JP5715962B2 - コラーゲン、キトサン、グリコシルアミノグリカンおよび細胞増殖促進ペプチドおよび/または細胞複合体よりなる、化粧品または皮膚科学的調製物 - Google Patents
コラーゲン、キトサン、グリコシルアミノグリカンおよび細胞増殖促進ペプチドおよび/または細胞複合体よりなる、化粧品または皮膚科学的調製物 Download PDFInfo
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Classifications
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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Description
素源および窒素源、リン酸塩化合物および硫黄化合物、並びに鉱物および場合により増殖促進剤および/またはビタミンを含んでなる。
刺激である。更に、例えば、皮膚の細胞の寿命を延長するためのラミニン物質および表皮の分化を刺激するための特定の抽出物が使用される。しかし、これらの幾つかは、副作用の高い可能性を伴う薬理学的に活性な物質である。
本発明は特定の物質を組み合わせる方法により得られる化粧品または皮膚科学的調製物を提供する。これらの物質は、
(a)コラーゲンおよび/またはその誘導体、
(b)キトサンおよび/または約50%までのアセチル化度をもつそのアセチル化誘導体、
(c)グリコシルアミノグリカンおよび/またはその誘導体の少なくともいずれか、並びに
(d)細胞増殖を促進することができる少なくとも1種のペプチド、および
(e)(i)糖タンパク質1、
(ii)糖タンパク質2、
(iii)朝鮮ニンジン抽出物、および
(iv)トクサ抽出物、
を含む組成物、
の少なくともいずれか(そして好ましくは両方)、を含んでなる。
糖、H2SeO3、HEPES、ヒポキサンチン、ヒトインスリン、KCl、リノール酸、リポ酸、MgCl2、MnCl2、MnSO4、ミオ−イノシトール、Na2HPO4、Na2SeO3、Na2SiO3、NaCl、NaH2PO4、NaHCO3、ピルビン酸ナトリウム、酢酸ナトリウム、NH4VO3、NiCl2、ニコチンアミド、フェノールレッド、ポリソルベート80、プトレッシン、プトレッシン2HCl、ピリドキシンHCl、ピリドキサールHCl、リボフラヴィン、SnCl2、チアミンHCl、チミジン、ビタミンB12、セラミドおよびZnSO4から選択される少なくともいずれかの物質を含んでなることができる。例えば、L−アラニン、L−アルギニン、L−アスパラギン、L−アスパラギン酸、L−システイン、L−シスチン、グリシン、L−グルタミン、L−グルタミン酸、L−ヒスチジン、L−イソロイシン、L−ロイシン、L−リシン、L−メチオニン、L−フェニルアラニン、L−プロリン、L−セリン、L−スレオニン、L−トリプトファン、L−チロシンおよびL−ヴァリンのうちの1種以上が存在することができる。これに関して、本明細書および付記の請求項中でアミノ酸に言及される場合は常に、その言及はまた、アミノ酸の塩酸塩を含む。例えば、「L−リシン」は「L−リシンおよび/またはL−リシンHCl」を意味することが意図される。
(a)コラーゲンおよび/またはその誘導体、
(b)キトサンおよび/または50%までのアセチル化度をもつアセチル化キトサン、
(c)グリコシルアミノグリカンおよび/またはその誘導体の少なくともいずれか、並びに
(d)オリゴペプチド−21または、皮膚細胞受容体に結合することができる少なくともその一部、並びに/あるいは
(e)(i)糖タンパク質1、
(ii)糖タンパク質2、
(iii)朝鮮ニンジン抽出物と、
(iv)トクサ抽出物、
を含む組成物、並びに
(f)調製物の総重量の少なくとも40重量%の水、
を含んでなる種々の物質を組み合わせる方法により得られる、化粧品または皮膚科学的調製物を提供する。
L−ヴァリンから選択される1種または複数の物質を更にその中に使用することができる。
(a)水と(i)を含んでなる溶液を提供し、
(b)(a)の溶液に(ii)を添加して混合物を形成し、そして
(c)(b)の混合物に(iii)を添加して更なる混合物を形成し、そして
(d)(iv)を、(a)〜(c)に従う1種または複数の溶液および混合物と合わせる方法、
