JP2010523671A5 - - Google Patents
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- Publication number
- JP2010523671A5 JP2010523671A5 JP2010503048A JP2010503048A JP2010523671A5 JP 2010523671 A5 JP2010523671 A5 JP 2010523671A5 JP 2010503048 A JP2010503048 A JP 2010503048A JP 2010503048 A JP2010503048 A JP 2010503048A JP 2010523671 A5 JP2010523671 A5 JP 2010523671A5
- Authority
- JP
- Japan
- Prior art keywords
- pth
- polypeptide fragment
- collagen
- binding polypeptide
- receptor agonist
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims description 93
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 93
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 93
- 239000012634 fragment Substances 0.000 claims description 90
- 108090000445 Parathyroid hormone Proteins 0.000 claims description 68
- 102000008186 Collagen Human genes 0.000 claims description 57
- 108010035532 Collagen Proteins 0.000 claims description 57
- 229920001436 collagen Polymers 0.000 claims description 57
- 102000006461 Parathyroid Hormone Receptors Human genes 0.000 claims description 53
- 108010058828 Parathyroid Hormone Receptors Proteins 0.000 claims description 53
- 239000000018 receptor agonist Substances 0.000 claims description 41
- 229940044601 receptor agonist Drugs 0.000 claims description 41
- 241000124008 Mammalia Species 0.000 claims description 40
- 108020001507 fusion proteins Proteins 0.000 claims description 39
- 102000037865 fusion proteins Human genes 0.000 claims description 39
- 239000000203 mixture Substances 0.000 claims description 38
- 210000000988 bone and bone Anatomy 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 19
- 230000001737 promoting effect Effects 0.000 claims description 14
- 210000001185 bone marrow Anatomy 0.000 claims description 10
- 210000000130 stem cell Anatomy 0.000 claims description 10
- 239000007943 implant Substances 0.000 claims description 8
- 230000008468 bone growth Effects 0.000 claims description 6
- 206010027476 Metastases Diseases 0.000 claims description 5
- 206010028980 Neoplasm Diseases 0.000 claims description 5
- 102000003982 Parathyroid hormone Human genes 0.000 claims description 5
- 201000011510 cancer Diseases 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 5
- 230000012010 growth Effects 0.000 claims description 5
- 239000000199 parathyroid hormone Substances 0.000 claims description 5
- OGBMKVWORPGQRR-UMXFMPSGSA-N teriparatide Chemical compound C([C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CNC=N1 OGBMKVWORPGQRR-UMXFMPSGSA-N 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 4
- 230000009401 metastasis Effects 0.000 claims description 4
- 230000008467 tissue growth Effects 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 3
- 230000003779 hair growth Effects 0.000 claims description 3
- 208000010125 myocardial infarction Diseases 0.000 claims description 3
- 150000001413 amino acids Chemical class 0.000 claims 4
- 230000001580 bacterial effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 241000699670 Mus sp. Species 0.000 description 15
- 229910052500 inorganic mineral Inorganic materials 0.000 description 12
- 239000011707 mineral Substances 0.000 description 12
- 239000002464 receptor antagonist Substances 0.000 description 11
- 229940044551 receptor antagonist Drugs 0.000 description 11
- 239000000556 agonist Substances 0.000 description 9
