EA201390333A1 - Конденсированные триазолы для лечения или профилактики умеренного когнитивного нарушения - Google Patents

Конденсированные триазолы для лечения или профилактики умеренного когнитивного нарушения

Info

Publication number
EA201390333A1
EA201390333A1 EA201390333A EA201390333A EA201390333A1 EA 201390333 A1 EA201390333 A1 EA 201390333A1 EA 201390333 A EA201390333 A EA 201390333A EA 201390333 A EA201390333 A EA 201390333A EA 201390333 A1 EA201390333 A1 EA 201390333A1
Authority
EA
Eurasian Patent Office
Prior art keywords
breach
prevention
treatment
moderate cognitive
triazoles
Prior art date
Application number
EA201390333A
Other languages
English (en)
Inventor
Тацуки Койке
Минору Накамура
Есихиде Томата
Такафуми Такаи
Ясутака Хоаси
Юити Кадзита
Тецуя Цукамото
Макото Камата
Original Assignee
Такеда Фармасьютикал Компани Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45094181&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201390333(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Такеда Фармасьютикал Компани Лимитед filed Critical Такеда Фармасьютикал Компани Лимитед
Publication of EA201390333A1 publication Critical patent/EA201390333A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

В рассматриваемом изобретении предложены гетероциклические производные, обладающие превосходной активностью ингибирования продуцирования β-амилоида и/или превосходной активностью модулирования γ-секретазы, и их использование. Соединение, представленное формулой (I)где каждый из символов имеет указанные в настоящем описании значения, или его соль.
EA201390333A 2010-09-02 2011-09-01 Конденсированные триазолы для лечения или профилактики умеренного когнитивного нарушения EA201390333A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2010197064 2010-09-02
JP2011143548 2011-06-28
PCT/JP2011/070419 WO2012029991A1 (en) 2010-09-02 2011-09-01 Fused triazoles for the treatment or prophylaxis of mild cognitive impairment

Publications (1)

Publication Number Publication Date
EA201390333A1 true EA201390333A1 (ru) 2013-08-30

Family

ID=45094181

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201390333A EA201390333A1 (ru) 2010-09-02 2011-09-01 Конденсированные триазолы для лечения или профилактики умеренного когнитивного нарушения

Country Status (21)

Country Link
US (3) US8822699B2 (ru)
EP (1) EP2611805A1 (ru)
JP (1) JP5871909B2 (ru)
KR (1) KR20130139895A (ru)
CN (1) CN103249733A (ru)
AR (1) AR082865A1 (ru)
AU (1) AU2011296887A1 (ru)
BR (1) BR112013004746A2 (ru)
CA (1) CA2809779A1 (ru)
CL (1) CL2013000575A1 (ru)
DO (1) DOP2013000051A (ru)
EA (1) EA201390333A1 (ru)
EC (1) ECSP13012535A (ru)
MA (1) MA34556B1 (ru)
MX (1) MX2013002511A (ru)
PE (1) PE20131305A1 (ru)
SG (1) SG187917A1 (ru)
TW (1) TW201213327A (ru)
UY (1) UY33586A (ru)
WO (1) WO2012029991A1 (ru)
ZA (1) ZA201301929B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2011007756A1 (ja) * 2009-07-13 2012-12-27 武田薬品工業株式会社 複素環化合物及びその用途
PE20131305A1 (es) * 2010-09-02 2013-10-31 Takeda Pharmaceutical Compuesto heterociclico y sus usos
EP2687528A1 (en) * 2012-07-17 2014-01-22 Ares Trading S.A. Fused triazole derivatives as gamma secretase modulators
RU2563254C2 (ru) * 2013-07-08 2015-09-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ получения производных 7-(гетеро)арил-4,5,6,7-тетрагидро[1,2,3]триазоло[1,5-a]пиридина
CN107592862B (zh) * 2015-05-12 2021-06-15 Fmc公司 作为除草剂的芳基取代的双环化合物
US20210079182A1 (en) * 2019-09-12 2021-03-18 Dupont Electronics, Inc. Polyimide films and electronic devices
KR20240121239A (ko) * 2021-12-17 2024-08-08 아티라 파마, 인코포레이티드 질환 치료를 위한 이환식 화합물의 용도

