JP5956448B2 - 医薬組成物 - Google Patents

医薬組成物 Download PDF

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Publication number
JP5956448B2
JP5956448B2 JP2013530177A JP2013530177A JP5956448B2 JP 5956448 B2 JP5956448 B2 JP 5956448B2 JP 2013530177 A JP2013530177 A JP 2013530177A JP 2013530177 A JP2013530177 A JP 2013530177A JP 5956448 B2 JP5956448 B2 JP 5956448B2
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Japan
Prior art keywords
methyl
hydrogen
pharmaceutically acceptable
cancer
methoxy
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JP2013530177A
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Japanese (ja)
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JP2013538825A (ja
JP2013538825A5 (https=
Inventor
スパイヴィー，マーク
サトー，タカシ
カールソン，ジョナサン・エリック
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Eisai R&D Management Co Ltd
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Eisai R&D Management Co Ltd
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Publication of JP2013538825A5 publication Critical patent/JP2013538825A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2013530177A 2010-09-21 2011-09-12 医薬組成物 Active JP5956448B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38478110P 2010-09-21 2010-09-21
US61/384,781 2010-09-21
PCT/US2011/051163 WO2012039972A1 (en) 2010-09-21 2011-09-12 Pharmaceutical composition

Publications (3)

Publication Number Publication Date
JP2013538825A JP2013538825A (ja) 2013-10-17
JP2013538825A5 JP2013538825A5 (https=) 2014-10-30
JP5956448B2 true JP5956448B2 (ja) 2016-07-27

Family

ID=44674894

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013530177A Active JP5956448B2 (ja) 2010-09-21 2011-09-12 医薬組成物

Country Status (31)

Country Link
US (2) US8686018B2 (https=)
EP (2) EP2619182B1 (https=)
JP (1) JP5956448B2 (https=)
KR (1) KR101911105B1 (https=)
CN (1) CN103097358B (https=)
AU (1) AU2011305872B2 (https=)
BR (1) BR112013002484B1 (https=)
CA (1) CA2806121C (https=)
CL (1) CL2013000675A1 (https=)
CY (1) CY1118680T1 (https=)
DK (1) DK2619182T3 (https=)
ES (1) ES2610185T3 (https=)
HR (1) HRP20170042T1 (https=)
HU (1) HUE031408T2 (https=)
IL (1) IL224288A (https=)
LT (1) LT2619182T (https=)
ME (1) ME02575B (https=)
MX (1) MX2013003162A (https=)
MY (1) MY162146A (https=)
NZ (1) NZ606629A (https=)
PE (1) PE20131343A1 (https=)
PH (1) PH12013500467A1 (https=)
PL (1) PL2619182T3 (https=)
PT (1) PT2619182T (https=)
RS (1) RS55566B1 (https=)
RU (1) RU2606510C2 (https=)
SG (1) SG188188A1 (https=)
SI (1) SI2619182T1 (https=)
SM (2) SMT201700008T1 (https=)
UA (1) UA113499C2 (https=)
WO (1) WO2012039972A1 (https=)

