JP5535088B2 - いぼ、肬贅および乾癬性プラークの治療のための、サンギナリン、ケレリトリンまたはケリドニンを有する製剤 - Google Patents
いぼ、肬贅および乾癬性プラークの治療のための、サンギナリン、ケレリトリンまたはケリドニンを有する製剤 Download PDFInfo
- Publication number
- JP5535088B2 JP5535088B2 JP2010550076A JP2010550076A JP5535088B2 JP 5535088 B2 JP5535088 B2 JP 5535088B2 JP 2010550076 A JP2010550076 A JP 2010550076A JP 2010550076 A JP2010550076 A JP 2010550076A JP 5535088 B2 JP5535088 B2 JP 5535088B2
- Authority
- JP
- Japan
- Prior art keywords
- warts
- chelerythrine
- sanguinarine
- treatment
- formulations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Paper (AREA)
- Polishing Bodies And Polishing Tools (AREA)
- Paints Or Removers (AREA)
Description
本発明は、尋常性皮膚いぼおよび肬贅、肛門および外陰いぼならびに乾癬性プラークの治療に有用な医薬製剤に関する。
さて、驚いたことに、ベンゾフェナントリジンアルカロイドであるサンギナリン、ケレリトリンおよびケリドニンは、遊離形または塩化形で、尋常性皮膚いぼおよび肬贅(高齢者に特有のものを含む)、肛門および外陰いぼならびに乾癬性プラークを治療するのに有利に使用することができることが見出された。
マクレアヤコルダータ親油性抽出物(75%) 15mg
プロシアニジンA2 20mg
エキナセアアングスティフォリアイソブチルアミド 0.5mg
大豆レシチン 50mg
蜜ろう 50mg
植物油 適量 800mgにする。
ケリドニンルテイン酸塩 200.00mg
プロシアニジンA2 400.00mg
カホクザンショウ親油性抽出物 200.00mg
プロピレングリコール 10.00g
ミリスチン酸イソプロピル 5.00g
セチルアルコール 5.00g
ポリソルベート 3.00g
カルボマー 0.40g
p−ヒドロキシ安息香酸メチル 0.10g
p−ヒドロキシ安息香酸プロピル 0.05g
精製水 適量 100gにする。
マクレアヤアルカロイド画分 3.0mg
プロアントシアニジンA2 20.0mg
エキナセアアングスティフォリアイソブチルアミド 0.5mg
脂肪酸のグリセリド 適量 2.0gにする。
マクレアヤアルカロイド画分 300.00mg
ヴィティスヴィニフェラ総プロシアニジン 300.00mg
プロピレングリコール 10.00g
ミリスチン酸イソプロピル 3.00g
エノテラビエンニス油 2.00g
セチルアルコール 5.00g
ポリソルベート 3.00g
カルボマー 0.40g
p−ヒドロキシ安息香酸メチル 0.10g
p−ヒドロキシ安息香酸プロピル 0.05g
精製水 適量 100.00gにする。
Claims (9)
- サンギナリン、ケレリトリンもしくはケリドニンまたはそれらの塩またはそれらを含有する抽出物、エキナセアアングスティフォリア(Echinacea angustifolia)の親油性抽出物のイソブチルアミド、ならびに、媒体および/または添加剤を混合して含有する、尋常性皮膚いぼおよび肬贅、ならびに肛門および外陰いぼの治療のための製剤。
- サンギナリンを含有する請求項1に記載の製剤。
- ケレリトリンを含有する請求項1に記載の製剤。
- ケリドニンを含有する請求項1に記載の製剤。
- サンギナリアカナデンシス(Sanguinaria canadensis)、マクレアヤコルダータ(Macleaya cordata)もしくはマクレアヤマクロカルパ(Macleaya macrocarpa)またはケリドニウムマジュス(Chelidonium majus)の抽出物を含有する、請求項1に記載の製剤。
- サンギナリン、ケレリトリンまたはケリドニンが、ルテイン酸との塩の形である、請求項1に記載の製剤。
- ヴィティスヴィニフェラ(Vitis vinifera)の抽出物、プロシアニジンA2、B2およびB6ならびにプロアントシアニジンA2から選択されるプロシアニジン化合物も含有する、請求項1から6のいずれかに記載の製剤。
- プロアントシアニジンA2を含有する請求項7に記載の製剤。
- クリーム、軟膏、散剤、ローション、膣ペッサリーもしくは膣坐剤、または体内温度で溶解するカプセル剤の製剤の形である、請求項1から8のいずれかに記載の製剤。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT000395A ITMI20080395A1 (it) | 2008-03-10 | 2008-03-10 | Formulazioni per il trattamento delle verruche e delle placche psoriatiche |
ITMI2008A000395 | 2008-03-10 | ||
PCT/EP2009/001672 WO2009112226A1 (en) | 2008-03-10 | 2009-03-09 | Formulations with sanguinarine, chelerythrine or chelidonine for the treatment of warts, verrucas and psoriatic plaques |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2011513449A JP2011513449A (ja) | 2011-04-28 |
JP5535088B2 true JP5535088B2 (ja) | 2014-07-02 |
Family
ID=40292856
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010550076A Expired - Fee Related JP5535088B2 (ja) | 2008-03-10 | 2009-03-09 | いぼ、肬贅および乾癬性プラークの治療のための、サンギナリン、ケレリトリンまたはケリドニンを有する製剤 |
Country Status (17)
Country | Link |
---|---|
US (2) | US8226994B2 (ja) |
EP (1) | EP2262503B1 (ja) |
JP (1) | JP5535088B2 (ja) |
KR (1) | KR20100126367A (ja) |
CN (1) | CN101959517A (ja) |