- 108700020797 Parathyroid Hormone-Related Proteins 0.000 description 6
- 102000043299 Parathyroid hormone-related Human genes 0.000 description 6
- 239000005557 antagonist Substances 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 239000013543 active substance Substances 0.000 description 5
- VHYRHFNOWKMCHQ-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 4-formylbenzoate Chemical compound C1=CC(C=O)=CC=C1C(=O)ON1C(=O)CCC1=O VHYRHFNOWKMCHQ-UHFFFAOYSA-N 0.000 description 4
- 102000029816 Collagenase Human genes 0.000 description 4
- 108060005980 Collagenase Proteins 0.000 description 4
- 125000003277 amino group Chemical group 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 229960002424 collagenase Drugs 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 238000011476 stem cell transplantation Methods 0.000 description 4
- VOYADQIFGGIKAT-UHFFFAOYSA-N 1,3-dibutyl-4-hydroxy-2,6-dioxopyrimidine-5-carboximidamide Chemical compound CCCCn1c(O)c(C(N)=N)c(=O)n(CCCC)c1=O VOYADQIFGGIKAT-UHFFFAOYSA-N 0.000 description 3
- 230000000975 bioactive effect Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- RVJFYAXPARXKHK-UHFFFAOYSA-N 2-(2,5-dioxopyrrolidin-1-yl)-4-hydrazinylpyridine-3-carboxylic acid propan-2-ylidenehydrazine Chemical compound CC(C)=NN.NNc1ccnc(N2C(=O)CCC2=O)c1C(O)=O RVJFYAXPARXKHK-UHFFFAOYSA-N 0.000 description 2
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 2
- 206010065687 Bone loss Diseases 0.000 description 2
- 108700015210 PTH-CBD fusion Proteins 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 208000017169 kidney disease Diseases 0.000 description 2
- 210000000440 neutrophil Anatomy 0.000 description 2
- 241000193403 Clostridium Species 0.000 description 1
- 208000013558 Developmental Bone disease Diseases 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 206010072610 Skeletal dysplasia Diseases 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000012062 aqueous buffer Substances 0.000 description 1
- 239000012867 bioactive agent Substances 0.000 description 1
- LNQHREYHFRFJAU-UHFFFAOYSA-N bis(2,5-dioxopyrrolidin-1-yl) pentanedioate Chemical compound O=C1CCC(=O)N1OC(=O)CCCC(=O)ON1C(=O)CCC1=O LNQHREYHFRFJAU-UHFFFAOYSA-N 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 238000010382 chemical cross-linking Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229940125782 compound 2 Drugs 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000004700 fetal blood Anatomy 0.000 description 1
- 210000003754 fetus Anatomy 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-N glutaric acid Chemical compound OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 208000037819 metastatic cancer Diseases 0.000 description 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 206010038433 renal dysplasia Diseases 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92243307P | 2007-04-09 | 2007-04-09 | |
| US60/922,433 | 2007-04-09 | ||
| PCT/US2008/004589 WO2008124166A2 (en) | 2007-04-09 | 2008-04-09 | Fusion proteins of collagen-binding domain and parathyroid hormone |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013194484A Division JP5821066B2 (ja) | 2007-04-09 | 2013-09-19 | コラーゲン結合領域と副甲状腺ホルモンとの融合タンパク |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010523671A JP2010523671A (ja) | 2010-07-15 |
| JP2010523671A5 true JP2010523671A5 (OSRAM) | 2011-05-26 |
| JP5520811B2 JP5520811B2 (ja) | 2014-06-11 |
Family
ID=39831527
