JP5878757B2 - Ｆｇｆ２１変異体およびその使用 - Google Patents

Ｆｇｆ２１変異体およびその使用 Download PDF

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JP5878757B2
JP5878757B2 JP2011531178A JP2011531178A JP5878757B2 JP 5878757 B2 JP5878757 B2 JP 5878757B2 JP 2011531178 A JP2011531178 A JP 2011531178A JP 2011531178 A JP2011531178 A JP 2011531178A JP 5878757 B2 JP5878757 B2 JP 5878757B2
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polypeptide
fgf21
peg
composition
polyethylene glycol
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JP2012504965A5 (enExample
JP2012504965A (ja
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ウオーカー，ケネス・ダブリユ
ゲツグ，コリン・ブイ・ジユニア
ヘクト，ランデイー・アイ
ベロウスキ，エドワード・ジエイ
リー，ユエ−シヨン
マイケルズ，マーク・エル
シユイ，ジーン
エリソン，ムリール・エム
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アムジエン・インコーポレーテツド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2011531178A 2008-10-10 2009-10-08 Ｆｇｆ２１変異体およびその使用 Active JP5878757B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19576108P 2008-10-10 2008-10-10
US61/195,761 2008-10-10
PCT/US2009/060045 WO2010042747A2 (en) 2008-10-10 2009-10-08 Fgf21 mutants and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015075667A Division JP2015165801A (ja) 2008-10-10 2015-04-02 Ｆｇｆ２１変異体およびその使用

Publications (3)

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JP2012504965A JP2012504965A (ja) 2012-03-01
JP2012504965A5 JP2012504965A5 (enExample) 2012-11-22
JP5878757B2 true JP5878757B2 (ja) 2016-03-08

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JP2011531178A Active JP5878757B2 (ja) 2008-10-10 2009-10-08 Ｆｇｆ２１変異体およびその使用
JP2015075667A Pending JP2015165801A (ja) 2008-10-10 2015-04-02 Ｆｇｆ２１変異体およびその使用

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US (2) US9279013B2 (enExample)
EP (1) EP2358749B1 (enExample)
JP (2) JP5878757B2 (enExample)
KR (1) KR101651703B1 (enExample)
CN (1) CN102625811B (enExample)
AU (1) AU2009302318A1 (enExample)
CA (1) CA2739615C (enExample)
CL (1) CL2011000792A1 (enExample)
CO (1) CO6362020A2 (enExample)
CR (1) CR20110245A (enExample)
EA (2) EA032727B1 (enExample)
IL (1) IL212061A0 (enExample)
MA (1) MA32771B1 (enExample)
MX (1) MX341149B (enExample)
NZ (1) NZ592009A (enExample)
PE (1) PE20120021A1 (enExample)
SG (1) SG195542A1 (enExample)
TN (1) TN2011000161A1 (enExample)
UA (1) UA105016C2 (enExample)
WO (1) WO2010042747A2 (enExample)
ZA (1) ZA201103356B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018082699A (ja) * 2008-06-04 2018-05-31 アムジエン・インコーポレーテツド Ｆｇｆ２１突然変異体及びその使用

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