AU (1) | AU2009224936B2 (ja) |
CA (1) | CA2718384C (ja) |
DK (1) | DK2262503T3 (ja) |
ES (1) | ES2467104T3 (ja) |
HR (1) | HRP20140552T1 (ja) |
IL (1) | IL208030A (ja) |
IT (1) | ITMI20080395A1 (ja) |
PL (1) | PL2262503T3 (ja) |
PT (1) | PT2262503E (ja) |
RU (1) | RU2486898C2 (ja) |
SI (1) | SI2262503T1 (ja) |
WO (1) | WO2009112226A1 (ja) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITMI20080395A1 (it) * | 2008-03-10 | 2009-09-11 | Indena Spa | Formulazioni per il trattamento delle verruche e delle placche psoriatiche |
US20110218241A1 (en) * | 2010-03-06 | 2011-09-08 | Cacao Bio-Technologies, Llc | Antiviral epicatechins, epicatechin oligomers, or thiolated epicatechins from theobroma cacao for treatment of genital warts |
ITMI20112216A1 (it) * | 2011-12-05 | 2013-06-06 | Fond Salvatore Maugeri Clinic A Del Lavoro E | Composizione comprendente un estratto di chelidonium majus e copaiba e il suo impiego per il trattamento di disfunzioni cutanee |
EP2687097A1 (en) * | 2012-07-16 | 2014-01-22 | Universite D'angers | Potentiating agents for protecting plants from fungal infections |
US11566260B2 (en) | 2012-07-16 | 2023-01-31 | Universite D'angers | Potentiating agents for protecting plants from fungal infections |
JP6211380B2 (ja) * | 2012-10-17 | 2017-10-11 | 丸善製薬株式会社 | Tie2活性化剤、血管新生抑制剤、血管の成熟化剤、血管の正常化剤、及び血管の安定化剤 |
KR101431987B1 (ko) * | 2013-09-12 | 2014-08-22 | 중앙대학교 산학협력단 | 펠리토린을 유효성분으로 포함하는 접촉성 피부염 개선용 조성물 |
CN105641576A (zh) * | 2014-12-06 | 2016-06-08 | 石万桃 | 一种治疗各种皮肤疣的外用药膏 |
CN104800216B (zh) * | 2015-01-26 | 2019-03-22 | 东北师范大学 | 氯化两面针碱及其衍生物在制备防治皮肤病药物中的应用 |
IT201600097120A1 (it) * | 2016-09-28 | 2018-03-28 | Michele Miglio | Formulazione topica per il trattamento della psoriasi |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4590061A (en) * | 1983-12-29 | 1986-05-20 | Vipont Laboratories, Inc. | Antimicrobial plaque disclosing agent |
HU194052B (en) * | 1985-03-12 | 1988-01-28 | Caola Kozmetikai | Cosmetic composition against verrucae |
AU610551B2 (en) * | 1987-12-23 | 1991-05-23 | Psoricur Ltd. | Therapeutical compositions against psoriasis |
FR2661330B1 (fr) * | 1990-02-07 | 1995-01-06 | Marlene Azoulay | Compose permettant des soins de manucure et pedicure et le traitement des cors aux pieds, durillons et verrues. |
DE4031960A1 (de) * | 1990-10-09 | 1992-04-16 | Dieter Dr Wendorff | Pharmazeutische zubereitung zur externen behandlung von schuppenflechte (psoriasis vulgaris) |
US6355684B1 (en) * | 1990-10-11 | 2002-03-12 | Meryl J. Squires | Antimicrobial treatment for herpes simplex virus and other infectious diseases |
IT1254321B (it) * | 1992-04-10 | 1995-09-14 | Kemiprogress S R L | Composizione farmaceutica per il trattamento e la prevenzione delle infiammazioni cutanee e della mucosa orale. |
US6593371B1 (en) * | 1993-05-19 | 2003-07-15 | Jeff J. Staggs | Treatment for wart and related disorders |
FR2710266B1 (fr) * | 1993-09-21 | 1995-11-17 | Paul Dupont | Nouvelles compositions en cosmétologie et dermatologie proposées dans le traitement des verrues. |
