 2018-04-04 2021-08-19 ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド 皮膚を治療するための組成物
CN109601761A (zh) * 2018-11-01 2019-04-12 山东大学 一种大菱鲆肠炎病的营养性修复剂
WO2020185544A1 (en) 2019-03-08 2020-09-17 Mevion Medical Systems, Inc. Delivery of radiation by column and generating a treatment plan therefor
US20200352968A1 (en) * 2019-04-26 2020-11-12 Increvet, Inc. Methods for reducing the weight loss or increasing the weight of a feline in need thereof
RU2699222C1 (ru) * 2019-04-29 2019-09-04 Алексей Владимирович Воронов Солевой электролитный раствор для проведения энтеральных инфузий
WO2020251208A1 (ko) * 2019-06-14 2020-12-17 씨제이제일제당 (주) 코리네박테리움 속 균주 및 이의 배양물을 포함하는 위장질환 예방, 치료 또는 개선용 조성물
AU2021284284A1 (en) * 2020-06-02 2022-11-17 Entrinsic, LLC Formulations and methods for treating diarrhea
JP2023533617A (ja) * 2020-07-02 2023-08-03 ユニバーシティ オブ フロリダ リサーチ ファウンデーション，インコーポレイティド 水分補給を促進するための製剤およびその使用方法
WO2023248035A1 (en) * 2022-06-23 2023-12-28 Professional Dietetics S.P.A. Compositions comprising amino acids for use in the prevention and/or treatment of intestinal diseases
US11878073B1 (en) 2022-09-20 2024-01-23 Entrinsic, LLC Generation of hydration-targeted formulations and methods of use therein

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1285491C (en) * 1985-09-12 1991-07-02 Robert J. Smith Method of treating catabolic dysfunction
SE8601828D0 (sv) 1986-04-21 1986-04-21 Novo Industri As Enteral diet product and agent for production thereof
US5254572A (en) * 1987-11-27 1993-10-19 Vesta Medicines (Pty) Ltd. Method and composition for supplementing vitamin B6 where the PN-PLP pathway is disturbed
US5290538A (en) 1988-12-22 1994-03-01 Skrezek Christian Nephro protective infusion solutions
WO1994016759A1 (en) 1991-03-05 1994-08-04 Miris Medical Corporation An automatic aerosol medication delivery system and methods
AU662919B2 (en) 1991-07-02 1995-09-21 Inhale, Inc. Method and device for delivering aerosolized medicaments
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
US5934272A (en) 1993-01-29 1999-08-10 Aradigm Corporation Device and method of creating aerosolized mist of respiratory drug
US5558085A (en) 1993-01-29 1996-09-24 Aradigm Corporation Intrapulmonary delivery of peptide drugs
NZ248605A (en) 1993-05-28 1994-12-22 Abbott Lab Enteral nutritional product comprising protein and fat
US5514656A (en) 1993-05-28 1996-05-07 Abbott Laboratories Method of providing enteral nutritional support for patients undergoing radiation therapy and/or chemotherapy
JP3177918B2 (ja) * 1993-06-24 2001-06-18 日本電信電話株式会社 パケット交換機のルーチング装置
US6051256A (en) 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
US5780451A (en) 1994-04-01 1998-07-14 Abbott Laboratories Nutritional product for a person having ulcerative colitis
JPH07330583A (ja) * 1994-06-03 1995-12-19 Terumo Corp 遊離型グルタミン酸を含有する液状製剤
EP0689835A3 (en) 1994-06-30 1996-04-17 Ajinomoto Kk Composition containing an amino acid mixture and at least one N-3 fatty acid
JPH0873351A (ja) * 1994-06-30 1996-03-19 Ajinomoto Co Inc 炎症性腸疾患用栄養組成物
JP4011638B2 (ja) * 1994-12-27 2007-11-21 イーエヌ大塚製薬株式会社 経口経腸栄養組成物
CN1175887A (zh) 1995-02-23 1998-03-11 诺瓦蒂斯营养有限公司 氨基酸组合物及其在临床营养中的应用
ATE287703T1 (de) 1995-04-14 2005-02-15 Nektar Therapeutics Pulverförmige pharmazeutische formulierungen mit verbesserter dispergierbarkeit
AU6387196A (en) 1995-06-14 1997-01-15 Baylor College Of Medicine Rotavirus enterotoxin nsp4 and methods of using same
US6673355B1 (en) 1995-06-14 2004-01-06 Baylor College Of Medicine Rotavirus enterotoxin NSP4 and methods of using same
US5821217A (en) 1995-10-27 1998-10-13 Beth Israel Deaconess Medical Center, Inc. Enteral formulation: low in fat and containing protein hydrolysates
JP2001507702A (ja) 1996-12-31 2001-06-12 インヘイル・セラピューティックス・システムズ・インコーポレテッド 親水性賦形剤を有する疎水性薬剤の水性懸濁液を噴霧乾燥させる方法およびその方法によって作製された組成物
MXPA01002875A (es) 1998-11-13 2002-04-08 Los Angeles Childrens Hospital Metodos para facilitar el crecimiento vascular.
