JP5520811B2 - コラーゲン結合領域と副甲状腺ホルモンとの融合タンパク - Google Patents

コラーゲン結合領域と副甲状腺ホルモンとの融合タンパク Download PDF

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JP5520811B2
JP5520811B2 JP2010503048A JP2010503048A JP5520811B2 JP 5520811 B2 JP5520811 B2 JP 5520811B2 JP 2010503048 A JP2010503048 A JP 2010503048A JP 2010503048 A JP2010503048 A JP 2010503048A JP 5520811 B2 JP5520811 B2 JP 5520811B2
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pth
fusion protein
collagen
seq
bone
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JP2010523671A5 (OSRAM
JP2010523671A (ja
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治 松下
ロバート シー ジェンシュア
ジョシュア サコン
トゥラシ ポンナパッカム
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ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ アーカンソー
国立大学法人 香川大学
オクスナー クリニック ファウンデイション
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    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
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    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
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    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
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    • C12N9/14—Hydrolases (3)
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    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
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JP2010503048A 2007-04-09 2008-04-09 コラーゲン結合領域と副甲状腺ホルモンとの融合タンパク Active JP5520811B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92243307P 2007-04-09 2007-04-09
US60/922,433 2007-04-09
PCT/US2008/004589 WO2008124166A2 (en) 2007-04-09 2008-04-09 Fusion proteins of collagen-binding domain and parathyroid hormone

Related Child Applications (1)

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JP2013194484A Division JP5821066B2 (ja) 2007-04-09 2013-09-19 コラーゲン結合領域と副甲状腺ホルモンとの融合タンパク

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JP2010523671A JP2010523671A (ja) 2010-07-15
JP2010523671A5 JP2010523671A5 (OSRAM) 2011-05-26
JP5520811B2 true JP5520811B2 (ja) 2014-06-11

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JP2010503048A Active JP5520811B2 (ja) 2007-04-09 2008-04-09 コラーゲン結合領域と副甲状腺ホルモンとの融合タンパク
JP2013194484A Active JP5821066B2 (ja) 2007-04-09 2013-09-19 コラーゲン結合領域と副甲状腺ホルモンとの融合タンパク
JP2015173678A Active JP5989876B2 (ja) 2007-04-09 2015-09-03 コラーゲン結合領域と副甲状腺ホルモンとの融合タンパク
JP2016157345A Active JP6366653B2 (ja) 2007-04-09 2016-08-10 コラーゲン結合領域と副甲状腺ホルモンとの融合タンパク

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JP2013194484A Active JP5821066B2 (ja) 2007-04-09 2013-09-19 コラーゲン結合領域と副甲状腺ホルモンとの融合タンパク
JP2015173678A Active JP5989876B2 (ja) 2007-04-09 2015-09-03 コラーゲン結合領域と副甲状腺ホルモンとの融合タンパク
JP2016157345A Active JP6366653B2 (ja) 2007-04-09 2016-08-10 コラーゲン結合領域と副甲状腺ホルモンとの融合タンパク

