JP5816100B2 - 多能性細胞の分化 - Google Patents
多能性細胞の分化 Download PDFInfo
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- JP5816100B2 JP5816100B2 JP2011552223A JP2011552223A JP5816100B2 JP 5816100 B2 JP5816100 B2 JP 5816100B2 JP 2011552223 A JP2011552223 A JP 2011552223A JP 2011552223 A JP2011552223 A JP 2011552223A JP 5816100 B2 JP5816100 B2 JP 5816100B2
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- C—CHEMISTRY; METALLURGY
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
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- C12N5/0692—Stem cells; Progenitor cells; Precursor cells
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/02—Atmosphere, e.g. low oxygen conditions
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/14—Erythropoietin [EPO]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/145—Thrombopoietin [TPO]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/165—Vascular endothelial growth factor [VEGF]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/03—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from non-embryonic pluripotent stem cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15630409P | 2009-02-27 | 2009-02-27 | |
| US61/156,304 | 2009-02-27 | ||
| PCT/US2010/025776 WO2010099539A1 (en) | 2009-02-27 | 2010-03-01 | Differentiation of pluripotent cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015158092A Division JP2015192681A (ja) | 2009-02-27 | 2015-08-10 | 多能性細胞の分化 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012519005A JP2012519005A (ja) | 2012-08-23 |
| JP2012519005A5 JP2012519005A5 (cg-RX-API-DMAC7.html) | 2013-04-18 |
| JP5816100B2 true JP5816100B2 (ja) | 2015-11-18 |
Family
ID=42097524
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011552223A Active JP5816100B2 (ja) | 2009-02-27 | 2010-03-01 | 多能性細胞の分化 |
| JP2015158092A Pending JP2015192681A (ja) | 2009-02-27 | 2015-08-10 | 多能性細胞の分化 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015158092A Pending JP2015192681A (ja) | 2009-02-27 | 2015-08-10 | 多能性細胞の分化 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8372642B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2401364B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP5816100B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101720961B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN102388130B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2010217739B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2753679C (cg-RX-API-DMAC7.html) |
| IL (1) | IL214818A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010099539A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (138)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2013331A2 (en) | 2006-04-14 | 2009-01-14 | Advanced Cell Technology, Inc. | Hemangio-colony forming cells |
| JP5804280B2 (ja) * | 2009-09-08 | 2015-11-04 | 国立大学法人京都大学 | 多能性幹細胞からの肥満細胞の製造方法 |
| EP3633025B1 (en) | 2009-11-12 | 2022-09-14 | Technion Research & Development Foundation Ltd. | Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state |
| US8703487B2 (en) * | 2009-12-01 | 2014-04-22 | The Regents Of The University Of California | Compositions and methods for making and using bone marrow mesenchymal stem cells and erythroid progenitor cells |