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010503048A Active JP5520811B2 (ja) | 2007-04-09 | 2008-04-09 | コラーゲン結合領域と副甲状腺ホルモンとの融合タンパク |
| JP2013194484A Active JP5821066B2 (ja) | 2007-04-09 | 2013-09-19 | コラーゲン結合領域と副甲状腺ホルモンとの融合タンパク |
| JP2015173678A Active JP5989876B2 (ja) | 2007-04-09 | 2015-09-03 | コラーゲン結合領域と副甲状腺ホルモンとの融合タンパク |
| JP2016157345A Active JP6366653B2 (ja) | 2007-04-09 | 2016-08-10 | コラーゲン結合領域と副甲状腺ホルモンとの融合タンパク |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013194484A Active JP5821066B2 (ja) | 2007-04-09 | 2013-09-19 | コラーゲン結合領域と副甲状腺ホルモンとの融合タンパク |
| JP2015173678A Active JP5989876B2 (ja) | 2007-04-09 | 2015-09-03 | コラーゲン結合領域と副甲状腺ホルモンとの融合タンパク |
| JP2016157345A Active JP6366653B2 (ja) | 2007-04-09 | 2016-08-10 | コラーゲン結合領域と副甲状腺ホルモンとの融合タンパク |
Country Status (7)
| Country | Link |
|---|---|
| US (6) | US8450273B2 (OSRAM) |
| EP (2) | EP2155874B1 (OSRAM) |
| JP (4) | JP5520811B2 (OSRAM) |
| CA (2) | CA2683862C (OSRAM) |
| DK (2) | DK2155874T3 (OSRAM) |
| ES (2) | ES2583002T3 (OSRAM) |
| WO (1) | WO2008124166A2 (OSRAM) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2155874T3 (en) * | 2007-04-09 | 2016-08-01 | Univ Arkansas | FUSION PROTEIN OF COLLAGE BINDING DOMAIN AND parathyroid hormone |
| US20110294192A1 (en) * | 2008-11-19 | 2011-12-01 | Tohoku University | Fusion collagenase in which affinity tag is linked and method for producing the same |
| EP2405008A1 (en) * | 2010-07-06 | 2012-01-11 | LanthioPep B.V. | Bacterial surface display of thioether-bridge-containing peptides |
| US9173919B2 (en) | 2011-02-16 | 2015-11-03 | Purdue Research Foundation | Collagen-targeted nanoparticles |
| JP5512887B2 (ja) * | 2011-05-13 | 2014-06-04 | 学校法人北里研究所 | 成長因子アンカーリング型骨移植材料および成長因子アンカーリング型骨移植材料製造用キット |
| ES2816009T3 (es) * | 2011-12-14 | 2021-03-31 | Univ Arkansas | Administración de agentes terapéuticos mediante una proteína de unión a colágeno |
| US9526765B2 (en) | 2012-02-09 | 2016-12-27 | The Kitasato Institute | Delivery of therapeutic agents by a collagen binding protein |
| US8969290B2 (en) | 2012-06-26 | 2015-03-03 | Worcester Polytechnic Institute | Matrix scaffold with antimicrobial activity |
| WO2016085280A1 (ko) | 2014-11-28 | 2016-06-02 | 서울대학교산학협력단 | 세포 투과성 스테이플 펩타이드, 이의 제조방법 및 그 용도 |
| US11213613B2 (en) | 2015-06-12 | 2022-01-04 | Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences | Three-dimensional tissue scaffold with stem cell attracting element and use thereof |
| BR112018017091A2 (pt) | 2016-03-01 | 2019-01-02 | Ascendis Pharma Bone Diseases As | profármacos de pth |
| CN109789189B (zh) | 2016-09-29 | 2024-01-23 | 阿森迪斯药物骨疾病股份有限公司 | 控释pth化合物的剂量方案 |
| NZ751745A (en) | 2016-09-29 | 2023-05-26 | Ascendis Pharma Bone Diseases As | Pth compounds with low peak-to-trough ratios |
| ES3012647T3 (en) | 2016-09-29 | 2025-04-09 | Ascendis Pharma Bone Diseases As | Controlled-release pth compounds |
| CA3045458A1 (en) * | 2016-11-30 | 2018-06-07 | Purdue Research Foundation | Fracture targeted bone regeneration through parathyroid hormone receptor stimulation |
| WO2018148573A1 (en) * | 2017-02-10 | 2018-08-16 | The Board Of Trustees Of The University Of Arkansas | Collagen-binding agent compositions and methods of using the same |
| GB201706781D0 (en) | 2017-04-28 | 2017-06-14 | Univ Sheffield | Parathyroid hormone fusion polypeptide |
| CN107213517B (zh) * | 2017-05-17 | 2020-03-27 | 宁波大学 | 一种复合骨水泥及其制备方法 |
| JP6577683B2 (ja) * | 2017-09-22 | 2019-09-18 | 旭化成ファーマ株式会社 | 安定性に優れるテリパラチド含有液状医薬組成物 |