を含んでなる。更に、糖タンパク質1と2およびニンジンとトクサ抽出物を含んでなる組成物が存在する場合は、この組成物を工程(a)、(b)、(c)および(d)のいずれの期間中またはその後に添加することができるが、好ましくは(d)の開始より前に添加される。
(A)皮膚細胞増殖を促進することができる少なくとも1種のペプチド、並びに
(B)(i)糖タンパク質1
(ii)糖タンパク質2
(iii)ニンジン抽出物、および
(iv)トクサ抽出物、
を含んでなる組成物、
を含んでなる、化粧品または皮膚科学的調製物を提供する。
る。
本明細書に示される具体例は実施例によるものであり、本発明の態様の説明的考察のみの目的のためであり、本発明の原理と概念的態様の説明を、最も有用でありそして容易に理解されると考えられるものを提供するために提示される。これに関し、本発明の基本的理解のために必要である以上に、更に詳細に本発明の詳細を示すことは試みられず、図面と合わせた説明は、当業者に、本発明の幾つかの形態が実地に以下に具体化されるかを明
確にさせる。
/またはカルボン酸基の誘導体化、例えば、1種または複数のアミノ酸基のアシル化(例えば、アセチル化)および1種または複数のカルボン酸基のエステル化(例えば、メタノール、エタノール、プロパノールおよびイソプロパノールのようなアルコールとのエステル化)を含む。従って、用語「ペプチド」が本明細書および添付の請求の範囲に使用される場合は、本用語は対応する修飾(誘導体化)ペプチドおよび/または、皮膚細胞受容体に結合可能で、そしてまだ(完全な)ペプチド分子の機能を果たすことができるペプチド分子の少なくともその部分を含んでなる、対応する部分ペプチドを包含することが意図される。
、約0.5〜約50グラム/1リットル、好ましくは約3〜約10グラム/1リットルの総量の成分(i)〜(iv)を含んでなる。
有効である。
ウレタンもしくはシリコーン・マトリックスとの好ましい相互反応、をもたらさない。
皮膚の再生過程を支持する、
皮膚に最適な環境を提供する、
皮膚の構造改善において役立つ、
刺激性皮膚を緩和する、
皮膚の全体的状態を改善する、
皮膚の外観を実質的に改善する、
皮膚がその弾力性および健康な印象を取り戻す補助をする。
できるコラーゲン/水溶液に対する、場合によりアセチル化されたキトサンの添加、並びにグリコシルアミノグリカン、好ましくは、少なくともコンドロイチン4−硫酸および/またはコンドロイチン6−硫酸のその後の添加、を含んでなることができる。1種または複数のペプチド(d)が使用される時は、それは好ましくはナノエマルションの形態であるマトリックスの生成前、その期間中そして/またはその後に添加することができる。1種または複数のペプチドの安定度に悪影響を与えないように、それらの添加は好ましくは約40℃以下、例えば、約30℃以下の温度で実施される。組成物(e)が使用される場合は、それはマトリックスの生成の前、その期間中そして/またはその後に、好ましくはペプチド(d)が使用される場合は、その添加の前に添加することができる。
繊維芽細胞の培養、
角化細胞の培養、
角化細胞と繊維芽細胞の共存培養、
繊維芽細胞/角化細胞と、更なる、免疫細胞、メラニン細胞等のような皮膚関連細胞との共存培養、
三次元皮膚モデルを形成するための培地、
のために、それらの個々の成分の組成物中で、適切であると記載される皮膚細胞の培地である。
−D皮膚モデルに作用することができる。
形態の例は、水溶液および水性アルコール溶液、スプレー、発泡体、発泡エアゾール、軟膏、水性ゲル、O/WまたはW/O型のエマルション、ミクロエマルション、親水性または親油性パッチおよび化粧品スティック製品を含む。特に適した溶媒は水性ゲル、O/Wエマルション、W/O/Wエマルションおよびミクロエマルションを含む。該調製物はまた、例えば、身体洗浄組成物、例えば、セッケン、シャワー浴剤、シャンプー等中にも使用することができる。