| AU2010326027A1 (en) * | 2009-12-04 | 2012-06-21 | Stem Cell & Regenerative Medicine International, Inc. | Method of generating natural killer cells and dendritic cells from human embryonic stem cell-derived hemangioblasts |
| WO2011106681A2 (en) | 2010-02-25 | 2011-09-01 | The Johns Hopkins University | SMOOTH MUSCLE-LIKE CELLS (SMLCs) DERIVED FROM HUMAN PLURIPOTENT STEM CELLS |
| EP2582794B2 (en) | 2010-06-15 | 2024-04-24 | FUJIFILM Cellular Dynamics, Inc. | Generation of induced pluripotent stem cells from small volumes of peripheral blood |
| US8765470B2 (en) | 2010-08-04 | 2014-07-01 | Cellular Dynamics International, Inc. | Reprogramming immortalized B-cells to induced pluripotent stem cells |
| EP2615165B1 (en) | 2010-09-10 | 2016-08-03 | The University of Tokyo | Culture method related to differentiation of pluripotent stem cells into blood cells |
| WO2012103098A2 (en) * | 2011-01-24 | 2012-08-02 | Immunepath, Inc. | Compositions and methods for treating hematological cytopenias |
| JP6148429B2 (ja) * | 2011-01-31 | 2017-06-14 | 協和発酵バイオ株式会社 | ヒト多能性幹細胞の培養方法 |
| CA2826386C (en) * | 2011-02-08 | 2020-04-28 | Cellular Dynamics International, Inc. | Hematopoietic precursor cell production by programming |
| CN102161980B (zh) * | 2011-02-12 | 2013-07-31 | 浙江大学 | 用人间充质干细胞为滋养层培养诱导多能干细胞的方法 |
| US9499789B2 (en) | 2011-02-23 | 2016-11-22 | Kyoto University | Method for producing dendritic cells from pluripotent stem cells |
| US9169309B2 (en) * | 2011-03-01 | 2015-10-27 | Humanzyme Inc. | Thermostable variants of fibroblast growth factors |
| GB201103600D0 (en) | 2011-03-01 | 2011-04-13 | Isis Innovation | Dendritic cells |
| JP6185907B2 (ja) * | 2011-03-30 | 2017-08-23 | セルラー ダイナミクス インターナショナル, インコーポレイテッド | 神経分化のための多能性幹細胞の予備刺激 |
| JP6124880B2 (ja) * | 2011-06-09 | 2017-05-10 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 多能性幹細胞の血管床細胞への分化のための方法 |
| EP2761065B1 (en) * | 2011-09-29 | 2017-12-06 | Cellsnap, LLC | Compositions and methods for toxigenicity testing |
| RU2014117642A (ru) * | 2011-10-03 | 2015-11-10 | Ниссан Кемикал Индастриз, Лтд. | Способ получения мегакариоцитов и/или тромбоцитов из плюрипотентных стволовых клеток |
| US9834754B2 (en) * | 2011-11-21 | 2017-12-05 | University Health Network | Populations of hematopoietic progenitors and methods of enriching stem cells therefor |
| CN104136034B (zh) | 2011-11-30 | 2018-04-24 | 安斯泰来再生医药协会 | 间充质基质细胞及其相关用途 |
| US8961956B2 (en) | 2011-11-30 | 2015-02-24 | Ocata Therapeutics, Inc. | Mesenchymal stromal cells and uses related thereto |
| US10428309B2 (en) | 2011-12-01 | 2019-10-01 | New York Stem Cell Foundation, Inc. | Systems and methods for producing stem cells and differentiated cells |
| BR112014013152B1 (pt) | 2011-12-01 | 2021-08-31 | New York Stem Cell Foundation, Inc | Sistema automatizado para geração de células-tronco pluripotentes induzidas (ipscs) |
| WO2013130820A1 (en) * | 2012-02-29 | 2013-09-06 | The Johns Hopkins University | Method for guiding the derivation of endothelial cells from human pluripotent stem cells employing two-dimensional, feeder-free differentiation |
