BR112013002484B1 - Composto, composição farmacêutica, e, usos de um composto - Google Patents

Composto, composição farmacêutica, e, usos de um composto Download PDF

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Publication number
BR112013002484B1
BR112013002484B1 BR112013002484-4A BR112013002484A BR112013002484B1 BR 112013002484 B1 BR112013002484 B1 BR 112013002484B1 BR 112013002484 A BR112013002484 A BR 112013002484A BR 112013002484 B1 BR112013002484 B1 BR 112013002484B1
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BR
Brazil
Prior art keywords
methyl
cancer
hydrogen
compound
pharmaceutically acceptable
Prior art date
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BR112013002484-4A
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English (en)
Portuguese (pt)
Other versions
BR112013002484A2 (pt
Inventor
Mark Spyvee
Takashi Satoh
Jonathan Eric Carlson
Original Assignee
Eisai R&D Management Co. , Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Management Co. , Ltd. filed Critical Eisai R&D Management Co. , Ltd.
Publication of BR112013002484A2 publication Critical patent/BR112013002484A2/pt
Publication of BR112013002484B1 publication Critical patent/BR112013002484B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BR112013002484-4A 2010-09-21 2011-09-12 Composto, composição farmacêutica, e, usos de um composto BR112013002484B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38478110P 2010-09-21 2010-09-21
US61/384781 2010-09-21
PCT/US2011/051163 WO2012039972A1 (en) 2010-09-21 2011-09-12 Pharmaceutical composition

Publications (2)

Publication Number Publication Date
BR112013002484A2 BR112013002484A2 (pt) 2016-05-31
BR112013002484B1 true BR112013002484B1 (pt) 2021-10-13

Family

ID=44674894

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013002484-4A BR112013002484B1 (pt) 2010-09-21 2011-09-12 Composto, composição farmacêutica, e, usos de um composto

Country Status (31)

Country Link
US (2) US8686018B2 (https=)
EP (2) EP2619182B1 (https=)
JP (1) JP5956448B2 (https=)
KR (1) KR101911105B1 (https=)
CN (1) CN103097358B (https=)
AU (1) AU2011305872B2 (https=)
BR (1) BR112013002484B1 (https=)
CA (1) CA2806121C (https=)
CL (1) CL2013000675A1 (https=)
CY (1) CY1118680T1 (https=)
DK (1) DK2619182T3 (https=)
ES (1) ES2610185T3 (https=)
HR (1) HRP20170042T1 (https=)
HU (1) HUE031408T2 (https=)
IL (1) IL224288A (https=)
LT (1) LT2619182T (https=)
ME (1) ME02575B (https=)
MX (1) MX2013003162A (https=)
MY (1) MY162146A (https=)
NZ (1) NZ606629A (https=)
PE (1) PE20131343A1 (https=)
PH (1) PH12013500467A1 (https=)
PL (1) PL2619182T3 (https=)
PT (1) PT2619182T (https=)
RS (1) RS55566B1 (https=)
RU (1) RU2606510C2 (https=)
SG (1) SG188188A1 (https=)
SI (1) SI2619182T1 (https=)
SM (2) SMT201700008T1 (https=)
UA (1) UA113499C2 (https=)
WO (1) WO2012039972A1 (https=)

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TWI730959B (zh) 2015-05-19 2021-06-21 英商葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之雜環醯胺
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BR112018007664B1 (pt) 2015-10-16 2023-12-19 Eisai R&D Management Co., Ltd Compostos antagonistas de ep4, composição compreendendo o composto e uso dos mesmos para tratar câncer
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TWI877433B (zh) 2020-11-30 2025-03-21 大陸商杭州阿諾生物醫藥科技有限公司 用於治療ｐｉｋ３ｃａ突變癌症的組合療法
CN114790176A (zh) * 2021-01-25 2022-07-26 武汉人福创新药物研发中心有限公司 咪唑类化合物及其制备方法和用途
US20240409516A1 (en) * 2021-01-28 2024-12-12 Shenzhen Zhongge Biological Technology Co., Ltd. Pyrazolamide derivative, preparation method therefor, and application thereof
TW202328073A (zh) * 2021-09-03 2023-07-16 大陸商武漢人福創新藥物研發中心有限公司 Ｅｐ４拮抗劑化合物及其鹽、多晶型及其製備方法和用途
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Also Published As

Publication number Publication date
PH12013500467A1 (en) 2013-04-29
CA2806121A1 (en) 2012-03-29
US20130237578A1 (en) 2013-09-12
MY162146A (en) 2017-05-31
SMT201700008T1 (it) 2017-03-08
ES2610185T3 (es) 2017-04-26
CA2806121C (en) 2018-10-09
AU2011305872B2 (en) 2015-03-26
EP2619182A1 (en) 2013-07-31
MX2013003162A (es) 2013-05-06
RS55566B1 (sr) 2017-05-31
US9000024B2 (en) 2015-04-07
SI2619182T1 (sl) 2017-03-31
EP3061751A1 (en) 2016-08-31
HRP20170042T1 (hr) 2017-03-10
PT2619182T (pt) 2017-01-17
CL2013000675A1 (es) 2013-07-05
CN103097358B (zh) 2015-04-08
US8686018B2 (en) 2014-04-01
CN103097358A (zh) 2013-05-08
JP2013538825A (ja) 2013-10-17
KR20130099008A (ko) 2013-09-05
WO2012039972A1 (en) 2012-03-29
NZ606629A (en) 2015-03-27
BR112013002484A2 (pt) 2016-05-31
HUE031408T2 (en) 2017-07-28
DK2619182T3 (en) 2017-01-30
IL224288A (en) 2015-02-26
KR101911105B1 (ko) 2018-10-23
SG188188A1 (en) 2013-04-30
RU2606510C2 (ru) 2017-01-10
CY1118680T1 (el) 2017-07-12
RU2013118209A (ru) 2014-10-27
AU2011305872A1 (en) 2013-01-31
JP5956448B2 (ja) 2016-07-27
PL2619182T3 (pl) 2017-03-31
UA113499C2 (xx) 2017-02-10
SMT201700008B (it) 2017-03-08
EP2619182B1 (en) 2016-11-09
LT2619182T (lt) 2017-01-25
ME02575B (me) 2017-06-20
US20140155452A1 (en) 2014-06-05
PE20131343A1 (es) 2013-11-18

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