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US (6) US8450273B2 (OSRAM)
EP (2) EP2155874B1 (OSRAM)
JP (4) JP5520811B2 (OSRAM)
CA (2) CA2683862C (OSRAM)
DK (2) DK2155874T3 (OSRAM)
ES (2) ES2583002T3 (OSRAM)
WO (1) WO2008124166A2 (OSRAM)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2155874T3 (en) * 2007-04-09 2016-08-01 Univ Arkansas FUSION PROTEIN OF COLLAGE BINDING DOMAIN AND parathyroid hormone
US20110294192A1 (en) * 2008-11-19 2011-12-01 Tohoku University Fusion collagenase in which affinity tag is linked and method for producing the same
EP2405008A1 (en) * 2010-07-06 2012-01-11 LanthioPep B.V. Bacterial surface display of thioether-bridge-containing peptides
US9173919B2 (en) 2011-02-16 2015-11-03 Purdue Research Foundation Collagen-targeted nanoparticles
JP5512887B2 (ja) * 2011-05-13 2014-06-04 学校法人北里研究所 成長因子アンカーリング型骨移植材料および成長因子アンカーリング型骨移植材料製造用キット
ES2816009T3 (es) * 2011-12-14 2021-03-31 Univ Arkansas Administración de agentes terapéuticos mediante una proteína de unión a colágeno
US9526765B2 (en) 2012-02-09 2016-12-27 The Kitasato Institute Delivery of therapeutic agents by a collagen binding protein
US8969290B2 (en) 2012-06-26 2015-03-03 Worcester Polytechnic Institute Matrix scaffold with antimicrobial activity
WO2016085280A1 (ko) 2014-11-28 2016-06-02 서울대학교산학협력단 세포 투과성 스테이플 펩타이드, 이의 제조방법 및 그 용도
US11213613B2 (en) 2015-06-12 2022-01-04 Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences Three-dimensional tissue scaffold with stem cell attracting element and use thereof
BR112018017091A2 (pt) 2016-03-01 2019-01-02 Ascendis Pharma Bone Diseases As profármacos de pth
CN109789189B (zh) 2016-09-29 2024-01-23 阿森迪斯药物骨疾病股份有限公司 控释pth化合物的剂量方案
NZ751745A (en) 2016-09-29 2023-05-26 Ascendis Pharma Bone Diseases As Pth compounds with low peak-to-trough ratios
ES3012647T3 (en) 2016-09-29 2025-04-09 Ascendis Pharma Bone Diseases As Controlled-release pth compounds
CA3045458A1 (en) * 2016-11-30 2018-06-07 Purdue Research Foundation Fracture targeted bone regeneration through parathyroid hormone receptor stimulation
WO2018148573A1 (en) * 2017-02-10 2018-08-16 The Board Of Trustees Of The University Of Arkansas Collagen-binding agent compositions and methods of using the same
GB201706781D0 (en) 2017-04-28 2017-06-14 Univ Sheffield Parathyroid hormone fusion polypeptide
CN107213517B (zh) * 2017-05-17 2020-03-27 宁波大学 一种复合骨水泥及其制备方法
JP6577683B2 (ja) * 2017-09-22 2019-09-18 旭化成ファーマ株式会社 安定性に優れるテリパラチド含有液状医薬組成物
KR101964376B1 (ko) * 2017-09-29 2019-04-01 주식회사 나이벡 부갑상선호르몬(parathyroid hormone, PTH)에 골조직 선택성 펩타이드가 결합되어 있는 융합 펩타이드를 포함하는 약학 조성물 및 생체재료
EP3796941A4 (en) 2018-05-30 2022-12-28 Purdue Research Foundation Targeting anabolic drugs for accelerated fracture repair
KR102891411B1 (ko) 2019-02-11 2025-11-25 아센디스 파마 본 디지즈 에이/에스 Pth 접합체의 액체 약학 제제
WO2021030196A1 (en) * 2019-08-09 2021-02-18 Phasebio Pharmaceuticals, Inc. Elp fusion proteins comprising parathyroid hormone for controlled and sustained release
US12403179B2 (en) 2021-02-18 2025-09-02 The Board Of Trustees Of The University Of Arkansas Release of growth factors at wound healing stages
JP2025534350A (ja) 2022-09-30 2025-10-15 エクステンド バイオサイエンシズ インコーポレーテッド 長時間作用型副甲状腺ホルモン