| US9260696B2 (en) | 2012-04-24 | 2016-02-16 | Dan S. Kaufman | Method for developing natural killer cells from stem cells |
| GB201210857D0 (en) | 2012-06-19 | 2012-08-01 | Cambridge Entpr Ltd | Transcription factor mediated programming towards megakaryocytes |
| CN104471059B (zh) | 2012-07-12 | 2018-04-17 | 珠海横琴爱姆斯坦生物科技有限公司 | 人胚胎干细胞衍生的间充质样干细胞、方法及其应用 |
| US10286014B2 (en) * | 2012-09-28 | 2019-05-14 | Foundation For Biomedical Research And Innovation At Kobe | Method for in vitro proliferation of cell population containing cells suitable for treatment of ischemic disease |
| HK1210190A1 (en) | 2012-11-21 | 2016-04-15 | Merz Pharma Gmbh & Co. Kgaa. | Means and methods for determination of botulinum neurotoxin biological activity |
| WO2014100779A1 (en) | 2012-12-21 | 2014-06-26 | Advanced Cell Technology, Inc. | Methods ofr production of platelets from pluripotent stem cells and compositions thereof |
| PL2970912T3 (pl) | 2013-03-13 | 2019-08-30 | Wisconsin Alumni Research Foundation | Sposoby i materiały do hematopoetyczno-śródbłonkowego różnicowania ludzkich pluripotentnych komórek macierzystych w zdefiniowanych warunkach |
| US9994825B2 (en) | 2013-03-15 | 2018-06-12 | The Johns Hopkins University | Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix |
| EP2970913B1 (en) * | 2013-03-15 | 2018-08-22 | LongBoat Explorers AB | Cells, methods and apparatuses for umbilical cord blood collection and isolation of cells |
| AU2014232381A1 (en) * | 2013-03-15 | 2015-10-29 | The Johns Hopkins University | Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix |
| US9506037B2 (en) | 2013-03-15 | 2016-11-29 | The Johns Hopkins University | Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix |
| US9822342B2 (en) | 2013-05-14 | 2017-11-21 | Kyoto University | Method of efficiently inducing cardiomyocytes |
| JP5511039B1 (ja) * | 2013-05-22 | 2014-06-04 | 国立大学法人九州大学 | Nk細胞の調製方法 |
| US20160146788A1 (en) * | 2013-05-23 | 2016-05-26 | Kyoto University | Method for screening drugs for treating/preventing myelodysplastic syndrome, etc. |
| WO2014200340A1 (en) * | 2013-06-10 | 2014-12-18 | Academisch Ziekenhuis Leiden | Differentiation and expansion of endothelial cells from pluripotent stem cells and the in vitro formation of vasculature like structures |
| PL3014267T3 (pl) | 2013-06-28 | 2019-05-31 | Merz Pharma Gmbh & Co Kgaa | Środki i sposoby określania aktywności biologicznej polipeptydów neurotoksyny w komórkach |
| WO2015050963A1 (en) * | 2013-10-01 | 2015-04-09 | Manfred Boehm | Human ipsc-derived vascular-related and hematopoetic cells for therapies and toxicology/drug screenings |
| US11352606B2 (en) * | 2014-02-10 | 2022-06-07 | The Johns Hopkins University | Low oxygen tension enhances endothelial fate of human pluripotent stem cells |
| MX377115B (es) | 2014-02-19 | 2025-03-07 | Merz Pharma Gmbh & Co Kgaa | Gangliosidos para estandarizacion y aumento de la sensibilidad de las celulas a las neurotoxinas botulinicas en sistemas de prueba in vitro. |