ITMI981542A1 (it) * | 1998-07-07 | 2000-01-07 | Indena Spa | Estratti di zanthoxylum bungeanum e loro formulazioni farmaceutiche e cosmetiche |
WO2000048541A1 (en) * | 1999-02-19 | 2000-08-24 | Brooks Norman A | Zinc chloride in treating skin diseases |
US20020150630A1 (en) * | 1999-02-19 | 2002-10-17 | Brooks Norman A. | Zinc chloride composition, unit dose packaging, applicator, and method of use in treating cancer and other skin diseases |
HU227318B1 (en) * | 2000-03-08 | 2011-03-28 | Tibor Bodnar | Cosmetical and dematological composition for treating, grooming of psoric skin and scalp |
ITMI20032286A1 (it) * | 2003-11-24 | 2005-05-25 | Indena Spa | Composizioni per il trattamento di dermatiti atopiche di stati allergici cutanei e dell'acne |
DE102005049981A1 (de) * | 2005-10-17 | 2007-04-19 | Henkel Kgaa | Prickelnde Mundwässer |
DE102005060182A1 (de) * | 2005-12-14 | 2007-06-21 | Henkel Kgaa | Remineralisierende Erzeugnisse |
JP2007217410A (ja) * | 2006-01-20 | 2007-08-30 | Tsutomu Yoshida | 抗ウイルス組成物、それを含む抗ウィルス剤及び抗ウイルス機能性食品 |
EP1882473A1 (en) * | 2006-07-28 | 2008-01-30 | Indena S.P.A. | Use of anthocyanosides to prepare formulations for the treatment of mucositis induced by antitumoral drugs |
ITMI20080395A1 (it) * | 2008-03-10 | 2009-09-11 | Indena Spa | Formulazioni per il trattamento delle verruche e delle placche psoriatiche |
-
2008
- 2008-03-10 IT IT000395A patent/ITMI20080395A1/it unknown
-
2009
- 2009-03-09 PL PL09718874T patent/PL2262503T3/pl unknown
- 2009-03-09 WO PCT/EP2009/001672 patent/WO2009112226A1/en active Application Filing
- 2009-03-09 PT PT97188742T patent/PT2262503E/pt unknown
- 2009-03-09 EP EP09718874.2A patent/EP2262503B1/en active Active
- 2009-03-09 SI SI200930948T patent/SI2262503T1/sl unknown
- 2009-03-09 CA CA2718384A patent/CA2718384C/en not_active Expired - Fee Related
- 2009-03-09 CN CN2009801082260A patent/CN101959517A/zh active Pending
- 2009-03-09 ES ES09718874.2T patent/ES2467104T3/es active Active
- 2009-03-09 DK DK09718874.2T patent/DK2262503T3/da active
- 2009-03-09 JP JP2010550076A patent/JP5535088B2/ja not_active Expired - Fee Related
- 2009-03-09 US US12/921,476 patent/US8226994B2/en active Active
- 2009-03-09 RU RU2010137335/15A patent/RU2486898C2/ru not_active IP Right Cessation
- 2009-03-09 KR KR1020107020090A patent/KR20100126367A/ko not_active Application Discontinuation
- 2009-03-09 AU AU2009224936A patent/AU2009224936B2/en not_active Ceased
-
2010
- 2010-09-07 IL IL208030A patent/IL208030A/en active IP Right Grant
-
2012
- 2012-06-22 US US13/530,721 patent/US9393280B2/en active Active
-
2014
- 2014-06-11 HR HRP20140552AT patent/HRP20140552T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
AU2009224936B2 (en) | 2014-11-13 |
US20120263810A1 (en) | 2012-10-18 |
ITMI20080395A1 (it) | 2009-09-11 |
US20110014306A1 (en) | 2011-01-20 |
EP2262503A1 (en) | 2010-12-22 |
RU2486898C2 (ru) | 2013-07-10 |
US9393280B2 (en) | 2016-07-19 |
AU2009224936A1 (en) | 2009-09-17 |
KR20100126367A (ko) | 2010-12-01 |
PL2262503T3 (pl) | 2014-09-30 |
HRP20140552T1 (hr) | 2014-07-18 |
IL208030A (en) | 2016-12-29 |
CA2718384A1 (en) | 2009-09-17 |
