JP5938082B2 - 紫斑を治療する組成物および方法 - Google Patents
紫斑を治療する組成物および方法 Download PDFInfo
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- JP5938082B2 JP5938082B2 JP2014214612A JP2014214612A JP5938082B2 JP 5938082 B2 JP5938082 B2 JP 5938082B2 JP 2014214612 A JP2014214612 A JP 2014214612A JP 2014214612 A JP2014214612 A JP 2014214612A JP 5938082 B2 JP5938082 B2 JP 5938082B2
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/4164—1,3-Diazoles
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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Description
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紫斑形成の1、3、4、6、11および13日後に、部位を臨床的および写真によって追跡した。α作動薬調製物の少なくとも1つによって治療した部位それぞれにおいて、紫斑の回復は非治療対照部位よりも迅速であった。この効果は、部位2(ナファゾリン0.03%)、部位4(フェニレフリン1.0%)、部位1(オキシメタゾリン0.05%)、および部位6(塩酸オキシメタゾリン0.05%+酒石酸ブリモニジン0.2%)で最も顕著であった。局部的または全身的副作用は見られず、特に、反跳紅斑または浮腫は認められなかった。
レーザエネルギーの送達前にα作動薬調製物の少なくとも1つによって治療した部位それぞれにおいて、形成された紫斑性斑/パッチは、非前処置部位よりも小さかった。紫斑の回復の時間経過も短縮された。この効果は、塩酸オキシメタゾリン0.05%、塩酸ナファゾリン0.03%、塩酸テトラヒドロゾリン0.05%、および塩酸フェニレフリン1.0%によって前処置した部位でより顕著であり、あまり顕著でないが、酒石酸ブリモニジン0.2%のみによって前処置した部位、および塩酸オキシメタゾリン0.05%+酒石酸ブリモニジン0.2%によって前処置した部位で見られた)。局部的または全身的副作用は見られず、特に、反跳紅斑または浮腫は認められなかった。
塩酸オキシメタゾリン0.05%液剤(塩酸オキシメタゾリン0.05%、塩化ベンザルコニウム液、エデト酸2ナトリウム、ポリエチレングリコール、ポビドン、プロピレングリコール、精製水、リン酸水素ナトリウム、リン酸2水素ナトリウム(0.005%)を含有する(Afrin(登録商標)Original 12 Hour Nasal Spray(Schering−Plough Healthcare Products))を、患者が左背側前腕に1日2回(朝および晩)適用した。液剤は、綿球を用いて手首から肘まで伸筋前腕全体の皮膚に適用した。部位を臨床的および写真によって追跡した。
Claims (11)
- 対象における紫斑を治療するための局所用医薬組成物であって、αアドレナリン受容体作動薬の治療的有効量を有し、前記αアドレナリン受容体作動薬がオキシメタゾリンまたは薬学的に許容可能なその塩であり、前記局所用医薬組成物が、液剤、ゲル、ローション、クリーム、軟膏、フォーム、乳剤、マイクロエマルジョン、ミルク、セラム、エアゾール、スプレー、分散剤、マイクロカプセル剤、ベシクルおよびその微粒子、石鹸、ならびにクレンジングバーから選択される薬理学的に許容される形で投与されるものである、上記組成物。
- 請求項1記載の局所用医薬組成物であって、前記局所用医薬組成物が前記対象の皮膚に投与され、または前記対象に局部的投与によって投与されるものである、上記組成物。
- 請求項1記載の局所用医薬組成物であって、前記局所用医薬組成物が、抗菌剤、駆虫剤、抗真菌剤、抗炎症剤、抗ヒスタミン薬、抗痒疹剤、麻酔薬、抗ウイルス剤、角質溶解剤、抗フリーラジカル剤、酸化防止剤、ビタミンK、ビタミンE、ビタミンC、ビタミンA、植物のスーパーオキシドジスムターゼ誘導体、セスキテルペンラクトン、抗脂漏剤、ふけ防止剤、抗ざ瘡剤、サンスクリーンおよび日光遮断剤、ならびにこれに限定されるものではないが、トレチノイン、レチノール、レチナール、アルファヒドロキシル酸、ベータヒドロキシル酸を含む、皮膚分化、増殖、および色素沈着の少なくとも1つを変更する活性剤、ならびにその組合せから選択される少なくとも1つの他の活性剤の治療的有効量と共に投与されるものである、上記組成物。