| AU2015249371B2 (en) | 2014-04-24 | 2020-04-30 | Board Of Regents, The University Of Texas System | Application of induced pluripotent stem cells to generate adoptive cell therapy products |
| CN103937743B (zh) * | 2014-04-27 | 2017-12-01 | 浙江大学 | 一种利用三维诱导系统获得造血干细胞的方法 |
| MA40552A (fr) | 2014-08-04 | 2021-05-19 | Nuevolution As | Derives de pyrimidine eventuellement condensee substituee par un heterocycle utiles dans le traitement de maladies inflammatoires, metaboliques, oncologiques et auto-immunes |
| EP3233911B1 (en) | 2014-12-19 | 2020-10-14 | Merz Pharma GmbH & Co. KGaA | Means and methods for the determination of the biological activity of bont/e in cells |
| JP6774952B2 (ja) * | 2015-01-16 | 2020-10-28 | エージェンシー フォー サイエンス, テクノロジー アンド リサーチ | 多能性幹細胞のマクロファージへの分化 |
| US9828634B2 (en) | 2015-01-22 | 2017-11-28 | Regenerative Medical Solutions, Inc. | Markers for differentiation of stem cells into differentiated cell populations |
| JP6800859B2 (ja) * | 2015-01-26 | 2020-12-16 | フェイト セラピューティクス,インコーポレイテッド | 造血細胞分化を誘導するための方法および組成物 |
| TWI704156B (zh) | 2015-03-04 | 2020-09-11 | 德商曼茲法瑪股份有限公司 | 用於增進肉毒桿菌神經毒素進入細胞之特定攝取的方法 |
| US11680244B2 (en) | 2015-05-20 | 2023-06-20 | The Regents Of The University Of California | Method for generating human dendritic cells for immunotherapy |
| WO2016203477A1 (en) * | 2015-06-18 | 2016-12-22 | Yeda Research And Development Co. Ltd. | Conditioning protocols and use of same for tissue regeneration |
| ES2971677T3 (es) * | 2015-09-08 | 2024-06-06 | Sumitomo Pharma Co Ltd | Método para la producción de tejido retiniano |
| CN108350429B (zh) | 2015-10-20 | 2022-02-25 | 富士胶片细胞动力公司 | 用于将多能干细胞定向分化为免疫细胞的方法 |
| IL258899B2 (en) | 2015-10-30 | 2024-03-01 | Univ California | Methods of generating t-cells from stem cells and immunotherapeutic methods using the t-cells |
| EP3371314B1 (en) | 2015-11-04 | 2023-07-05 | Fate Therapeutics, Inc. | Genomic engineering of pluripotent cells |
| KR20250033315A (ko) | 2015-11-04 | 2025-03-07 | 페이트 세러퓨틱스, 인코포레이티드 | 조혈 세포 분화를 유도하기 위한 방법 및 조성물 |
| CN105296428A (zh) * | 2015-12-03 | 2016-02-03 | 广州医科大学附属第三医院 | 一种提高诱导多能干细胞的体外分化造血效率的方法 |
| WO2017115865A1 (ja) * | 2015-12-29 | 2017-07-06 | 株式会社クラレ | 幹細胞の凝集塊の集団の調製方法 |
| GB201601503D0 (en) | 2016-01-27 | 2016-03-09 | Isis Innovation | Dendritic cells |
| JP7367951B2 (ja) | 2016-05-18 | 2023-10-24 | 慶應義塾 | オルガノイド培養用細胞培養培地 |
| WO2018021566A1 (ja) * | 2016-07-29 | 2018-02-01 | ダイキン工業株式会社 | 分化細胞の製造方法、及びその製造方法のために使用する培養バッグ |
| WO2018043714A1 (ja) * | 2016-09-02 | 2018-03-08 | 塩野義製薬株式会社 | 多能性幹細胞からミクログリアを得る方法 |
| US11525119B2 (en) | 2016-09-06 | 2022-12-13 | The Children's Medical Center Corporation | Immune cells derived from induced pluripotent stem cell |
| BR112019006910A2 (pt) * | 2016-10-05 | 2019-07-02 | Fujifilm Cellular Dynamics Inc | métodos para diferenciação dirigida de células-tronco pluripotentes para células imunes homozigóticas de hla |
| WO2018067826A1 (en) | 2016-10-05 | 2018-04-12 | Cellular Dynamics International, Inc. | Generating mature lineages from induced pluripotent stem cells with mecp2 disruption |
| CN106479968A (zh) * | 2016-10-11 | 2017-03-08 | 海南博鳌龄迈迪精准医学研究院有限公司 | 脐带间充质干细胞的培养方法 |