WO2000036915A1 (en) 1998-12-22 2000-06-29 The University Of North Carolina At Chapel Hill Compounds and methods for the treatment of airway diseases and for the delivery of airway drugs
GB0009056D0 (en) 2000-04-12 2000-05-31 Nestle Sa Composition comprising free amino acids
US6956023B1 (en) * 2001-04-19 2005-10-18 University Of Florida Materials and methods for providing nutrition to neonates
JP4255656B2 (ja) 2001-09-17 2009-04-15 株式会社メニコン 眼科用液剤及びコンタクトレンズ用液剤
US20030105104A1 (en) 2001-11-27 2003-06-05 Burzynski Stanislaw R. Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy
US20030143293A1 (en) 2002-01-31 2003-07-31 Sergei Shushunov Compositions and methods for treating diarrhea
JP2004123642A (ja) 2002-10-04 2004-04-22 Shimizu Pharmaceutical Co Ltd 電解質組成物
DK175877B1 (da) 2002-11-11 2005-05-09 Pharmalett As Præparater til anvendelse som terapeutisk middel
US20040213838A1 (en) 2003-04-24 2004-10-28 Mazer Terrence B. Medical food tablets containing free amino acids
US20050100637A1 (en) 2003-11-12 2005-05-12 Robert Murray Carbohydrate and electrolyte replacement composition
WO2006049286A1 (ja) 2004-11-02 2006-05-11 Ajinomoto Co., Inc. アレルギー性疾患予防・治療剤
US20070010459A1 (en) 2005-01-14 2007-01-11 Ying Liu Application of asiatic acid and its derivatives to treat pulmonary fibrosis
GB0503337D0 (en) 2005-02-17 2005-03-23 Glaxosmithkline Biolog Sa Compositions
JP4811576B2 (ja) 2005-03-31 2011-11-09 味の素株式会社 水分電解質補給飲料
JPWO2007004613A1 (ja) 2005-07-01 2009-01-29 味の素株式会社 炎症性腸疾患治療薬及びＴＮＦ−α産生抑制剤
US7595079B2 (en) 2005-07-08 2009-09-29 Bomac Vets Plus, Inc. Nutritional conjunctive support therapy for recovery in animals following stress or illness
JP4512013B2 (ja) 2005-09-07 2010-07-28 和光堂株式会社 液体飲料組成物及びその製造方法
US20070202058A1 (en) 2006-02-27 2007-08-30 Calwood Nutritionals, Inc. Compositions for treating gastric reflux
CN100522183C (zh) 2006-03-02 2009-08-05 上海交通大学 治疗咳喘病的地龙酸性部位药及其制备方法
EP1864692A1 (en) 2006-06-07 2007-12-12 Biotempt B.V. Use of peptides for the control of radiation injury
DE102006018293A1 (de) 2006-04-20 2007-10-25 Fresenius Kabi Deutschland Gmbh Pädiatrische Aminosäurelösung zur parenteralen Ernäherung
WO2007133642A1 (en) * 2006-05-11 2007-11-22 Garcia Ramon D Sport drink containing amino acids and carbohydrates
EP2037765A1 (en) 2006-05-12 2009-03-25 The Coca-Cola Company Beverage preservatives
JP5100033B2 (ja) 2006-05-16 2012-12-19 大塚製薬株式会社 消化管及び腎臓の萎縮抑制剤
GB0612671D0 (en) * 2006-06-27 2006-08-09 Shs Int Ltd Nutritional formulation
US8691213B2 (en) 2006-08-04 2014-04-08 SHS International Protein free formula
WO2009020394A1 (en) 2007-08-03 2009-02-12 Aminotech As Amino acid and peptide products
EP2255818B1 (en) 2008-02-19 2018-08-22 Earnest Medicine Co., Ltd. Oral or enteral composition useful for recovery of physical functions
