JP5705748B2 - Ｃｂ２受容体を変調する複素環化合物 - Google Patents
Ｃｂ２受容体を変調する複素環化合物 Download PDFInfo
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- JP5705748B2 JP5705748B2 JP2011551161A JP2011551161A JP5705748B2 JP 5705748 B2 JP5705748 B2 JP 5705748B2 JP 2011551161 A JP2011551161 A JP 2011551161A JP 2011551161 A JP2011551161 A JP 2011551161A JP 5705748 B2 JP5705748 B2 JP 5705748B2
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- Prior art keywords
- alkyl
- carboxylic acid
- tert
- mmol
- butyl
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- 0 **(CCC1)CN(*)C1C(N*)=O Chemical compound **(CCC1)CN(*)C1C(N*)=O 0.000 description 3
- OUFKIBUQQUMICD-UHFFFAOYSA-N CC(C)(C)c1cc(NC(C(CCCC2)N2C(c2ccc(C(F)(F)F)cc2)=O)=O)n[o]1 Chemical compound CC(C)(C)c1cc(NC(C(CCCC2)N2C(c2ccc(C(F)(F)F)cc2)=O)=O)n[o]1 OUFKIBUQQUMICD-UHFFFAOYSA-N 0.000 description 1
- IMDQBBXLORZTCH-UHFFFAOYSA-N CC(C)(C)c1cc(NC(C2NCCCC2)=O)n[o]1 Chemical compound CC(C)(C)c1cc(NC(C2NCCCC2)=O)n[o]1 IMDQBBXLORZTCH-UHFFFAOYSA-N 0.000 description 1
- OJQARSASKTUHLM-VIFPVBQESA-N CC(C)(C)c1cc(NC([C@H](CCCC2)N2C(C(F)(F)F)=O)=O)n[o]1 Chemical compound CC(C)(C)c1cc(NC([C@H](CCCC2)N2C(C(F)(F)F)=O)=O)n[o]1 OJQARSASKTUHLM-VIFPVBQESA-N 0.000 description 1
- IMDQBBXLORZTCH-VIFPVBQESA-N CC(C)(C)c1cc(NC([C@H]2NCCCC2)=O)n[o]1 Chemical compound CC(C)(C)c1cc(NC([C@H]2NCCCC2)=O)n[o]1 IMDQBBXLORZTCH-VIFPVBQESA-N 0.000 description 1
- AHHMUMBVZVNFLB-MBIQTGHCSA-N CC(C)(C)c1n[o]c(NC([C@H](CCCC2O)N2c(cc2)ccc2Cl)=O)c1 Chemical compound CC(C)(C)c1n[o]c(NC([C@H](CCCC2O)N2c(cc2)ccc2Cl)=O)c1 AHHMUMBVZVNFLB-MBIQTGHCSA-N 0.000 description 1
- FDKVKABRLWOVMI-UHFFFAOYSA-N CC(C)c1ncc(C(F)(F)F)cc1 Chemical compound CC(C)c1ncc(C(F)(F)F)cc1 FDKVKABRLWOVMI-UHFFFAOYSA-N 0.000 description 1
- UOXMZABWZARXSX-JTQLQIEISA-N OC([C@H](CCCC1=O)N1c(cc1)ccc1Cl)O Chemical compound OC([C@H](CCCC1=O)N1c(cc1)ccc1Cl)O UOXMZABWZARXSX-JTQLQIEISA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15333309P | 2009-02-18 | 2009-02-18 | |
| US61/153,333 | 2009-02-18 | ||
| PCT/US2010/024270 WO2010096371A2 (en) | 2009-02-18 | 2010-02-16 | Heterocyclic compounds which modulate the cb2 receptor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012518038A JP2012518038A (ja) | 2012-08-09 |
| JP2012518038A5 JP2012518038A5 (https=) | 2014-09-18 |
| JP5705748B2 true JP5705748B2 (ja) | 2015-04-22 |
Family
ID=42154367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011551161A Active JP5705748B2 (ja) | 2009-02-18 | 2010-02-16 | Ｃｂ２受容体を変調する複素環化合物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8889670B2 (https=) |
| EP (1) | EP2398771B1 (https=) |
| JP (1) | JP5705748B2 (https=) |
| WO (1) | WO2010096371A2 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2657247A1 (en) | 2006-07-28 | 2008-01-31 | Boehringer Ingelheim International Gmbh | Compounds which modulate the cb2 receptor |
| US7928123B2 (en) | 2006-09-25 | 2011-04-19 | Boehringer Ingelheim International Gmbh | Compounds which modulate the CB2 receptor |
| WO2008048914A1 (en) | 2006-10-17 | 2008-04-24 | Boehringer Ingelheim International Gmbh | Polycyclic compounds which modulate the cb2 receptor |
| US8173638B2 (en) | 2006-11-21 | 2012-05-08 | Boehringer Ingelheim International Gmbh | Compounds which modulate the CB2 receptor |
| CA2704684A1 (en) | 2007-11-07 | 2009-05-14 | Boehringer Ingelheim International Gmbh | Compounds which modulate the cb2 receptor |