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AR091429A1 (es) * 2012-06-29 2015-02-04 Lilly Co Eli Compuestos de fenoxietil piperidina
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TW201623277A (zh) 2014-03-26 2016-07-01 安斯泰來製藥股份有限公司 醯胺化合物
KR102535283B1 (ko) 2014-05-23 2023-05-22 에자이 알앤드디 매니지먼트 가부시키가이샤 암의 치료를 위한 조합 요법
TWI730959B (zh) 2015-05-19 2021-06-21 英商葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之雜環醯胺
EP3325490B1 (en) 2015-07-23 2019-12-18 Takeda Pharmaceutical Company Limited 1-substituted 1,2,3,4-tetrahydro-1,7-naphthyridin-8-amine derivatives and their use as ep4 receptor antagonists
BR112018007664B1 (pt) 2015-10-16 2023-12-19 Eisai R&D Management Co., Ltd Compostos antagonistas de ep4, composição compreendendo o composto e uso dos mesmos para tratar câncer
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
CN110621667A (zh) 2017-05-18 2019-12-27 爱杜西亚药品有限公司 嘧啶衍生物
PL3625228T3 (pl) 2017-05-18 2021-12-20 Idorsia Pharmaceuticals Ltd Pochodne pirymidyny jako modulatory receptora pge2
EA201992676A1 (ru) 2017-05-18 2020-05-06 Идорсия Фармасьютиклз Лтд Фенильные производные в качестве модуляторов pge2 рецепторов
CN110621671A (zh) 2017-05-18 2019-12-27 爱杜西亚药品有限公司 作为pge2受体调节剂的苯并呋喃及苯并噻吩衍生物
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KR102796877B1 (ko) * 2020-03-04 2025-04-15 우한 휴먼웰 이노베이티브 드러그 리서치 앤드 디벨롭먼트 센터 리미티드 컴퍼니 신규 ep4 길항제의 합성 및 암과 염증에서의 이의 용도
CN114075140A (zh) * 2020-08-18 2022-02-22 武汉人福创新药物研发中心有限公司 作为ep4受体拮抗剂的吡唑酰胺衍生物及其在癌症和炎症中的用途
US20230390303A1 (en) 2020-11-13 2023-12-07 Ono Pharmaceutical Co., Ltd. Cancer treatment by combination of ep4 antagonist and immune checkpoint inhibitor
TWI877433B (zh) 2020-11-30 2025-03-21 大陸商杭州阿諾生物醫藥科技有限公司 用於治療ｐｉｋ３ｃａ突變癌症的組合療法
CN114790176A (zh) * 2021-01-25 2022-07-26 武汉人福创新药物研发中心有限公司 咪唑类化合物及其制备方法和用途
US20240409516A1 (en) * 2021-01-28 2024-12-12 Shenzhen Zhongge Biological Technology Co., Ltd. Pyrazolamide derivative, preparation method therefor, and application thereof
TW202328073A (zh) * 2021-09-03 2023-07-16 大陸商武漢人福創新藥物研發中心有限公司 Ｅｐ４拮抗劑化合物及其鹽、多晶型及其製備方法和用途
CN115364222A (zh) * 2021-09-09 2022-11-22 首都医科大学附属北京地坛医院 Ep4受体抑制剂治疗肝纤维化的应用
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Also Published As

Publication number Publication date
PH12013500467A1 (en) 2013-04-29
CA2806121A1 (en) 2012-03-29
US20130237578A1 (en) 2013-09-12
MY162146A (en) 2017-05-31
SMT201700008T1 (it) 2017-03-08
ES2610185T3 (es) 2017-04-26
CA2806121C (en) 2018-10-09
AU2011305872B2 (en) 2015-03-26
EP2619182A1 (en) 2013-07-31
MX2013003162A (es) 2013-05-06
RS55566B1 (sr) 2017-05-31
US9000024B2 (en) 2015-04-07
SI2619182T1 (sl) 2017-03-31
EP3061751A1 (en) 2016-08-31
HRP20170042T1 (hr) 2017-03-10
PT2619182T (pt) 2017-01-17
CL2013000675A1 (es) 2013-07-05
CN103097358B (zh) 2015-04-08
US8686018B2 (en) 2014-04-01
CN103097358A (zh) 2013-05-08
JP2013538825A (ja) 2013-10-17
KR20130099008A (ko) 2013-09-05
WO2012039972A1 (en) 2012-03-29
NZ606629A (en) 2015-03-27
BR112013002484A2 (pt) 2016-05-31
HUE031408T2 (en) 2017-07-28
DK2619182T3 (en) 2017-01-30
IL224288A (en) 2015-02-26
KR101911105B1 (ko) 2018-10-23
SG188188A1 (en) 2013-04-30
RU2606510C2 (ru) 2017-01-10
CY1118680T1 (el) 2017-07-12
RU2013118209A (ru) 2014-10-27
AU2011305872A1 (en) 2013-01-31
PL2619182T3 (pl) 2017-03-31
UA113499C2 (xx) 2017-02-10
SMT201700008B (it) 2017-03-08
EP2619182B1 (en) 2016-11-09
LT2619182T (lt) 2017-01-25
ME02575B (me) 2017-06-20
BR112013002484B1 (pt) 2021-10-13
US20140155452A1 (en) 2014-06-05
PE20131343A1 (es) 2013-11-18

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