US20090318556A1 (en) 2008-05-15 2009-12-24 Idle Jeffrey R Biomarkers for detecting radiation exposure: methods and uses thereof
JP5576097B2 (ja) 2009-11-17 2014-08-20 大塚製薬株式会社 気道抵抗改善剤
IT1396935B1 (it) 2009-11-26 2012-12-20 Solartium Entpr Ltd Uso di una combinazione per il trattamento delle mucositi indotte da radiazioni o da chemioterapici
CN101779750A (zh) * 2010-03-24 2010-07-21 舒世洪 一种乳猪教槽料及制备方法
WO2011127056A2 (en) 2010-04-05 2011-10-13 The Uab Research Foundation Biomarkers for assessing exposure to ionizing radiation and absorbed dose
WO2012020357A1 (en) 2010-08-09 2012-02-16 Advinus Therapeutics Ltd. Acetamide compounds, their process and pharmaceutical application
KR102069790B1 (ko) * 2010-09-24 2020-01-23 유니버시티 오브 플로리다 리서치 파운데이션, 인크. 위장 기능을 증진시키기 위한 물질 및 방법
US20120321729A1 (en) 2011-06-15 2012-12-20 Ven Subbiah Nutritional formula for managing chronic obstructive pulmonary disease (copd) and lung health
US8557301B2 (en) 2011-07-01 2013-10-15 Drip Drop, Inc. Oral rehydration composition
CN104093410B (zh) 2012-02-08 2018-04-27 佛罗里达大学研究基金会有限公司 用于治疗腹泻的物质和方法
WO2013151744A1 (en) 2012-04-05 2013-10-10 University Of Florida Research Foundation, Inc. Materials and methods for treatment of cystic fibrosis and for induction of ion secretion
EP3427730A1 (en) 2013-03-11 2019-01-16 University of Florida Research Foundation, Inc. Materials and methods for improving lung function
US20200269072A1 (en) 2016-01-06 2020-08-27 Parasonic Ltd. Device And Method For Damaging Parasites Using Ultrasonic Reflection
CA3135553C (en) 2016-10-04 2024-05-21 University Of Florida Research Foundation, Incorporated Amino acid compositions and uses thereof

Also Published As

Publication number Publication date
JP6000253B2 (ja) 2016-09-28
AP2013006826A0 (en) 2013-04-30
US20210196679A1 (en) 2021-07-01
IL277166A (en) 2020-10-29
KR20170084354A (ko) 2017-07-19
CA2809489C (en) 2017-10-24
EA030970B1 (ru) 2018-10-31
AU2015207919A1 (en) 2015-08-20
US11752132B2 (en) 2023-09-12
KR20180132974A (ko) 2018-12-12
KR20200009145A (ko) 2020-01-29
US10940137B2 (en) 2021-03-09
KR20130108308A (ko) 2013-10-02
KR101758424B1 (ko) 2017-07-14
CA2809489A1 (en) 2012-03-29
JP2013542195A (ja) 2013-11-21
CN103153298B (zh) 2015-11-25
ES2639888T3 (es) 2017-10-30
MX350541B (es) 2017-09-08
EP2624825A4 (en) 2014-02-19
CN105663106A (zh) 2016-06-15
EP3494969A1 (en) 2019-06-12
ES2805535T3 (es) 2021-02-12
EP3173079A1 (en) 2017-05-31
NZ607189A (en) 2015-04-24
EA030970B8 (ru) 2019-01-31
WO2012040707A3 (en) 2012-07-05
JP2019011361A (ja) 2019-01-24
JP6425356B2 (ja) 2018-11-21
AU2011305124A1 (en) 2013-03-14
JP2016222712A (ja) 2016-12-28
EP3970715A1 (en) 2022-03-23
EP3494969B1 (en) 2024-03-13
IL277166B (en) 2021-06-30
EP2624825B1 (en) 2017-06-14
US20190307724A1 (en) 2019-10-10
