JP2011513449A - いぼ、肬贅および乾癬性プラークの治療のための、サンギナリン、ケレリトリンまたはケリドニンを有する製剤 - Google Patents
いぼ、肬贅および乾癬性プラークの治療のための、サンギナリン、ケレリトリンまたはケリドニンを有する製剤 Download PDFInfo
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- JP2011513449A JP2011513449A JP2010550076A JP2010550076A JP2011513449A JP 2011513449 A JP2011513449 A JP 2011513449A JP 2010550076 A JP2010550076 A JP 2010550076A JP 2010550076 A JP2010550076 A JP 2010550076A JP 2011513449 A JP2011513449 A JP 2011513449A
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- Prior art keywords
- warts
- chelerythrine
- sanguinarine
- treatment
- formulation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Paints Or Removers (AREA)
- Paper (AREA)
- Polishing Bodies And Polishing Tools (AREA)
Abstract
Description
本発明は、尋常性皮膚いぼおよび肬贅、肛門および外陰いぼならびに乾癬性プラークの治療に有用な医薬製剤に関する。
さて、驚いたことに、ベンゾフェナントリジンアルカロイドであるサンギナリン、ケレリトリンおよびケリドニンは、遊離形または塩化形で、尋常性皮膚いぼおよび肬贅(高齢者に特有のものを含む)、肛門および外陰いぼならびに乾癬性プラークを治療するのに有利に使用することができることが見出された。
マクレアヤコルダータ親油性抽出物(75%) 15mg
プロシアニジンA2 20mg
エキナセアアングスティフォリアイソブチルアミド 0.5mg
大豆レシチン 50mg
蜜ろう 50mg
植物油 適量 800mgにする。
ケリドニンルテイン酸塩 200.00mg
プロシアニジンA2 400.00mg
カホクザンショウ親油性抽出物 200.00mg
プロピレングリコール 10.00g
ミリスチン酸イソプロピル 5.00g
セチルアルコール 5.00g
ポリソルベート 3.00g
カルボマー 0.40g
p−ヒドロキシ安息香酸メチル 0.10g
p−ヒドロキシ安息香酸プロピル 0.05g
精製水 適量 100gにする。
マクレアヤアルカロイド画分 3.0mg
プロアントシアニジンA2 20.0mg
エキナセアアングスティフォリアイソブチルアミド 0.5mg
脂肪酸のグリセリド 適量 2.0gにする。
マクレアヤアルカロイド画分 300.00mg
ヴィティスヴィニフェラ総プロシアニジン 300.00mg
プロピレングリコール 10.00g
ミリスチン酸イソプロピル 3.00g
エノテラビエンニス油 2.00g
セチルアルコール 5.00g
ポリソルベート 3.00g
カルボマー 0.40g
p−ヒドロキシ安息香酸メチル 0.10g
p−ヒドロキシ安息香酸プロピル 0.05g
精製水 適量 100.00gにする。
Claims (16)
- サンギナリン、ケレリトリンもしくはケリドニンまたはそれらの塩またはそれらを含有する抽出物を、適した媒体および/または添加剤と混合して含有する、尋常性皮膚いぼおよび肬贅、肛門および外陰いぼならびに乾癬性プラークの治療のための製剤。
- サンギナリンを含有する請求項1に記載の製剤。
- ケレリトリンを含有する請求項1に記載の製剤。
- ケリドニンを含有する請求項1に記載の製剤。
- サンギナリアカナデンシス(Sanguinaria canadensis)、マクレアヤコルダータ(Macleaya cordata)もしくはマクレアヤマクロカルパ(Macleaya macrocarpa)またはケリドニウムマジュス(Chelidonium majus)の抽出物を含有する、請求項1に記載の製剤。
- サンギナリン、ケレリトリンまたはケリドニンが、ルテイン酸との塩の形である、請求項1に記載の製剤。
- ヴィティスヴィニフェラ(Vitis vinifera)の抽出物、プロシアニジンA2、B2およびB6ならびにプロアントシアニジンA2から選択されるプロシアニジン化合物も含有する、請求項1から6のいずれかに記載の製剤。
- プロアントシアニジンA2を含有する請求項7に記載の製剤。
- 天然または合成のイソブチルアミドも含有する、請求項1から8のいずれかに記載の製剤。
- イソブチルアミドが、カホクザンショウ(Zanthoxylum bungeanum)またはエキナセアアングスティフォリア(Echinacea angustifolia)の親油性抽出物中に含有される、請求項9に記載の製剤。
- イソブチルアミドがペリトリンからなる請求項9に記載の製剤。
- クリーム、軟膏、散剤、ローション、膣ペッサリーもしくは膣坐剤、体内温度で溶解するカプセル剤または相当する製剤の形である、請求項1から10のいずれかに記載の製剤。
- 尋常性皮膚いぼおよび肬贅、肛門および外陰いぼならびに乾癬性プラークの治療用の医薬品を調製するための、サンギナリン、ケレリトリンもしくはケリドニンもしくはそれらの塩またはそれらを含有する抽出物の使用。
- サンギナリン、ケレリトリンまたはケリドニンがルテイン酸で塩化されている、請求項13に記載の使用。
- ヴィティスヴィニフェラの抽出物、プロシアニジンA2、B2およびB6ならびにプロアントシアニジンA2から選択されるプロシアニジン化合物と組み合わされる、請求項13および14の一項または二項に記載の使用。
- 天然または合成のイソブチルアミドと組み合わされる、請求項13から15の一項または複数項に記載の使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI2008A000395 | 2008-03-10 | ||
