JP5871909B2 - 複素環化合物及びその用途 - Google Patents

複素環化合物及びその用途 Download PDF

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Publication number
JP5871909B2
JP5871909B2 JP2013510386A JP2013510386A JP5871909B2 JP 5871909 B2 JP5871909 B2 JP 5871909B2 JP 2013510386 A JP2013510386 A JP 2013510386A JP 2013510386 A JP2013510386 A JP 2013510386A JP 5871909 B2 JP5871909 B2 JP 5871909B2
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Japan
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group
compound
reaction
methyl
optionally substituted
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JP2013510386A
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English (en)
Japanese (ja)
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JP2013536798A5 (enExample
JP2013536798A (ja
Inventor
小池　竜樹
竜樹 小池
中村　実
実 中村
慶英 遠又
慶英 遠又
隆文 高井
隆文 高井
保孝 帆足
保孝 帆足
雄一 梶田
雄一 梶田
徹哉 塚本
徹哉 塚本
信 鎌田
鎌田　　信
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
Priority to JP2013510386A priority Critical patent/JP5871909B2/ja
Publication of JP2013536798A publication Critical patent/JP2013536798A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2013510386A 2010-09-02 2011-09-01 複素環化合物及びその用途 Expired - Fee Related JP5871909B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2013510386A JP5871909B2 (ja) 2010-09-02 2011-09-01 複素環化合物及びその用途

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2010197064 2010-09-02
JP2010197064 2010-09-02
JP2011143548 2011-06-28
JP2011143548 2011-06-28
JP2013510386A JP5871909B2 (ja) 2010-09-02 2011-09-01 複素環化合物及びその用途
PCT/JP2011/070419 WO2012029991A1 (en) 2010-09-02 2011-09-01 Fused triazoles for the treatment or prophylaxis of mild cognitive impairment

Publications (3)

Publication Number Publication Date
JP2013536798A JP2013536798A (ja) 2013-09-26
JP2013536798A5 JP2013536798A5 (enExample) 2014-10-16
JP5871909B2 true JP5871909B2 (ja) 2016-03-01

Family

ID=45094181

Family Applications (1)

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JP2013510386A Expired - Fee Related JP5871909B2 (ja) 2010-09-02 2011-09-01 複素環化合物及びその用途

Country Status (22)

Country Link
US (3) US8822699B2 (enExample)
EP (1) EP2611805A1 (enExample)
JP (1) JP5871909B2 (enExample)
KR (1) KR20130139895A (enExample)
CN (1) CN103249733A (enExample)
AR (1) AR082865A1 (enExample)
AU (1) AU2011296887A1 (enExample)
BR (1) BR112013004746A2 (enExample)
CA (1) CA2809779A1 (enExample)
CL (1) CL2013000575A1 (enExample)
DO (1) DOP2013000051A (enExample)
EA (1) EA201390333A1 (enExample)
EC (1) ECSP13012535A (enExample)
MA (1) MA34556B1 (enExample)
MX (1) MX2013002511A (enExample)
PE (1) PE20131305A1 (enExample)
PH (1) PH12013500403A1 (enExample)
SG (1) SG187917A1 (enExample)
TW (1) TW201213327A (enExample)
UY (1) UY33586A (enExample)
WO (1) WO2012029991A1 (enExample)
ZA (1) ZA201301929B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011007756A1 (ja) * 2009-07-13 2011-01-20 武田薬品工業株式会社 複素環化合物及びその用途
US8822699B2 (en) * 2010-09-02 2014-09-02 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
EP2687528A1 (en) * 2012-07-17 2014-01-22 Ares Trading S.A. Fused triazole derivatives as gamma secretase modulators
RU2563254C2 (ru) * 2013-07-08 2015-09-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ получения производных 7-(гетеро)арил-4,5,6,7-тетрагидро[1,2,3]триазоло[1,5-a]пиридина
PL3294743T3 (pl) * 2015-05-12 2020-03-31 Fmc Corporation Podstawione arylem związki bicykliczne jako środki chwastobójcze
US20210079182A1 (en) * 2019-09-12 2021-03-18 Dupont Electronics, Inc. Polyimide films and electronic devices
WO2023114456A1 (en) * 2021-12-17 2023-06-22 Athira Pharma, Inc. Uses of bicyclic compounds for the treatment of diseases