US10322109B2 (en) 2019-06-18
US8993522B2 (en) 2015-03-31
EP2624825A2 (en) 2013-08-14
AU2011305124B2 (en) 2015-04-30
US20120077748A1 (en) 2012-03-29
CN103153298A (zh) 2013-06-12
KR102205124B1 (ko) 2021-01-20
EP3173079B1 (en) 2020-04-22
MX2013003282A (es) 2013-05-09
SG188293A1 (en) 2013-04-30
US20150196534A1 (en) 2015-07-16
JP6698777B2 (ja) 2020-05-27
AU2015207919B2 (en) 2017-03-02
WO2012040707A2 (en) 2012-03-29
BR112013006044B1 (pt) 2022-03-29
KR102069790B1 (ko) 2020-01-23
US20190046504A1 (en) 2019-02-14
US20240024286A1 (en) 2024-01-25
BR112013006044A2 (pt) 2016-06-07

Similar Documents

Publication Publication Date Title
EA201300323A1 (ru) Материалы и способы улучшения функции желудочно-кишечного тракта
CL2013000018A1 (es) Compuestos derivados de indolizina , su procedimiento de preparacion; composicion farmaceutica; y uso en el tratamiento del cancer, entre otros.
EA201390803A1 (ru) Ингибиторы бромодомена и их применение
ECSP11011297A (es) Proteinas ligadoras il-17
EA201390682A1 (ru) Спирооксиндольные антагонисты mdm2
MX2013004061A (es) Analogos de ciclosporina.
CL2013000016A1 (es) Compuestos derivados de imidazopiridina; procedimiento de preparacion; composicion farmaceutica y su uso en el tratamiento del cancer.
MY162146A (en) Pharmaceutical composition
EA201491617A1 (ru) Соединения для лечения спинальной мышечной атрофии
EA201200951A1 (ru) Определенные триазолопиридины и триазолопиразины, их композиции и способы их применения
EA201290980A1 (ru) Производные 1-амино-2-циклопропилэтилбороновой кислоты
EA201370018A1 (ru) Составы рифаксимина и их применение
EA201201324A1 (ru) Профилактика колоректального и желудочно-кишечного рака
EA201290131A1 (ru) Производные пурина или деазапурина для применения при лечении вирусных инфекций и других заболеваний
CL2008000592A1 (es) Compuestos derivados de pirrol sustituido, supresores de la secrecion de acidos; composicion farmaceutica; y uso en el tratamiento o profilaxis en enfermedades tales como ulcera peptica, gastritis, esofagitis, entre otras.
EA201391030A1 (ru) Композиции моноциклина для местного применения и способы их применения
EA201391285A1 (ru) Производные тетрагидрохинолина, полезные в качестве ингибиторов бромодомена
EA201390274A1 (ru) Борсодержащие малые молекулы
UA110806C2 (ru) Микобактериальная антигенная композиция
EA201270703A1 (ru) Ингибиторы трипсиноподобных сериновых протеаз, их получение и применение
BRPI0912292A2 (pt) composições e métodos para o uso de células no tratamento do tecido cardíaco.
EA201171435A1 (ru) Твердые фармацевтические композиции и способы их получения
MX2013004062A (es) Analogos de ciclosporina.
ATE528013T1 (de) Impfstoff-zusammensetzungen
EA201400748A1 (ru) Композиция для обработки семян

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM