EA201390333A1 - Конденсированные триазолы для лечения или профилактики умеренного когнитивного нарушения - Google Patents
Конденсированные триазолы для лечения или профилактики умеренного когнитивного нарушенияInfo
- Publication number
- EA201390333A1 EA201390333A1 EA201390333A EA201390333A EA201390333A1 EA 201390333 A1 EA201390333 A1 EA 201390333A1 EA 201390333 A EA201390333 A EA 201390333A EA 201390333 A EA201390333 A EA 201390333A EA 201390333 A1 EA201390333 A1 EA 201390333A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- breach
- prevention
- treatment
- moderate cognitive
- triazoles
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
В рассматриваемом изобретении предложены гетероциклические производные, обладающие превосходной активностью ингибирования продуцирования β-амилоида и/или превосходной активностью модулирования γ-секретазы, и их использование. Соединение, представленное формулой (I)где каждый из символов имеет указанные в настоящем описании значения, или его соль.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010197064 | 2010-09-02 | ||
JP2011143548 | 2011-06-28 | ||
PCT/JP2011/070419 WO2012029991A1 (en) | 2010-09-02 | 2011-09-01 | Fused triazoles for the treatment or prophylaxis of mild cognitive impairment |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201390333A1 true EA201390333A1 (ru) | 2013-08-30 |
Family
ID=45094181
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201390333A EA201390333A1 (ru) | 2010-09-02 | 2011-09-01 | Конденсированные триазолы для лечения или профилактики умеренного когнитивного нарушения |
Country Status (21)
Country | Link |
---|---|
US (3) | US8822699B2 (ru) |
EP (1) | EP2611805A1 (ru) |
JP (1) | JP5871909B2 (ru) |
KR (1) | KR20130139895A (ru) |
CN (1) | CN103249733A (ru) |
AR (1) | AR082865A1 (ru) |
AU (1) | AU2011296887A1 (ru) |
BR (1) | BR112013004746A2 (ru) |
CA (1) | CA2809779A1 (ru) |
CL (1) | CL2013000575A1 (ru) |
DO (1) | DOP2013000051A (ru) |
EA (1) | EA201390333A1 (ru) |
EC (1) | ECSP13012535A (ru) |
MA (1) | MA34556B1 (ru) |
MX (1) | MX2013002511A (ru) |
PE (1) | PE20131305A1 (ru) |
SG (1) | SG187917A1 (ru) |
TW (1) | TW201213327A (ru) |
UY (1) | UY33586A (ru) |
WO (1) | WO2012029991A1 (ru) |
ZA (1) | ZA201301929B (ru) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPWO2011007756A1 (ja) * | 2009-07-13 | 2012-12-27 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
PE20131305A1 (es) * | 2010-09-02 | 2013-10-31 | Takeda Pharmaceutical | Compuesto heterociclico y sus usos |
EP2687528A1 (en) * | 2012-07-17 | 2014-01-22 | Ares Trading S.A. | Fused triazole derivatives as gamma secretase modulators |
RU2563254C2 (ru) * | 2013-07-08 | 2015-09-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Способ получения производных 7-(гетеро)арил-4,5,6,7-тетрагидро[1,2,3]триазоло[1,5-a]пиридина |
CN107592862B (zh) * | 2015-05-12 | 2021-06-15 | Fmc公司 | 作为除草剂的芳基取代的双环化合物 |
US20210079182A1 (en) * | 2019-09-12 | 2021-03-18 | Dupont Electronics, Inc. | Polyimide films and electronic devices |
KR20240121239A (ko) * | 2021-12-17 | 2024-08-08 | 아티라 파마, 인코포레이티드 | 질환 치료를 위한 이환식 화합물의 용도 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1261610A2 (en) | 2000-02-17 | 2002-12-04 | Bristol-Myers Squibb Pharma Company | Succinoylamino carbocycles and heterocycles as inhibitors of a-beta protein production |
MXPA05012281A (es) | 2003-05-14 | 2006-05-19 | Torreypines Therapeutics Inc | Compuestos y uso de los mismos en la modulacion beta amiloide. |
CA2539811A1 (en) * | 2003-10-15 | 2005-04-28 | Targacept, Inc. | Azabicycyclic compounds for relieving pain and treating central nervous system disorders |
KR101128065B1 (ko) | 2004-05-26 | 2012-04-12 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 신나미드 화합물 |
EP1808432B1 (en) | 2004-10-26 | 2010-02-24 | Eisai R&D Management Co., Ltd. | Amorphous form of cinnamide compound |
EP1976527A4 (en) | 2006-01-11 | 2009-04-22 | Merck & Co Inc | CONDENSED TRIAZOL TACHYKININE RECEPTOR ANTAGONISTS |
WO2007102580A1 (ja) * | 2006-03-09 | 2007-09-13 | Eisai R & D Management Co., Ltd. | 多環式シンナミド誘導体 |
TWI378091B (en) | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
TW200808800A (en) | 2006-05-05 | 2008-02-16 | Astrazeneca Ab | MGluR5 modulators V |
EP2119719A1 (en) | 2006-12-26 | 2009-11-18 | Daiichi Sankyo Company, Limited | Thiazepine derivative |
WO2008077649A1 (en) | 2006-12-26 | 2008-07-03 | Gilead Sciences, Inc. | Pyrido(3,2-d)pyrimidines useful for treating viral infectons |