IT000395A ITMI20080395A1 (it) | 2008-03-10 | 2008-03-10 | Formulazioni per il trattamento delle verruche e delle placche psoriatiche |
PCT/EP2009/001672 WO2009112226A1 (en) | 2008-03-10 | 2009-03-09 | Formulations with sanguinarine, chelerythrine or chelidonine for the treatment of warts, verrucas and psoriatic plaques |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2011513449A true JP2011513449A (ja) | 2011-04-28 |
JP5535088B2 JP5535088B2 (ja) | 2014-07-02 |
Family
ID=40292856
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010550076A Expired - Fee Related JP5535088B2 (ja) | 2008-03-10 | 2009-03-09 | いぼ、肬贅および乾癬性プラークの治療のための、サンギナリン、ケレリトリンまたはケリドニンを有する製剤 |
Country Status (17)
Country | Link |
---|---|
US (2) | US8226994B2 (ja) |
EP (1) | EP2262503B1 (ja) |
JP (1) | JP5535088B2 (ja) |
KR (1) | KR20100126367A (ja) |
CN (1) | CN101959517A (ja) |
AU (1) | AU2009224936B2 (ja) |
CA (1) | CA2718384C (ja) |
DK (1) | DK2262503T3 (ja) |
ES (1) | ES2467104T3 (ja) |
HR (1) | HRP20140552T1 (ja) |
IL (1) | IL208030A (ja) |
IT (1) | ITMI20080395A1 (ja) |
PL (1) | PL2262503T3 (ja) |
PT (1) | PT2262503E (ja) |
RU (1) | RU2486898C2 (ja) |
SI (1) | SI2262503T1 (ja) |
WO (1) | WO2009112226A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014097977A (ja) * | 2012-10-17 | 2014-05-29 | Maruzen Pharmaceut Co Ltd | Tie2活性化剤、血管新生抑制剤、血管の成熟化剤、血管の正常化剤、及び血管の安定化剤、並びに医薬品組成物 |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITMI20080395A1 (it) * | 2008-03-10 | 2009-09-11 | Indena Spa | Formulazioni per il trattamento delle verruche e delle placche psoriatiche |
US20110218241A1 (en) * | 2010-03-06 | 2011-09-08 | Cacao Bio-Technologies, Llc | Antiviral epicatechins, epicatechin oligomers, or thiolated epicatechins from theobroma cacao for treatment of genital warts |
ITMI20112216A1 (it) | 2011-12-05 | 2013-06-06 | Fond Salvatore Maugeri Clinic A Del Lavoro E | Composizione comprendente un estratto di chelidonium majus e copaiba e il suo impiego per il trattamento di disfunzioni cutanee |
US11566260B2 (en) | 2012-07-16 | 2023-01-31 | Universite D'angers | Potentiating agents for protecting plants from fungal infections |
EP2687097A1 (en) * | 2012-07-16 | 2014-01-22 | Universite D'angers | Potentiating agents for protecting plants from fungal infections |
KR101431987B1 (ko) * | 2013-09-12 | 2014-08-22 | 중앙대학교 산학협력단 | 펠리토린을 유효성분으로 포함하는 접촉성 피부염 개선용 조성물 |
CN105641576A (zh) * | 2014-12-06 | 2016-06-08 | 石万桃 | 一种治疗各种皮肤疣的外用药膏 |
CN104800216B (zh) * | 2015-01-26 | 2019-03-22 | 东北师范大学 | 氯化两面针碱及其衍生物在制备防治皮肤病药物中的应用 |
IT201600097120A1 (it) * | 2016-09-28 | 2018-03-28 | Michele Miglio | Formulazione topica per il trattamento della psoriasi |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
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JPH02502631A (ja) * | 1987-12-23 | 1990-08-23 | プソリツル・リミテッド | 乾癬に対する治療用組成物 |