| US11542473B2 (en) | 2016-10-21 | 2023-01-03 | Amniotics Ab | Methods and compositions for generating hematopoietic cells |
| CN106754684A (zh) * | 2017-01-05 | 2017-05-31 | 厚朴生物科技(苏州)有限公司 | 一种睾丸间质干细胞分离培养分化方法 |
| EP3587560A4 (en) | 2017-01-27 | 2020-12-16 | Kaneka Corporation | Endodermal cell mass, and method for producing any one of three primary germ layer cell mass from pluripotent cells |
| EP3576756A4 (en) * | 2017-02-03 | 2020-12-16 | Cornell University | STABLE THREE-DIMENSIONAL BLOOD VESSELS AND THEIR FORMATION PROCESSES |
| AU2018240416B2 (en) * | 2017-03-21 | 2024-07-11 | Centre National De La Recherche Scientifique | Methods of improving hematopoietic grafts |
| KR102668891B1 (ko) * | 2017-04-18 | 2024-05-29 | 후지필름 셀룰러 다이내믹스, 인코포레이티드 | 항원-특이적 면역 이펙터 세포 |
| EP3399027A1 (en) | 2017-05-04 | 2018-11-07 | Medizinische Hochschule Hannover | Stem-cell derived myeloid cells, generation and use thereof |
| CN107083367B (zh) * | 2017-07-03 | 2020-07-14 | 广州润虹医药科技股份有限公司 | 培养基及其用途与由尿液细胞制备间充质干细胞的方法 |
| WO2019117444A1 (ko) * | 2017-12-11 | 2019-06-20 | 대한민국(관리부서 질병관리본부장) | 전분화능 줄기세포를 이용한 면역세포 분화 |
| WO2019126146A1 (en) | 2017-12-19 | 2019-06-27 | Xcell Biosciences, Inc. | Methods of modulating cell phenotype by way of regulating the gaseous environment |
| CN108048390B (zh) * | 2017-12-21 | 2021-04-27 | 清华大学 | 一种制备血管内皮细胞的方法及其专用试剂盒 |
| CN108588024B (zh) * | 2017-12-29 | 2020-04-21 | 广州医科大学附属第三医院(广州重症孕产妇救治中心、广州柔济医院) | 诱导多能干细胞分化成造血干细胞的培养基及方法 |
| MX2020007071A (es) | 2018-01-05 | 2020-11-11 | Platelet Biogenesis Inc | Composiciones y metodos para producir megacariocitos. |
| MY199514A (en) | 2018-02-01 | 2023-11-02 | Nkmax Co Ltd | Method of producing natural killer cells and composition for treating cancer |
| FR3079239A1 (fr) * | 2018-03-23 | 2019-09-27 | Centre National De La Recherche Scientifique | Nouvelle methode d’obtention de cellules t a partir de cellules souches pluripotentes, et leurs utilisations |
| WO2020006539A1 (en) | 2018-06-29 | 2020-01-02 | Platelet Biogenesis, Inc. | Compositions for drug delivery and methods of use thereof |
| IL281413B2 (en) | 2018-09-19 | 2024-09-01 | Fujifilm Cellular Dynamics Inc | Protein l for activation and expansion of chimeric antigen receptor-modified immune cells |
| CN109266618B (zh) * | 2018-10-18 | 2021-04-23 | 赛元生物科技(杭州)有限公司 | 能够靶向肿瘤细胞的巨噬细胞及其制备方法 |
| WO2020086889A1 (en) * | 2018-10-24 | 2020-04-30 | Hebecell Corporation | Methods and systems for manufacturing hematopoietic lineage cells |
| KR102111441B1 (ko) * | 2018-11-12 | 2020-05-15 | 대한민국 | 전분화능 줄기세포 유래 대식세포를 기반으로 하는 감염질환 치료용 약물 스크리닝 방법 |
| SG11202106642YA (en) | 2018-12-20 | 2021-07-29 | Sumitomo Chemical Co | Embryonic erythroblast-containing cell population and method for producing same, cell culture composition, and compound test method |
| JP7634938B2 (ja) * | 2019-02-21 | 2025-02-25 | ピービーエス バイオテック インコーポレイテッド | バイオリアクターにおける治療細胞の膨張および分化のためのシステムおよび方法 |
| CN111206017B (zh) * | 2019-04-30 | 2022-02-18 | 浙江大学 | 一种干细胞无血清培养基及其应用 |
| WO2020252477A1 (en) * | 2019-06-14 | 2020-12-17 | FUJIFILM Cellular Dynamics, Inc. | Methods for the production of multiple lineages from induced pluripotent stem cells using charged surfaces |