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8516421D0 (en) 1985-06-28 1985-07-31 Biotechnology Interface Ltd Fibronectins
WO1994022468A1 (en) 1993-04-02 1994-10-13 Anticancer, Inc. Method for delivering beneficial compositions to hair follicles
US5925552A (en) 1996-04-25 1999-07-20 Medtronic, Inc. Method for attachment of biomolecules to medical devices surfaces
WO1998004591A1 (en) 1996-07-31 1998-02-05 The General Hospital Corporation Novel parathyroid hormone-related peptide analogs
US6428579B1 (en) 1998-07-01 2002-08-06 Brown University Research Foundation Implantable prosthetic devices coated with bioactive molecules
US6387663B1 (en) * 1998-07-31 2002-05-14 University Of Southern California Targeting pharmaceutical agents to injured tissues
US7601685B2 (en) * 1998-08-27 2009-10-13 Eidgenossische Technische Hochschule Zurich Growth factor modified protein matrices for tissue engineering
EP1151116A1 (en) 1999-02-19 2001-11-07 Terumo Kabushiki Kaisha Collagen-binding physiologically active polypeptide
JP2001190280A (ja) * 1999-02-19 2001-07-17 Terumo Corp コラーゲン結合性生理活性ポリペプチド
US20020102709A1 (en) * 1999-02-19 2002-08-01 Tetsuya Ishikawa Collagen-binding physiologically active polypeptide
US6908994B1 (en) * 1999-05-10 2005-06-21 The Texas A&M University System Collagen-binding proteins from enterococcal bacteria
US20050124537A1 (en) 2000-04-27 2005-06-09 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US20040053368A1 (en) * 2000-08-15 2004-03-18 Tetsuya Ishikawa Collagen-binding hybrid polypeptide
JP2002058485A (ja) 2000-08-16 2002-02-26 Terumo Corp コラーゲン結合性を有する骨形成促進融合蛋白質
US20020063621A1 (en) 2000-09-01 2002-05-30 Next Planet, Inc. Method and apparatus for device communications
US6812217B2 (en) 2000-12-04 2004-11-02 Medtronic, Inc. Medical device and methods of use
JP4560291B2 (ja) 2001-12-18 2010-10-13 イジュノシッヒ テクニッヒ ホッフシューラ チューリッヒ 組織操作のための成長因子改変タンパク質マトリクス
JP4750416B2 (ja) * 2002-07-25 2011-08-17 ザ ジェネラル ホスピタル コーポレイション 副甲状腺ホルモン受容体の活性化と造血前駆細胞の増殖
US7060299B2 (en) 2002-12-31 2006-06-13 Battelle Memorial Institute Biodegradable microparticles that stabilize and control the release of proteins
ES2269973T3 (es) 2003-02-13 2007-04-01 Synthes Ag Chur Mezcla inyectable para sustituir un tejido oseo.
US20040220094A1 (en) 2003-05-01 2004-11-04 Skinner Keith K. Inverse agonist and agonist peptides that stimulate/inhibit hair growth
EP1680073B1 (en) 2003-10-21 2013-01-02 IGF Oncology, LLC Compounds and method for treating cancer
WO2005046798A1 (en) * 2003-11-12 2005-05-26 Nps Allelix Corp. Treatment of bone loss utilizing full length parathyroid hormone
EP1557176A1 (en) 2004-01-26 2005-07-27 Ferring B.V. Treatment of bone metastases by means of PTH receptor agonists
US20090005298A1 (en) 2004-02-27 2009-01-01 The University Of Western Ontario Bone Sialoprotein Collagen-Binding Peptides
HUE055861T2 (hu) 2004-04-21 2021-12-28 Alexion Pharma Inc Csontbejuttató konjugátumok és azok alkalmazási módszere fehérjék csonthoz kötéséhez
EP1812082B1 (en) 2004-10-21 2013-08-14 IGF Oncology, LLC Toxins and radionuclides coupled to IGF-1 receptor ligands for the treatment of cancer
WO2006073711A2 (en) * 2005-01-06 2006-07-13 Kuros Biosurgery Ag Use of a matrix comprising a contrast agent in soft tissues
ATE514712T1 (de) 2005-12-26 2011-07-15 Yantai Zhenghai Bio Technology Co Ltd Aktivierte collagen-gerüstmaterialien und ihre speziellen kondensierten aktiven restorationsfaktoren
DK2155874T3 (en) * 2007-04-09 2016-08-01 Univ Arkansas FUSION PROTEIN OF COLLAGE BINDING DOMAIN AND parathyroid hormone
JP2010172247A (ja) 2009-01-29 2010-08-12 Kitasato Institute 積層型高密度培養人工組織の製造方法及び積層型高密度培養人工組織
JPWO2011142425A1 (ja) 2010-05-12 2013-07-22 国立大学法人 香川大学 上皮層含有組織の再生材および再生評価方法
JP5512887B2 (ja) 2011-05-13 2014-06-04 学校法人北里研究所 成長因子アンカーリング型骨移植材料および成長因子アンカーリング型骨移植材料製造用キット
ES2816009T3 (es) 2011-12-14 2021-03-31 Univ Arkansas Administración de agentes terapéuticos mediante una proteína de unión a colágeno
US9526765B2 (en) 2012-02-09 2016-12-27 The Kitasato Institute Delivery of therapeutic agents by a collagen binding protein

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