JP5871909B2 - 複素環化合物及びその用途 - Google Patents

複素環化合物及びその用途 Download PDF

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Publication number
JP5871909B2
JP5871909B2 JP2013510386A JP2013510386A JP5871909B2 JP 5871909 B2 JP5871909 B2 JP 5871909B2 JP 2013510386 A JP2013510386 A JP 2013510386A JP 2013510386 A JP2013510386 A JP 2013510386A JP 5871909 B2 JP5871909 B2 JP 5871909B2
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group
compound
reaction
methyl
optionally substituted
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Expired - Fee Related
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JP2013510386A
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English (en)
Japanese (ja)
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JP2013536798A5 (enExample
JP2013536798A (ja
Inventor
小池　竜樹
竜樹 小池
中村　実
実 中村
慶英 遠又
慶英 遠又
隆文 高井
隆文 高井
保孝 帆足
保孝 帆足
雄一 梶田
雄一 梶田
徹哉 塚本
徹哉 塚本
信 鎌田
鎌田　　信
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
Priority to JP2013510386A priority Critical patent/JP5871909B2/ja
Publication of JP2013536798A publication Critical patent/JP2013536798A/ja
Publication of JP2013536798A5 publication Critical patent/JP2013536798A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2013510386A 2010-09-02 2011-09-01 複素環化合物及びその用途 Expired - Fee Related JP5871909B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2013510386A JP5871909B2 (ja) 2010-09-02 2011-09-01 複素環化合物及びその用途

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2010197064 2010-09-02
JP2010197064 2010-09-02
JP2011143548 2011-06-28
JP2011143548 2011-06-28
PCT/JP2011/070419 WO2012029991A1 (en) 2010-09-02 2011-09-01 Fused triazoles for the treatment or prophylaxis of mild cognitive impairment
JP2013510386A JP5871909B2 (ja) 2010-09-02 2011-09-01 複素環化合物及びその用途

Publications (3)

Publication Number Publication Date
JP2013536798A JP2013536798A (ja) 2013-09-26
JP2013536798A5 JP2013536798A5 (enExample) 2014-10-16
JP5871909B2 true JP5871909B2 (ja) 2016-03-01

Family

ID=45094181

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013510386A Expired - Fee Related JP5871909B2 (ja) 2010-09-02 2011-09-01 複素環化合物及びその用途

Country Status (22)

Country Link
US (3) US8822699B2 (enExample)
EP (1) EP2611805A1 (enExample)
JP (1) JP5871909B2 (enExample)
KR (1) KR20130139895A (enExample)
CN (1) CN103249733A (enExample)
AR (1) AR082865A1 (enExample)
AU (1) AU2011296887A1 (enExample)
BR (1) BR112013004746A2 (enExample)
CA (1) CA2809779A1 (enExample)
CL (1) CL2013000575A1 (enExample)
DO (1) DOP2013000051A (enExample)
EA (1) EA201390333A1 (enExample)
EC (1) ECSP13012535A (enExample)
MA (1) MA34556B1 (enExample)
MX (1) MX2013002511A (enExample)
PE (1) PE20131305A1 (enExample)
PH (1) PH12013500403A1 (enExample)
SG (1) SG187917A1 (enExample)
TW (1) TW201213327A (enExample)
UY (1) UY33586A (enExample)
WO (1) WO2012029991A1 (enExample)
ZA (1) ZA201301929B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120142672A1 (en) * 2009-07-13 2012-06-07 Tatsuki Koike Heterocyclic compound and use thereof
UY33586A (es) * 2010-09-02 2012-03-30 Takeda Pharmaceutical Compuesto heterocíclico y sus usos
EP2687528A1 (en) * 2012-07-17 2014-01-22 Ares Trading S.A. Fused triazole derivatives as gamma secretase modulators
RU2563254C2 (ru) * 2013-07-08 2015-09-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ получения производных 7-(гетеро)арил-4,5,6,7-тетрагидро[1,2,3]триазоло[1,5-a]пиридина
RU2750293C2 (ru) * 2015-05-12 2021-06-25 ЭфЭмСи Корпорейшн Арилзамещенные бициклические соединения в качестве гербицидов
MY202326A (en) * 2017-09-14 2024-04-24 Daiichi Sankyo Co Ltd Compound having cyclic structure
US20210079182A1 (en) * 2019-09-12 2021-03-18 Dupont Electronics, Inc. Polyimide films and electronic devices
IL313039A (en) * 2021-12-17 2024-07-01 Athira Pharma Inc Uses of bicyclic compounds for the treatment of diseases
CN118047687A (zh) * 2024-01-29 2024-05-17 湖州澄博生物科技有限公司 一种用于对20（s）喜树碱结构进行修饰的化合物及其合成方法