| US12465878B2 (en) | 2019-06-20 | 2025-11-11 | Amniotics Ab | Apparatus for filtering amniotic fluid |
| CA3154422A1 (en) | 2019-10-18 | 2021-04-22 | Jan TALTS | Processes and apparatuses for obtaining amniotic mesenchymal stem cells from amniotic fluid and cells derived thereof |
| JP7479466B2 (ja) * | 2019-11-13 | 2024-05-08 | カリス バイオ インコーポレイテッド | 血管内皮細胞純粋分離方法、血管内皮細胞特性維持培地及びそれを含む培養方法 |
| CN110938584B (zh) * | 2019-11-25 | 2021-12-03 | 广州赛莱拉干细胞科技股份有限公司 | 一种人胚胎干细胞向内皮细胞诱导分化的方法 |
| US11447479B2 (en) | 2019-12-20 | 2022-09-20 | Nuevolution A/S | Compounds active towards nuclear receptors |
| AU2020408107A1 (en) | 2019-12-20 | 2022-04-14 | Nuevolution A/S | Compounds active towards nuclear receptors |
| WO2021173458A1 (en) * | 2020-02-28 | 2021-09-02 | Purdue Research Foundation | Generating aorta-gonad-mesonephros-like hematopoietic cells from human pluripotent stem cells under a defined condition |
| US12220445B2 (en) | 2020-03-09 | 2025-02-11 | Amprion, Inc. | Inert matrices for qualitative and semi-quantitative seed amplification assays |
| CN111440760B (zh) * | 2020-03-09 | 2022-09-23 | 浙江大学 | 一种人多能干细胞高效分化得到内皮祖细胞的方法 |
| US11547726B2 (en) | 2020-03-26 | 2023-01-10 | Honed Life Sciences, Llc | Enhancement of production of NK cells from stem cells |
| JP7713954B2 (ja) | 2020-03-31 | 2025-07-28 | ヌエヴォリューション・アクティーゼルスカブ | 核内受容体に対して活性な化合物 |
| CA3174252A1 (en) | 2020-03-31 | 2021-10-07 | Nuevolution A/S | Compounds active towards nuclear receptors |
| CN115885038A (zh) | 2020-06-17 | 2023-03-31 | 国立大学法人京都大学 | 表达嵌合抗原受体的免疫活性细胞 |
| CA3174380A1 (en) * | 2020-07-27 | 2022-02-03 | Stemcell Technologies Canada Inc. | Systems and methods for differentiating hematopoietic cells |
| CN111808812B (zh) * | 2020-08-31 | 2020-12-15 | 首都医科大学附属北京友谊医院 | 一种用于多能干细胞向造血干细胞分化的材料和方法 |
| US12435308B2 (en) | 2020-11-06 | 2025-10-07 | Amniotics Ab | Immunomodulation by amniotic fluid mesenchymal stem cells |
| US11591381B2 (en) | 2020-11-30 | 2023-02-28 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
| EP4255922A1 (en) | 2020-12-03 | 2023-10-11 | Century Therapeutics, Inc. | Genetically engineered cells and uses thereof |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| CN112608895B (zh) * | 2020-12-18 | 2024-02-27 | 深圳市济因生物科技有限公司 | 一种人多能干细胞分化的自然杀伤细胞及其制备方法与应用 |
| WO2022144632A1 (en) | 2020-12-30 | 2022-07-07 | Crispr Therapeutics Ag | Compositions and methods for differentiating stem cells into nk cells |
| AU2022255166A1 (en) | 2021-04-07 | 2023-09-28 | Century Therapeutics, Inc. | Compositions and methods for generating alpha-beta t cells from induced pluripotent stem cells |
| AU2022253891A1 (en) | 2021-04-07 | 2023-08-24 | Century Therapeutics, Inc. | Gene transfer vectors and methods of engineering cells |
| IL307358A (en) | 2021-04-07 | 2023-11-01 | Century Therapeutics Inc | Compositions and methods for generating gamma-delta t cells from induced pluripotent stem cells |
| WO2022216524A1 (en) | 2021-04-07 | 2022-10-13 | Century Therapeutics, Inc. | Combined artificial cell death/reporter system polypeptide for chimeric antigen receptor cell and uses thereof |
| KR20240006059A (ko) | 2021-05-05 | 2024-01-12 | 후지필름 셀룰러 다이내믹스, 인코포레이티드 | Ipsc-유래된 미세아교세포에 대한 방법 및 조성물 |