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003523345A (ja) 2000-02-17 2003-08-05 ブリストル−マイヤーズ スクイブ ファーマ カンパニー Ａβタンパク質産生の阻害剤としてのスクシノイルアミノ炭素環および複素環
US7244739B2 (en) 2003-05-14 2007-07-17 Torreypines Therapeutics, Inc. Compounds and uses thereof in modulating amyloid beta
SI1678172T1 (sl) * 2003-10-15 2010-04-30 Targacept Inc AzabicikliŽŤne spojine za lajšanje boleŽŤine in zdravljenje motenj centralnega ĹľivŽŤnega sistema
US7667041B2 (en) 2004-05-26 2010-02-23 Eisai R&D Management Co., Ltd. Cinnamide compound
ATE458729T1 (de) 2004-10-26 2010-03-15 Eisai R&D Man Co Ltd Amorphe form einer zimtsäureamidverbindung
EP1976527A4 (en) 2006-01-11 2009-04-22 Merck & Co Inc CONDENSED TRIAZOL TACHYKININE RECEPTOR ANTAGONISTS
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
PL1992618T3 (pl) * 2006-03-09 2012-06-29 Eisai R&D Man Co Ltd Policykliczna pochodna cynamidowa
TW200808800A (en) 2006-05-05 2008-02-16 Astrazeneca Ab MGluR5 modulators V
EP2119719A1 (en) 2006-12-26 2009-11-18 Daiichi Sankyo Company, Limited Thiazepine derivative
WO2008077649A1 (en) 2006-12-26 2008-07-03 Gilead Sciences, Inc. Pyrido(3,2-d)pyrimidines useful for treating viral infectons
CA2677296A1 (en) 2007-02-08 2008-08-14 Merck & Co., Inc. Therapeutic agents
CA2707712A1 (en) 2007-12-06 2009-06-11 Schering Corporation Gamma secretase modulators
TW201030002A (en) 2009-01-16 2010-08-16 Bristol Myers Squibb Co Bicyclic compounds for the reduction of beta-amyloid production
JP2010197064A (ja) 2009-02-23 2010-09-09 Chugoku Electric Power Co Inc:The 直下位置測定装置
JP2012051806A (ja) 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd イミダゾリルピラジン誘導体
EP2401276B1 (en) * 2009-02-26 2013-06-05 Eisai R&D Management Co., Ltd. Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors
JP2012051807A (ja) 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd アリールイミダゾール化合物
WO2011002067A1 (ja) 2009-07-02 2011-01-06 武田薬品工業株式会社 複素環化合物およびその用途
WO2011007756A1 (ja) 2009-07-13 2011-01-20 武田薬品工業株式会社 複素環化合物及びその用途
NZ597505A (en) 2009-07-15 2013-05-31 Janssen Pharmaceuticals Inc Substituted triazole and imidazole derivatives as gamma secretase modulators
US8637525B2 (en) 2009-07-31 2014-01-28 Bristol-Myers Squibb Company Compounds for the reduction of beta-amyloid production
TWI468402B (zh) 2009-07-31 2015-01-11 必治妥美雅史谷比公司 降低β－類澱粉生成之化合物
WO2011016559A1 (ja) 2009-08-07 2011-02-10 武田薬品工業株式会社 複素環化合物およびその用途
JP2011143548A (ja) 2010-01-12 2011-07-28 Panasonic Corp スクリーン印刷機及びスクリーン印刷方法
US9145399B2 (en) 2010-01-15 2015-09-29 Janssen Pharmaceuticals, Inc. Substituted bicyclic triazole derivatives as gamma secretase modulators
US8822699B2 (en) * 2010-09-02 2014-09-02 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof

Also Published As

Publication number Publication date
PH12013500403A1 (en) 2013-03-25
SG187917A1 (en) 2013-04-30
KR20130139895A (ko) 2013-12-23
MX2013002511A (es) 2013-07-29
AU2011296887A1 (en) 2013-04-11
ZA201301929B (en) 2013-11-27
UY33586A (es) 2012-03-30
DOP2013000051A (es) 2013-04-30
EA201390333A1 (ru) 2013-08-30
CL2013000575A1 (es) 2013-08-23
US20130178497A1 (en) 2013-07-11
CN103249733A (zh) 2013-08-14
CA2809779A1 (en) 2012-03-08
AR082865A1 (es) 2013-01-16
US8901309B2 (en) 2014-12-02
US8822699B2 (en) 2014-09-02
WO2012029991A1 (en) 2012-03-08
EP2611805A1 (en) 2013-07-10
TW201213327A (en) 2012-04-01
US20120059030A1 (en) 2012-03-08
BR112013004746A2 (pt) 2016-06-07
MA34556B1 (fr) 2013-09-02
ECSP13012535A (es) 2013-06-28
US20140350260A1 (en) 2014-11-27
JP2013536798A (ja) 2013-09-26
PE20131305A1 (es) 2013-10-31

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