JP5635516B2 - ヒドロキシプロピルセルロース粒子 - Google Patents

ヒドロキシプロピルセルロース粒子 Download PDF

Info

Publication number
JP5635516B2
JP5635516B2 JP2011529895A JP2011529895A JP5635516B2 JP 5635516 B2 JP5635516 B2 JP 5635516B2 JP 2011529895 A JP2011529895 A JP 2011529895A JP 2011529895 A JP2011529895 A JP 2011529895A JP 5635516 B2 JP5635516 B2 JP 5635516B2
Authority
JP
Japan
Prior art keywords
particles
hydroxypropyl cellulose
weight
range
particle size
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2011529895A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2011027729A1 (ja
Inventor
佑介 増江
佑介 増江
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Soda Co Ltd
Original Assignee
Nippon Soda Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Soda Co Ltd filed Critical Nippon Soda Co Ltd
Priority to JP2011529895A priority Critical patent/JP5635516B2/ja
Publication of JPWO2011027729A1 publication Critical patent/JPWO2011027729A1/ja
Application granted granted Critical
Publication of JP5635516B2 publication Critical patent/JP5635516B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/02—Alkyl or cycloalkyl ethers
    • C08B11/04—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals
    • C08B11/08—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals with hydroxylated hydrocarbon radicals; Esters, ethers, or acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/02—Alkyl or cycloalkyl ethers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
    • C08B15/02—Oxycellulose; Hydrocellulose; Cellulosehydrate, e.g. microcrystalline cellulose
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/08—Cellulose derivatives
    • C08L1/26—Cellulose ethers
    • C08L1/28—Alkyl ethers
    • C08L1/284—Alkyl ethers with hydroxylated hydrocarbon radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Jellies, Jams, And Syrups (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • General Preparation And Processing Of Foods (AREA)
JP2011529895A 2009-09-02 2010-08-30 ヒドロキシプロピルセルロース粒子 Active JP5635516B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2011529895A JP5635516B2 (ja) 2009-09-02 2010-08-30 ヒドロキシプロピルセルロース粒子

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2009202246 2009-09-02
JP2009202246 2009-09-02
JP2011529895A JP5635516B2 (ja) 2009-09-02 2010-08-30 ヒドロキシプロピルセルロース粒子
PCT/JP2010/064690 WO2011027729A1 (ja) 2009-09-02 2010-08-30 ヒドロキシプロピルセルロース粒子

Publications (2)

Publication Number Publication Date
JPWO2011027729A1 JPWO2011027729A1 (ja) 2013-02-04
JP5635516B2 true JP5635516B2 (ja) 2014-12-03

Family

ID=43649266

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011529895A Active JP5635516B2 (ja) 2009-09-02 2010-08-30 ヒドロキシプロピルセルロース粒子

Country Status (9)

Country Link
US (1) US9561185B2 (zh)
EP (1) EP2474559B1 (zh)
JP (1) JP5635516B2 (zh)
KR (1) KR101421846B1 (zh)
CN (1) CN102482358B (zh)
ES (1) ES2533987T3 (zh)
PT (1) PT2474559E (zh)
TW (1) TWI454485B (zh)
WO (1) WO2011027729A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013087170A (ja) * 2011-10-17 2013-05-13 Nippon Soda Co Ltd ヒドロキシプロピルセルロース微粒子
WO2014129382A1 (ja) * 2013-02-25 2014-08-28 テルモ株式会社 多糖粉末およびこれを含む癒着防止材
JP2015020964A (ja) * 2013-07-17 2015-02-02 日本曹達株式会社 ヒドロキシプロピルセルロース

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06199660A (ja) * 1993-01-08 1994-07-19 Sekisui Chem Co Ltd 貼付剤及びその製造方法
JPH09291026A (ja) * 1996-02-28 1997-11-11 Teijin Ltd 即効性と持続性を兼ね備えた粉末状経鼻投与用組成物
JPH1059841A (ja) * 1996-02-27 1998-03-03 Teijin Ltd 吸収性が改善された粉末状経鼻投与組成物
JPH10287701A (ja) * 1997-04-11 1998-10-27 Nippon Soda Co Ltd ヒドロキシアルキルセルロース誘導体の造粒乾燥法
JP2001200001A (ja) * 1999-11-09 2001-07-24 Shin Etsu Chem Co Ltd 低置換度ヒドロキシプロピルセルロース及びその製造方法
JP2001322927A (ja) * 2000-05-12 2001-11-20 Shin Etsu Chem Co Ltd 低置換度ヒドロキシプロピルセルロース含有固形製剤及びその製造方法
JP2002207030A (ja) * 2001-01-09 2002-07-26 Nippon Soda Co Ltd ヒドロキシプロピル基含量測定方法及び装置