オレイル、γ−リノレイル、コレステリルおよびグリセリルエステル)およびそれらの塩、チオジプロピオン酸ジラウリル、チオジプロピオン酸ジステアリル、チオジプロピオン酸およびそれらの誘導体(例えば、塩、エステル、エーテル、糖、ヌクレオチド、ヌクレオシド、ペプチドおよび/または脂質化合物として)並びにスルホキシイミン化合物(例えば、ホモシステイン・スルホキシイミン、ブチオニン・スルホン、ペンタ−、ヘキサ−、ヘプタチオニン・スルホキシイミン)、から選択することができる。更に、(金属)錯体形成剤(例えば、アポフェリチン、デスフェラール、ラクトフェリン、α−ヒドロキシ脂肪酸、パルミチン酸、フィチン酸、)およびそれらの誘導体(例えば、塩、エステル、エーテル、糖、ヌクレオチド、ヌクレオシド、ペプチドおよび/または脂質化合物として)、α−ヒドロキシ酸(例えば、クエン酸、乳酸、リンゴ酸)、フミン酸、胆汁酸、胆汁抽出物、ビリルビン、ビリベルジン、EDTA、EGTAおよびそれらの誘導体、不飽和脂肪酸およびそれらの誘導体(例えば、γ−リノレン酸、リノール酸、オレイン酸)、葉酸およびその誘導体、フルフリルインデンソルビトールおよびその誘導体、ユビキノン、ユビキノール、プラストキノンおよびそれらの誘導体(例えば、塩、エステル、エーテル、糖、ヌクレオチド、ヌクレオシド、ペプチドおよび脂質化合物として)、ビタミンCおよび誘導体(例えば、パルミチン酸アスコルビル、リン酸アスコルビルMg、酢酸アスコルビル)、トコフェロールおよび誘導体(例えば、酢酸ビタミンE)およびフェノール化合物およびそれらを含む植物抽出物、例えば、フラボノイド(例えば、グリコシルルチン、フェルラ酸、カフェイン酸)、フルフリリデングルシトール、ブチル化ヒドロキシトルエン、ブチル化ヒドロキシアニソール、ノルジヒドログアヤレチン樹脂酸、ノルジヒドログアヤレチン酸、トリヒドロキシブチロフェノンおよびその誘導体(塩、エステル、エーテル、糖、ヌクレオチド、ヌクレオシド、ペプチドおよび脂質化合物として)、尿酸およびその誘導体、マンノースおよびその誘導体(例えば、塩、エステル、エーテル、糖、ヌクレオチド、ヌクレオシド、ペプチドおよび脂質化合物として)、亜鉛およびその誘導体(例えば、ZnO、ZnSO4)、セレンおよびその誘導体(例えば、セレノメチオニン、エブセレン(ebselen))、スチルベンおよびそれらの誘導体(例えば、酸化スチルベン、トランス−酸化スチルベン)並びに、本発明に従って適切なこれらの有効成分の誘導体(例えば、塩、エステル、エーテル、糖、チオール、ヌクレオチド、ヌクレオシド、ペプチドおよび/または脂質化合物)も含まれる。
(a)(i)コラーゲン、キトサンおよびコンドロイチン硫酸ナトリウムの組み合わせ物(以後「MPC」)並びに(ii)MPC+オリゴペプチド−21(以後「MPC+IDP4」)、
(b)(i)糖タンパク質1と2およびニンジンとトクサの抽出物を含んでなる組成物(以後「GPVE」)並びに(ii)GPVE+オリゴペプチド−21(以後「GPVE+IDP4」)、
(c)(i)MPCとGPVEの組み合わせ物(以後「GPVE/MPC」)および(ii)GPVE/MPCとオリゴペプチド−21の組み合わせ物(以後「GPVE/MPC+IDP4」)、
を使用して実施された比較実験を説明する。
以下の細胞の増殖に対する、MPC対(MPC+IDP4)、GPVE対(GPVE+IDP4)およびGPVE/MPC対(GPVE/MPC=IDP4)の添加の効果を研究した:
1.HacaT角化細胞の細胞系
2.NIH3T3繊維芽細胞の細胞系
3.MSC(間葉幹細胞)。
(1)細胞接種
(2)無血清DMEM培地を使用して24時間の飢餓
(3)サンプルの処理
(4)72時間培養
(5)細胞の収穫
(6)細胞増殖のアッセイ。
PC、GPVE/MPC、GPVE/MPC+IDPEおよび幾つかのその他の物質(THE TPS、CbglycおよびMEYM7)の添加の効果を比較した。結果を以下の表に示す。
以下の細胞によるプロコラーゲン、フィブロネクチン、エラスチン、ヒアルロン酸およびラミニンの細胞外マトリックスの発現に対するMPCとMPC+IDP4の添加の効果を研究した:
1.HacaT角化細胞の細胞系(ヒアルロン酸、ラミニン)
2.NIH3T3繊維芽細胞の細胞系(プロコラーゲン、フィブロネクチン、エラスチン)。
(1)細胞接種、
(2)無血清DMEM培地による24時間の飢餓
(3)サンプルの処理
(4)72時間の培養
(5)細胞上澄み回収、
(6)アッセイ。
(a)捕捉抗体でコートする、
(b)阻止する(阻止溶液)、
(c)各ウェルを吸引し、5回洗浄する、
(d)各ウェルにサンプルと標準物を添加する、