| KR101964376B1 (ko) * | 2017-09-29 | 2019-04-01 | 주식회사 나이벡 | 부갑상선호르몬(parathyroid hormone, PTH)에 골조직 선택성 펩타이드가 결합되어 있는 융합 펩타이드를 포함하는 약학 조성물 및 생체재료 |
| EP3796941A4 (en) | 2018-05-30 | 2022-12-28 | Purdue Research Foundation | Targeting anabolic drugs for accelerated fracture repair |
| KR102891411B1 (ko) | 2019-02-11 | 2025-11-25 | 아센디스 파마 본 디지즈 에이/에스 | Pth 접합체의 액체 약학 제제 |
| WO2021030196A1 (en) * | 2019-08-09 | 2021-02-18 | Phasebio Pharmaceuticals, Inc. | Elp fusion proteins comprising parathyroid hormone for controlled and sustained release |
| US12403179B2 (en) | 2021-02-18 | 2025-09-02 | The Board Of Trustees Of The University Of Arkansas | Release of growth factors at wound healing stages |
| JP2025534350A (ja) | 2022-09-30 | 2025-10-15 | エクステンド バイオサイエンシズ インコーポレーテッド | 長時間作用型副甲状腺ホルモン |
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| GB8516421D0 (en) | 1985-06-28 | 1985-07-31 | Biotechnology Interface Ltd | Fibronectins |
| WO1994022468A1 (en) | 1993-04-02 | 1994-10-13 | Anticancer, Inc. | Method for delivering beneficial compositions to hair follicles |
| US5925552A (en) | 1996-04-25 | 1999-07-20 | Medtronic, Inc. | Method for attachment of biomolecules to medical devices surfaces |
| WO1998004591A1 (en) | 1996-07-31 | 1998-02-05 | The General Hospital Corporation | Novel parathyroid hormone-related peptide analogs |
| US6428579B1 (en) | 1998-07-01 | 2002-08-06 | Brown University Research Foundation | Implantable prosthetic devices coated with bioactive molecules |
| US6387663B1 (en) * | 1998-07-31 | 2002-05-14 | University Of Southern California | Targeting pharmaceutical agents to injured tissues |
| US7601685B2 (en) * | 1998-08-27 | 2009-10-13 | Eidgenossische Technische Hochschule Zurich | Growth factor modified protein matrices for tissue engineering |
| EP1151116A1 (en) | 1999-02-19 | 2001-11-07 | Terumo Kabushiki Kaisha | Collagen-binding physiologically active polypeptide |
| JP2001190280A (ja) * | 1999-02-19 | 2001-07-17 | Terumo Corp | コラーゲン結合性生理活性ポリペプチド |
| US20020102709A1 (en) * | 1999-02-19 | 2002-08-01 | Tetsuya Ishikawa | Collagen-binding physiologically active polypeptide |
| US6908994B1 (en) * | 1999-05-10 | 2005-06-21 | The Texas A&M University System | Collagen-binding proteins from enterococcal bacteria |
| US20050124537A1 (en) | 2000-04-27 | 2005-06-09 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
| US20040053368A1 (en) * | 2000-08-15 | 2004-03-18 | Tetsuya Ishikawa | Collagen-binding hybrid polypeptide |
| JP2002058485A (ja) | 2000-08-16 | 2002-02-26 | Terumo Corp | コラーゲン結合性を有する骨形成促進融合蛋白質 |
| US20020063621A1 (en) | 2000-09-01 | 2002-05-30 | Next Planet, Inc. | Method and apparatus for device communications |
| US6812217B2 (en) | 2000-12-04 | 2004-11-02 | Medtronic, Inc. | Medical device and methods of use |
| JP4560291B2 (ja) | 2001-12-18 | 2010-10-13 | イジュノシッヒ テクニッヒ ホッフシューラ チューリッヒ | 組織操作のための成長因子改変タンパク質マトリクス |
| JP4750416B2 (ja) * | 2002-07-25 | 2011-08-17 | ザ ジェネラル ホスピタル コーポレイション | 副甲状腺ホルモン受容体の活性化と造血前駆細胞の増殖 |
| US7060299B2 (en) | 2002-12-31 | 2006-06-13 | Battelle Memorial Institute | Biodegradable microparticles that stabilize and control the release of proteins |
| ES2269973T3 (es) | 2003-02-13 | 2007-04-01 | Synthes Ag Chur | Mezcla inyectable para sustituir un tejido oseo. |
| US20040220094A1 (en) | 2003-05-01 | 2004-11-04 | Skinner Keith K. | Inverse agonist and agonist peptides that stimulate/inhibit hair growth |