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EP1261610A2 (en) 2000-02-17 2002-12-04 Bristol-Myers Squibb Pharma Company Succinoylamino carbocycles and heterocycles as inhibitors of a-beta protein production
CN102584813B (zh) 2003-05-14 2016-07-06 Ngc药物公司 化合物及其在调节淀粉样蛋白β中的用途
CA2539811A1 (en) * 2003-10-15 2005-04-28 Targacept, Inc. Azabicycyclic compounds for relieving pain and treating central nervous system disorders
EP2261218B1 (en) 2004-05-26 2013-04-03 Eisai R&D Management Co., Ltd. Imidazole compound for use as an intermediate in the production of cinnamide compounds
KR20070083781A (ko) 2004-10-26 2007-08-24 에자이 알앤드디 매니지먼트 가부시키가이샤 신나미드 화합물의 비정질체
JP2009523170A (ja) 2006-01-11 2009-06-18 メルク エンド カムパニー インコーポレーテッド 縮合トリアゾールタキキニン受容体アンダニスト
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
GEP20115139B (en) 2006-03-09 2011-01-10 Eisai R&D Man Co Ltd Polycyclic cinnamide derivative
TW200808800A (en) 2006-05-05 2008-02-16 Astrazeneca Ab MGluR5 modulators V
TW200835502A (en) 2006-12-26 2008-09-01 Daiichi Sankyo Co Ltd Thiazepine derivatives
US8143394B2 (en) 2006-12-26 2012-03-27 Gilead Sciences, Inc. Pyrido(3,2-d)pyrimidines useful for treating viral infections
WO2008097538A1 (en) 2007-02-08 2008-08-14 Merck & Co., Inc. Therapeutic agents
MX2010006243A (es) 2007-12-06 2010-08-31 Schering Corp Moduladores de gamma secretasa.
TW201030002A (en) * 2009-01-16 2010-08-16 Bristol Myers Squibb Co Bicyclic compounds for the reduction of beta-amyloid production
JP2010197064A (ja) 2009-02-23 2010-09-09 Chugoku Electric Power Co Inc:The 直下位置測定装置
JP2012051806A (ja) * 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd イミダゾリルピラジン誘導体
RU2515976C2 (ru) 2009-02-26 2014-05-20 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Азотсодержащие конденсированные гетероциклические соединения и их применение в качестве ингибиторов продукции бета-амилоида
JP2012051807A (ja) 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd アリールイミダゾール化合物
WO2011002067A1 (ja) 2009-07-02 2011-01-06 武田薬品工業株式会社 複素環化合物およびその用途
US20120142672A1 (en) * 2009-07-13 2012-06-07 Tatsuki Koike Heterocyclic compound and use thereof
WO2011006903A1 (en) 2009-07-15 2011-01-20 Ortho-Mcneil-Janssen Pharmaceuticals, Inc Substituted triazole and imidazole derivatives as gamma secretase modulators
US8637525B2 (en) 2009-07-31 2014-01-28 Bristol-Myers Squibb Company Compounds for the reduction of beta-amyloid production
TWI468402B (zh) 2009-07-31 2015-01-11 必治妥美雅史谷比公司 降低β－類澱粉生成之化合物
WO2011016559A1 (ja) 2009-08-07 2011-02-10 武田薬品工業株式会社 複素環化合物およびその用途
JP2011143548A (ja) 2010-01-12 2011-07-28 Panasonic Corp スクリーン印刷機及びスクリーン印刷方法
PH12012501381A1 (en) 2010-01-15 2012-10-22 Janssen Pharmaceuticals Inc Novel substituted bicyclic triazole derivatives as gamma secretase modulators
UY33586A (es) * 2010-09-02 2012-03-30 Takeda Pharmaceutical Compuesto heterocíclico y sus usos

Also Published As

Publication number Publication date
CN103249733A (zh) 2013-08-14
MX2013002511A (es) 2013-07-29
PE20131305A1 (es) 2013-10-31
WO2012029991A1 (en) 2012-03-08
SG187917A1 (en) 2013-04-30
CA2809779A1 (en) 2012-03-08
UY33586A (es) 2012-03-30
CL2013000575A1 (es) 2013-08-23
EP2611805A1 (en) 2013-07-10
EA201390333A1 (ru) 2013-08-30
US20130178497A1 (en) 2013-07-11
AU2011296887A1 (en) 2013-04-11
ECSP13012535A (es) 2013-06-28
AR082865A1 (es) 2013-01-16
US8822699B2 (en) 2014-09-02
US20120059030A1 (en) 2012-03-08
DOP2013000051A (es) 2013-04-30
TW201213327A (en) 2012-04-01
PH12013500403A1 (en) 2013-03-25
JP2013536798A (ja) 2013-09-26
MA34556B1 (fr) 2013-09-02
US20140350260A1 (en) 2014-11-27
KR20130139895A (ko) 2013-12-23
BR112013004746A2 (pt) 2016-06-07
US8901309B2 (en) 2014-12-02
ZA201301929B (en) 2013-11-27

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