JP5463034B2 - ピリミジン若しくはトリアジン縮合二環式メタロプロテアーゼ阻害薬 - Google Patents

ピリミジン若しくはトリアジン縮合二環式メタロプロテアーゼ阻害薬 Download PDF

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JP5463034B2
JP5463034B2 JP2008512617A JP2008512617A JP5463034B2 JP 5463034 B2 JP5463034 B2 JP 5463034B2 JP 2008512617 A JP2008512617 A JP 2008512617A JP 2008512617 A JP2008512617 A JP 2008512617A JP 5463034 B2 JP5463034 B2 JP 5463034B2
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mixture
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JP2008540687A5 (https=
JP2008540687A (ja
Inventor
シユテーネツク，クリストフ
ゲーゲー，クリスチヤン
リヒター，フランク
ホーホゲルテル，マテイアス
フオイアーシユタイン，テイム
ブルーム，ハラルト
スチヨライキ，アービング
ボアー，ユルゲン
ウー，シンユワン
シユナイダー，マテイアス
ノルテ，ベルト
ギヤラガー，ブライアン
バン・ベルデイーゼン，ジヨシユア
デン，ホンボー
エツサース，ミヒヤエル
クロート，ハイコ
キーリイ，アンドリユー
パワーズ，テイモシー
タベラズ，アーサー・ジー
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アラントス・フアーマシユーテイカルズ・ホールデイング・インコーポレイテツド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Nutrition Science (AREA)
  • Virology (AREA)
  • Endocrinology (AREA)
JP2008512617A 2005-05-20 2006-05-22 ピリミジン若しくはトリアジン縮合二環式メタロプロテアーゼ阻害薬 Expired - Fee Related JP5463034B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US68347005P 2005-05-20 2005-05-20
US60/683,470 2005-05-20
US70646505P 2005-08-08 2005-08-08
US60/706,465 2005-08-08
US73499105P 2005-11-09 2005-11-09
US60/734,991 2005-11-09
PCT/US2006/020970 WO2006128184A2 (en) 2005-05-20 2006-05-22 Pyrimidine or triazine fused bicyclic metalloprotease inhibitors

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2013089076A Division JP5391351B2 (ja) 2005-05-20 2013-04-22 ヘテロ二環式メタロプロテアーゼ阻害薬
JP2013254709A Division JP2014088396A (ja) 2005-05-20 2013-12-10 ヘテロ二環式メタロプロテアーゼ阻害薬

Publications (3)

Publication Number Publication Date
JP2008540687A JP2008540687A (ja) 2008-11-20
JP2008540687A5 JP2008540687A5 (https=) 2009-07-30
JP5463034B2 true JP5463034B2 (ja) 2014-04-09

Family

ID=37239216

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2008512617A Expired - Fee Related JP5463034B2 (ja) 2005-05-20 2006-05-22 ピリミジン若しくはトリアジン縮合二環式メタロプロテアーゼ阻害薬
JP2013089076A Expired - Fee Related JP5391351B2 (ja) 2005-05-20 2013-04-22 ヘテロ二環式メタロプロテアーゼ阻害薬
JP2013254709A Withdrawn JP2014088396A (ja) 2005-05-20 2013-12-10 ヘテロ二環式メタロプロテアーゼ阻害薬

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2013089076A Expired - Fee Related JP5391351B2 (ja) 2005-05-20 2013-04-22 ヘテロ二環式メタロプロテアーゼ阻害薬
JP2013254709A Withdrawn JP2014088396A (ja) 2005-05-20 2013-12-10 ヘテロ二環式メタロプロテアーゼ阻害薬

Country Status (13)

Country Link
US (2) US20060293345A1 (https=)
EP (1) EP1910367A2 (https=)
JP (3) JP5463034B2 (https=)
KR (1) KR20080087070A (https=)
CN (1) CN101238127A (https=)
AU (1) AU2006251989B2 (https=)
BR (1) BRPI0609802A2 (https=)
CA (1) CA2608890C (https=)
CR (1) CR9614A (https=)
EA (1) EA013525B1 (https=)
IL (1) IL187495A0 (https=)
NO (1) NO20076554L (https=)
WO (1) WO2006128184A2 (https=)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
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US20070155737A1 (en) * 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
US20070155738A1 (en) 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
AU2007321923A1 (en) * 2006-11-20 2008-05-29 Alantos Pharmaceuticals Holding, Inc. Heterobicyclic matrix metalloprotease inhibitors
WO2008063671A2 (en) * 2006-11-20 2008-05-29 Alantos Pharmaceuticals Holding, Inc. Heterobicyclic metalloprotease inhibitors
AU2008223348A1 (en) * 2007-03-07 2008-09-12 Alantos Pharmaceuticals Holding, Inc. Metalloprotease inhibitors containing a heterocyclic moiety
WO2008149181A1 (en) 2007-06-04 2008-12-11 Techfields Inc Pro-drugs of nsaias with very high skin and membranes penetration rates and their new medicinal uses
WO2009075790A1 (en) * 2007-12-07 2009-06-18 Alantos Pharmaceuticals Holding, Inc. Metalloprotease inhibitors for intra-articular application
RU2529484C2 (ru) 2008-05-05 2014-09-27 Санофи-Авентис Ациламино-замещенные производные конденсированных циклопентанкарбоновых кислот и их применение в качестве фармацевтических средств
WO2010065936A1 (en) 2008-12-04 2010-06-10 Chongxi Yu High penetration compositions and their applications
AR079022A1 (es) 2009-11-02 2011-12-21 Sanofi Aventis Derivados de acido carboxilico ciclico sustituidos con acilamino, su uso como productos farmaceuticos, composicion farmaceutica y metodo de preparacion
CN101709034B (zh) * 2009-12-14 2017-05-31 大连九信精细化工有限公司 双环[2.2.2]辛烷‑1，4‑二羧酸单甲酯的合成方法
US8343977B2 (en) 2009-12-30 2013-01-01 Arqule, Inc. Substituted triazolo-pyrimidine compounds
DK2649075T3 (en) 2010-12-08 2018-07-30 Us Health SUBSTITUTED PYRAZOLOPYRIMIDINES AS GLUCOCEREBROSIDASE ACTIVATORS
WO2012178125A1 (en) 2011-06-22 2012-12-27 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
KR101935868B1 (ko) 2011-12-30 2019-04-03 에스케이이노베이션 주식회사 폴리프로필렌 카보네이트 발포체 조성물 제조방법 및 이로부터 제조된 성형품
CN116898848A (zh) 2012-01-18 2023-10-20 苏州泰飞尔医药有限公司 治疗肺部疾病的高穿透力前药组合物和医药组合物
SI2941432T1 (en) 2012-12-07 2018-07-31 Vertex Pharmaceuticals Incorporated 2-AMINO-6-FLUORO-N- (5-FLUORO-4- (4- (4- (OXETHAN-3-YL) PIPERAZIN-1-CARBONYL) PIPERIDIN-1-YLIPRIDIN-3-YL) 1,5 ALFA) PYRIMIDINE-3-CARBOXAMIDE AS ATR KINAZE INHIBITOR
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