PE20131305A1 - Compuesto heterociclico y sus usos - Google Patents

Compuesto heterociclico y sus usos

Info

Publication number
PE20131305A1
PE20131305A1 PE2013000360A PE2013000360A PE20131305A1 PE 20131305 A1 PE20131305 A1 PE 20131305A1 PE 2013000360 A PE2013000360 A PE 2013000360A PE 2013000360 A PE2013000360 A PE 2013000360A PE 20131305 A1 PE20131305 A1 PE 20131305A1
Authority
PE
Peru
Prior art keywords
pyridin
ring
metoxy
triazolo
propan
Prior art date
Application number
PE2013000360A
Other languages
English (en)
Inventor
Tatsuki Koike
Minoru Nakamura
Yoshihide Tomata
Takafumi Takai
Yuichi Kajita
Makoto Kamata
Yasutaka Hoashi
Tetsuya Tsukamoto
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45094181&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20131305(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of PE20131305A1 publication Critical patent/PE20131305A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

SE REFIERE A COMPUESTOS HETEROCICLICOS DE FORMULA (I) DONDE: EL ANILLO A ES OXAZOL, TRIAZOL, IMIDAZOL, ENTRE OTROS OPCIONALMENTE SUSTITUIDOS; EL ANILLO B ES UN ANILLO BENCENO, PIRIDINA O PIRIMIDINA OPCIONALMENTE SUSTITUIDOS; LA ESTRUCTURA PARCIAL (1) ES a) O b), R1 Y R2 SON IGUALES O DIFERENTES Y CADA UNO ES UN SUSTITUYENTE; DONDE R1 ES HIDROXI, ALCOXI (C1-C6), CARBOXI, ENTRE OTROS; R2 ES HALOGENO, UN GRUPO HETEROCICLICO, ENTRE OTROS; R3 ES UN SUSTITUYENTE; n ES UN ENTERO DE 0 A 6; L ES O, S, SO, SO2, ENTRE OTROS. ES UN COMPUESTO PREFERIDO: 2-{8-(4-CLORO-3-FLUOROFENOXI)-3-[3-METOXI-4-(2-METIL-1,3-OXAZOL-5-IL)FENIL]-5,6,7,8-TETRAHIDRO[1,2,4]TRIAZOLO[4,3-a]PIRIDIN-8-IL}PROPAN-2-OL; 2-{(8R)-3-[6-METOXI-5-(4-METIL-1H-IMIDAZOL-1-IL)PIRIDIN-2-IL]-8-(3,4,5-TRIFLUOROFENOXI)-5,6,7,8-TETRAHIDRO[1,2,4]TRIAZOLO[4,3-a]PIRIDIN-8-IL}PROPAN-2-OL; ENTRE OTROS. DICHOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER
PE2013000360A 2010-09-02 2011-09-01 Compuesto heterociclico y sus usos PE20131305A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010197064 2010-09-02
JP2011143548 2011-06-28

Publications (1)

Publication Number Publication Date
PE20131305A1 true PE20131305A1 (es) 2013-10-31

Family

ID=45094181

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2013000360A PE20131305A1 (es) 2010-09-02 2011-09-01 Compuesto heterociclico y sus usos

Country Status (21)

Country Link
US (3) US8901309B2 (es)
EP (1) EP2611805A1 (es)
JP (1) JP5871909B2 (es)
KR (1) KR20130139895A (es)
CN (1) CN103249733A (es)
AR (1) AR082865A1 (es)
AU (1) AU2011296887A1 (es)
BR (1) BR112013004746A2 (es)
CA (1) CA2809779A1 (es)
CL (1) CL2013000575A1 (es)
DO (1) DOP2013000051A (es)
EA (1) EA201390333A1 (es)
EC (1) ECSP13012535A (es)
MA (1) MA34556B1 (es)
MX (1) MX2013002511A (es)
PE (1) PE20131305A1 (es)
SG (1) SG187917A1 (es)
TW (1) TW201213327A (es)
UY (1) UY33586A (es)
WO (1) WO2012029991A1 (es)
ZA (1) ZA201301929B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102482276A (zh) * 2009-07-13 2012-05-30 武田药品工业株式会社 杂环化合物及其用途
MA34556B1 (fr) * 2010-09-02 2013-09-02 Takeda Pharmaceutcal Company Ltd Triazoles fusionnés pour le traitement ou la prophylaxie du trouble cognitif léger
EP2687528A1 (en) * 2012-07-17 2014-01-22 Ares Trading S.A. Fused triazole derivatives as gamma secretase modulators
RU2563254C2 (ru) * 2013-07-08 2015-09-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ получения производных 7-(гетеро)арил-4,5,6,7-тетрагидро[1,2,3]триазоло[1,5-a]пиридина
WO2016182780A1 (en) * 2015-05-12 2016-11-17 E I Du Pont De Nemours And Company Aryl substituted bicyclic compounds as herbicides
US11603440B2 (en) * 2019-09-12 2023-03-14 Dupont Electronics, Inc. Polyimide films and electronic devices
WO2023114456A1 (en) * 2021-12-17 2023-06-22 Athira Pharma, Inc. Uses of bicyclic compounds for the treatment of diseases