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3278521A (en) * 1963-02-08 1966-10-11 Hercules Inc Hydroxypropyl cellulose and process
US3728331A (en) * 1969-04-04 1973-04-17 Dow Chemical Co Process for reducing the viscosity of a cellulose ether with hydrogen peroxide
JPH05163162A (ja) 1991-12-12 1993-06-29 Shin Etsu Chem Co Ltd 球形顆粒の製造方法
JP3634380B2 (ja) 1996-02-27 2005-03-30 帝人株式会社 粉末状経鼻投与組成物
US6680069B1 (en) 1999-11-09 2004-01-20 Shin-Etsu Chemical Co., Ltd. Low-substituted hydroxypropyl cellulose and process for manufacturing the same
JP2005325258A (ja) 2004-05-14 2005-11-24 Fuji Photo Film Co Ltd セルロースアシレート製剤、及びセルロースアシレートフィルム

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06199660A (ja) * 1993-01-08 1994-07-19 Sekisui Chem Co Ltd 貼付剤及びその製造方法
JPH1059841A (ja) * 1996-02-27 1998-03-03 Teijin Ltd 吸収性が改善された粉末状経鼻投与組成物
JPH09291026A (ja) * 1996-02-28 1997-11-11 Teijin Ltd 即効性と持続性を兼ね備えた粉末状経鼻投与用組成物
JPH10287701A (ja) * 1997-04-11 1998-10-27 Nippon Soda Co Ltd ヒドロキシアルキルセルロース誘導体の造粒乾燥法
JP2001200001A (ja) * 1999-11-09 2001-07-24 Shin Etsu Chem Co Ltd 低置換度ヒドロキシプロピルセルロース及びその製造方法
JP2001322927A (ja) * 2000-05-12 2001-11-20 Shin Etsu Chem Co Ltd 低置換度ヒドロキシプロピルセルロース含有固形製剤及びその製造方法
JP2002207030A (ja) * 2001-01-09 2002-07-26 Nippon Soda Co Ltd ヒドロキシプロピル基含量測定方法及び装置

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6008027987; 橋田充: 経口投与製剤の設計と評価 , 19950210, ｐ．１６８-１７１, 株式会社薬事時報社 *
JPN6010057612; 改訂　医薬品添加物ハンドブック , 20070228, ｐ．７００-７０５, 株式会社薬事日報社 *

Also Published As

Publication number Publication date
ES2533987T3 (es) 2015-04-16
EP2474559B1 (en) 2015-01-21
TW201120056A (en) 2011-06-16
US20120164451A1 (en) 2012-06-28
CN102482358B (zh) 2014-12-10
US9561185B2 (en) 2017-02-07
EP2474559A4 (en) 2013-10-02
KR101421846B1 (ko) 2014-07-22
EP2474559A1 (en) 2012-07-11
KR20120038016A (ko) 2012-04-20
TWI454485B (zh) 2014-10-01
JPWO2011027729A1 (ja) 2013-02-04
WO2011027729A1 (ja) 2011-03-10
PT2474559E (pt) 2015-04-13
CN102482358A (zh) 2012-05-30

Similar Documents

Publication Publication Date Title
CN103459430B (zh) 生产具有高堆积密度和良好流动性的纤维素衍生物的方法
JP6542767B2 (ja) 粒度分布が調節されたヒドロキシプロピルメチルセルロースアセテートサクシネート（ｈｐｍｃａｓ）粒子の製造方法、及びｈｐｍｃａｓ粉末
JP6039812B2 (ja) 冷水中で高い嵩密度、良好な流動性、および／または分散性、ならびに低い溶液色を有するセルロース誘導体の製造方法
JP6034365B2 (ja) 高い嵩密度、良好な流動性及び改善された冷水分散性を有するセルロース誘導体の製造方法。
KR20140000679A (ko) 신규 셀룰로스 에테르 및 이들의 용도
JP6794216B2 (ja) 溶解性に優れる細孔水溶性非イオン性セルロースエーテル及びその製造方法
EP2829553B1 (en) Method for producing water-soluble nonionic cellulose ether excellent in storage stability
JP5635516B2 (ja) ヒドロキシプロピルセルロース粒子
JP2003252902A (ja) 低置換度セルロースエーテル粉末とその製造方法
WO2021111730A1 (ja) セルロース粒子、セルロース粒子の製造方法
JP4410581B2 (ja) 溶解性の改善されたセルロース誘導体の製造製法
EP3395838A1 (en) Hydroxypropyl methylcellulose phthalate particles, and preparation method therefor
JP6174806B2 (ja) セルロース誘導体及び液体希釈剤の混合物を調製するためのプロセス
JP2013532686A (ja) 剤形からの活性含有成分の放出の制御方法
JP6670778B2 (ja) ヒプロメロース酢酸エステルコハク酸エステル及びその製造方法並びにこれを含む組成物
JP2013133398A (ja) カルボキシメチルセルロースの製造方法
KR101156365B1 (ko) 용해성이 개선된 셀룰로오스 유도체의 제조 방법

Legal Events

Date Code Title Description
A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130917

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20131107

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20131107

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140729

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140912

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20141014

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20141016

R150 Certificate of patent or registration of utility model

Ref document number: 5635516

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S531 Written request for registration of change of domicile

Free format text: JAPANESE INTERMEDIATE CODE: R313531

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250