JP5702392B2 - キサンチンオキシダーゼ阻害剤として効果的な新規化合物、その製造方法及びそれを含有する医薬組成物 - Google Patents
キサンチンオキシダーゼ阻害剤として効果的な新規化合物、その製造方法及びそれを含有する医薬組成物 Download PDFInfo
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- JP5702392B2 JP5702392B2 JP2012533074A JP2012533074A JP5702392B2 JP 5702392 B2 JP5702392 B2 JP 5702392B2 JP 2012533074 A JP2012533074 A JP 2012533074A JP 2012533074 A JP2012533074 A JP 2012533074A JP 5702392 B2 JP5702392 B2 JP 5702392B2
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- Prior art keywords
- indol
- cyano
- carboxylic acid
- pyrazole
- mmol
- Prior art date
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- -1 salt compound Chemical class 0.000 claims description 84
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- 239000000203 mixture Substances 0.000 claims description 70
- 229910052739 hydrogen Inorganic materials 0.000 claims description 43
- 239000001257 hydrogen Substances 0.000 claims description 43
- 125000000217 alkyl group Chemical group 0.000 claims description 27
- 108010093894 Xanthine oxidase Proteins 0.000 claims description 22
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- 150000003839 salts Chemical class 0.000 claims description 22
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| JP2014510133A (ja) * | 2011-04-06 | 2014-04-24 | エルジー・ライフ・サイエンシーズ・リミテッド | １−（３−シアノ−１−イソプロピル−インドール−５−イル）ピラゾール−４−カルボン酸の結晶形とその製造方法 |
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| PT2750677T (pt) * | 2011-08-30 | 2017-07-03 | Chdi Foundation Inc | Inibidores de quinurenina-3-monooxigenase, composições farmacêuticas e métodos de utilização dos mesmos |
| SMT201800387T1 (it) | 2013-03-29 | 2018-09-13 | Teijin Pharma Ltd | Derivato pirazolico |
| EA034528B1 (ru) | 2014-07-17 | 2020-02-17 | Сиэйчдиай Фаундэйшн, Инк. | Способ лечения нарушений, связанных с вич |
| CN104774172B (zh) * | 2015-04-08 | 2017-03-22 | 河南师范大学 | 一种3‑氰基吲哚类化合物的合成方法 |
| ES2839201T3 (es) * | 2015-09-02 | 2021-07-05 | Sunshine Lake Pharma Co Ltd | Derivados de anillo (hetero)aromático sustituidos en carboxilo y método de preparación y usos de los mismos |
| CN106008488B (zh) * | 2016-05-20 | 2018-10-30 | 广东东阳光药业有限公司 | 氰基吲哚类衍生物及其制备方法和用途 |
| JP2020500874A (ja) | 2016-12-02 | 2020-01-16 | バイオベラティブ セラピューティクス インコーポレイテッド | キメラ凝固因子を使用して血友病性関節症を処置する方法 |
| WO2018157801A1 (zh) * | 2017-02-28 | 2018-09-07 | 广东东阳光药业有限公司 | 氰基取代的稠合双环衍生物及其制备方法和用途 |
| JP2021523878A (ja) | 2018-05-18 | 2021-09-09 | バイオベラティブ セラピューティクス インコーポレイテッド | 血友病ａを処置する方法 |
| AU2019279441B2 (en) * | 2018-06-01 | 2024-02-29 | Autophagysciences Inc. | Novel compound and pharmaceutical composition comprising same |
| CN111072647B (zh) * | 2019-12-11 | 2021-02-26 | 沈阳药科大学 | 3-取代吲哚-5-氧代-4,5-二氢-1,2,4-噁二唑类化合物及其用途 |