| CN118234849A (zh) | 2021-09-10 | 2024-06-21 | 富士胶片细胞动力公司 | 诱导多能干细胞衍生细胞的组合物及其使用方法 |
| EP4402164A4 (en) * | 2021-09-13 | 2025-07-02 | Amprion Inc | INERT MATRICES FOR QUALITATIVE AND SEMI-QUANTITATIVE SEED AMPLIFICATION ASSAYS |
| CA3238399A1 (en) | 2021-12-15 | 2023-06-22 | Torben LUND-HANSEN | Scfv and antibodies with reduced multimerisation |
| US20250064934A1 (en) | 2021-12-29 | 2025-02-27 | Century Therapeutics, Inc. | Genetically engineered cells having anti-cd19 / anti-cd22 chimeric antigen receptors, and uses thereof |
| IL314801A (en) | 2022-02-22 | 2024-10-01 | Juno Therapeutics Inc | Proteinase 3 (PR3) Chimeric Autoantigen Receptor T Cells and Related Methods and Uses |
| EP4519319A1 (en) | 2022-05-04 | 2025-03-12 | Century Therapeutics, Inc. | Cells engineered with an hla-e and hla-g transgene |
| WO2023240212A2 (en) | 2022-06-08 | 2023-12-14 | Century Therapeutics, Inc. | Genetically engineered cells having anti-cd133 / anti-egfr chimeric antigen receptors, and uses thereof |
| CA3257424A1 (en) | 2022-06-08 | 2023-12-14 | Century Therapeutics, Inc. | Genetically modified cells expressing variants of CD16 and NKG2D and their uses |
| CA3257650A1 (en) | 2022-06-08 | 2023-12-14 | Century Therapeutics, Inc. | Immunoeffector cells derived from genetically modified, multipotential stem cells with membrane IL-12 and their uses |
| WO2024102838A1 (en) | 2022-11-09 | 2024-05-16 | Century Therapeutics, Inc. | Engineered interleukin-7 receptors and uses thereof |
| EP4615876A2 (en) | 2022-11-10 | 2025-09-17 | Century Therapeutics, Inc. | Genetically engineered cells having anti-nectin4 chimeric antigen receptors, and uses thereof |
| US20240269189A1 (en) | 2022-12-19 | 2024-08-15 | FUJIFILM Holdings America Corporation | Extracellular vesicle-enriched secretome composition derived from induced pluripotent stem cell derived-microglia and methods of use thereof |
| AU2024223390A1 (en) * | 2023-02-16 | 2025-08-28 | Syntax Bio, Inc. | Systems for cell programming towards hematopoietic lineage and methods thereof |
| CN116426472A (zh) * | 2023-06-08 | 2023-07-14 | 呈诺再生医学科技(北京)有限公司 | 一种促进造血干细胞或造血祖细胞分化为红细胞的诱导分化体系及其应用 |
| WO2025101938A2 (en) | 2023-11-10 | 2025-05-15 | Century Therapeutics, Inc. | Genetically engineered cells having multi-transmembrane domain chimeric antigen receptors utilizing g protein-coupled receptor scaffolds, and uses thereof |
| WO2025106626A1 (en) | 2023-11-15 | 2025-05-22 | Century Therapeutics, Inc. | Genetically engineered cells expressing c-x-c chemokine receptor type 4, and uses thereof |
| WO2025207795A1 (en) | 2024-03-26 | 2025-10-02 | Juno Therapeutics, Inc. | Genetically engineered cells having anti-cd33 / anti-cd123 chimeric antigen receptors, and uses thereof |
| WO2025207798A1 (en) | 2024-03-26 | 2025-10-02 | Century Therapeutics, Inc. | Genetically engineered cells having anti-cd123 chimeric antigen receptors, and uses thereof |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0187371B1 (en) | 1984-12-27 | 1991-06-19 | Asahi Kasei Kogyo Kabushiki Kaisha | Substituted isoquinolinesulfonyl compounds |