FR2661330A1 (fr) * | 1990-02-07 | 1991-10-31 | Azoulay Marlene | Compose permettant des soins de manucure et pedicure et le traitement des cors aux pieds, durillons et verrues. |
DE4031960A1 (de) * | 1990-10-09 | 1992-04-16 | Dieter Dr Wendorff | Pharmazeutische zubereitung zur externen behandlung von schuppenflechte (psoriasis vulgaris) |
FR2710266A1 (fr) * | 1993-09-21 | 1995-03-31 | Dupont Paul | Nouvelles compositions en cosmétologie et dermatologie proposées dans le traitement des verrues. |
WO2001066079A1 (en) * | 2000-03-08 | 2001-09-13 | Bodnar Tibor | Cosmetic and dermatological composition for psoriatic skin, scalp treatment and care |
JP2007512271A (ja) * | 2003-11-24 | 2007-05-17 | インデナ エッセ ピ ア | アトピー性皮膚炎、皮膚のアレルギー状態、および座瘡の治療用組成物 |
JP2007217410A (ja) * | 2006-01-20 | 2007-08-30 | Tsutomu Yoshida | 抗ウイルス組成物、それを含む抗ウィルス剤及び抗ウイルス機能性食品 |
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HU194052B (en) * | 1985-03-12 | 1988-01-28 | Caola Kozmetikai | Cosmetic composition against verrucae |
US6355684B1 (en) * | 1990-10-11 | 2002-03-12 | Meryl J. Squires | Antimicrobial treatment for herpes simplex virus and other infectious diseases |
IT1254321B (it) * | 1992-04-10 | 1995-09-14 | Kemiprogress S R L | Composizione farmaceutica per il trattamento e la prevenzione delle infiammazioni cutanee e della mucosa orale. |
US6593371B1 (en) * | 1993-05-19 | 2003-07-15 | Jeff J. Staggs | Treatment for wart and related disorders |
ITMI981542A1 (it) * | 1998-07-07 | 2000-01-07 | Indena Spa | Estratti di zanthoxylum bungeanum e loro formulazioni farmaceutiche e cosmetiche |
US20020150630A1 (en) * | 1999-02-19 | 2002-10-17 | Brooks Norman A. | Zinc chloride composition, unit dose packaging, applicator, and method of use in treating cancer and other skin diseases |
US6558694B2 (en) * | 1999-02-19 | 2003-05-06 | Norman A. Brooks | Zinc chloride unit dose packaging, applicator, and method of use in treating cancer and other skin diseases |
DE102005049981A1 (de) * | 2005-10-17 | 2007-04-19 | Henkel Kgaa | Prickelnde Mundwässer |
DE102005060182A1 (de) * | 2005-12-14 | 2007-06-21 | Henkel Kgaa | Remineralisierende Erzeugnisse |
EP1882473A1 (en) * | 2006-07-28 | 2008-01-30 | Indena S.P.A. | Use of anthocyanosides to prepare formulations for the treatment of mucositis induced by antitumoral drugs |
ITMI20080395A1 (it) * | 2008-03-10 | 2009-09-11 | Indena Spa | Formulazioni per il trattamento delle verruche e delle placche psoriatiche |
-
2008
- 2008-03-10 IT IT000395A patent/ITMI20080395A1/it unknown
-
2009
- 2009-03-09 US US12/921,476 patent/US8226994B2/en active Active
- 2009-03-09 RU RU2010137335/15A patent/RU2486898C2/ru not_active IP Right Cessation
- 2009-03-09 CA CA2718384A patent/CA2718384C/en not_active Expired - Fee Related
- 2009-03-09 DK DK09718874.2T patent/DK2262503T3/da active
- 2009-03-09 ES ES09718874.2T patent/ES2467104T3/es active Active