EP2117311A4 (en) | 2007-02-08 | 2011-05-11 | Merck Sharp & Dohme | THERAPEUTICS |
MX2010006243A (es) | 2007-12-06 | 2010-08-31 | Schering Corp | Moduladores de gamma secretasa. |
TW201030002A (en) | 2009-01-16 | 2010-08-16 | Bristol Myers Squibb Co | Bicyclic compounds for the reduction of beta-amyloid production |
JP2010197064A (ja) | 2009-02-23 | 2010-09-09 | Chugoku Electric Power Co Inc:The | 直下位置測定装置 |
JP2012051806A (ja) * | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | イミダゾリルピラジン誘導体 |
JP2012051807A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | アリールイミダゾール化合物 |
MX2011008501A (es) | 2009-02-26 | 2011-09-01 | Eisai R&D Man Co Ltd | Compuestos heterociclicos fusionados que contienen nitrogeno y su uso como inhibidores de la produccion de beta-amiloide. |
WO2011002067A1 (ja) | 2009-07-02 | 2011-01-06 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
JPWO2011007756A1 (ja) | 2009-07-13 | 2012-12-27 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
US8946266B2 (en) | 2009-07-15 | 2015-02-03 | Janssen Pharmaceuticals, Inc. | Substituted triazole and imidazole derivatives as gamma secretase modulators |
TWI468402B (zh) | 2009-07-31 | 2015-01-11 | 必治妥美雅史谷比公司 | 降低β-類澱粉生成之化合物 |
US8637525B2 (en) | 2009-07-31 | 2014-01-28 | Bristol-Myers Squibb Company | Compounds for the reduction of beta-amyloid production |
WO2011016559A1 (ja) | 2009-08-07 | 2011-02-10 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
JP2011143548A (ja) | 2010-01-12 | 2011-07-28 | Panasonic Corp | スクリーン印刷機及びスクリーン印刷方法 |
BR112012017310A2 (pt) | 2010-01-15 | 2016-04-19 | Janssen Pharmaceuticals Inc | derivados de triazol substituídos como moduladores de gama secretase |
PE20131305A1 (es) * | 2010-09-02 | 2013-10-31 | Takeda Pharmaceutical | Compuesto heterociclico y sus usos |
-
2011
- 2011-09-01 PE PE2013000360A patent/PE20131305A1/es not_active Application Discontinuation
- 2011-09-01 JP JP2013510386A patent/JP5871909B2/ja not_active Expired - Fee Related
- 2011-09-01 SG SG2013012604A patent/SG187917A1/en unknown
- 2011-09-01 TW TW100131443A patent/TW201213327A/zh unknown
- 2011-09-01 CN CN2011800518621A patent/CN103249733A/zh active Pending
- 2011-09-01 EP EP11791058.8A patent/EP2611805A1/en not_active Withdrawn
- 2011-09-01 AU AU2011296887A patent/AU2011296887A1/en not_active Abandoned
- 2011-09-01 UY UY0001033586A patent/UY33586A/es unknown
- 2011-09-01 MA MA35785A patent/MA34556B1/fr unknown
- 2011-09-01 EA EA201390333A patent/EA201390333A1/ru unknown
- 2011-09-01 WO PCT/JP2011/070419 patent/WO2012029991A1/en active Application Filing
- 2011-09-01 KR KR1020137008170A patent/KR20130139895A/ko not_active Application Discontinuation
- 2011-09-01 AR ARP110103195A patent/AR082865A1/es unknown
- 2011-09-01 MX MX2013002511A patent/MX2013002511A/es not_active Application Discontinuation
- 2011-09-01 US US13/223,455 patent/US8822699B2/en not_active Expired - Fee Related
- 2011-09-01 US US13/819,239 patent/US8901309B2/en not_active Expired - Fee Related
- 2011-09-01 BR BR112013004746A patent/BR112013004746A2/pt not_active IP Right Cessation
- 2011-09-01 CA CA2809779A patent/CA2809779A1/en not_active Abandoned
-
2013
- 2013-02-28 CL CL2013000575A patent/CL2013000575A1/es unknown
- 2013-03-01 DO DO2013000051A patent/DOP2013000051A/es unknown
- 2013-03-14 ZA ZA2013/01929A patent/ZA201301929B/en unknown
- 2013-03-28 EC ECSP13012535 patent/ECSP13012535A/es unknown
-
2014
- 2014-08-08 US US14/454,993 patent/US20140350260A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CL2013000575A1 (es) | 2013-08-23 |
US8901309B2 (en) | 2014-12-02 |
ZA201301929B (en) | 2013-11-27 |
SG187917A1 (en) | 2013-04-30 |
PE20131305A1 (es) | 2013-10-31 |
JP5871909B2 (ja) | 2016-03-01 |
BR112013004746A2 (pt) | 2016-06-07 |
ECSP13012535A (es) | 2013-06-28 |
EP2611805A1 (en) | 2013-07-10 |
KR20130139895A (ko) | 2013-12-23 |
UY33586A (es) | 2012-03-30 |
US20140350260A1 (en) | 2014-11-27 |
TW201213327A (en) | 2012-04-01 |
AU2011296887A1 (en) | 2013-04-11 |
CA2809779A1 (en) | 2012-03-08 |
DOP2013000051A (es) | 2013-04-30 |
US20130178497A1 (en) | 2013-07-11 |
US8822699B2 (en) | 2014-09-02 |
US20120059030A1 (en) | 2012-03-08 |
CN103249733A (zh) | 2013-08-14 |
WO2012029991A1 (en) | 2012-03-08 |
AR082865A1 (es) | 2013-01-16 |
MX2013002511A (es) | 2013-07-29 |
JP2013536798A (ja) | 2013-09-26 |
MA34556B1 (fr) | 2013-09-02 |
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