JP5785189B2 - C型肝炎ウイルス阻害剤 - Google Patents

C型肝炎ウイルス阻害剤 Download PDF

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Publication number
JP5785189B2
JP5785189B2 JP2012544681A JP2012544681A JP5785189B2 JP 5785189 B2 JP5785189 B2 JP 5785189B2 JP 2012544681 A JP2012544681 A JP 2012544681A JP 2012544681 A JP2012544681 A JP 2012544681A JP 5785189 B2 JP5785189 B2 JP 5785189B2
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Japan
Prior art keywords
cap
mmol
calculated
mixture
hcv
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Expired - Fee Related
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JP2012544681A
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English (en)
Japanese (ja)
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JP2013514359A5 (https=
JP2013514359A (ja
Inventor
マコネン・ベレマ
ジェフリー・リー・ロマイン
バン・エヌ・ヌグイェン
ガン・ワン
オマール・ディ・ロペス
デニス・アール・セイント・ローレント
チェン・キ
ジョン・エイ・ベンダー
ヤン・ゾン
ピヤセナ・ヘワワサム
スー・ニンニン
ニコラス・エイ・ミーンウェル
ジョン・エイ・イースター
ス・バオ−ニン
マイケル・ジェイ・スミス
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of JP2013514359A publication Critical patent/JP2013514359A/ja
Publication of JP2013514359A5 publication Critical patent/JP2013514359A5/ja
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41781,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2012544681A 2009-12-16 2010-12-13 C型肝炎ウイルス阻害剤 Expired - Fee Related JP5785189B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28694209P 2009-12-16 2009-12-16
US61/286,942 2009-12-16
US12/957,512 2010-12-01
US12/957,512 US8377980B2 (en) 2009-12-16 2010-12-01 Hepatitis C virus inhibitors
PCT/US2010/060077 WO2011075439A1 (en) 2009-12-16 2010-12-13 Hepatitis c virus inhibitors

Publications (3)

Publication Number Publication Date
JP2013514359A JP2013514359A (ja) 2013-04-25
JP2013514359A5 JP2013514359A5 (https=) 2014-01-09
JP5785189B2 true JP5785189B2 (ja) 2015-09-24

Family

ID=43479603

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012544681A Expired - Fee Related JP5785189B2 (ja) 2009-12-16 2010-12-13 C型肝炎ウイルス阻害剤

Country Status (21)

Country Link
US (1) US8377980B2 (https=)
EP (1) EP2513091B1 (https=)
JP (1) JP5785189B2 (https=)
KR (1) KR20120107991A (https=)
CN (1) CN102741242B (https=)
AR (1) AR079634A1 (https=)
AU (1) AU2010332034B2 (https=)
BR (1) BR112012014677A2 (https=)
CA (1) CA2784662A1 (https=)
CL (1) CL2012001637A1 (https=)
CO (1) CO6561788A2 (https=)
EA (1) EA020815B1 (https=)
MA (1) MA33806B1 (https=)
MX (1) MX2012006635A (https=)
NZ (1) NZ601220A (https=)
PE (1) PE20121479A1 (https=)
PH (1) PH12012500979A1 (https=)
SG (1) SG181700A1 (https=)
TN (1) TN2012000264A1 (https=)
TW (1) TWI487702B (https=)
WO (1) WO2011075439A1 (https=)

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