(e)各ウェルを吸引し、5回洗浄する、
(f)各ウェルに複合物(conjugate)を添加する、
(g)各ウェルを吸引し、5回洗浄する、
(h)各ウェルに基質溶液を添加する、
(i)各ウェルに停止溶液を添加する、
(j)450nmの光学密度で読み取る。
H2O2(フリーラジカル形成体)に対する間葉幹細胞に対するMPCとMPC+IDP4の添加の防護(抗アポトーシス)効果を試験した。
(1)細胞の接種、
(2)無血清DMEM培地で24時間飢餓、
(3)サンプルの処理、
(4)24時間培養、
(5)5mMのH2O2で処理、
(6)24時間保温、
(7)細胞増殖アッセイ。
スの統計的に有意な減少および細胞増殖の増加が、2%MPCの添加時に、しかしIDP4と組み合わせた時のみ(右側の棒)、間葉幹細胞により得られたことを示す。
以下の細胞によるプロコラーゲン、フィブロネクチン、エラスチン、ヒアルロン酸およびラミニンの細胞外マトリックスの発現に対するGPVEとGPVE+IDP4の添加の効果を研究した:
1.HacaT角化細胞の細胞系(ヒアルロン酸、ラミニン)
2.NIH3T3繊維芽細胞の細胞系(プロコラーゲン、フィブロネクチン、エラスチン)。
(1)細胞の接種、
(2)無血清DMEM培地で24時間飢餓、
(3)サンプルの処理、
(4)72時間培養、
(5)細胞上澄み物の回収、
(6)アッセイ。
(a)捕捉抗体でコートする、
(b)阻止する(阻止溶液)、
(c)各ウェルを吸引し、5回洗浄する、
(d)各ウェルにサンプルと標準物を添加、
(e)各ウェルを吸引し、5回洗浄する、
(f)各ウェルに複合物(conjugate)を添加する、
(g)各ウェルを吸引し、5回洗浄する、
(h)各ウェルに基質溶液を添加する、
(i)各ウェルに停止溶液を添加する、
(j)450nmの光学密度で読み取る。
以下の細胞によるプロコラーゲン、フィブロネクチン、エラスチン、ヒアルロン酸およびラミニンの細胞外マトリックスの発現に対するGPVE/MPCとGPVE/MPC+IDP4の添加の効果を研究した:
1.HacaT角化細胞の細胞系(ヒアルロン酸、ラミニン)
2.NIH3T3繊維芽細胞の細胞系(プロコラーゲン、フィブロネクチン、エラスチン)。
(1)細胞の接種、
(2)無血清DMEM培地で24時間飢餓、
(3)サンプルの処理、
(4)72時間培養、
(5)細胞上澄み物の回収、
(6)アッセイ。
(a)捕捉抗体でコートする、
(b)阻止する(阻止溶液)、
(c)各ウェルを吸引し、5回洗浄する、
(d)各ウェルにサンプルと標準物を添加、
(e)各ウェルを吸引し、5回洗浄する、
(f)各ウェルに複合物(conjugate)を添加する、
(g)各ウェルを吸引し、5回洗浄する、
(h)各ウェルに基質溶液を添加する、
(i)各ウェルに停止溶液を添加する、
(j)450nmの光学密度で読み取る。
Claims (21)
- (a)コラーゲンとその誘導体の少なくともいずれか、
(b)キトサンと50%までのアセチル化度をもつそのアセチル誘導体の少なくともいずれか、
(c)グリコシルアミノグリカンとその誘導体の少なくともいずれか、
の組み合わせ
並びに
(d)オリゴペプチド‐21、および
(e)(i)糖タンパク質1、
(ii)糖タンパク質2、
(iii)朝鮮ニンジン抽出物および、
(iv)トクサ抽出物、
を含む組成物、
の少なくともいずれか、
を組み合わせる方法により得られる、化粧品または皮膚科学的調製物。 - (a)がタイプ1、3、4と5から選択される1種以上のコラーゲンを含んでなる、請求項1の調製物。
- (b)が80,000g/モル〜15,000,000g/モルの分子量をもつキトサンを含んでなる、請求項1〜2のいずれか1項の調製物。
- (c)がコンドロイチン4−硫酸とコンドロイチン6−硫酸のいずれかを含んでなる、請求項1〜3のいずれか1項の調製物。
- 調製物が(d)を含んでなる、請求項1〜4のいずれか1項の調製物。
- 調製物が(e)を含んでなる、請求項1〜5のいずれか1項の調製物。
- (ii)、(iii)および(iv)の総量に対する(i)の重量比が25:75である、請求項1〜6のいずれか1項の調製物。
- (e)が、(e)の総重量の0.3%〜1.2重量%の総量の(i)、(ii)、(iii)および(iv)を含んでなる、請求項1〜7のいずれか1項の調製物。
