JP5791825B2 - １−（２−フルオロベンジル）−１Ｈ−ピラゾロ［３，４−ｂ］ピリジン−３−ホルムアミジン塩酸塩の合成方法 - Google Patents

１−（２−フルオロベンジル）−１Ｈ−ピラゾロ［３，４−ｂ］ピリジン−３−ホルムアミジン塩酸塩の合成方法 Download PDF

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JP5791825B2
JP5791825B2 JP2014545075A JP2014545075A JP5791825B2 JP 5791825 B2 JP5791825 B2 JP 5791825B2 JP 2014545075 A JP2014545075 A JP 2014545075A JP 2014545075 A JP2014545075 A JP 2014545075A JP 5791825 B2 JP5791825 B2 JP 5791825B2
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reaction step
reaction
compound
added
pyridine
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JP2015500248A (ja
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リ，ジン
ヤン，シャオユ
ジュ，ジンウェイ
ヤン，ミンミン
ウ，シーハン
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Pharmablock Nanjing R&d Co ltd
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Pharmablock Nanjing R&d Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2014545075A 2011-12-12 2012-11-28 １−（２−フルオロベンジル）−１Ｈ−ピラゾロ［３，４−ｂ］ピリジン−３−ホルムアミジン塩酸塩の合成方法 Active JP5791825B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201110414004.0A CN102491974B (zh) 2011-12-12 2011-12-12 1-（2-氟苄基）-1H-吡唑并[3，4-b]吡啶-3-甲脒盐酸盐的合成方法
CN201110414004.0 2011-12-12
PCT/CN2012/085451 WO2013086935A1 (zh) 2011-12-12 2012-11-28 1-（2-氟苄基）-1H -吡唑并[3，4- b]吡啶-3 -甲脒盐酸盐的合成方法

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JP2015500248A JP2015500248A (ja) 2015-01-05
JP5791825B2 true JP5791825B2 (ja) 2015-10-07

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JP2014545075A Active JP5791825B2 (ja) 2011-12-12 2012-11-28 １−（２−フルオロベンジル）−１Ｈ−ピラゾロ［３，４−ｂ］ピリジン−３−ホルムアミジン塩酸塩の合成方法

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US (1) US8957210B2 (enrdf_load_stackoverflow)
JP (1) JP5791825B2 (enrdf_load_stackoverflow)
CN (1) CN102491974B (enrdf_load_stackoverflow)
DE (1) DE112012005176B4 (enrdf_load_stackoverflow)
IL (1) IL233066B (enrdf_load_stackoverflow)
IN (1) IN2014DN05281A (enrdf_load_stackoverflow)
WO (1) WO2013086935A1 (enrdf_load_stackoverflow)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102491974B (zh) 2011-12-12 2013-08-07 南京药石药物研发有限公司 1-（2-氟苄基）-1H-吡唑并[3，4-b]吡啶-3-甲脒盐酸盐的合成方法
CN104086545A (zh) * 2014-07-29 2014-10-08 安徽联创药物化学有限公司 1-(2-氟苄基)-1H-吡唑并[3,4-b]吡啶-3-甲脒盐酸盐的合成方法
CN105237531A (zh) * 2015-10-15 2016-01-13 湖南华腾制药有限公司 一种利奥西呱中间体的制备方法及其中间体化合物
MX2018007152A (es) 2015-12-14 2018-08-15 Ironwood Pharmaceuticals Inc Uso de estimuladores de guanilato ciclasa soluble (sgc) para el tratamiento de la disfuncion del esfinter gastrointestinal.
WO2018111795A2 (en) 2016-12-13 2018-06-21 Ironwood Pharmaceuticals, Inc. Use of sgc stimulators for the treatment of esophageal motility disorders
MX2021000363A (es) 2018-07-11 2021-04-29 Cyclerion Therapeutics Inc Uso de estimuladores de la guanilato ciclasa soluble (sgc) para el tratamiento de trastornos mitocondriales.
CN115947689B (zh) * 2022-09-23 2025-08-29 湖南华腾制药有限公司 一种连续流微反应器合成利奥西呱中间体的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR031176A1 (es) * 2000-11-22 2003-09-10 Bayer Ag Nuevos derivados de pirazolpiridina sustituidos con piridina
DE10220570A1 (de) * 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
CA2716952A1 (en) 2008-02-29 2009-09-11 Array Biopharma Inc. Pyrazole [3,4-b] pyridine raf inhibitors
AU2009308687A1 (en) * 2008-11-03 2010-05-06 Chemocentryx, Inc. Compounds for the treatment of osteoporosis and cancers
CN101648909B (zh) * 2009-09-14 2011-10-05 南京第一农药集团有限公司 一种氯代吡啶在无配体钯催化下制备氰基吡啶的方法
US20110225969A1 (en) 2010-03-19 2011-09-22 Gm Global Technology Operations, Inc. Compressor bypass to exhaust for particulate trap regeneration
DK2576548T3 (en) 2010-05-26 2015-09-28 Adverio Pharma Gmbh USE OF sGC stimulators, sGC activators alone and in combination with PDE5 inhibitors for treating systemic sclerosis (SSc)
DE102010021637A1 (de) 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
MX2012013774A (es) * 2010-05-27 2012-12-17 Merck Sharp & Dohme Activadores de guanilato ciclasa soluble.
PL2699576T3 (pl) * 2011-04-22 2016-05-31 Pfizer Pochodne pirazolospiroketonu do zastosowania jako inhibitory karboksylazy acetylo-COA
AU2012300844B2 (en) * 2011-09-02 2017-03-30 Bayer Intellectual Property Gmbh Substituted annellated pyrimidine and the use thereof
CN102491974B (zh) 2011-12-12 2013-08-07 南京药石药物研发有限公司 1-（2-氟苄基）-1H-吡唑并[3，4-b]吡啶-3-甲脒盐酸盐的合成方法

Also Published As

Publication number Publication date
CN102491974B (zh) 2013-08-07
DE112012005176B4 (de) 2018-10-11
IL233066A0 (en) 2014-07-31
IL233066B (en) 2019-01-31
JP2015500248A (ja) 2015-01-05
US8957210B2 (en) 2015-02-17
CN102491974A (zh) 2012-06-13
IN2014DN05281A (enrdf_load_stackoverflow) 2015-04-03
WO2013086935A1 (zh) 2013-06-20
DE112012005176T5 (de) 2014-08-28
US20140309425A1 (en) 2014-10-16

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