| EP1680073B1 (en) | 2003-10-21 | 2013-01-02 | IGF Oncology, LLC | Compounds and method for treating cancer |
| WO2005046798A1 (en) * | 2003-11-12 | 2005-05-26 | Nps Allelix Corp. | Treatment of bone loss utilizing full length parathyroid hormone |
| EP1557176A1 (en) | 2004-01-26 | 2005-07-27 | Ferring B.V. | Treatment of bone metastases by means of PTH receptor agonists |
| US20090005298A1 (en) | 2004-02-27 | 2009-01-01 | The University Of Western Ontario | Bone Sialoprotein Collagen-Binding Peptides |
| HUE055861T2 (hu) | 2004-04-21 | 2021-12-28 | Alexion Pharma Inc | Csontbejuttató konjugátumok és azok alkalmazási módszere fehérjék csonthoz kötéséhez |
| EP1812082B1 (en) | 2004-10-21 | 2013-08-14 | IGF Oncology, LLC | Toxins and radionuclides coupled to IGF-1 receptor ligands for the treatment of cancer |
| WO2006073711A2 (en) * | 2005-01-06 | 2006-07-13 | Kuros Biosurgery Ag | Use of a matrix comprising a contrast agent in soft tissues |
| ATE514712T1 (de) | 2005-12-26 | 2011-07-15 | Yantai Zhenghai Bio Technology Co Ltd | Aktivierte collagen-gerüstmaterialien und ihre speziellen kondensierten aktiven restorationsfaktoren |
| DK2155874T3 (en) * | 2007-04-09 | 2016-08-01 | Univ Arkansas | FUSION PROTEIN OF COLLAGE BINDING DOMAIN AND parathyroid hormone |
| JP2010172247A (ja) | 2009-01-29 | 2010-08-12 | Kitasato Institute | 積層型高密度培養人工組織の製造方法及び積層型高密度培養人工組織 |
| JPWO2011142425A1 (ja) | 2010-05-12 | 2013-07-22 | 国立大学法人 香川大学 | 上皮層含有組織の再生材および再生評価方法 |
| JP5512887B2 (ja) | 2011-05-13 | 2014-06-04 | 学校法人北里研究所 | 成長因子アンカーリング型骨移植材料および成長因子アンカーリング型骨移植材料製造用キット |
| ES2816009T3 (es) | 2011-12-14 | 2021-03-31 | Univ Arkansas | Administración de agentes terapéuticos mediante una proteína de unión a colágeno |
| US9526765B2 (en) | 2012-02-09 | 2016-12-27 | The Kitasato Institute | Delivery of therapeutic agents by a collagen binding protein |
-
2008
- 2008-04-09 DK DK08742686.2T patent/DK2155874T3/en active
- 2008-04-09 US US12/594,547 patent/US8450273B2/en active Active
- 2008-04-09 CA CA2683862A patent/CA2683862C/en active Active
- 2008-04-09 WO PCT/US2008/004589 patent/WO2008124166A2/en not_active Ceased
- 2008-04-09 JP JP2010503048A patent/JP5520811B2/ja active Active
- 2008-04-09 EP EP08742686.2A patent/EP2155874B1/en active Active
- 2008-04-09 ES ES08742686.2T patent/ES2583002T3/es active Active
- 2008-04-09 ES ES16169069.8T patent/ES2675174T3/es active Active
- 2008-04-09 CA CA2930681A patent/CA2930681C/en active Active
- 2008-04-09 EP EP16169069.8A patent/EP3091075B1/en active Active
- 2008-04-09 DK DK16169069.8T patent/DK3091075T3/en active
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2013
- 2013-05-20 US US13/898,058 patent/US9062300B2/en active Active
- 2013-09-19 JP JP2013194484A patent/JP5821066B2/ja active Active
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2015
- 2015-06-18 US US14/743,629 patent/US9528099B2/en active Active
- 2015-09-03 JP JP2015173678A patent/JP5989876B2/ja active Active
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2016
- 2016-08-10 JP JP2016157345A patent/JP6366653B2/ja active Active
- 2016-12-22 US US15/387,817 patent/US10202434B2/en active Active
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2019
- 2019-01-16 US US16/249,540 patent/US10358471B2/en active Active
- 2019-07-22 US US16/517,988 patent/US10519213B2/en active Active
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