CA2718384C (en) | 2016-06-07 |
CN101959517A (zh) | 2011-01-26 |
RU2010137335A (ru) | 2012-03-20 |
WO2009112226A8 (en) | 2009-11-12 |
PT2262503E (pt) | 2014-06-09 |
SI2262503T1 (sl) | 2014-07-31 |
WO2009112226A1 (en) | 2009-09-17 |
EP2262503B1 (en) | 2014-04-30 |
DK2262503T3 (da) | 2014-05-19 |
ES2467104T3 (es) | 2014-06-11 |
US8226994B2 (en) | 2012-07-24 |
IL208030A0 (en) | 2010-12-30 |
JP2011513449A (ja) | 2011-04-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5535088B2 (ja) | いぼ、肬贅および乾癬性プラークの治療のための、サンギナリン、ケレリトリンまたはケリドニンを有する製剤 | |
US4654373A (en) | Pharmaceutical formulations containing coenzyme Q10 suitable for topic administration | |
JPS5913715A (ja) | 新規医薬製剤 | |
CA2419404A1 (en) | Compositions and methods for treating sexual dysfunction | |
ES2319626T3 (es) | Farmaco para el tratamiento de enfermedades tumorales y de la piel virales. | |
JP2017506241A (ja) | ウコンならびにホソババレンギクの抽出物を含有する、末梢性炎症ならびに疼痛の軽減に有用な組成物 | |
KR20010031149A (ko) | 항소양 활성을 가진 화합물의 신규한 용도 | |
EP2059259A1 (en) | Pharmaceutical compositions for the treatment of fungal infections | |
KR20020000316A (ko) | 알프로스타딜 외용제 | |
KR20010071319A (ko) | 미녹시딜 함유 외용 조성물 | |
WO2006085127A1 (en) | Topical compositions | |
EP2343038A1 (fr) | Compositions dermatologiques contenant une association de lipides peroxydés et de zinc et leurs utilisations notamment dans le traitement de l'herpès | |
ES2569395T3 (es) | Fármaco que contiene miristato de isopropilo y una catequina | |
JP5677936B2 (ja) | 慢性炎症を有する膣感染治療の組成物 | |
JPH03215435A (ja) | アルドース還元酵素阻害剤を主成分とする潰瘍治療剤 | |
JP2016518424A (ja) | ヘルペス処置のための薬剤と方法 | |
ES2235443T3 (es) | Composiciones farmaceuticas topicas para curar heridas, que constan de borneol y subgalato de bismuto. | |
RU2003106417A (ru) | Применение комбинации витаминов для лечения первичных головных болей | |
AU2005100183B4 (en) | Treatment of premature ejaculation | |
EP1700597B1 (en) | Pharmaceutical composition containing in association ubidecarenone, dexpanthenol and chlorhexidine or a pharmaceutically acceptable salt thereof for cutaneous application | |
JP2896993B2 (ja) | 坐 剤 | |
Turner | Talampicillin Antimicrobial ester of Ampicillin to which it is rapidly metabolized after absorption. Uses and adverse effects similar to Ampicillin. Said to maintain higher blood levels and to cause less diarrhoea. Talc Has lubricant and anti-irritant properties. Used topically on skin and as an aid to the manufacture of some tablets. | |
JP2003089642A (ja) | 勃起機能障害の治療用医薬組成物 | |
JP2003238397A (ja) | 痔疾治療剤 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20120217 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20130820 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20131120 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20131127 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20131220 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20140325 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20140422 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5535088 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
LAPS | Cancellation because of no payment of annual fees |