| CN111072634B (zh) * | 2020-01-03 | 2022-07-22 | 中国医科大学 | 1-取代-3-取代-5-取代酰胺-1h-吲哚类化合物及其制备方法和应用 |
| AU2021374260B2 (en) * | 2020-11-04 | 2024-12-19 | Lg Chem, Ltd. | Method for preparing crystalline particles of 1-(3-cyano-1-isopropyl-indole-5-yl)pyrazole-4-carboxylic acid, and pharmaceutical composition comprising same |
| CN116528853A (zh) * | 2020-12-01 | 2023-08-01 | 株式会社Lg化学 | 包含1-(3-氰基-1-异丙基-吲哚-5-基)吡唑-4-甲酸的口服制剂及其制备方法 |
| US20240000751A1 (en) * | 2020-12-01 | 2024-01-04 | Lg Chem, Ltd. | Stable oral formulation containing 1-(3-cyano-1-isopropyl-indol-5-yl)pyrazole-4-carboxylic acid |
| CN112920170B (zh) * | 2021-01-29 | 2023-06-20 | 中国医科大学 | N-（吲哚-5-基）芳香杂环酰胺类化合物及其制备方法和用途 |
| AU2022257531A1 (en) * | 2021-04-16 | 2023-10-26 | Lg Chem, Ltd. | Oral formulation containing 1-(3-cyano-1-isopropyl-indol-5-yl)pyrazole-4-carboxylic acid |
| CN117242062A (zh) * | 2021-04-27 | 2023-12-15 | 株式会社Lg化学 | 用于合成黄嘌呤氧化酶抑制剂的中间体的制备方法 |
| US20240352001A1 (en) * | 2021-04-27 | 2024-10-24 | Lg Chem, Ltd. | Method for preparing intermediate for synthesis of xanthine oxidase inhibitor |
| KR20220147531A (ko) * | 2021-04-27 | 2022-11-03 | 주식회사 엘지화학 | 잔틴 옥시다아제 저해제의 제조 방법 |
| KR20240005050A (ko) * | 2021-04-29 | 2024-01-11 | 쟝쑤 애텀 바이오사이언스 앤드 파머수티컬 컴퍼니 리미티드 | 크산틴 옥시다아제 억제제 |
| EP4344701A4 (en) | 2021-06-15 | 2024-10-23 | Lg Chem, Ltd. | PHARMACEUTICAL COMPOSITION COMPRISING 1-(3-CYANO-1-ISOPROPYL-INDOL-5-YL)PYRAZOLE-4-CARBOXYLIC ACID |
| AR126164A1 (es) * | 2021-06-17 | 2023-09-27 | Lg Chemical Ltd | Formulación compuesta para dosificación oral que comprende ácido 1-(3-ciano-1-isopropil-indol-5-il)pirazol-4-carboxílico |
| TWI822151B (zh) * | 2021-07-02 | 2023-11-11 | 南韓商Ｌｇ化學股份有限公司 | 製備黃嘌呤氧化酶抑制劑的方法 |
| CN117561237A (zh) | 2021-07-02 | 2024-02-13 | 株式会社Lg化学 | 用于合成黄嘌呤氧化酶抑制剂的中间体的制备方法 |
| TWI870839B (zh) * | 2022-04-27 | 2025-01-21 | 大陸商杭州新元素藥業有限公司 | 可用於降尿酸的化合物 |
| TW202342455A (zh) * | 2022-04-27 | 2023-11-01 | 大陸商江蘇新元素醫藥科技有限公司 | 可用於痛風的化合物 |
| CN116283946B (zh) * | 2023-03-27 | 2024-05-07 | 武汉工程大学 | 5-(n-取代吲哚-5-基)异噁唑-3-甲酸衍生物及其合成方法和应用 |
| WO2025014292A1 (ko) * | 2023-07-10 | 2025-01-16 | 주식회사 엘지화학 | 잔틴 옥시다아제 저해제 합성을 위한 중간체의 제조 방법 |
| CN118598859A (zh) * | 2024-05-21 | 2024-09-06 | 武汉工程大学 | 一种含氮杂环吲哚类黄嘌呤氧化酶抑制剂及其制备方法和应用 |
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| ID21775A (id) | 1996-10-25 | 1999-07-22 | Yoshitomi Pharmaceutical | Senyawa-senyawa 1-fenilpirazol dan penggunaan farmasinya |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2014510133A (ja) * | 2011-04-06 | 2014-04-24 | エルジー・ライフ・サイエンシーズ・リミテッド | １−（３−シアノ−１−イソプロピル−インドール−５−イル）ピラゾール−４−カルボン酸の結晶形とその製造方法 |
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