| CA2259012C (en) | 1996-07-19 | 2008-05-13 | Gunnar Aberg | S(-)-tolterodine in the treatment of urinary and gastrointestinal disorders |
| WO1998030679A1 (en) | 1997-01-10 | 1998-07-16 | Life Technologies, Inc. | Embryonic stem cell serum replacement |
| ATE374026T1 (de) | 1999-03-25 | 2007-10-15 | Mitsubishi Pharma Corp | Rho-kinase-inhibitoren für die vorbeugung oder behandlung von interstitieller pneumonie und pulmonaler fibrose |
| WO2000078351A1 (en) | 1999-06-18 | 2000-12-28 | Mitsubishi Pharma Corporation | Osteogenesis promoters |
| EP1491093B1 (en) * | 2001-02-14 | 2013-07-31 | ABT Holding Company | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
| IL162130A0 (en) * | 2001-12-07 | 2005-11-20 | Robarts Res Inst | Hematopoietic cells from human embryonic stem cells |
| EP1458854B1 (en) * | 2001-12-21 | 2010-04-14 | Mount Sinai Hospital | Cellular compositions and methods of making and using them |
| JP4423043B2 (ja) | 2002-01-23 | 2010-03-03 | バイエル ファーマセチカル コーポレーション | Rho−キナーゼ阻害剤 |
| US6664266B2 (en) | 2002-03-14 | 2003-12-16 | Children's Medical Center Corporation | Axon regeneration with PKC inhibitiors |
| GB0206860D0 (en) | 2002-03-22 | 2002-05-01 | Glaxo Group Ltd | Compounds |
| WO2003089457A2 (en) | 2002-04-22 | 2003-10-30 | The Board Of Trustees Of The Leland Stanford Junior University | Peptide inhibitors of protein kinase c ϝ for pain management |
| US7723106B2 (en) * | 2004-07-29 | 2010-05-25 | Food Industry Research & Development Institute | Stroma-free, serum-free, and chemically defined medium and method for ex vivo mononuclear cell expansion using the same |
| CN1938023A (zh) | 2004-03-08 | 2007-03-28 | 惠氏公司 | 离子通道调节剂 |
| US7452718B2 (en) * | 2004-03-26 | 2008-11-18 | Geron Corporation | Direct differentiation method for making cardiomyocytes from human embryonic stem cells |
| GB2432846B (en) * | 2004-09-08 | 2009-12-30 | Wisconsin Alumni Res Found | Medium and culture of embryonic stem cells |
| WO2006050330A2 (en) | 2004-11-01 | 2006-05-11 | Wisconsin Alumni Research Foundation | Platelets from stem cells |
| US20070077654A1 (en) | 2004-11-01 | 2007-04-05 | Thomson James A | Platelets from stem cells |
| EP1860180A4 (en) | 2005-02-23 | 2009-03-11 | Found Biomedical Res & Innov | METHOD FOR THE AMPLIFICATION OF AN ENDOTHEL PREPARATION CELL IN VITRO |
| JP2009517085A (ja) * | 2005-11-28 | 2009-04-30 | チョンウェ ファーマ コーポレイション | 培養における細胞の無血清増殖 |
| JP2008099662A (ja) * | 2006-09-22 | 2008-05-01 | Institute Of Physical & Chemical Research | 幹細胞の培養方法 |
| JP5067949B2 (ja) * | 2006-11-09 | 2012-11-07 | 独立行政法人国立国際医療研究センター | 霊長類動物胚性幹細胞の培養及び継代方法、並びにその分化誘導方法 |
| JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| SG10201610881UA (en) * | 2008-03-27 | 2017-03-30 | Asterias Biotherapeutics Inc | Differentiation of primate pluripotent stem cells to hematopoietic lineage cells |
| WO2009135206A1 (en) * | 2008-05-02 | 2009-11-05 | Stem Cell Products, Inc. | Method for production of mast cells from stem cells |
| WO2010035136A2 (en) * | 2008-09-25 | 2010-04-01 | Uti Limited Partnership | Expansion of embryonic stem cells |
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