EA201200102A1 - Соединения, применимые в качестве лекарственных средств - Google Patents

Соединения, применимые в качестве лекарственных средств

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Publication number
EA201200102A1
EA201200102A1 EA201200102A EA201200102A EA201200102A1 EA 201200102 A1 EA201200102 A1 EA 201200102A1 EA 201200102 A EA201200102 A EA 201200102A EA 201200102 A EA201200102 A EA 201200102A EA 201200102 A1 EA201200102 A1 EA 201200102A1
Authority
EA
Eurasian Patent Office
Prior art keywords
medicine
compounds applicable
compounds
applicable
useful
Prior art date
Application number
EA201200102A
Other languages
English (en)
Other versions
EA026674B1 (ru
Inventor
Якоб Вестман
Аллан Халлет
Ян Вагберг
Original Assignee
Балтик Био Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Балтик Био Аб filed Critical Балтик Био Аб
Publication of EA201200102A1 publication Critical patent/EA201200102A1/ru
Publication of EA026674B1 publication Critical patent/EA026674B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Согласно настоящему изобретению предоставляется соединение формулы Iгде X, W, A-Аи D являются такими, как указано в раскрытии изобретения, где данные соединения являются пригодными для лечения рака.
EA201200102A 2009-07-08 2010-07-08 Соединения, применимые в качестве лекарственных средств EA026674B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21373509P 2009-07-08 2009-07-08
PCT/GB2010/001315 WO2011004162A2 (en) 2009-07-08 2010-07-08 Compounds useful as medicaments

Publications (2)

Publication Number Publication Date
EA201200102A1 true EA201200102A1 (ru) 2012-08-30
EA026674B1 EA026674B1 (ru) 2017-05-31

Family

ID=43086401

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201200102A EA026674B1 (ru) 2009-07-08 2010-07-08 Соединения, применимые в качестве лекарственных средств

Country Status (25)