Family Cites Families (27)

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US6525044B2 (en) 2000-02-17 2003-02-25 Bristol-Myers Squibb Company Succinoylamino carbocycles and heterocycles as inhibitors of a-β protein production
BRPI0410348A (pt) 2003-05-14 2006-05-30 Torreypines Therapeutics Inc compostos e usos dos mesmos na modulação de amilóide-beta
DK1678172T3 (da) * 2003-10-15 2010-04-06 Targacept Inc Azabicykliske forbindelser til lindring af smerte og behandling af sygdomme i centralnervesystemet
MY149038A (en) 2004-05-26 2013-07-15 Eisai R&D Man Co Ltd Cinnamide compound
JPWO2006046575A1 (ja) 2004-10-26 2008-05-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 シンナミド化合物の非晶質体
WO2007081897A2 (en) 2006-01-11 2007-07-19 Merck & Co., Inc. Fused triazole tachykinin receptor antagonists
CA2643796A1 (en) 2006-03-09 2007-09-13 Eisai R & D Management Co., Ltd. Polycyclic cinnamide derivatives
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
TW200808800A (en) 2006-05-05 2008-02-16 Astrazeneca Ab MGluR5 modulators V
US8143394B2 (en) 2006-12-26 2012-03-27 Gilead Sciences, Inc. Pyrido(3,2-d)pyrimidines useful for treating viral infections
WO2008078725A1 (ja) 2006-12-26 2008-07-03 Daiichi Sankyo Company, Limited チアゼピン誘導体
US8183276B2 (en) 2007-02-08 2012-05-22 Christian Fischer Therapeutic agents
MX2010006243A (es) 2007-12-06 2010-08-31 Schering Corp Moduladores de gamma secretasa.
TW201030002A (en) * 2009-01-16 2010-08-16 Bristol Myers Squibb Co Bicyclic compounds for the reduction of beta-amyloid production
JP2010197064A (ja) 2009-02-23 2010-09-09 Chugoku Electric Power Co Inc:The 直下位置測定装置
JP2012051806A (ja) * 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd イミダゾリルピラジン誘導体
JP2012051807A (ja) 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd アリールイミダゾール化合物
EP2401276B1 (en) * 2009-02-26 2013-06-05 Eisai R&D Management Co., Ltd. Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors
WO2011002067A1 (ja) 2009-07-02 2011-01-06 武田薬品工業株式会社 複素環化合物およびその用途
CN102482276A (zh) * 2009-07-13 2012-05-30 武田药品工业株式会社 杂环化合物及其用途
KR20120050450A (ko) 2009-07-15 2012-05-18 얀센 파마슈티칼즈, 인코포레이티드 감마 세크레타제 조절제로서의 치환된 트리아졸 및 이미다졸 유도체
US8637525B2 (en) 2009-07-31 2014-01-28 Bristol-Myers Squibb Company Compounds for the reduction of beta-amyloid production
TWI468402B (zh) 2009-07-31 2015-01-11 必治妥美雅史谷比公司 降低β－類澱粉生成之化合物
WO2011016559A1 (ja) 2009-08-07 2011-02-10 武田薬品工業株式会社 複素環化合物およびその用途
JP2011143548A (ja) 2010-01-12 2011-07-28 Panasonic Corp スクリーン印刷機及びスクリーン印刷方法
US9145399B2 (en) 2010-01-15 2015-09-29 Janssen Pharmaceuticals, Inc. Substituted bicyclic triazole derivatives as gamma secretase modulators
MA34556B1 (fr) * 2010-09-02 2013-09-02 Takeda Pharmaceutcal Company Ltd Triazoles fusionnés pour le traitement ou la prophylaxie du trouble cognitif léger

Also Published As

Publication number Publication date
SG187917A1 (en) 2013-04-30
MA34556B1 (fr) 2013-09-02
AU2011296887A1 (en) 2013-04-11
CL2013000575A1 (es) 2013-08-23
ZA201301929B (en) 2013-11-27
EA201390333A1 (ru) 2013-08-30
JP5871909B2 (ja) 2016-03-01
BR112013004746A2 (pt) 2016-06-07
CA2809779A1 (en) 2012-03-08
TW201213327A (en) 2012-04-01
DOP2013000051A (es) 2013-04-30
JP2013536798A (ja) 2013-09-26
US8822699B2 (en) 2014-09-02
KR20130139895A (ko) 2013-12-23
US20120059030A1 (en) 2012-03-08
US20130178497A1 (en) 2013-07-11
CN103249733A (zh) 2013-08-14
EP2611805A1 (en) 2013-07-10
US20140350260A1 (en) 2014-11-27
US8901309B2 (en) 2014-12-02
AR082865A1 (es) 2013-01-16
UY33586A (es) 2012-03-30
WO2012029991A1 (en) 2012-03-08
MX2013002511A (es) 2013-07-29
ECSP13012535A (es) 2013-06-28

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