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EP1261610A2 (en) 2000-02-17 2002-12-04 Bristol-Myers Squibb Pharma Company Succinoylamino carbocycles and heterocycles as inhibitors of a-beta protein production
MXPA05012281A (es) 2003-05-14 2006-05-19 Torreypines Therapeutics Inc Compuestos y uso de los mismos en la modulacion beta amiloide.
CA2539811A1 (en) * 2003-10-15 2005-04-28 Targacept, Inc. Azabicycyclic compounds for relieving pain and treating central nervous system disorders
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EP1808432B1 (en) 2004-10-26 2010-02-24 Eisai R&D Management Co., Ltd. Amorphous form of cinnamide compound
EP1976527A4 (en) 2006-01-11 2009-04-22 Merck & Co Inc CONDENSED TRIAZOL TACHYKININE RECEPTOR ANTAGONISTS
WO2007102580A1 (ja) * 2006-03-09 2007-09-13 Eisai R & D Management Co., Ltd. 多環式シンナミド誘導体
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
TW200808800A (en) 2006-05-05 2008-02-16 Astrazeneca Ab MGluR5 modulators V
EP2119719A1 (en) 2006-12-26 2009-11-18 Daiichi Sankyo Company, Limited Thiazepine derivative
WO2008077649A1 (en) 2006-12-26 2008-07-03 Gilead Sciences, Inc. Pyrido(3,2-d)pyrimidines useful for treating viral infectons
EP2117311A4 (en) 2007-02-08 2011-05-11 Merck Sharp & Dohme THERAPEUTICS
MX2010006243A (es) 2007-12-06 2010-08-31 Schering Corp Moduladores de gamma secretasa.
TW201030002A (en) 2009-01-16 2010-08-16 Bristol Myers Squibb Co Bicyclic compounds for the reduction of beta-amyloid production
JP2010197064A (ja) 2009-02-23 2010-09-09 Chugoku Electric Power Co Inc:The 直下位置測定装置
JP2012051806A (ja) * 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd イミダゾリルピラジン誘導体
JP2012051807A (ja) 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd アリールイミダゾール化合物
MX2011008501A (es) 2009-02-26 2011-09-01 Eisai R&D Man Co Ltd Compuestos heterociclicos fusionados que contienen nitrogeno y su uso como inhibidores de la produccion de beta-amiloide.
WO2011002067A1 (ja) 2009-07-02 2011-01-06 武田薬品工業株式会社 複素環化合物およびその用途
JPWO2011007756A1 (ja) 2009-07-13 2012-12-27 武田薬品工業株式会社 複素環化合物及びその用途
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PE20131305A1 (es) * 2010-09-02 2013-10-31 Takeda Pharmaceutical Compuesto heterociclico y sus usos

Also Published As

Publication number Publication date
CL2013000575A1 (es) 2013-08-23
US8901309B2 (en) 2014-12-02
ZA201301929B (en) 2013-11-27
SG187917A1 (en) 2013-04-30
PE20131305A1 (es) 2013-10-31
JP5871909B2 (ja) 2016-03-01
BR112013004746A2 (pt) 2016-06-07
ECSP13012535A (es) 2013-06-28
EP2611805A1 (en) 2013-07-10
KR20130139895A (ko) 2013-12-23
UY33586A (es) 2012-03-30
US20140350260A1 (en) 2014-11-27
TW201213327A (en) 2012-04-01
AU2011296887A1 (en) 2013-04-11
CA2809779A1 (en) 2012-03-08
DOP2013000051A (es) 2013-04-30
US20130178497A1 (en) 2013-07-11
US8822699B2 (en) 2014-09-02
US20120059030A1 (en) 2012-03-08
CN103249733A (zh) 2013-08-14
WO2012029991A1 (en) 2012-03-08
AR082865A1 (es) 2013-01-16
MX2013002511A (es) 2013-07-29
JP2013536798A (ja) 2013-09-26
MA34556B1 (fr) 2013-09-02

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