- 2009-03-09 EP EP09718874.2A patent/EP2262503B1/en active Active
- 2009-03-09 JP JP2010550076A patent/JP5535088B2/ja not_active Expired - Fee Related
- 2009-03-09 PT PT97188742T patent/PT2262503E/pt unknown
- 2009-03-09 WO PCT/EP2009/001672 patent/WO2009112226A1/en active Application Filing
- 2009-03-09 AU AU2009224936A patent/AU2009224936B2/en not_active Ceased
- 2009-03-09 PL PL09718874T patent/PL2262503T3/pl unknown
- 2009-03-09 SI SI200930948T patent/SI2262503T1/sl unknown
- 2009-03-09 KR KR1020107020090A patent/KR20100126367A/ko not_active Application Discontinuation
- 2009-03-09 CN CN2009801082260A patent/CN101959517A/zh active Pending
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2010
- 2010-09-07 IL IL208030A patent/IL208030A/en active IP Right Grant
-
2012
- 2012-06-22 US US13/530,721 patent/US9393280B2/en active Active
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2014
- 2014-06-11 HR HRP20140552AT patent/HRP20140552T1/hr unknown
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JPH02502631A (ja) * | 1987-12-23 | 1990-08-23 | プソリツル・リミテッド | 乾癬に対する治療用組成物 |
FR2661330A1 (fr) * | 1990-02-07 | 1991-10-31 | Azoulay Marlene | Compose permettant des soins de manucure et pedicure et le traitement des cors aux pieds, durillons et verrues. |
DE4031960A1 (de) * | 1990-10-09 | 1992-04-16 | Dieter Dr Wendorff | Pharmazeutische zubereitung zur externen behandlung von schuppenflechte (psoriasis vulgaris) |
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JP2007512271A (ja) * | 2003-11-24 | 2007-05-17 | インデナ エッセ ピ ア | アトピー性皮膚炎、皮膚のアレルギー状態、および座瘡の治療用組成物 |
JP2007217410A (ja) * | 2006-01-20 | 2007-08-30 | Tsutomu Yoshida | 抗ウイルス組成物、それを含む抗ウィルス剤及び抗ウイルス機能性食品 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014097977A (ja) * | 2012-10-17 | 2014-05-29 | Maruzen Pharmaceut Co Ltd | Tie2活性化剤、血管新生抑制剤、血管の成熟化剤、血管の正常化剤、及び血管の安定化剤、並びに医薬品組成物 |
Also Published As
Publication number | Publication date |
---|---|
RU2010137335A (ru) | 2012-03-20 |
US8226994B2 (en) | 2012-07-24 |
US20120263810A1 (en) | 2012-10-18 |
AU2009224936B2 (en) | 2014-11-13 |
PT2262503E (pt) | 2014-06-09 |
EP2262503A1 (en) | 2010-12-22 |
RU2486898C2 (ru) | 2013-07-10 |
KR20100126367A (ko) | 2010-12-01 |
SI2262503T1 (sl) | 2014-07-31 |
CA2718384A1 (en) | 2009-09-17 |
WO2009112226A1 (en) | 2009-09-17 |
AU2009224936A1 (en) | 2009-09-17 |
CA2718384C (en) | 2016-06-07 |
IL208030A0 (en) | 2010-12-30 |
CN101959517A (zh) | 2011-01-26 |
WO2009112226A8 (en) | 2009-11-12 |
ES2467104T3 (es) | 2014-06-11 |
JP5535088B2 (ja) | 2014-07-02 |
US20110014306A1 (en) | 2011-01-20 |
US9393280B2 (en) | 2016-07-19 |
IL208030A (en) | 2016-12-29 |
ITMI20080395A1 (it) | 2009-09-11 |
DK2262503T3 (da) | 2014-05-19 |
EP2262503B1 (en) | 2014-04-30 |
PL2262503T3 (pl) | 2014-09-30 |
HRP20140552T1 (hr) | 2014-07-18 |
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