- (i)、(ii)、(iii)および(iv)が、調製物の総重量の0.0001%〜1重量%の総量で使用される、請求項1〜8のいずれか1項の調製物。
- 調製物が更に、1種以上の皮膚細胞の培地を含んでなる、請求項1〜9のいずれか1項の調製物。
- 皮膚細胞の培地がDMEM/HAM F12(1:1)とMCDB 153の少なくともいずれかを含んでなる、請求項10の調製物。
- 調製物が更に、Q10、アルファ−グルコシルルチン、アルファ−ヒドロキシ酸、オロチン酸Zn、カルニチン、クレアチンおよびタウリンのうちの少なくともいずれかを含んでなる、請求項1〜11のいずれか1項の調製物。
- 調製物が、調製物の総重量の少なくとも30重量%の水を含んでなる、請求項1〜12のいずれか1項の調製物。
- 請求項1〜13のいずれか1項の調製物を含んでなり、そして水性ゲル、O/Wエマルション、W/O/Wエマルション、W/Oエマルション、ミクロエマルションおよび化粧品スティックから選択される、化粧品または皮膚科学的製品。
- 傷害を受けた皮膚と疾病に罹った皮膚の少なくともいずれかおよび/または創傷に適用する医薬品の製造のための請求項1〜13のいずれか1項の調製物の使用方法。
- (i)コラーゲンとその誘導体の少なくともいずれか、(ii)キトサンと、50%までのアセチル化度を有するその誘導体の少なくともいずれか、(iii)グリコシルアミノグリカンとその誘導体の少なくともいずれか、および(iv)オリゴペプチド‐21、を含んでなる、化粧品または皮膚科学的調製物を調製する方法であって、
(a)水と(i)とを含んでなる溶液を提供し、
(b)(ii)を(a)の溶液に添加して混合物を形成し、そして
(c)(iii)を(b)の混合物に添加して更なる混合物を形成し、そして
(d)(iv)を、(a)〜(c)に従う溶液と混合物の1種以上と混合する方法、
を含んでなる方法。 - (iv)が(c)の混合物と合わされる、請求項16の方法。
- (d)が40℃を超えない温度で実施される、請求項16〜17のいずれか1項の方法。
- 更に、(e)(d)の混合物を凍結乾燥して、エアロゲルを提供する工程を含んでなる、請求項16〜18のいずれか1項の方法。
- 更に、エアロゲルを、化粧品または皮膚科学的調製物の水相、有効成分相および培地相の少なくともいずれかの中に導入することにより、(e)のエアロゲルをヒドロゲルに転化させる工程を含んでなる、請求項19の方法。
- (A)オリゴペプチド‐21、並びに
(B)(i)糖タンパク質1、
(ii)糖タンパク質2、
(iii)朝鮮ニンジン抽出物、および
(iv)トクサ抽出物、
を含んでなる組成物、
を含んでなる、化粧品または皮膚科学的調製物。
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US61/148,711 | 2009-01-30 | ||
PCT/IB2010/000736 WO2010086754A2 (en) | 2009-01-30 | 2010-02-01 | Cosmetic or dermatological preparation comprising collagen, chitosan, glycosylaminoglycan and cell growth promoting peptide and/or cellular complex |
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JP2012516841A JP2012516841A (ja) | 2012-07-26 |
JP2012516841A5 JP2012516841A5 (ja) | 2012-09-06 |
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US (1) | US9610463B2 (ja) |
EP (1) | EP2391424B1 (ja) |
JP (1) | JP5715962B2 (ja) |
WO (1) | WO2010086754A2 (ja) |
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