- 請求項1記載の局所用医薬組成物であって、対象における紫斑を外科的手法の前に低減するために使用され、前記αアドレナリン受容体作動薬の治療的有効量を含む前記局所用医薬組成物が、前記外科的手法の部位に投与される、上記組成物。
- 請求項4記載の局所用医薬組成物であって、前記局所用医薬組成物が前記外科的手法の前記部位に局所的投与によって投与され、または前記外科的手法の前記部位に局部的投与によって投与されるものである、上記組成物。
- 請求項4記載の局所用医薬組成物であって、前記局所用医薬組成物が、抗菌剤、駆虫剤、抗真菌剤、抗炎症剤、抗ヒスタミン薬、抗痒疹剤、麻酔薬、抗ウイルス剤、角質溶解剤、抗フリーラジカル剤、酸化防止剤、ビタミンK、ビタミンE、ビタミンC、ビタミンA、植物のスーパーオキシドジスムターゼ誘導体、セスキテルペンラクトン、抗脂漏剤、ふけ防止剤、抗ざ瘡剤、サンスクリーンおよび日光遮断剤、ならびにこれに限定されるものではないが、トレチノイン、レチノール、レチナール、アルファヒドロキシル酸、ベータヒドロキシル酸を含む、皮膚分化、増殖、および色素沈着の少なくとも1つを変更する活性剤、ならびにその組合せから選択される少なくとも1つの他の活性剤の治療的有効量と共に投与されるものである、上記組成物。
- 請求項4記載の局所用医薬組成物であって、前記外科的手法がレーザ治療である、上記組成物。
- 請求項4記載の局所用医薬組成物であって、前記局所用医薬組成物が、前記外科的手法の前、前記外科的手法の間、前記外科的手法の後、またはその組み合わせのときに投与されるものである、上記組成物。
- 請求項1記載の局所用医薬組成物であって、前記オキシメタゾリンまたは薬学的に許容可能なその塩が塩酸オキシメタゾリンである、上記組成物。
- 請求項1または9記載の局所用医薬組成物であって、前記オキシメタゾリンまたは薬学的に許容可能なその塩が前記局所用医薬組成物の0.05%〜1%の量で存在するものである、上記組成物。
- 請求項1または9記載の局所用医薬組成物であって、前記オキシメタゾリンまたは薬学的に許容可能なその塩が前記局所用医薬組成物の0.1%〜0.5%の量で存在するものである、上記組成物。
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US98856407P | 2007-11-16 | 2007-11-16 | |
US60/988,564 | 2007-11-16 |
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JP2010534258A Division JP5670196B2 (ja) | 2007-11-16 | 2008-11-17 | 紫斑を治療する組成物および方法 |
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JP2015071601A JP2015071601A (ja) | 2015-04-16 |
JP5938082B2 true JP5938082B2 (ja) | 2016-06-22 |
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JP2010534258A Active JP5670196B2 (ja) | 2007-11-16 | 2008-11-17 | 紫斑を治療する組成物および方法 |
JP2014214612A Active JP5938082B2 (ja) | 2007-11-16 | 2014-10-21 | 紫斑を治療する組成物および方法 |
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US (4) | US8114898B2 (ja) |
EP (3) | EP3498299A1 (ja) |
JP (2) | JP5670196B2 (ja) |
KR (1) | KR101577471B1 (ja) |
CN (1) | CN101896204B (ja) |
AU (1) | AU2008322411C1 (ja) |
BR (1) | BRPI0819075A2 (ja) |
CA (1) | CA2703109C (ja) |
DK (1) | DK2818184T3 (ja) |
ES (1) | ES2709120T3 (ja) |
HR (1) | HRP20190214T1 (ja) |
HU (1) | HUE042931T2 (ja) |
IL (1) | IL205704A (ja) |
MX (1) | MX2010005331A (ja) |
PL (1) | PL2818184T3 (ja) |
PT (1) | PT2818184T (ja) |
SI (1) | SI2818184T1 (ja) |
TR (1) | TR201901431T4 (ja) |
WO (1) | WO2009065116A1 (ja) |
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