| US8957063B2 (en) * | 2008-02-21 | 2015-02-17 | Boehringer Ingelheim International Gmbh | Amine and ether compounds which modulate the CB2 receptor |
| US8178568B2 (en) * | 2008-07-10 | 2012-05-15 | Boehringer Ingelheim International Gmbh | Sulfone compounds which modulate the CB2 receptor |
| CA2737639A1 (en) | 2008-09-25 | 2010-04-01 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the cb2 receptor |
| US8629157B2 (en) | 2009-01-05 | 2014-01-14 | Boehringer Ingelheim International Gmbh | Pyrrolidine compounds which modulate the CB2 receptor |
| JP5705748B2 (ja) | 2009-02-18 | 2015-04-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を変調する複素環化合物 |
| US8299103B2 (en) | 2009-06-15 | 2012-10-30 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the CB2 receptor |
| JP5756800B2 (ja) | 2009-06-16 | 2015-07-29 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を調節するアゼチジン２−カルボキサミド誘導体 |
| WO2011037795A1 (en) | 2009-09-22 | 2011-03-31 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the cb2 receptor |
| WO2011088015A1 (en) | 2010-01-15 | 2011-07-21 | Boehringer Ingelheim International Gmbh | Compounds which modulate the cb2 receptor |
| US8329735B2 (en) | 2010-03-05 | 2012-12-11 | Boehringer Ingelheim International Gmbh | Tetrazole compounds which selectively modulate the CB2 receptor |
| WO2012012307A1 (en) | 2010-07-22 | 2012-01-26 | Boehringer Ingelheim International Gmbh | Sulfonyl compounds which modulate the cb2 rece |
| WO2012090177A2 (en) | 2010-12-30 | 2012-07-05 | Lupin Limited | Cannabinoid receptor modulators |
| WO2012090179A2 (en) | 2010-12-30 | 2012-07-05 | Lupin Limited | Isoquinoline derivatives as cannabinoid receptor modulators |
| WO2013005168A2 (en) | 2011-07-05 | 2013-01-10 | Lupin Limited | Cannabinoid receptor modulators |
| US20150065717A1 (en) | 2012-03-29 | 2015-03-05 | Toray Industries, Inc. | Nipecotic acid derivative and use thereof for medical purposes |
| EP2803668A1 (en) | 2013-05-17 | 2014-11-19 | Boehringer Ingelheim International Gmbh | Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles |
| SG10202103278TA (en) | 2013-10-14 | 2021-04-29 | Eisai R&D Man Co Ltd | Selectively substituted quinoline compounds |
| ES2670550T3 (es) | 2013-10-14 | 2018-05-30 | Eisai R&D Management Co., Ltd. | Derivados de quinolina selectivamente sustituidos |
| GB201401886D0 (en) | 2014-02-04 | 2014-03-19 | Lytix Biopharma As | Neurodegenerative therapies |
| KR101555033B1 (ko) * | 2014-07-28 | 2015-09-23 | 충남대학교산학협력단 | 신규한 메타논 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 망막 질환의 예방 또는 치료용 약학적 조성물 |
| TWI691486B (zh) * | 2016-01-29 | 2020-04-21 | 日商東麗股份有限公司 | 環狀胺衍生物及其醫藥用途 |
| CN108218846A (zh) * | 2016-12-22 | 2018-06-29 | 四川海思科制药有限公司 | 噻吩衍生物的新固态形式及其制备方法和用途 |
| US10881649B2 (en) | 2017-07-27 | 2021-01-05 | Toray Industries, Inc. | Therapeutic agent or preventive agent for alopecia areata |
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| TW201920137A (zh) * | 2017-08-31 | 2019-06-01 | 日商東麗股份有限公司 | 環狀胺衍生物及其醫藥用途 |
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| EP2398771A2 (en) | 2011-12-28 |
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| US20110312944A1 (en) | 2011-12-22 |
| EP2398771B1 (en) | 2015-07-29 |
| JP2012518038A (ja) | 2012-08-09 |
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