Country Link
US (2) US9162994B2 (ru)
EP (1) EP2451794B1 (ru)
JP (1) JP5982281B2 (ru)
KR (1) KR101765957B1 (ru)
CN (1) CN102596923B (ru)
AU (1) AU2010270030B2 (ru)
BR (1) BR112012000370B1 (ru)
CA (1) CA2767291C (ru)
DK (1) DK2451794T3 (ru)
EA (1) EA026674B1 (ru)
ES (1) ES2567753T3 (ru)
HK (1) HK1170485A1 (ru)
HR (1) HRP20160353T1 (ru)
HU (1) HUE027263T2 (ru)
IL (1) IL216723A (ru)
ME (1) ME02443B (ru)
MX (1) MX337516B (ru)
NZ (1) NZ597075A (ru)
PL (1) PL2451794T3 (ru)
RS (1) RS54718B1 (ru)
SG (1) SG177558A1 (ru)
SI (1) SI2451794T1 (ru)
SM (1) SMT201600225B (ru)
WO (1) WO2011004162A2 (ru)
ZA (1) ZA201108901B (ru)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100931145B1 (ko) * 2008-07-04 2009-12-10 현대자동차주식회사 조정식 킥 다운 스위치의 조작기구
WO2013108026A1 (en) 2012-01-17 2013-07-25 Baltic Bio Ab Thiadiazolone derivatives useful in the treatment of diabetes
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
US9394285B2 (en) 2013-03-15 2016-07-19 Pfizer Inc. Indole and indazole compounds that activate AMPK
GB201308325D0 (en) * 2013-05-09 2013-06-19 Immodulon Therapeutics Ltd Cancer Therapy
WO2017210545A1 (en) 2016-06-02 2017-12-07 Cadent Therapeutics, Inc. Potassium channel modulators
CA3026784A1 (en) 2016-06-07 2017-12-14 Jacobio Pharmaceuticals Co., Ltd. Heterocyclic pyrazine derivatives useful as shp2 inhibitors
UA123810C2 (uk) 2017-01-23 2021-06-02 Цадент Терапеутікс, Інк. Модулятори калієвих каналів
WO2018172984A1 (en) 2017-03-23 2018-09-27 Jacobio Pharmaceuticals Co., Ltd. Novel heterocyclic derivatives useful as shp2 inhibitors
WO2020095010A1 (en) 2018-11-05 2020-05-14 Balticgruppen Bio Ab Methods of treating diabetes in severe insulin-resistant diabetic subjects
CN109879808B (zh) * 2019-03-05 2020-10-16 北京工业大学 一种含五元唑类杂环基查尔酮类衍生物及制备方法和医药用途
GB201910092D0 (en) 2019-07-15 2019-08-28 Balticgruppen Bio Ab New formulations
GB201910093D0 (en) 2019-07-15 2019-08-28 Balticgruppen Bio Ab New formulations
GB201915094D0 (en) * 2019-10-18 2019-12-04 Balticgruppen Bio Ab New formulations
US11691954B2 (en) * 2019-10-18 2023-07-04 Betagenon Ab Formulations
GB202015585D0 (en) 2020-10-01 2020-11-18 Betagenon Bio Ab New compounds
GB202100352D0 (en) 2021-01-12 2021-02-24 Balticgruppen Bio Ab New methods
GB202112529D0 (en) 2021-09-02 2021-10-20 Betagenon Bio Ab New compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4093624A (en) 1977-01-31 1978-06-06 Icn Pharmaceuticals, Inc. 1,2,4-Thiadiazolidine-3,5-dione
ES2166328B1 (es) * 2000-05-11 2003-09-16 Consejo Superior Investigacion Inhibidores heterociclicos del enzima gsk 3 utiles en el tratamiento de procesos neurodegenerativos e hiperproliferativos
KR100812407B1 (ko) * 2000-05-11 2008-03-11 콘세호 수페리오르 데 인베스티가시오네스 시엔티피카스 글리코겐 신타제 키나제 ｇｓｋ-3의 헤테로사이클릭 억제제
WO2006045581A1 (en) 2004-10-21 2006-05-04 Neuropharma, S.A. The use of 1, 2, 4-thiadiazolidine-3, 5-diones as ppar activators
JP2009501775A (ja) 2005-07-21 2009-01-22 ベタゲノン・エイビー 癌治療におけるチアゾール誘導体およびアナログの使用
WO2008090356A1 (en) * 2007-01-25 2008-07-31 Betagenon Ab Thiazolidinone derivatives useful in the treatment of cancer and disorders caused by excess adiposity

Also Published As

Publication number Publication date
WO2011004162A3 (en) 2011-03-03
AU2010270030B2 (en) 2015-12-24
ZA201108901B (en) 2017-08-30
HRP20160353T1 (hr) 2016-05-06
CA2767291A1 (en) 2011-01-13
WO2011004162A2 (en) 2011-01-13
KR20120054568A (ko) 2012-05-30
SMT201600225B (it) 2016-08-31
US20160128993A1 (en) 2016-05-12
SI2451794T1 (sl) 2016-05-31
US20120183537A1 (en) 2012-07-19
ES2567753T3 (es) 2016-04-26
EP2451794A2 (en) 2012-05-16
SG177558A1 (en) 2012-02-28
HUE027263T2 (en) 2016-10-28
PL2451794T3 (pl) 2016-07-29
JP5982281B2 (ja) 2016-08-31
KR101765957B1 (ko) 2017-08-07
CN102596923B (zh) 2015-04-29
RS54718B1 (en) 2016-08-31
CA2767291C (en) 2020-01-28
MX337516B (es) 2016-03-09
AU2010270030A1 (en) 2012-01-12
DK2451794T3 (en) 2016-03-14
US9675596B2 (en) 2017-06-13
BR112012000370A2 (pt) 2016-11-22
IL216723A0 (en) 2012-03-01
EP2451794B1 (en) 2016-01-27
JP2012532854A (ja) 2012-12-20
BR112012000370B1 (pt) 2019-04-16
NZ597075A (en) 2013-03-28
MX2012000441A (es) 2012-04-19
IL216723A (en) 2017-09-28
ME02443B (me) 2016-09-20
US9162994B2 (en) 2015-10-20
CN102596923A (zh) 2012-07-18
HK1170485A1 (zh) 2013-03-01
EA026674B1 (ru) 2017-05-31

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM