PE20061424A1 - Compuestos triciclicos de base 1,6-dihidro-1-3,5,6-tetraaza-as-indaceno y composiciones farmaceuticas que comprenden los mismos - Google Patents

Compuestos triciclicos de base 1,6-dihidro-1-3,5,6-tetraaza-as-indaceno y composiciones farmaceuticas que comprenden los mismos

Info

Publication number
PE20061424A1
PE20061424A1 PE2006000492A PE2006000492A PE20061424A1 PE 20061424 A1 PE20061424 A1 PE 20061424A1 PE 2006000492 A PE2006000492 A PE 2006000492A PE 2006000492 A PE2006000492 A PE 2006000492A PE 20061424 A1 PE20061424 A1 PE 20061424A1
Authority
PE
Peru
Prior art keywords
dihydro
alkyl
alkenyl
indaceno
tetraaza
Prior art date
Application number
PE2006000492A
Other languages
English (en)
Inventor
William J Pitts
James Kempson
Junqing Guo
Charles M Langevine
Scout H Watterson
Steven H Spergel
Jagabandhu Das
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20061424A1 publication Critical patent/PE20061424A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

REFERIDA A UN COMPUESTO DERIVADO DE IMIDAZOPIRROLOPIRIDINA DE FORMULA (I), DONDE R1 ES H, ALQUILO C1-C3, ALQUENILO C2-C3, ALQUINILO C2-C3; R2 ES H, HALO, ALQUILO, ENTRE OTROS; R5 ES H, HALO, ALQUILO, ENTRE OTROS; R3 Y R4 SON H, ALQUILO, ALQUENILO, ALQUINILO, ENTRE OTROS; R6 ES ALQUILO, ALQUINILO, ALQUENILO, ENTRE OTROS; R7 ES H, HALO, CIANO, ENTRE OTROS; R8 ES H, ALQUILO, ALQUENILO, ARILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 1,6-DIHIDRO-N,1-DIMETIL-7-FENILOIMIDAZO[4,5-d]PIRROLO[2,3-b]PIRIDIN-4-AMINA, 3-[1,5-DIHIDRO-1-METIL-4-(METILAMINO)IMIDAZO[4,5-d]PIRROLO[2,3-b]PIRIDIN-7-IL]BENZONITRILO, SAL DE TRIFLUOROACETATO DE 7-[3-(AMINOMETIL)FENIL]-1,6-DIHIDRO-N,1-DIMETIL-IMIDAZO[4,5-d]PIRROLO[2,3-b]PIRIDIN-4-AMINA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA ACTIVIDAD DE LA ENZIMA IKK Y SON UTILES EN EL TRATAMIENTO DE LA ARTRITIS REUMATOIDE, CANCER, ASMA, PSORIASIS, ENTRE OTRAS
PE2006000492A 2005-05-10 2006-05-10 Compuestos triciclicos de base 1,6-dihidro-1-3,5,6-tetraaza-as-indaceno y composiciones farmaceuticas que comprenden los mismos PE20061424A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67969205P 2005-05-10 2005-05-10
US11/430,215 US7737279B2 (en) 2005-05-10 2006-05-08 1,6-dihydro-1,3,5,6-tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same

Publications (1)

Publication Number Publication Date
PE20061424A1 true PE20061424A1 (es) 2006-12-17

Family

ID=36808856

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000492A PE20061424A1 (es) 2005-05-10 2006-05-10 Compuestos triciclicos de base 1,6-dihidro-1-3,5,6-tetraaza-as-indaceno y composiciones farmaceuticas que comprenden los mismos

Country Status (15)

Country Link
US (2) US7737279B2 (es)
EP (1) EP1888584B1 (es)
JP (1) JP5047164B2 (es)
AR (1) AR053725A1 (es)
AT (1) ATE465162T1 (es)
CY (1) CY1110419T1 (es)
DE (1) DE602006013816D1 (es)
DK (1) DK1888584T3 (es)
ES (1) ES2342976T3 (es)
PE (1) PE20061424A1 (es)
PL (1) PL1888584T3 (es)
PT (1) PT1888584E (es)
SI (1) SI1888584T1 (es)
TW (1) TW200718422A (es)
WO (1) WO2006122137A1 (es)

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AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
WO2015031562A1 (en) * 2013-08-29 2015-03-05 Bristol-Myers Squibb Company PROCESS FOR THE PREPARATION OF N,N-DICYCLOPROPYL-4-(1,5-DIMETHYL-1H-PYRAZOL-3-YLAMINO)-6-ETHYL-1-METHYL-1,6-DIHYDROIMIDAZO[4,5-d]PYRROLO[2,3-b]PYRIDINE-7-CARBOXAMIDE
JPWO2015060368A1 (ja) 2013-10-23 2017-03-09 武田薬品工業株式会社 複素環化合物
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UA119347C2 (uk) 2014-03-26 2019-06-10 Ф. Хоффманн-Ля Рош Аг Конденсовані [1,4]діазепінові сполуки як інгібітори продукції аутотаксину (atх) та лізофосфатидилової кислоти (lpa)
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WO2017050792A1 (en) 2015-09-24 2017-03-30 F. Hoffmann-La Roche Ag Bicyclic compounds as atx inhibitors
KR20180053408A (ko) 2015-09-24 2018-05-21 에프. 호프만-라 로슈 아게 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서의 신규한 이환형 화합물
US11365198B2 (en) 2015-10-16 2022-06-21 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US11773106B2 (en) 2015-10-16 2023-10-03 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US10550126B2 (en) 2015-10-16 2020-02-04 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
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CN109843294A (zh) * 2016-08-15 2019-06-04 普渡研究基金会 4-取代的氨基异喹啉衍生物
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Also Published As

Publication number Publication date
US20100210629A1 (en) 2010-08-19
TW200718422A (en) 2007-05-16
EP1888584A1 (en) 2008-02-20
US20060270654A1 (en) 2006-11-30
EP1888584B1 (en) 2010-04-21
JP2008540547A (ja) 2008-11-20
JP5047164B2 (ja) 2012-10-10
ATE465162T1 (de) 2010-05-15
US7737279B2 (en) 2010-06-15
DK1888584T3 (da) 2010-08-09
DE602006013816D1 (de) 2010-06-02
US8268855B2 (en) 2012-09-18
WO2006122137A1 (en) 2006-11-16
CY1110419T1 (el) 2015-04-29
ES2342976T3 (es) 2010-07-20
AR053725A1 (es) 2007-05-16
PL1888584T3 (pl) 2010-09-30
PT1888584E (pt) 2010-06-22
SI1888584T1 (sl) 2010-07-30

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